Navigation

name Structure Reference Source Properties Activities Metabolism

Quinidine

AlkaPlorer ID: AK000041

Synonym: None

IUPAC Name: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-1-ium-4-yl)methanol

Structure

SMILES: C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)C1=CC=[NH+]C2=CC=C(OC)C=C12

copy

InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/p+1/t13-,14-,19+,20-/m0/s1

copy

InChIKey: LOUPRKONTZGTKE-LHHVKLHASA-O

copy

Properties Information

Molecule Weight: 325.43200000000013

TPSA？: 46.84

MolLogP？: 2.5923000000000007

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 15.14 % 10.6019/CHEMBL4513141
Candida albicans Candida albicans Inhibition -0.46 % 10.6019/CHEMBL4513141
Canis lupus familiaris Canis familiaris Activity 21.0 bpm 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Activity 24.0 bpm 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Activity 25.0 % 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Activity 31.0 bpm 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Activity 46.0 % 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Activity 89.0 % 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Actual duraction 60.0 min 10.1021/jm00357a026
Canis lupus familiaris Canis familiaris ADI 0.4 None 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris APD95 -39.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris APD95 -24.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris APD95 -21.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris APD95 -19.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris APD95 -9.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris AR 2.2 None 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris CT 7.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 10.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 11.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 15.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 17.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 38.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 51.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 72.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris CT 79.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Delta APD95 -17.0 % 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris Delta APD95 -14.0 % 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris Delta APD95 -4.0 % 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris Delta APD95 2.0 % 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris Delta APD95 4.0 % 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris DOSE 9.0 mg.kg-1 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris DOSE 10.5 mg.kg-1 10.1021/jm00376a022
Canis lupus familiaris Canis familiaris DOSE 10.5 mg.kg-1 10.1021/jm00381a006
Canis lupus familiaris Canis familiaris Duration 60.0 min 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris Duration 60.0 min 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris Duration 90.0 min 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris Duration 110.0 min 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris Duration 120.0 min 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris Duration 240.0 min 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris Duration 300.0 min 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris Duration of reversal 31.0 min 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris ED50 1.0 mg.kg-1 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris ED50 1.0 mg.kg-1 10.1021/jm00388a005
Canis lupus familiaris Canis familiaris ED50 5.5 mg.kg-1 10.1021/jm00388a005
Canis lupus familiaris Canis familiaris ED50 10.0 mg.kg-1 10.1021/jm00164a025
Canis lupus familiaris Canis familiaris ED75 9.4 mg kg-1 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Effective dose 1.0 mg kg-1 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Effective dose 3.0 mg kg-1 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Effective dose 5.0 mg kg-1 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Effective dose 10.0 mg kg-1 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Effective dose 15.0 mg kg-1 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 9.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 14.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 21.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 22.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 24.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 27.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FRP 46.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris FSC 25.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris FSC 56.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris FSC 67.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris Heart rate 170.0 min-1 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris Heart rate 211.0 min-1 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris HR -42.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris HR -39.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris HR -22.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris HR -18.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris ISC 5.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris ISC 9.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris LV FRP 13.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris LV FRP 16.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris LV FRP 20.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris LV FRP 28.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Mean blood pressure -7.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Mean blood pressure -4.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Mean blood pressure 2.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Mean blood pressure 15.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris MED 7.5 mg kg-1 10.1021/jm00202a005
Canis lupus familiaris Canis familiaris MED 12.8 mg kg-1 10.1021/jm00202a005
Canis lupus familiaris Canis familiaris MED 13.5 mg kg-1 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris MED 30.0 mg kg-1 10.1021/jm00074a017
Canis lupus familiaris Canis familiaris No. of dogs reverted 10.0 None 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris No. of dogs used 13.0 None 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris Onset of action 110.0 min 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris Ouabain 59.0 ug kg-1 10.1021/jm00176a014
Canis lupus familiaris Canis familiaris Reduction 57.0 % 10.1021/jm00184a008
Canis lupus familiaris Canis familiaris Sinus beats 4.2 % 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris Sinus beats 14.1 % 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris Sinus beats 58.3 % 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris Sinus beats 74.1 % 10.1021/jm00375a010
Canis lupus familiaris Canis familiaris SRR 50.0 % 10.1021/jm00134a007
Canis lupus familiaris Canis familiaris TIME 0.0 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris TIME 0.1333 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris TIME 0.25 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris TIME 0.3833 hr 10.1021/jm00202a005
Canis lupus familiaris Canis familiaris TIME 0.5 hr 10.1021/jm00202a005
Canis lupus familiaris Canis familiaris TIME 0.55 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris TIME 0.6 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris TIME 1.3 hr 10.1021/jm00213a021
Canis lupus familiaris Canis familiaris Vmax -53.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Vmax -40.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Vmax -19.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Vmax -11.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Vmax -10.0 % 10.1021/jm00395a014
Canis lupus familiaris Canis familiaris Vmax 10.0 % 10.1021/jm00395a014
Canis lupus familiaris MDCK Papp 9.98 10'-6 cm/s 10.1016/j.ejmech.2015.10.040
Canis lupus familiaris MDCK Papp 23.39 10'-6 cm/s 10.1016/j.ejmech.2015.10.040
Canis lupus familiaris MDCK Ratio 2.34 None 10.1016/j.ejmech.2015.10.040
Cavia porcellus Aorta Activity 30.0 % 10.1021/jm201197z
Cavia porcellus Aorta Inhibition 30.0 % 10.1021/jm060878m
Cavia porcellus Aorta Inhibition 30.0 % 10.1021/jm100298d
Cavia porcellus Cavia porcellus Activity 1.15 None 10.1021/jm00176a014
Cavia porcellus Cavia porcellus Average dose 195.4 ug kg-1 10.1021/jm00157a005
Cavia porcellus Cavia porcellus Average dose 291.1 ug kg-1 10.1021/jm00157a005
Cavia porcellus Cavia porcellus Average dose 313.9 ug kg-1 10.1021/jm00157a005
Cavia porcellus Cavia porcellus Change 28.0 % 10.1021/jm00164a025
Cavia porcellus Cavia porcellus Decrease 26.4 % 10.1021/jm00375a010
Cavia porcellus Cavia porcellus dP/dt20 2.5 mg kg-1 10.1021/jm00074a017
Cavia porcellus Cavia porcellus EC30 6.5 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC30 7.2 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC30 62.0 ug ml-1 10.1021/jm00185a013
Cavia porcellus Cavia porcellus EC50 8.34 umol/Kg 10.1016/j.ejmech.2007.12.025
Cavia porcellus Cavia porcellus EC50 2818382.93 nM 10.1016/j.ejmech.2007.12.025
Cavia porcellus Cavia porcellus ED20 7.2 mg kg-1 10.1021/jm00074a017
Cavia porcellus Cavia porcellus Emax 78.6 ms 10.1016/j.ejmech.2007.12.025
Cavia porcellus Cavia porcellus Inhibition 62.0 % 10.1021/jm00376a022
Cavia porcellus Cavia porcellus Inhibition 62.0 % 10.1021/jm00381a006
Cavia porcellus Cavia porcellus Kd 1000.0 nM 10.1021/jm00376a022
Cavia porcellus Cavia porcellus MED 1.0 mg kg-1 10.1021/jm00074a017
Cavia porcellus Heart Activity -36.3 % 10.1021/jm00225a009
Cavia porcellus Heart Activity -36.1 % 10.1021/jm00225a009
Cavia porcellus Heart Activity -28.6 % 10.1021/jm00225a009
Cavia porcellus Heart Activity -22.8 % 10.1021/jm00225a009
Cavia porcellus Heart Activity -18.8 % 10.1021/jm00225a009
Cavia porcellus Heart Activity -13.3 % 10.1021/jm00225a009
Cavia porcellus Heart Activity 25.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 27.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 31.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 35.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 39.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 53.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 54.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 57.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 60.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 70.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 107.0 % 10.1021/jm100298d
Cavia porcellus Heart Activity 107.0 None 10.1021/jm060878m
Cavia porcellus Heart Activity 123.0 % 10.1021/jm100298d
Cavia porcellus Heart Activity 123.0 None 10.1021/jm060878m
Cavia porcellus Heart Activity 140.0 % 10.1021/jm100298d
Cavia porcellus Heart Activity 140.0 None 10.1021/jm060878m
Cavia porcellus Heart Activity 153.0 % 10.1021/jm100298d
Cavia porcellus Heart Activity 153.0 None 10.1021/jm060878m
Cavia porcellus Heart Activity 158.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 160.0 % 10.1021/jm100298d
Cavia porcellus Heart Activity 160.0 None 10.1021/jm060878m
Cavia porcellus Heart Activity 170.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 182.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 200.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity 229.0 ms 10.1021/jm060878m
Cavia porcellus Heart Activity nan None 10.1021/jm00225a009
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 15600.0 nM 10.1002/jat.2784
Cavia porcellus Voltage-dependent L-type calcium channel subunit alpha-1C IC50 15600.0 nM 10.1093/cvr/cvr044
Cryptococcus neoformans Cryptococcus neoformans Inhibition 2.25 % 10.6019/CHEMBL4513141
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.bmc.2012.09.040
Entamoeba histolytica Entamoeba histolytica IC50 16.6 ug.mL-1 10.1007/s00044-011-9767-1
Equus caballus Cholinesterase IC50 7370.0 nM 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli Inhibition -1.55 % 10.6019/CHEMBL4513141
Escherichia coli K-12 Beta-lactamase AmpC Potency 8912.5 nM None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 12589.3 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 922.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 3700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 12000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 6499.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 17999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Ataxin-2 Potency 35481.3 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 64000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump Activity nan None 10.1023/a:1023278211849
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Butyrylcholinesterase IC50 1230.0 nM 10.1016/j.bmc.2012.09.040
Homo sapiens Caco-2 logPapp -4.73 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 logPapp -4.69 None 10.1016/j.bmc.2009.08.022
Homo sapiens Caco-2 logPapp -4.25 None 10.1016/j.bmc.2011.03.011
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 64.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 1 Ki nan None 10.1023/a:1016192413308
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholesterol 24-hydroxylase Activity 68.0 % None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 IC50 nan None 10.1016/j.ejmech.2016.03.083
Homo sapiens Cytochrome P450 1A2 Inhibition 23.0 % 10.1021/jm401067s
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1B1 Inhibition nan % 10.1016/j.ejmech.2020.112235
Homo sapiens Cytochrome P450 2C19 Activity nan None 10.1021/jm801084u
Homo sapiens Cytochrome P450 2C19 IC50 nan None 10.1016/j.ejmech.2016.03.083
Homo sapiens Cytochrome P450 2C19 Ratio IC50 2.0 None 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Activity nan None 10.1021/jm801084u
Homo sapiens Cytochrome P450 2C9 IC50 nan None 10.1016/j.ejmech.2016.03.083
Homo sapiens Cytochrome P450 2C9 Inhibition 9.0 % 10.1021/jm401067s
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki 32000.0 nM 10.1021/jm030972s
Homo sapiens Cytochrome P450 2D6 Activity 0.0 % 10.1371/journal.pmed.0030466
Homo sapiens Cytochrome P450 2D6 Activity 21.0 % 10.1021/acs.jmedchem.6b00624
Homo sapiens Cytochrome P450 2D6 Activity 28.4 % 10.1021/acs.jmedchem.1c00271
Homo sapiens Cytochrome P450 2D6 Activity 74.2 % 10.1021/acs.jmedchem.1c00271
Homo sapiens Cytochrome P450 2D6 Activity nan None None
Homo sapiens Cytochrome P450 2D6 IC50 2.0 nM 10.1021/jm400766k
Homo sapiens Cytochrome P450 2D6 IC50 3.3 nM 10.1021/jm0209578
Homo sapiens Cytochrome P450 2D6 IC50 6.0 nM 10.1016/j.bmcl.2014.07.026
Homo sapiens Cytochrome P450 2D6 IC50 6.9 nM 10.1016/j.bmc.2017.07.058
Homo sapiens Cytochrome P450 2D6 IC50 7.3 nM 10.1021/acs.jmedchem.0c00564
Homo sapiens Cytochrome P450 2D6 IC50 8.1 nM 10.1021/acs.jmedchem.9b00062
Homo sapiens Cytochrome P450 2D6 IC50 9.0 nM 10.1021/acs.jmedchem.6b00030
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1021/acs.jmedchem.8b01464
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1021/acs.jmedchem.9b00952
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1021/jm049934e
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1021/jm1009082
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1021/np100665j
Homo sapiens Cytochrome P450 2D6 IC50 10.0 nM 10.1039/C8MD00313K
Homo sapiens Cytochrome P450 2D6 IC50 11.0 nM 10.1021/jm701447v
Homo sapiens Cytochrome P450 2D6 IC50 14.0 nM 10.1021/jm101470k
Homo sapiens Cytochrome P450 2D6 IC50 14.0 nM 10.1021/jm800377h
Homo sapiens Cytochrome P450 2D6 IC50 14.0 nM 10.1021/jm800683c
Homo sapiens Cytochrome P450 2D6 IC50 17.0 nM 10.1016/j.ejmech.2016.03.083
Homo sapiens Cytochrome P450 2D6 IC50 17.0 nM 10.1021/jm500109z
Homo sapiens Cytochrome P450 2D6 IC50 18.0 nM 10.1016/j.ejmech.2015.06.029
Homo sapiens Cytochrome P450 2D6 IC50 18.0 nM 10.1021/acs.jmedchem.1c00633
Homo sapiens Cytochrome P450 2D6 IC50 19.6 nM 10.1021/jm801084u
Homo sapiens Cytochrome P450 2D6 IC50 20.0 nM 10.1021/acs.jmedchem.1c02071
Homo sapiens Cytochrome P450 2D6 IC50 20.0 nM 10.1021/jm060055x
Homo sapiens Cytochrome P450 2D6 IC50 25.0 nM 10.1016/j.bmc.2018.05.006
Homo sapiens Cytochrome P450 2D6 IC50 30.0 nM 10.1016/j.ejmech.2015.08.001
Homo sapiens Cytochrome P450 2D6 IC50 35.0 nM 10.1021/acsmedchemlett.6b00491
Homo sapiens Cytochrome P450 2D6 IC50 35.6 nM 10.1016/j.ejmech.2020.112465
Homo sapiens Cytochrome P450 2D6 IC50 40.8 nM 10.1016/j.ejmech.2021.113174
Homo sapiens Cytochrome P450 2D6 IC50 41.3 nM 10.1021/acs.jmedchem.6b00624
Homo sapiens Cytochrome P450 2D6 IC50 44.0 nM 10.1021/acs.jmedchem.0c00500
Homo sapiens Cytochrome P450 2D6 IC50 60.0 nM 10.1021/acs.jmedchem.1c01559
Homo sapiens Cytochrome P450 2D6 IC50 60.0 nM 10.1021/acs.jmedchem.5b01891
Homo sapiens Cytochrome P450 2D6 IC50 64.0 nM 10.1021/acs.jmedchem.1c01157
Homo sapiens Cytochrome P450 2D6 IC50 65.0 nM 10.1021/acs.jmedchem.2c00468
Homo sapiens Cytochrome P450 2D6 IC50 78.0 nM 10.1021/acs.jmedchem.9b01562
Homo sapiens Cytochrome P450 2D6 IC50 78.0 nM 10.1021/np030556a
Homo sapiens Cytochrome P450 2D6 IC50 82.0 nM 10.1021/np0401765
Homo sapiens Cytochrome P450 2D6 IC50 118.0 nM 10.1016/j.bmc.2018.04.054
Homo sapiens Cytochrome P450 2D6 IC50 120.0 nM 10.1016/j.bmc.2014.09.026
Homo sapiens Cytochrome P450 2D6 IC50 120.0 nM 10.1021/acs.jmedchem.1c01015
Homo sapiens Cytochrome P450 2D6 IC50 120.0 nM 10.1021/acs.jmedchem.1c01366
Homo sapiens Cytochrome P450 2D6 IC50 134.0 nM 10.1021/acs.jmedchem.0c00223
Homo sapiens Cytochrome P450 2D6 IC50 134.0 nM 10.1021/acs.jmedchem.9b01769
Homo sapiens Cytochrome P450 2D6 IC50 135.0 nM 10.1016/j.ejmech.2017.05.043
Homo sapiens Cytochrome P450 2D6 IC50 136.0 nM 10.1021/acs.jmedchem.2c01497
Homo sapiens Cytochrome P450 2D6 IC50 137.0 nM 10.1016/j.ejmech.2022.114569
Homo sapiens Cytochrome P450 2D6 IC50 137.0 nM 10.1039/d2md00352j
Homo sapiens Cytochrome P450 2D6 IC50 146.0 nM 10.1021/acs.jmedchem.1c01970
Homo sapiens Cytochrome P450 2D6 IC50 151.0 nM 10.1016/j.bmc.2016.11.051
Homo sapiens Cytochrome P450 2D6 IC50 156.0 nM 10.1021/acs.jmedchem.0c00117
Homo sapiens Cytochrome P450 2D6 IC50 156.0 nM 10.1021/acs.jmedchem.1c02057
Homo sapiens Cytochrome P450 2D6 IC50 156.0 nM 10.1021/acs.jmedchem.8b01656
Homo sapiens Cytochrome P450 2D6 IC50 263.0 nM 10.1021/acs.jmedchem.8b01729
Homo sapiens Cytochrome P450 2D6 IC50 410.0 nM 10.1021/jm060983w
Homo sapiens Cytochrome P450 2D6 IC50 5000.0 nM 10.1021/acs.jmedchem.1c00708
Homo sapiens Cytochrome P450 2D6 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01676
Homo sapiens Cytochrome P450 2D6 IC50 5000.0 nM 10.1021/acs.jmedchem.7b01300
Homo sapiens Cytochrome P450 2D6 IC50 14000.0 nM 10.1021/jm800888q
Homo sapiens Cytochrome P450 2D6 IC50 20000.0 nM 10.1021/acs.jmedchem.8b01226
Homo sapiens Cytochrome P450 2D6 IC50 25000.0 nM 10.1016/j.bmcl.2014.06.026
Homo sapiens Cytochrome P450 2D6 IC50 25100.0 nM 10.1021/ml500187a
Homo sapiens Cytochrome P450 2D6 Inhibition 21.2 % 10.1016/j.bmcl.2014.06.026
Homo sapiens Cytochrome P450 2D6 Inhibition 88.0 % 10.1021/jm501203v
Homo sapiens Cytochrome P450 2D6 Inhibition 89.0 % 10.1021/acs.jmedchem.6b00912
Homo sapiens Cytochrome P450 2D6 Inhibition 90.0 % 10.1021/jm401067s
Homo sapiens Cytochrome P450 2D6 Inhibition 90.0 % 10.1021/jm900201b
Homo sapiens Cytochrome P450 2D6 Inhibition 90.1 % 10.1016/j.bmcl.2022.128673
Homo sapiens Cytochrome P450 2D6 Inhibition 91.0 % 10.1016/j.ejmech.2018.07.053
Homo sapiens Cytochrome P450 2D6 Inhibition 91.3 % 10.1016/j.ejmech.2021.113453
Homo sapiens Cytochrome P450 2D6 Inhibition 93.0 % 10.1021/acs.jmedchem.6b00273
Homo sapiens Cytochrome P450 2D6 Inhibition 93.28 % 10.1016/j.bmcl.2018.07.048
Homo sapiens Cytochrome P450 2D6 Inhibition 95.07 % 10.1021/ml4003293
Homo sapiens Cytochrome P450 2D6 Inhibition 95.9 % 10.1016/j.ejmech.2022.114424
Homo sapiens Cytochrome P450 2D6 Inhibition 96.2 % 10.1016/j.ejmech.2021.113740
Homo sapiens Cytochrome P450 2D6 Inhibition 96.25 % 10.1016/j.bmc.2016.04.065
Homo sapiens Cytochrome P450 2D6 Inhibition 96.25 % 10.1016/j.bmcl.2015.06.018
Homo sapiens Cytochrome P450 2D6 Inhibition 97.5 % 10.1016/j.bmc.2022.116862
Homo sapiens Cytochrome P450 2D6 Inhibition 97.9 % 10.1021/acs.jmedchem.8b01090
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1016/j.bmcl.2018.02.003
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/jm900201b
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki 9.8 nM 10.1021/jm801084u
Homo sapiens Cytochrome P450 2D6 Ki 30.0 nM 10.1021/jm049934e
Homo sapiens Cytochrome P450 2D6 Ki 40.0 nM 10.1021/jm00061a004
Homo sapiens Cytochrome P450 2D6 Ki 43.0 nM 10.1021/jm00061a004
Homo sapiens Cytochrome P450 2D6 Ki 60.0 nM 10.1021/jm00061a004
Homo sapiens Cytochrome P450 2D6 Ki 80.0 nM 10.1021/jm00061a004
Homo sapiens Cytochrome P450 3A4 Activity nan None 10.1021/jm801084u
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 28000.0 nM 10.1021/acs.jmedchem.9b01547
Homo sapiens Cytochrome P450 3A4 IC50 50000.0 nM 10.1021/jm021012t
Homo sapiens Cytochrome P450 3A4 IC50 nan None 10.1016/j.ejmech.2016.03.083
Homo sapiens Cytochrome P450 3A4 Inhibition 36.0 % 10.1021/jm401067s
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1124/dmd.111.038208
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 2800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 9560.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Fibroblast Growth Rate -1.0 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.43 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.17 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.36 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.74 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 0.9 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate 1.0 None 10.6019/CHEMBL5303304
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor Potency 17782.8 nM None
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HEK-293T Growth Rate 0.85 None 10.6019/CHEMBL5303304
Homo sapiens Hepatocyte CL 5.33 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte CL 13.5 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
Homo sapiens Hepatocyte logCL 0.7267 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HepG2 Inhibition 0.0 % 10.1038/nature09107
Homo sapiens HERG AC50 2927.5 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 300.0 nM 10.1093/cvr/cvr044
Homo sapiens HERG IC50 323.59 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 323.59 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 323.59 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 1440.0 nM None
Homo sapiens HERG IC50 2670.0 nM 10.1021/acs.jmedchem.5b01374
Homo sapiens HERG Inhibition 50.2 % 10.1016/j.bmcl.2018.12.020
Homo sapiens HERG Inhibition 85.5 % 10.1016/j.bmcl.2011.06.029
Homo sapiens HERG Inhibition 100.0 % 10.1021/jm501809x
Homo sapiens HERG Potency 7943.3 nM None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens Activity 0.81 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens CL 3.4 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 4.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 4.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 4.02 mL.min-1.kg-1 10.1124/dmd.111.042309
Homo sapiens Homo sapiens CL_renal 0.6 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.6 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 75.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.75 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.88 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.85 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 2.9 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 3.5 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens Huh-7 CC50 50750.0 nM 10.1073/pnas.0802982105
Homo sapiens Kappa opioid receptor AC50 4003.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Lymphoblastoid cell Potency 63095.7 nM None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug and toxin extrusion protein 1 Activity nan None 10.1038/nrd3028
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 11200.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 Inhibition 28.0 % 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 Activity nan None 10.1038/nrd3028
Homo sapiens Multidrug resistance-associated protein 4 IC50 45800.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 6200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 14960.1 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 44668.4 nM None
Homo sapiens P-glycoprotein 1 Activity 20.0 nM/mg*min 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity 36.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0378-5173(03)00372-7
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1025001131513
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1025032511040
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/nrd3028
Homo sapiens P-glycoprotein 1 Activity nan None 10.1161/01.cir.99.4.552
Homo sapiens P-glycoprotein 1 Activity nan None 10.1172/jci1269
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 Binding site fraction 0.2 None 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 IC50 1000.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 2200.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 2200.0 nM None
Homo sapiens P-glycoprotein 1 IC50 5600.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 18800.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 33800.0 nM 10.1124/jpet.102.046532
Homo sapiens P-glycoprotein 1 IC50 33900.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 340000.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Inhibition 21.1 % 10.1021/ml200293c
Homo sapiens P-glycoprotein 1 Inhibition 36.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Ki 430.0 nM 10.1023/a:1022359300826
Homo sapiens P-glycoprotein 1 Ki 1500.0 nM 10.1023/a:1011076217118
Homo sapiens P-glycoprotein 1 Ki 2600.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 5000.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 8590.0 nM 10.1023/a:1016140429238
Homo sapiens P-glycoprotein 1 Km 5420.0 nM 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Km 18200.0 nM None
Homo sapiens P-glycoprotein 1 % maximum response 30.0 % None
Homo sapiens P-glycoprotein 1 Papp 4.37 10'-6 cm/s 10.1016/j.ejmech.2015.10.040
Homo sapiens P-glycoprotein 1 Papp 34.1 10'-6 cm/s 10.1016/j.ejmech.2015.10.040
Homo sapiens P-glycoprotein 1 Papp 36.4 nm/s None
Homo sapiens P-glycoprotein 1 Papp 990.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio 7.81 None 10.1016/j.ejmech.2015.10.040
Homo sapiens P-glycoprotein 1 Ratio 21.8 None 10.1021/acs.jmedchem.0c02011
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 2.54 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 27.2 None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma PPB 71.1 % 10.1021/jm100732t
Homo sapiens Potassium channel subfamily K member 9 Inhibition 42.2 % 10.1021/acs.jmedchem.9b00248
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prion protein RUmax nan None 10.1016/j.ejmech.2011.04.016
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 3736.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 8999.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 976.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 1161.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 2000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 424.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum albumin Log K' 0.44 None 10.1021/jm010960b
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) IC50 3200.0 nM 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 74.1 % 10.1021/jm00381a019
Homo sapiens Sodium channel protein type V alpha subunit AC50 8799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Sodium channel protein type V alpha subunit IC50 6900.0 nM 10.1021/jm0604528
Homo sapiens Sodium channel protein type V alpha subunit IC50 16600.0 nM 10.1093/cvr/cvr044
Homo sapiens Solute carrier family 22 member 1 Activity 5.4 uM 10.1124/mol.63.3.489
Homo sapiens Solute carrier family 22 member 1 Activity 20.0 % 10.1124/dmd.104.003244
Homo sapiens Solute carrier family 22 member 1 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 1 Activity nan None 10.1124/mol.51.6.913
Homo sapiens Solute carrier family 22 member 1 Activity nan None None
Homo sapiens Solute carrier family 22 member 1 IC50 23400.0 nM None
Homo sapiens Solute carrier family 22 member 1 IC50 113800.0 nM 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Inhibition 62.9 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Ki 17500.0 nM None
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1038/nrd3028
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 4 Activity 15.2 % None
Homo sapiens Solute carrier family 22 member 4 Activity nan None None
Homo sapiens Solute carrier family 22 member 4 Inhibition 83.9 % 10.1124/dmd.112.048470
Homo sapiens Solute carrier family 22 member 5 Activity 9.1 % None
Homo sapiens Solute carrier family 22 member 5 Activity nan None None
Homo sapiens Solute carrier family 22 member 5 Inhibition 89.9 % 10.1124/dmd.112.048470
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1124/mol.59.5.1277
Homo sapiens Solute carrier organic anion transporter family member 1A2 Activity 91.0 % None
Homo sapiens Solute carrier organic anion transporter family member 1A2 Activity nan None None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Activity 81.0 % 10.1211/0022357021440
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 43.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 37.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -10.0 % 10.1021/jm300212s
Homo sapiens Thyroid stimulating hormone receptor Potency 25118.9 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 31.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12995.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23109.3 nM None
Homo sapiens U2OS Growth Rate -1.0 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.07 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.59 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.65 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.73 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.83 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.93 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.96 None 10.6019/CHEMBL5303304
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel IC50 6400.0 nM 10.1038/srep02100
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 19820.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated potassium channel subunit Kv1.5 IC50 7300.0 nM 10.1021/jm0604528
Homo sapiens WI-38 IC50 11.28 ug.mL-1 10.1016/j.ejmech.2013.06.004
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 12.62 % 10.6019/CHEMBL4513141
Leishmania mexicana mexicana Leishmania mexicana mexicana IC50 20.0 ug.mL-1 10.1016/j.ejmech.2013.06.004
Mus musculus Mus musculus Activity nan None 10.1021/jm00375a010
Mus musculus Mus musculus EC50 0.0098 ug.mL-1 10.1021/jm00388a005
Mus musculus Mus musculus ED50 14.0 mg.kg-1 10.1021/jm00388a005
Mus musculus Mus musculus ED50 15.2 mg.kg-1 10.1021/jm00388a005
Mus musculus Mus musculus ED50 122.0 mg.kg-1 10.1021/jm00388a005
Mus musculus Mus musculus ED50 122.0 umol.kg-1 10.1021/jm00176a018
Mus musculus Mus musculus ED50 158.0 mg.kg-1 10.1021/jm00388a005
Mus musculus Mus musculus ED50 160.0 uM/L 10.1021/jm00225a009
Mus musculus Mus musculus ED50 217.0 umol.kg-1 10.1021/jm00216a016
Mus musculus Mus musculus LD50 53.6 mg.kg-1 10.1021/jm00375a010
Mus musculus Mus musculus LD50 89.0 mg.kg-1 10.1021/jm00134a007
Mus musculus Mus musculus LD50 100.0 umol.kg-1 10.1021/jm0604528
Mus musculus Mus musculus LD50 175.0 mg.kg-1 10.1021/jm00388a005
Mus musculus Mus musculus LD50 524.0 umol.kg-1 10.1021/jm00176a018
Mus musculus Mus musculus LD50 533.0 uM/L 10.1021/jm00225a009
Mus musculus Mus musculus Ratio 4.3 None 10.1021/jm00176a018
Mus musculus P-glycoprotein 1 IC50 10000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Activity nan None 10.1023/a:1010984110732
Mus musculus P-glycoprotein 3 Activity nan None 10.1161/01.cir.99.4.552
Mus musculus P-glycoprotein 3 Activity nan None None
Mus musculus P-glycoprotein 3 IC50 13000.0 nM 10.1021/jm021012t
Mus musculus Plasma PPB 71.1 % 10.1021/jm100732t
Mus musculus ScN2a IC50 5000.0 nM 10.1021/jm070688r
Mus musculus Solute carrier family 22 member 1 Activity 0.0 % None
Mus musculus Solute carrier family 22 member 5 Activity 6.1 % 10.1124/mol.59.2.358
Oryctolagus cuniculus Heart Activity 136.0 bpm None
Oryctolagus cuniculus Heart Activity nan None 10.1021/jm00202a005
Oryctolagus cuniculus Heart TIME 0.0001087 hr None
Oryctolagus cuniculus Oryctolagus cuniculus EC30 3.9 ug ml-1 10.1021/jm00388a005
Plasmodium falciparum Ferriprotoporphyrin IX log K 5.26 None 10.1021/acs.jmedchem.6b00719
Plasmodium falciparum Histidine-rich protein IC50 325000.0 nM 10.1128/aac.00985-06
Plasmodium falciparum Plasmodium falciparum EC50 9.59 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum EC50 35.2 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum IC50 0.06 ug.mL-1 10.1016/j.ejmech.2013.06.004
Plasmodium falciparum Plasmodium falciparum IC50 4.0 nM 10.1016/s0960-894x(02)00173-7
Plasmodium falciparum Plasmodium falciparum IC50 18.0 nM 10.1016/j.bmc.2012.03.042
Plasmodium falciparum Plasmodium falciparum IC50 21.0 nM 10.1007/s00044-007-9025-8
Plasmodium falciparum Plasmodium falciparum IC50 51.0 nM 10.1007/s00044-007-9025-8
Plasmodium falciparum Plasmodium falciparum IC50 51.0 nM 10.1016/j.ejmech.2008.02.005
Plasmodium falciparum Plasmodium falciparum IC50 90.0 nM 10.1016/j.bmc.2012.03.042
Plasmodium falciparum Plasmodium falciparum IC50 160.0 nM 10.1016/s0960-894x(02)00173-7
Plasmodium falciparum Plasmodium falciparum IC50 194.4 nM 10.1016/j.ejmech.2015.05.044
Plasmodium falciparum Plasmodium falciparum IC50 24000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum Inhibition 0.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Inhibition 95.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Inhibition 98.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Potency 20.8 nM None
Plasmodium falciparum Plasmodium falciparum Potency 29.4 nM None
Plasmodium falciparum Plasmodium falciparum XC50 117.84 nM 10.1038/nature09107
Plasmodium yoelii Plasmodium yoelii Activity nan None 10.1126/science.1211936
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 8.31 % 10.6019/CHEMBL4513141
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Brain AUC 1850.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Brain AUC 1880.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Brain Fu 0.09 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Kp 3.45 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Vd 38.0 L.kg-1 10.1124/dmd.110.035998
Rattus norvegicus Cerebrospinal fluid AUC 302.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Cerebrospinal fluid AUC 304.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cytochrome P450 2D1 IC50 19900.0 nM 10.1021/jm0209578
Rattus norvegicus Cytochrome P450 2D18 IC50 47200.0 nM 10.1021/jm0209578
Rattus norvegicus Cytochrome P450 2D2 IC50 2800.0 nM 10.1021/jm0209578
Rattus norvegicus Cytochrome P450 2D3 IC50 26900.0 nM 10.1021/jm0209578
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Liver microsomes Stability 0.91 uM 10.1016/j.ejmech.2010.11.024
Rattus norvegicus Multidrug resistance protein 1a Km 5000.0 nM 10.1016/0014-5793(94)80312-9
Rattus norvegicus Plasma AUC 4920.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Plasma AUC 5310.0 ng.hr.mL-1 10.1124/dmd.112.046391
Rattus norvegicus Plasma Fu 0.26 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.13 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Potassium channel subfamily K member 9 Inhibition 37.0 % 10.1021/acs.jmedchem.9b00248
Rattus norvegicus Potassium voltage-gated channel subfamily B member 1 IC50 nan None 10.1021/jm0604528
Rattus norvegicus Potassium voltage-gated channel subfamily D member 2 IC50 2200.0 nM 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity -36.0 % 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus Activity -30.0 % 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus Activity 1.1 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 1.5 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 2.3 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 2.5 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 3.0 % 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus Activity 3.0 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 3.2 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity 20.3 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 24.2 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 26.1 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 27.6 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 28.2 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 50.6 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 51.6 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 52.9 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 54.4 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 54.6 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 76.3 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 85.8 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 88.3 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 90.6 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 91.3 min 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 246.18 bpm 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 261.63 bpm 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 285.16 bpm 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 286.32 bpm 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 311.8 bpm 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Activity 317.0 umol/Kg 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus ALB 29000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 30000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 31000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 32000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.0 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.1 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.2 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.3 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.4 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1010.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1069.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1231.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1250.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1297.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1324.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1392.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1426.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1429.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1446.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1460.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1472.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1487.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1495.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1496.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1497.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1503.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1521.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1521.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1538.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1558.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1563.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1568.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1610.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1616.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1623.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1625.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1626.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1671.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1697.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1706.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1744.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 32.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 33.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 34.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 35.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 37.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 37.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 37.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 38.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 45.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 45.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 45.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 47.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 47.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 25.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 25.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 26.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 62.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 65.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 65.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 72.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 72.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 74.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.02 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.04 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.02 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.025 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.04 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.08 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.1 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.14 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.16 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.18 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.2 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.22 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.24 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.26 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.28 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.34 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 84.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 90.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 94.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 100.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 116.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 124.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 132.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 136.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 152.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 156.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 158.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 164.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 172.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 176.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 180.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 182.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 184.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 185.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 196.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 98.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 103.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 104.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 105.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 107.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 109.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 110.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 640.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 662.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 696.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 724.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 726.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 740.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 746.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 748.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 754.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 764.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 768.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 770.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 776.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 778.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 780.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 786.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 788.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 790.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 804.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 812.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 828.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 830.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 838.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 842.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 850.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 858.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 864.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 880.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 902.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 103.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 103.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ED50 3.2 mg.kg-1 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus ED50 4.0 micromol/kg/min 10.1021/jm0604528
Rattus norvegicus Rattus norvegicus ED50 4.7 mg.kg-1 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus ED50 13.5 mg.kg-1 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus ED50 47.7 mg.kg-1 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus EOSLE 0.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2670.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2816.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2832.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2882.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2906.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2910.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2932.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2934.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2942.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2950.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2982.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3012.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3026.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3030.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3034.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3052.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3072.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3080.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3098.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3136.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3178.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3182.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3186.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3196.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3214.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3272.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3280.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3378.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3642.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 3.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1720.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1742.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1784.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1798.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1800.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1802.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1826.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1840.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1846.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1856.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1858.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1860.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1862.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1892.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1908.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1912.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1922.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1938.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1940.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1942.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1968.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1972.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1974.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1980.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1988.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1990.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1994.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2008.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2054.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2058.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2078.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 36.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 37.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 37.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 45.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 118000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 122000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 123000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 124000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 128000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 131000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 144000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 146000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 147000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 151000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 156000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LD50 48.0 mg.kg-1 10.1021/jm00388a005
Rattus norvegicus Rattus norvegicus LDH 118.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 121.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 125.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 131.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 133.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 136.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 136.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 141.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 142.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 144.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 150.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 150.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 151.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 153.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 155.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 167.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 170.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 171.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 173.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 174.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 178.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 181.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 181.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 182.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 185.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 187.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 198.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 202.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 207.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 209.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 212.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 235.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 72.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 81.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 81.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 84.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 18.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.4 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.5 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.4 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.6 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.0 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 53.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 56.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 56.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 56.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 58.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 59.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.3 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 64.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 1.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 1.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 11.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 20.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 62.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 70.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 72.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 73.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 74.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 76.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 77.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 79.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 81.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 82.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 85.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 87.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 88.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 89.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 91.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 93.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 94.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 95.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 96.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1268.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1316.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1348.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1360.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1368.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1374.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1398.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1406.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1442.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1450.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1468.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1470.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1482.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1494.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1498.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1500.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1524.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1540.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1548.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1554.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1558.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1560.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1574.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1622.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1626.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1632.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1636.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1670.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1718.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1730.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 934000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1029000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1154000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1155000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1160000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1171000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1184000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1185000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1195000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1201000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1212000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1215000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1219000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1222000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1226000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1228000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1232000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1237000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1240000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1243000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1244000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1248000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1250000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1256000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1259000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1271000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1278000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1296000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1300000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1301000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.7 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.9 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.1 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.3 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.5 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 51000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 52000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 53000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 54000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 64000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 14.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5716000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5848000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5880000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5910000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6006000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6080000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6148000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6150000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6174000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6184000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6228000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6234000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6290000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6328000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6332000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6336000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6410000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6420000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6488000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6500000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6502000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6508000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6592000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6694000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6698000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7056000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7202000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7404000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7414000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7755000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 8026000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 8360000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 139.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 207.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 212.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 212.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 213.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 214.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 218.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 218.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 218.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 218.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 222.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 225.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 227.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 228.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 228.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 231.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 232.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 234.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 239.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 248.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 254.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 261.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 268.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 296.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 308.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 320.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 326.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 346.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 370.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 418.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 438.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TIME 0.1097 hr 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus TIME 0.3561 hr 10.1016/j.ejmech.2014.02.048
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 468.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 554.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 556.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 562.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 606.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 660.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 682.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 716.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 736.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 740.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 832.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 834.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 964.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 992.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1018.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1026.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1048.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1050.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1054.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1144.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1168.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1186.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1238.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1256.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1316.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1332.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1434.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1478.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1496.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 2072.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 2095.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 5920.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 6080.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 6320.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7320.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7600.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7720.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8460.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8480.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8520.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8610.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8670.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8710.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8800.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9090.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9260.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9440.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9530.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9760.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10390.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10500.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10820.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11160.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11250.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11650.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12480.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12780.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 13040.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 13460.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 14160.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 0.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 3.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 3.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 18.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 18.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Sodium channel protein type V alpha subunit Inhibition 68.0 % 10.1021/jm00074a017
Rattus norvegicus Solute carrier family 22 member 1 Activity nan None 10.1016/0014-5793(96)01030-7
Rattus norvegicus Solute carrier family 22 member 1 Activity nan None None
Rattus norvegicus Solute carrier family 22 member 1 IC50 12700.0 nM 10.1152/ajprenal.2001.281.3.f454
Rattus norvegicus Solute carrier family 22 member 1 Ki 6000.0 nM 10.1007/bf00171063
Rattus norvegicus Solute carrier family 22 member 1 Ki 14600.0 nM None
Rattus norvegicus Solute carrier family 22 member 1 Km 2200.0 nM 10.1074/jbc.271.51.32599
Rattus norvegicus Solute carrier family 22 member 2 IC50 14600.0 nM 10.1152/ajprenal.2001.281.3.f454
Rattus norvegicus Solute carrier family 22 member 2 Ki 19100.0 nM None
Rattus norvegicus Solute carrier organic anion transporter family member 1A1 Ki 9270.0 nM 10.1023/a:1014264614637
Rattus norvegicus Solute carrier organic anion transporter family member 1A4 Ki 120000.0 nM 10.1023/a:1014264614637
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit IC50 5600.0 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit IC50 10000.0 nM 10.1002/jat.2784
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 8.0 mm 10.1016/j.ejmech.2010.07.050
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.3909 None 10.1101/2020.04.21.054387
Staphylococcus aureus Quinolone resistance protein norA Inhibition 31.5 % 10.1021/ml200293c
Staphylococcus aureus Staphylococcus aureus Inhibition 10.07 % 10.6019/CHEMBL4513141
Sus scrofa LLC-PK1 Ratio 7.4 None 10.1021/ml300314h
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 8.42 ug.mL-1 10.1016/j.ejmech.2013.06.004
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 25990.0 nM 10.1016/j.ejmech.2015.05.044
None ADMET B(DPB) 27.8 % 10.1021/jm040760a
None ADMET CL 4.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 4.5 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 5.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 6.17 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 13.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 20.3 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
None ADMET CL 33.3 mL.min-1.kg-1 10.1124/dmd.111.042309
None ADMET CL 34.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 72.44 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET Compound recovery 70.0 % 10.1124/dmd.110.036988
None ADMET delta logD -0.86 None 10.1021/jm0000564
None ADMET Delta Vmax -75.0 % 10.1021/jm00164a025
None ADMET Delta Vmax -23.0 % 10.1021/jm00164a025
None ADMET Delta Vmax -8.0 % 10.1021/jm00164a025
None ADMET Delta Vmax -1.0 % 10.1021/jm00164a025
None ADMET Delta Vmax 0.0 % 10.1021/jm00164a025
None ADMET EFTPC 2080.5 nM 10.1093/cvr/cvr044
None ADMET eLog D 1.51 None 10.1021/jm0200409
None ADMET F 79.0 % 10.1021/jm0000564
None ADMET Fraction ionised 0.817 None 10.1021/jm0200409
None ADMET Fu 0.019 None 10.1021/jm0200409
None ADMET Fu 0.073 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.13 None 10.1021/jm0200409
None ADMET Fu 0.13 None 10.1021/jm030408h
None ADMET Fu 0.15 None 10.1124/dmd.111.042309
None ADMET Fu 0.218 None 10.1124/dmd.110.036988
None ADMET Fu 0.243 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.251 None 10.1124/dmd.110.036988
None ADMET Fu 0.274 None 10.1124/dmd.110.036988
None ADMET Fu 0.299 None 10.1124/dmd.110.036988
None ADMET IC50 34810.0 nM 10.1016/j.ejmech.2015.05.044
None ADMET K(p,uu,brain) 0.065 None 10.1021/acs.jmedchem.0c02011
None ADMET Log k' -0.312 None 10.1021/jm00135a006
None ADMET Log k' -0.084 None 10.1021/jm00135a006
None ADMET Log k' 0.214 None 10.1021/jm00135a006
None ADMET Log k' 0.22 None 10.1021/jm00135a006
None ADMET Log k' 0.495 None 10.1021/jm00135a006
None ADMET Log k' 0.623 None 10.1021/jm00135a006
None ADMET Log k' 0.788 None 10.1021/jm00135a006
None ADMET Log k' 0.84 None 10.1021/jm00135a006
None ADMET Log k' 2.03 None 10.1021/jm00135a006
None ADMET Log k' 2.031 None 10.1021/jm00135a006
None ADMET logPapp 1.46 None 10.1016/j.ejmech.2015.04.049
None ADMET log Pe -5.12 None 10.1016/j.ejmech.2020.112282
None ADMET log Pe -3.5 None 10.1016/j.bmc.2015.03.051
None ADMET logPeff -4.0 None 10.1016/j.ejmech.2016.08.016
None ADMET logP(lung) 1.62 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 12.0 hr 10.1124/dmd.108.020479
None ADMET Papp 3.27 10^-6 cm/s 10.1016/j.ejmech.2021.113630
None ADMET Papp 4.0 10'-6 cm/s 10.1021/acs.jmedchem.8b00172
None ADMET Papp 13.03 10'-6 cm/s 10.1021/acs.jmedchem.8b00613
None ADMET Papp 21.42 10^-6 cm/s 10.1016/j.ejmech.2021.113630
None ADMET Papp 28.65 10'-6 cm/s 10.1016/j.ejmech.2015.04.049
None ADMET Papp 41.99 10'-6 cm/s 10.1021/acs.jmedchem.8b00613
None ADMET Papp 89.0 10'-6 cm/s 10.1021/acs.jmedchem.8b00172
None ADMET Peff 11.48 ucm/s 10.1016/j.ejmech.2011.04.016
None ADMET PPB 60.77 % 10.6019/CHEMBL3301361
None ADMET PPB 71.0 % 10.1021/acs.jmedchem.0c01120
None ADMET PPB 85.48 % 10.6019/CHEMBL3301361
None ADMET PPB 93.8 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.05 None 10.1124/dmd.112.046391
None ADMET Ratio 0.22 None 10.1124/dmd.112.046391
None ADMET Ratio 3.22 None 10.1021/acs.jmedchem.8b00613
None ADMET Ratio 6.6 None 10.1016/j.ejmech.2021.113630
None ADMET Ratio 15.89 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio 20.0 None 10.1021/acs.jmedchem.8b00172
None ADMET Ratio LD50/ED50 3.3 None 10.1021/jm00225a009
None ADMET T1/2 6.6 hr 10.1124/dmd.108.020479
None ADMET TR 3.3 None 10.1021/jm00184a008
None ADMET Vdss 0.55 L.kg-1 10.1002/jps.20373
None ADMET Vdss 2.7 L.kg-1 10.1021/jm0200409
None ADMET Vdss 2.9 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 3.0 L.kg-1 10.1002/jps.20373
None ADMET Vdss 3.5 L.kg-1 10.1021/jm030408h
None ADMET Vdss 4.8 L.kg-1 10.1002/jps.20373
None ADMET Vdss 6.0 mL/min/kg 10.1002/jps.20373
None Heme Activity nan None 10.1038/nchembio806
None Heme IC50 24000.0 nM 10.1007/s00044-007-9025-8
None Heme Inhibition nan % 10.1038/nchembio806
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 3.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports nan None 10.2174/1570163043334794
None Molecular identity unknown Activity 25.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 27.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 31.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 35.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 39.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 53.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 54.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 57.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 60.0 % 10.1021/jm100298d
None Molecular identity unknown Activity 70.0 % 10.1021/jm100298d
None Molecular identity unknown Potency 31622.8 nM None
None NON-PROTEIN TARGET Activity 69.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 71.0 % 10.1021/jm060878m
None NON-PROTEIN TARGET Activity 71.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 71.0 % 10.1021/jm201197z
None NON-PROTEIN TARGET Activity 86.0 % 10.1021/jm060878m
None NON-PROTEIN TARGET Activity 86.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 86.0 % 10.1021/jm201197z
None NON-PROTEIN TARGET Activity 158.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 170.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 182.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 200.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET Activity 229.0 % 10.1021/jm100298d
None NON-PROTEIN TARGET EC30 3.99 uM 10.1021/jm201197z
None NON-PROTEIN TARGET EC50 3380.0 nM 10.1021/jm060878m
None NON-PROTEIN TARGET EC50 3380.0 nM 10.1021/jm100298d
None NON-PROTEIN TARGET EC50 3380.0 nM 10.1021/jm201197z
None NON-PROTEIN TARGET EC50 3990.0 nM 10.1021/jm060878m
None NON-PROTEIN TARGET EC50 3990.0 nM 10.1021/jm100298d
None NON-PROTEIN TARGET EC50 10260.0 nM 10.1021/jm100298d
None NON-PROTEIN TARGET EC50 10260.0 nM 10.1021/jm201197z
None NON-PROTEIN TARGET Emax 69.0 % 10.1021/jm201197z
None NON-PROTEIN TARGET Fu 0.26 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.876 None 10.1124/dmd.111.042309
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.1 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 11.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None No relevant target LogD 1.08 None 10.1021/jm0000564
None No relevant target LogD 1.45 None 10.1021/jm8005228
None No relevant target LogD 1.5 None 10.1021/jm8005228
None No relevant target LogD 2.04 None 10.1021/jm0100990
None No relevant target LogD 2.068 None 10.1021/jm00135a006
None No relevant target LogD7.4 2.21 None 10.6019/CHEMBL3301361
None No relevant target LogD7.4 2.41 None 10.1021/jm040760a
None No relevant target LogP 2.8 None 10.1021/jm021012t
None No relevant target LogP 3.552 None 10.1124/dmd.111.042309
None No relevant target logPapp 0.52 None 10.1016/j.ejmech.2015.04.049
None No relevant target Papp 3.28 10'-6 cm/s 10.1016/j.ejmech.2015.04.049
None No relevant target pKa 8.05 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.05 None 10.1016/j.ejmech.2009.06.004
None No relevant target pKa 8.05 None 10.1021/jm0200409
None No relevant target pKa 8.05 None 10.1021/jm030408h
None No relevant target pKa 8.1 None 10.1124/dmd.110.036988
None No relevant target pKa 8.3 None 10.1021/jm0000564
None No relevant target pKa 8.52 None 10.1021/jm040760a
None No relevant target pKa 8.8 None 10.1021/jm020941h
None No relevant target pKa 8.8 None 10.1124/dmd.110.035998
None No relevant target pKa 8.8 None 10.1124/dmd.111.042309
None No relevant target pKa 9.13 None 10.1021/jm020941h
None No relevant target pKa 13.93 None 10.1124/dmd.112.050278
None No relevant target solubility nan None 10.1021/acs.jmedchem.8b00613
None Nucleic Acid BPR 0.38 None 10.1124/dmd.112.046391
None Nucleic Acid Ratio 0.23 None 10.1124/dmd.112.046391
None Phospholipidosis Maximum test concentration that did not exhibit cytotoxicity 25.0 uM None
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Phospholipidosis Phospholipidosis as % of positive control 3.2 % None
None Unchecked Activity 69.0 % 10.1021/jm060878m
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/np960024c
None Unchecked APDc 66.37 None 10.6019/CHEMBL4295262
None Unchecked APDc 68.44 None 10.6019/CHEMBL4295262
None Unchecked APDc nan None 10.6019/CHEMBL4295262
None Unchecked EC50 10260.0 nM 10.1021/jm060878m
None Unchecked FC 3.2 None 10.1016/j.ejmech.2017.06.047
None Unchecked FPDc 23.33 None 10.6019/CHEMBL4295262
None Unchecked FPDc 48.01 None 10.6019/CHEMBL4295262
None Unchecked FPDc 51.52 None 10.6019/CHEMBL4295262
None Unchecked FPDc 51.68 None 10.6019/CHEMBL4295262
None Unchecked FPDc 56.69 None 10.6019/CHEMBL4295262
None Unchecked FPDc 66.27 None 10.6019/CHEMBL4295262
None Unchecked FPDc nan None 10.6019/CHEMBL4295262
None Unchecked FPD measurement 62.36 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 66.27 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 66.37 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 68.44 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement 114.6 FPDc 10.6019/CHEMBL4295262
None Unchecked FPD measurement nan None 10.6019/CHEMBL4295262
None Unchecked Hepatotoxicity (acute) 19.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 12.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 12.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 23000.0 nM 10.1016/j.bmc.2012.03.042
None Unchecked IC50 130000.0 nM 10.1016/j.bmc.2012.03.042
None Unchecked IC50 240000.0 nM 10.1016/j.bmcl.2004.05.031
None Unchecked IFI 0.0 % 10.1038/nature09107
None Unchecked IFI 1.667 % 10.1073/pnas.0802982105
None Unchecked Inhibition 40.0 % 10.1021/jm00074a017
None Unchecked Potency 25.1 nM None
None Unchecked Potency 35.5 nM None
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Ratio 0.9 None 10.1021/jm00185a013
None Unchecked Ratio 8.6 None 10.1021/jm00185a013
None Unchecked Ratio 115.0 None 10.1021/acs.jmedchem.6b00719
None Unchecked Ratio IC50 1.3 None 10.1016/j.ejmech.2013.06.004
None Unchecked Ratio IC50 1.3 None 10.1016/j.ejmech.2015.05.044
None Unchecked Ratio IC50 179.1 None 10.1016/j.ejmech.2013.06.004
None Unchecked Ratio IC50 179.1 None 10.1016/j.ejmech.2015.05.044
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2013.06.004

Metabolism Information