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Strychnine

alkaplorer_id: AK000008

Synonym: None

IUPAC_name: (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one

Structure

SMILES: O=C1C[C@@H]2OCC=C3CN4CC[C@]56C7=CC=CC=C7N1[C@H]5[C@H]2[C@H]3C[C@H]46

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InChI: InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

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InChIKey: QMGVPVSNSZLJIA-FVWCLLPLSA-N

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Reference

DOI

PubChem ID:441071

Cas ID:None

Source

Species Genus Family Order Class Phylum Kingdom Superkingdom
Pulicaria vulgaris Pulicaria Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae

Properties Information

Molecule Weight: 334.41900000000004

TPSA: 32.78

MolLogP: 2.0925

Number of H-Donors: 0

Number of H-Acceptors: 3

RingCount: 7

Activities Information

organism target_name standard_type standard_value standard_units doi
Homo sapiens Glycine receptor subunit alpha-1 IC50 150.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor subunit alpha-1 IC50 151.36 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor (alpha-1/beta) IC50 510.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor (alpha-1/beta) IC50 512.86 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor subunit alpha-1 IC50 50.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor (alpha-1/beta) IC50 60.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor subunit alpha-1 Ki 5.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor subunit alpha-1 IC50 134.0 nM 10.1021/acs.jnatprod.0c01030
Homo sapiens Glycine receptor subunit alpha-1 IC50 27.0 nM 10.1021/acs.jnatprod.0c01030
Mus musculus Mus musculus Retention 70.0 % 10.1021/jm00135a020
Mus musculus Mus musculus Retention 75.0 % 10.1021/jm00135a020
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) IC50 21000.0 nM 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 35.7 % 10.1021/jm00381a019
Homo sapiens GABA-C receptor Kb 69000.0 nM 10.1021/jm9904349
None Unchecked IC50 14.0 nM 10.1021/jm060585t
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 251.2 nM None
Homo sapiens A549 IC50 40000.0 nM 10.1021/np300339r
Homo sapiens SW480 IC50 40000.0 nM 10.1021/np300339r
Homo sapiens Glycine receptor (alpha-1/beta) IC50 181.97 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor (alpha-1/beta) IC50 180.0 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor subunit alpha-1 IC50 93.33 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor subunit alpha-1 IC50 93.0 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor subunit alpha-1 IC50 51.0 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor (alpha-1/beta) IC50 58.0 nM 10.1021/acs.jnatprod.6b00479
Rattus norvegicus Glycine receptor subunit alpha-1 Ki 12.0 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Glycine receptor subunit alpha-1 Ki 23.0 nM 10.1021/acs.jnatprod.6b00479
Homo sapiens Taste receptor type 2 member 46 Ratio 0.122 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.125 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.166 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.19 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.248 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.406 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.719 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.117 None None
Homo sapiens Taste receptor type 2 member 46 Ratio 0.096 None None
Homo sapiens Taste receptor type 2 member 46 EC50 690.0 nM None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
None Unchecked IC50 190000.0 nM 10.1016/j.bmcl.2004.05.031
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
None Unchecked IC50 16.0 nM 10.1016/j.bmc.2010.07.034
Homo sapiens Histone acetyltransferase GCN5 Potency 25118.9 nM None
None Unchecked Ki nan None None
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Rattus norvegicus Glycine receptor IC50 8.295 nM None
Rattus norvegicus Glycine receptor Ki 4.689 nM None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
Homo sapiens MCF7 IC50 40000.0 nM 10.1021/np300339r
None Unchecked Potency 35481.3 nM None
Homo sapiens Taste receptor type 2 member 10 EC50 5000.0 nM None
Homo sapiens Taste receptor type 2 member 10 Activity 0.1 uM None
Homo sapiens Taste receptor type 2 member 10 Activity 0.003 mM None
Homo sapiens Taste receptor type 2 member 10 EC50 40000.0 nM None
None ADMET LD50 0.96 mg.kg-1 10.1016/j.bmc.2021.116560
Homo sapiens HEK-293T Growth Rate 0.93 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.94 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.44 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.86 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.65 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.95 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.85 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.88 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.77 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.87 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.91 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.75 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.71 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.92 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.57 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.93 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.81 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.91 None 10.6019/CHEMBL5303304
Homo sapiens Muscarinic acetylcholine receptor M1 Affinity 4.9 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M1 Affinity 4.9 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M2 Affinity 5.0 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M2 Affinity 5.3 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M3 Affinity 4.2 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M3 Affinity 4.0 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M4 Affinity 5.0 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M4 Affinity 5.2 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M1 Cooperativity 1.19 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M2 Cooperativity 2.0 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M3 Cooperativity 0.8 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M4 Cooperativity 2.0 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M1 Cooperativity 0.8 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M2 Cooperativity 0.2 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M3 Cooperativity 0.2 None 10.1021/jm970799y
Homo sapiens Muscarinic acetylcholine receptor M4 Cooperativity 0.8 None 10.1021/jm970799y
None Unchecked IC50 14.0 nM 10.1021/jm061056s
Cricetulus griseus CHO Activity nan None 10.1021/np50028a027
Cricetulus griseus CHO Activity nan None 10.1021/np50028a027
None No relevant target LogP 1.93 None 10.1021/jm9003945
None No relevant target log K 0.06 None 10.1021/jm9003945
None No relevant target log K 1.18 None 10.1021/jm9003945
Mus musculus Mus musculus ED50 17.4 mg.kg-1 10.1021/jm901688m
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
None Unchecked IC50 nan None None
None Unchecked Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens SMMC-7721 IC50 40000.0 nM 10.1021/np300339r
Homo sapiens HL-60 IC50 40000.0 nM 10.1021/np300339r
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 93.97 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 79.74 % 10.1124/mol.112.084152
None Molecular identity unknown Potency 70794.6 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Potency 31622.8 nM None
Homo sapiens Glycine receptor (alpha-1/beta) IC50 512.86 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor subunit alpha-1 IC50 151.36 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor subunit alpha-1 Ki 123.0 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor (alpha-1/beta) IC50 58.0 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor subunit alpha-1 IC50 51.0 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor (alpha-1/beta) IC50 510.0 nM 10.1021/acs.jnatprod.9b00180
Homo sapiens Glycine receptor subunit alpha-1 IC50 150.0 nM 10.1021/acs.jnatprod.9b00180

Metabolism Information