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name Structure Reference Source Properties Activities Metabolism

Harman

alkaplorer_id: AK000001

Synonym: None

IUPAC_name: 1-methyl-9H-pyrido[3,4-b]indole

Structure

SMILES: CC1=NC=CC2=C1NC1=CC=CC=C12

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InChI: InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

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InChIKey: PSFDQSOCUJVVGF-UHFFFAOYSA-N

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Reference

DOI

PubChem ID:5281404

Cas ID:486-84-0

Source

Species Genus Family Order Class Phylum Kingdom Superkingdom
Ophiorrhiza liukiuensis Ophiorrhiza Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae

Properties Information

Molecule Weight: 182.226

TPSA: 28.68

MolLogP: 3.0245200000000008

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 3

Activities Information

organism target_name standard_type standard_value standard_units doi
Homo sapiens Histone deacetylase 6 Inhibition -27.15 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -4.98 % 10.6019/CHEMBL4808148
Alternaria solani Alternaria solani Activity 68.4 % 10.1016/j.ejmech.2021.114057
Bipolaris maydis Bipolaris maydis Activity 36.4 % 10.1016/j.ejmech.2021.114057
Homo sapiens Indoleamine 2,3-dioxygenase Inhibition 34.0 % 10.1021/acs.jmedchem.2c00677
Homo sapiens Tryptophan 2,3-dioxygenase Inhibition 85.0 % 10.1021/acs.jmedchem.2c00677
Homo sapiens Tryptophan 2,3-dioxygenase IC50 6310.0 nM 10.1021/acs.jmedchem.2c00677
Rattus norvegicus GABA-A receptor; anion channel IC50 12387.97 nM 10.1021/jm950589q
Rattus norvegicus GABA-A receptor; anion channel Ki 12400.0 nM 10.1021/jm00351a015
Rattus norvegicus GABA-A receptor; anion channel IC50 12387.97 nM 10.1021/jm00072a012
Homo sapiens GABA-A receptor; anion channel IC50 12302.69 nM 10.1021/jm970488n
Rattus norvegicus GABA-A receptor; anion channel IC50 12400.0 nM 10.1021/jm00171a007
None Unchecked Activity 27.0 pg/microg/hr 10.1016/j.bmc.2007.05.075
None Unchecked Activity 20.0 pg/microg/hr 10.1016/j.bmc.2007.05.075
None Unchecked Activity 37.0 pg/microg/hr 10.1016/j.bmc.2007.05.075
None Unchecked Ki 36.0 nM 10.1016/j.bmc.2007.05.075
None Unchecked Ki 54.0 nM 10.1016/j.bmc.2007.05.075
None Unchecked Ki 12000.0 nM 10.1016/j.bmc.2007.05.075
None Unchecked IC50 12302.69 nM 10.1016/j.ejmech.2007.09.004
Homo sapiens HepG2 IC50 115000.0 nM 10.1016/j.bmcl.2008.10.043
Homo sapiens Bel-7402 IC50 151000.0 nM 10.1016/j.bmcl.2008.10.043
Homo sapiens HeLa IC50 186000.0 nM 10.1016/j.bmcl.2008.10.043
Homo sapiens BGC-823 IC50 215000.0 nM 10.1016/j.bmcl.2008.10.043
None Unchecked IC50 12302.69 nM 10.1016/j.ejmech.2008.01.030
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 105.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 90.0 % 10.1042/bj20070797
None Unchecked Activity 102.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 80.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Activity 104.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Activity 90.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Activity 99.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Activity 85.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Activity 81.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 44.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 72.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 128.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Activity 82.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 82.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 112.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Activity 88.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 81.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens THP-1 IC50 121000.0 nM 10.1016/j.bmc.2009.08.057
Plasmodium falciparum Plasmodium falciparum IC50 7100.0 nM 10.1016/j.bmc.2009.08.057
Plasmodium falciparum Plasmodium falciparum IC50 12100.0 nM 10.1016/j.bmc.2009.08.057
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
None Unchecked Inhibition nan % 10.1038/nchembio873
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
None Unchecked Potency 10000.0 nM None
Trypanosoma cruzi Cruzipain Potency 25118.9 nM None
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 1995.3 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 25118.9 nM None
Bacillus anthracis Anthrax lethal factor Potency 1995.3 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 12589.3 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 22387.2 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 3162.3 nM None
None NON-PROTEIN TARGET EC50 14400.0 nM 10.1128/aac.01614-08
None ADMET Ratio 2.0 None 10.1128/aac.01614-08
None ADMET TC50 40.0 uM 10.1128/aac.01614-08
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 21192.3 nM None
None Unchecked Potency 16360.1 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 15848.9 nM None
Homo sapiens Cytochrome P450 2D6 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 22387.2 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 56234.1 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 100000.0 nM None
None Unchecked Potency 31622.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 31622.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 39810.7 nM None
None Unchecked Potency 15848.9 nM None
Leishmania infantum Leishmania infantum IC50 270.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania infantum Leishmania infantum IC50 19200.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 19200.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 270.0 nM 10.1016/j.bmcl.2014.06.030
Homo sapiens HEK-293T Activity nan None 10.1021/ml500516r
Onchocerca volvulus Chitinase IC50 7330.0 nM 10.1021/ml500516r
Onchocerca volvulus Onchocerca volvulus Inhibition nan % 10.1021/ml500516r
Onchocerca volvulus Onchocerca volvulus Activity nan None 10.1021/ml500516r
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.85 % 10.21203/rs.3.rs-23951/v1
Leishmania infantum Leishmania infantum IC50 19200.0 nM 10.1016/j.ejmech.2016.08.014
Homo sapiens KB ED50 8.9 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens A549 ED50 9.3 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens CAKI-1 ED50 8.0 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens MCF7 ED50 19.0 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens 1A9 ED50 6.1 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens SK-MEL-2 ED50 20.0 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens U-87 MG ED50 19.0 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens HEL ED50 9.8 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 16.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 17.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 15.0 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens H9 IC50 111500.0 nM 10.1021/np0101189
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10700.0 nM 10.1021/np0101189
None ADMET Ratio IC50/EC50 10.4 None 10.1021/np0101189
Trichophyton mentagrophytes Trichophyton mentagrophytes MID 3.7 ug ml-1 10.1021/np8007655
Candida albicans Candida albicans MID 1.9 ug ml-1 10.1021/np8007655
Bacillus subtilis Bacillus subtilis MID 7.5 ug ml-1 10.1021/np8007655
Mus musculus P388 IC50 12.5 ug.mL-1 10.1021/np8007655
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 98.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Activity 100.0 % 10.1042/bj20070797
Gallus gallus Tyrosine-protein kinase SRC Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 101.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Activity 107.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Activity 70.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 79.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 105.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 74.0 % 10.1042/bj20070797
None NON-PROTEIN TARGET IC50 130000.0 nM 10.1021/jm901816j
Homo sapiens Lysine-specific demethylase 4D-like Potency 31622.8 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 31622.8 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 7943.3 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 22387.2 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
None Unchecked Potency 12589.3 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
Trypanosoma cruzi Cruzipain Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 11220.2 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 562.3 nM None
None NON-PROTEIN TARGET Potency 14125.4 nM None
None NON-PROTEIN TARGET Potency 15848.9 nM None
Homo sapiens MAP kinase ERK2 Potency 100000.0 nM None
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
Homo sapiens Bloom syndrome protein Potency 19952.6 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 31622.8 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 35481.3 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2D6 Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
Homo sapiens Cytochrome P450 2D6 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 2D6 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 3981.1 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 756.9 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 15003.0 nM None
None Unchecked Potency 19952.6 nM None
None NON-PROTEIN TARGET IC50 130000.0 nM 10.1016/j.ejmech.2011.09.027
Electrophorus electricus Acetylcholinesterase IC50 20910.0 nM 10.1016/j.bmcl.2012.02.057
Electrophorus electricus Acetylcholinesterase Inhibition 83.19 % 10.1016/j.bmcl.2012.02.057
Homo sapiens Acetylcholinesterase IC50 nan None 10.1016/j.bmcl.2012.02.057
Homo sapiens Acetylcholinesterase Inhibition 43.54 % 10.1016/j.bmcl.2012.02.057
Homo sapiens DNA repair and recombination protein RAD54-like AC50 58370.0 nM None
None Unchecked IC50 12302.69 nM 10.1007/s00044-008-9111-6
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23715.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20596.2 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 81.51 % 10.1124/mol.112.084152
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 71.52 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.5 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Trichophyton interdigitale Trichophyton interdigitale MIC 200.0 ug.mL-1 10.1016/j.ejmech.2021.114057
Candida albicans Candida albicans MIC 583000.0 ug.mL-1 10.1016/j.ejmech.2021.114057
Homo sapiens DNA topoisomerase I ED50 23.8 ug ml-1 10.1016/j.ejmech.2021.113321
Homo sapiens Acetylcholinesterase IC50 10000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 1800.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Monoamine oxidase A IC50 29.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens GABA-A receptor; anion channel IC50 2500.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cytochrome P450 2D6 Ki 86000.0 nM 10.1021/jm00061a004
Homo sapiens Cyclin-dependent kinase 5 Inhibition 65.0 % 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 2 Inhibition 47.0 % 10.1016/s0960-894x(02)00094-x
Escherichia coli Escherichia coli MIC 60.0 ug 10.1021/np50076a023
Bacillus subtilis Bacillus subtilis MIC 7.5 ug 10.1021/np50076a023
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 60.0 ug 10.1021/np50076a023
Candida albicans Candida albicans MIC 1.9 ug 10.1021/np50076a023
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 3.7 ug 10.1021/np50076a023
Amorphotheca resinae Amorphotheca resinae MIC 15.0 ug 10.1021/np50076a023
Mus musculus P388 IC50 25.0 ug.mL-1 10.1021/np50076a023
Human alphaherpesvirus 1 Human alphaherpesvirus 1 IZ nan None 10.1021/np50076a023
Poliovirus 1 Poliovirus 1 IZ nan None 10.1021/np50076a023
None ADMET IZ nan None 10.1021/np50076a023
Trypanosoma cruzi Trypanothione reductase Inhibition 10.0 % 10.1016/j.bmc.2008.05.074
Homo sapiens Rho-associated protein kinase 2 Activity 104.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Activity 90.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Activity 90.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 103.0 % 10.1042/bj20070797
None Unchecked Activity 112.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 106.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 87.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Activity 101.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Activity 91.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Activity 86.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 93.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 103.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 99.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Activity 108.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 76.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Activity 92.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Activity 84.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Activity 89.0 % 10.1042/bj20070797
Mus musculus Tyrosine-protein kinase LCK Activity 93.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Activity 109.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Activity 104.0 % 10.1042/bj20070797
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 1995.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 15848.9 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
Equus caballus Ferritin light chain Potency 39810.7 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Equus caballus Ferritin light chain Potency 11220.2 nM None
Equus caballus Ferritin light chain Potency 19952.6 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 35481.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Neuropeptide S receptor Potency 5011.9 nM None
Homo sapiens Cytochrome P450 3A4 Potency 3981.1 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 9196.2 nM None
Homo sapiens Cytochrome P450 1A2 AC50 1258.93 nM None
Homo sapiens Cytochrome P450 3A4 AC50 3981.07 nM None
Homo sapiens Cytochrome P450 1A2 AC50 630.96 nM None
Homo sapiens DNA polymerase iota Potency 100000.0 nM None
Homo sapiens HepG2 Potency 2238.7 nM None
None Unchecked Potency 2818.4 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 79432.8 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 28183.8 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 19952.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 26608.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 25929.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 14963.1 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 99.56 % 10.1124/mol.112.084152
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 7079.5 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 44668.4 nM None
Homo sapiens Protein-tyrosine phosphatase 1B Inhibition 7.7 % 10.1016/j.bmcl.2015.03.014
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1039/C5MD00581G
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1039/C5MD00581G
Homo sapiens HeLa IC50 100000.0 nM 10.1039/C5MD00581G
Homo sapiens A549 IC50 100000.0 nM 10.1039/C5MD00581G
Homo sapiens MCF7 IC50 100000.0 nM 10.1039/C5MD00581G
Homo sapiens HL-60 IC50 10000.0 nM 10.1021/acs.jnatprod.6b01146
Homo sapiens PC-3 IC50 10000.0 nM 10.1021/acs.jnatprod.6b01146
Homo sapiens SGC-7901 IC50 10000.0 nM 10.1021/acs.jnatprod.6b01146
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 ug.mL-1 10.1016/j.ejmech.2018.10.012
Bos taurus Calf thymus DNA Activity nan None 10.1016/j.bmcl.2016.08.047
Bos taurus Calf thymus DNA Tm 65.0 degrees C 10.1016/j.bmcl.2016.08.047
Bos taurus Calf thymus DNA Activity nan None 10.1016/j.bmcl.2016.08.047
Bos taurus Calf thymus DNA Delta Tm 4.0 degrees C 10.1016/j.bmcl.2016.08.047
Bos taurus Calf thymus DNA Activity nan None 10.1016/j.bmcl.2016.08.047
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.5 % 10.6019/CHEMBL4495565

Metabolism Information