Navigation

name Structure Reference Source Properties Activities Metabolism

Rapamycin

AlkaPlorer ID: AK000461

Synonym: None

IUPAC Name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

Structure

SMILES: CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C

copy

InChI: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

copy

InChIKey: QFJCIRLUMZQUOT-HPLJOQBZSA-N

copy

Properties Information

Molecule Weight: 914.187

TPSA？: 195.42999999999995

MolLogP？: 6.180600000000006

Number of H-Donors: 3

Number of H-Acceptors: 13

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4296183
Aspergillus niger Aspergillus niger MIC 100.0 ug.mL-1 10.1016/s0960-894x(00)00184-0
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Caenorhabditis elegans Caenorhabditis elegans ILS 38.0 % 10.1021/acs.jnatprod.6b00648
Candida albicans Candida albicans IC50 514.0 nM 10.1021/acs.jmedchem.6b01203
Candida albicans Candida albicans MIC 0.2 ug.mL-1 10.1016/s0960-894x(00)00184-0
Candida albicans Candida albicans MIC 78.1 nM 10.6019/CHEMBL4296183
Candida albicans Candida albicans MIC 100.0 ug.mL-1 10.1016/s0960-894x(00)00184-0
Candida albicans Candida albicans MIC nan ug.mL-1 10.1016/s0960-894x(00)00184-0
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus aethiops COS-7 Activity nan None 10.1038/nchembio.79
Chlorocebus sabaeus Vero C1008 AUC cytotoxicity 161.5 None 10.1038/s41586-020-2286-9
Chlorocebus sabaeus Vero C1008 pCC50 9.32 None 10.1038/s41586-020-2286-9
Cryptococcus neoformans Cryptococcus neoformans MIC 156.3 nM 10.6019/CHEMBL4296183
Drosophila melanogaster Drosophila melanogaster Activity nan None 10.1038/nchembio832
Electrophorus electricus Acetylcholinesterase Inhibition 18.69 % 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition 4.03 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli Activity nan None 10.1021/jm101156y
Escherichia coli Escherichia coli MIC 10000.0 nM 10.6019/CHEMBL4296183
Gallus gallus Gallus gallus ED50 0.5 nM 10.1021/jm980307x
Gallus gallus Tyrosine-protein kinase SRC Activity 86.0 % 10.1042/bj20070797
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 85.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens 697 IC50 6.279 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 581.52 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 32.62 nM 10.6019/CHEMBL1201861
Homo sapiens A2058 Activity nan None 10.1021/acs.jmedchem.8b01262
Homo sapiens A253 cell line IC50 4021.01 nM 10.6019/CHEMBL1201861
Homo sapiens A388 IC50 44.82 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 2.994 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 9361.24 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 13.12 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity nan None 10.1021/jm901427g
Homo sapiens A549 IC50 18740.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens A549 IC50 30720.0 nM 10.1016/j.ejmech.2021.113424
Homo sapiens A549 IC50 49350.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens A704 IC50 899.15 nM 10.6019/CHEMBL1201861
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACN IC50 146.75 nM 10.6019/CHEMBL1201861
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 21300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 26433.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adenosine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ALK tyrosine kinase receptor Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens ALL-PO IC50 4840.77 nM 10.6019/CHEMBL1201861
Homo sapiens Alpha-1a adrenergic receptor AC50 156.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Alpha-synuclein Potency 3981.1 nM None
Homo sapiens AM-38 IC50 1307.2 nM 10.6019/CHEMBL1201861
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens ARH-77 IC50 52.8 nM 10.6019/CHEMBL1201861
Homo sapiens ATN-1 IC50 1262.09 nM 10.6019/CHEMBL1201861
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 1900.0 nM 10.1016/j.ejmech.2022.114346
Homo sapiens ATP-dependent RNA helicase DDX1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DHX30 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BB30-HNC IC50 388.32 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 1735.86 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 119.93 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 99.18 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 2.988 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 41.05 nM 10.6019/CHEMBL1201861
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 23800.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 1011.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 10000.0 nM 10.1124/dmd.112.047068
Homo sapiens BL-41 IC50 43.66 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 28.38 nM 10.6019/CHEMBL1201861
Homo sapiens BMP-2-inducible protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BOKU IC50 6475.97 nM 10.6019/CHEMBL1201861
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Brain glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 139.0 % 10.1042/bj20121418
Homo sapiens BT-474 IC50 647.06 nM 10.6019/CHEMBL1201861
Homo sapiens BV-173 IC50 83.97 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 167.76 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 6559.12 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 8950.98 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-148 IC50 2336.14 nM 10.6019/CHEMBL1201861
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calu-6 IC50 6153.16 nM 10.6019/CHEMBL1201861
Homo sapiens CaM kinase I alpha Activity 97.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 146.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase IV Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 131.0 % 10.1042/bj20121418
Homo sapiens CaM-kinase kinase alpha Activity 80.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 83.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 77.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 141.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens CAS-1 IC50 3137.07 nM 10.6019/CHEMBL1201861
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Activity 88.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I epsilon Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Activity 92.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Inhibition 104.0 % 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase II alpha (prime) Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM IC50 4.941 nM 10.6019/CHEMBL1201861
Homo sapiens CDK3/cyclin E Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Cell division cycle 7-related protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CESS IC50 13.13 nM 10.6019/CHEMBL1201861
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 128.0 % 10.1042/bj20121418
Homo sapiens CGTH-W-1 IC50 948.13 nM 10.6019/CHEMBL1201861
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Choline-phosphate cytidylyltransferase A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CHP-126 IC50 3764.58 nM 10.6019/CHEMBL1201861
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 98.0 % 10.1042/0264-6021:3510095
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Activity 81.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Activity 81.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 153.0 % 10.1042/bj20121418
Homo sapiens CMK IC50 84.16 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-320-HSR IC50 4444.27 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 2826.95 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 39.8 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 235.28 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 2897.68 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 8488.79 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L279 IC50 87.25 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 16314.02 nM 10.6019/CHEMBL1201861
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CP66-MEL IC50 3790.94 nM 10.6019/CHEMBL1201861
Homo sapiens CP67-MEL IC50 199.38 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 1088.0 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 4715.55 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 744.9 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 5859.59 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclin-dependent kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 92.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 129.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase-like 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclooxygenase-1 AC50 23260.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 26598.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 4000.0 nM None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 2000.0 nM None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 2000.0 nM None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Log 1/Km -0.9069 None 10.1016/j.bmcl.2005.06.015
Homo sapiens D-247MG IC50 7043.47 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 4229.61 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 4188.4 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 8401.16 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 3143.9 nM 10.6019/CHEMBL1201861
Homo sapiens Daudi IC50 0.4336 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 1272.42 nM 10.6019/CHEMBL1201861
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Death-associated protein kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 141.0 % 10.1042/bj20121418
Homo sapiens DEL IC50 17.99 nM 10.6019/CHEMBL1201861
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DG-75 IC50 1162.85 nM 10.6019/CHEMBL1201861
Homo sapiens Discoidin domain-containing receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens DJM-1 IC50 2606.3 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 IC50 150.67 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 3058.24 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 1368.66 nM 10.6019/CHEMBL1201861
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DOHH-2 IC50 3.353 nM 10.6019/CHEMBL1201861
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 980.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 870.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DSH1 IC50 458.91 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 IC50 4000.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens DU-4475 IC50 187.68 nM 10.6019/CHEMBL1201861
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 137.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase TTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 91.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 88.0 % 10.1042/bj20070797
Homo sapiens Dual specificty protein kinase CLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EB2 IC50 122084.33 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 52.67 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 44.78 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 21204.05 nM 10.6019/CHEMBL1201861
Homo sapiens EHEB IC50 337.52 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 672.71 nM 10.6019/CHEMBL1201861
Homo sapiens Electron transfer flavoprotein subunit beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EM-2 IC50 38.53 nM 10.6019/CHEMBL1201861
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens EOL1 IC50 437.98 nM 10.6019/CHEMBL1201861
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 1 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 129.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 5 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 147.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Equilibrative nucleoside transporter 1 AC50 6800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ES1 IC50 2898.79 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 15070.26 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 0.02146 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 15078.65 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 3.428 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 18543.05 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 225.94 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens ETK-1 IC50 2.824 nM 10.6019/CHEMBL1201861
Homo sapiens Eukaryotic translation initation factor Kd 0.5 nM 10.1016/j.bmc.2010.04.005
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 5B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EVSA-T IC50 2173.15 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 2.172 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 1087.43 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 243.1 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 256967.08 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 26.87 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 7072.92 nM 10.6019/CHEMBL1201861
Homo sapiens EW-22 IC50 5294.66 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 8765.4 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 10628.87 nM 10.6019/CHEMBL1201861
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 145.0 % 10.1042/bj20121418
Homo sapiens FK506-binding protein 1A EC50 36.39 nM 10.1016/j.ejmech.2021.113160
Homo sapiens FK506-binding protein 1A FC 100.0 None 10.1016/j.ejmech.2021.113160
Homo sapiens FK506-binding protein 1A IC50 0.45 nM 10.1021/jm050524f
Homo sapiens FK506-binding protein 1A IC50 0.6 nM 10.1016/s0960-894x(99)00007-4
Homo sapiens FK506-binding protein 1A IC50 1.1 nM 10.1021/jm960066y
Homo sapiens FK506-binding protein 1A IC50 1.6 nM 10.1016/s0960-894x(00)00184-0
Homo sapiens FK506-binding protein 1A IC50 1.6 nM 10.1039/C7MD00474E
Homo sapiens FK506-binding protein 1A IC50 20.0 nM 10.1021/acsmedchemlett.0c00272
Homo sapiens FK506-binding protein 1A Ki 0.2 nM 10.1021/jm980307x
Homo sapiens FK506-binding protein 1A Ki 0.6 nM 10.1039/C7MD00474E
Homo sapiens FK506-binding protein 1A Ki 5400.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens FK506-binding protein 1A Ratio 0.5 None 10.1021/jm3015052
Homo sapiens FK506-binding protein 1A Selectivity 0.9 None 10.1021/jm960066y
Homo sapiens FK506-binding protein 1B Kd 0.2 nM 10.1021/jm500325k
Homo sapiens FK506 binding protein 4 Kd 4.2 nM 10.1021/acs.jmedchem.6b00411
Homo sapiens Focal adhesion kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GAK IC50 675.3 nM 10.6019/CHEMBL1201861
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GB-1 IC50 109.02 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 53.46 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 614.09 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 33498.3 nM None
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GI-1 IC50 70.39 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 3009.04 nM 10.6019/CHEMBL1201861
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 193.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 83.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 89.0 % 10.1042/0264-6021:3510095
Homo sapiens Glycogen synthase kinase-3 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens GOTO IC50 16479.3 nM 10.6019/CHEMBL1201861
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens GR-ST IC50 0.8457 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 2890.55 nM 10.6019/CHEMBL1201861
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens H4 Activity 88.62 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 131.41 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 149.89 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 152.35 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 159.89 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 164.93 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 165.87 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 171.67 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 205.66 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 259.68 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 285.38 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity nan None 10.1073/pnas.0709695104
Homo sapiens HAL-01 IC50 389.26 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 335.5 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 307.25 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 261.47 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2157 IC50 3532.28 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 11398.64 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-4 IC50 477.66 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 9308.51 nM 10.6019/CHEMBL1201861
Homo sapiens HDLM-2 IC50 12415.93 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 1164.16 nM 10.6019/CHEMBL1201861
Homo sapiens HEK293 Activity nan None 10.1016/j.bmcl.2016.05.011
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4296183
Homo sapiens HEK-293T Activity nan None 10.1021/acsmedchemlett.0c00272
Homo sapiens HEL IC50 49.79 nM 10.6019/CHEMBL1201861
Homo sapiens HeLa Activity nan None 10.1016/j.bmc.2021.116041
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.7b01402
Homo sapiens HeLa IC50 770.0 nM 10.1016/j.ejmech.2018.07.004
Homo sapiens HeLa IC50 10000.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens HepG2 CC50 67200.0 nM 10.1021/acs.jmedchem.6b01203
Homo sapiens HepG2 Potency 35481.3 nM None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HH IC50 11.39 nM 10.6019/CHEMBL1201861
Homo sapiens Histamine H1 receptor AC50 860.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -28.21 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.89 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 IC50 1269.59 nM 10.6019/CHEMBL1201861
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 108.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Homo sapiens Activity 0.15 ug ml-1 10.1128/aac.01096-07
Homo sapiens Homo sapiens Activity 7.1 ng/ml 10.1128/aac.01096-07
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 14.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens F 14.0 % 10.1021/jm400887j
Homo sapiens Homo sapiens IC50 0.5 nM 10.1016/s0960-894x(97)10205-0
Homo sapiens Homo sapiens IC50 1.0 nM 10.1016/s0960-894x(00)00184-0
Homo sapiens Homo sapiens IC50 1.27 nM 10.1021/jm960066y
Homo sapiens Homo sapiens T1/2 62.0 hr 10.1039/C7MD00474E
Homo sapiens Homo sapiens T1/2 63.0 hr 10.1016/j.bmcl.2005.06.106
Homo sapiens HOP-62 IC50 126.89 nM 10.6019/CHEMBL1201861
Homo sapiens HT IC50 17.6 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 165.43 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity nan None 10.1021/jm901427g
Homo sapiens HT-29 Activity nan None 10.1021/ml4005039
Homo sapiens HuTu80 IC50 4.425 nM 10.6019/CHEMBL1201861
Homo sapiens IA-LM IC50 68.13 nM 10.6019/CHEMBL1201861
Homo sapiens IM-9 IC50 11510.63 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-5 IC50 21849.37 nM 10.6019/CHEMBL1201861
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 148.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 82.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 154.0 % 10.1042/bj20121418
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Isoleucine--tRNA ligase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens IST-MEL1 IC50 122.38 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 5954.43 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 8865.43 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 208.63 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 438.62 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 10.94 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 6.458 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-2 IC50 3364.33 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 18716.98 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 3379.68 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 411.37 nM 10.6019/CHEMBL1201861
Homo sapiens K562 Activity 75.5 % 10.1016/j.ejmech.2008.05.001
Homo sapiens K562 Activity 75.5 % 10.1021/jm800982q
Homo sapiens K562 IC50 669.51 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 1000000.0 nM 10.1016/j.ejmech.2008.05.001
Homo sapiens KALS-1 IC50 6.559 nM 10.6019/CHEMBL1201861
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KARPAS-299 IC50 61.82 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 102.09 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 647.6 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 2188.15 nM 10.6019/CHEMBL1201861
Homo sapiens KE-37 IC50 16.07 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 7627.38 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 96.29 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 51.55 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 585.2 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 IC50 2408.39 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 IC50 1264.08 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 3542.42 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 49530.17 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 586.81 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 2366.2 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-RT-BM-1 IC50 7930.29 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 21874.99 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 2.454 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 2.013 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 657.51 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 10763.04 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 44.73 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 177.7 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 10.42 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 4304.21 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 8300.01 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 34.69 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 2868.39 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 12681.48 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 4367.89 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 328.71 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 2909.46 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 9765.21 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 93.43 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 108.05 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 0.4227 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 86.72 nM 10.6019/CHEMBL1201861
Homo sapiens Leucyl-tRNA synthetase Inhibition nan % 10.1016/j.bmc.2017.06.002
Homo sapiens Leucyl-tRNA synthetase Inhibition nan % 10.1016/j.bmc.2018.06.034
Homo sapiens Leucyl-tRNA synthetase Inhibition nan % 10.1016/j.bmcl.2016.05.011
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LNCaP C4-2 Inhibition 35.0 % 10.1016/j.bmcl.2006.08.103
Homo sapiens LNCaP-Clone-FGC IC50 21676.81 nM 10.6019/CHEMBL1201861
Homo sapiens LOUCY IC50 1546.57 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI IC50 27805.12 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 5412.91 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 828.98 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 795.69 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 77.57 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 8595.99 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 3054.25 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 378.02 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 1849.86 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 5763.73 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 1732.68 nM 10.6019/CHEMBL1201861
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Activity 108.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 125.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Activity 104.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Activity 91.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 74.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 100.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Activity 94.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Inhibition 90.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 75.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Inhibition 93.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens MAP kinase p38 alpha Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Activity 84.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Inhibition 88.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Activity 92.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Inhibition 82.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 delta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Activity 81.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Inhibition 100.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 gamma Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 102.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Activity 74.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MC116 IC50 0.9847 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 4439.9 nM 10.6019/CHEMBL1201861
Homo sapiens MCF7 Activity 30.0 % 10.1039/C5MD00493D
Homo sapiens MCF7 Activity nan None 10.1021/acs.jmedchem.7b01402
Homo sapiens MCF7 Activity nan None 10.1021/np900632r
Homo sapiens MCF7 EC50 1.0 nM 10.1039/C5MD00493D
Homo sapiens MCF7 IC50 4980.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens MCF7 IC50 18740.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens MDA-MB-134-VI IC50 44.02 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 Activity 31.03 % 10.1016/j.ejmech.2021.113424
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.7b01402
Homo sapiens MDA-MB-231 GI50 100.0 nM 10.1021/acs.jnatprod.0c00404
Homo sapiens MDA-MB-231 IC50 900.0 nM 10.1016/j.ejmech.2020.112948
Homo sapiens MDA-MB-231 IC50 10000.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens MDA-MB-231 IC50 35790.0 nM 10.1016/j.ejmech.2021.113424
Homo sapiens MDA-MB-453 GI50 0.05 nM 10.1021/acs.jnatprod.0c00404
Homo sapiens MDA-MB-468 IC50 37200.0 nM 10.1016/j.ejmech.2021.113424
Homo sapiens MEG-01 IC50 201.96 nM 10.6019/CHEMBL1201861
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MFH-ino IC50 235.84 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 18053.76 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-CALL-2 IC50 5050.42 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 17968.35 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 32.44 nM 10.6019/CHEMBL1201861
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Misshapen-like kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Misshapen-like kinase 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 15 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ML-2 IC50 1415.29 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 159.88 nM 10.6019/CHEMBL1201861
Homo sapiens MM1.S Activity 0.45 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 0.47 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 1.74 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 2.81 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 15.0 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 29.7 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 53.6 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 96.3 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S TGI 73.8 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MMAC-SF IC50 6185.56 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 305.32 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 22218.47 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 647.93 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 96.79 nM 10.6019/CHEMBL1201861
Homo sapiens Monoamine oxidase A AC50 5600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MONO-MAC-6 IC50 756.93 nM 10.6019/CHEMBL1201861
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 12589.3 nM None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MPP-89 IC50 4273.04 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 0.0008452 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 7960.41 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 609.74 nM 10.6019/CHEMBL1201861
Homo sapiens mTORC1 IC50 0.05 nM 10.1016/j.ejmech.2022.114498
Homo sapiens mTORC1 IC50 450.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens mTORC1 Inhibition nan % 10.1016/j.bmc.2015.11.003
Homo sapiens mTORC1 Inhibition nan % 10.1016/j.ejmech.2014.05.014
Homo sapiens mTORC1 Inhibition nan % 10.1016/j.ejmech.2019.04.048
Homo sapiens mTORC1 Inhibition nan % 10.1021/acs.jmedchem.6b01190
Homo sapiens mTORC1 Inhibition nan % 10.1021/acs.jnatprod.0c00404
Homo sapiens mTORC1 Inhibition nan % 10.1021/np5002253
Homo sapiens mTOR/FKBP12A/FKBP12B Activity nan None 10.1073/pnas.0700816104
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mu opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 21849.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MV4-11 Activity 0.6 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 3.48 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 5.77 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 15.3 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 17.1 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 37.0 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 42.4 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 78.3 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 IC50 83.73 nM 10.6019/CHEMBL1201861
Homo sapiens MV4-11 IC50 500.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Myosin-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase, smooth muscle Activity 107.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 139.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 145.0 % 10.1042/bj20121418
Homo sapiens MZ1-PC IC50 3090.78 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 413.64 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 5406.91 nM 10.6019/CHEMBL1201861
Homo sapiens NALM-6 IC50 3009.33 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 384.45 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 1466.32 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 4.36 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 4104.79 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 13457.92 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 365292.35 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 3182.59 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 3318.91 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 814.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 3218.09 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 5265.55 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 3116.1 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 23585.28 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 IC50 17159.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 57.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 1.009 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 2526.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 1122.6 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 2856.15 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1522 IC50 1288.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 17421.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 417.53 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 15497.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 4131.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 8380.02 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 8986.02 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 462.81 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 5020.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 1032.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2081 IC50 1266.37 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 87.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 726.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 3174.52 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 24248.53 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 4171.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 IC50 15876.82 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 13242.46 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M IC50 14406.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H345 IC50 943.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 1321.21 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 IC50 10000.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens NCI-H510A IC50 985.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H524 IC50 780.73 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 93.59 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H64 IC50 2342.32 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 4019.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 1389.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 9252.79 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 25.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H747 IC50 1753.46 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 758.99 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 6204.89 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H889 IC50 11531.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-N87 IC50 121.98 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 8306.91 nM 10.6019/CHEMBL1201861
Homo sapiens Nerve growth factor receptor Trk-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens NH-12 IC50 1363.74 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 2254.72 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 33.67 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 7.288 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 83.24 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 300.21 nM 10.6019/CHEMBL1201861
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NOS-1 IC50 0.8712 nM 10.6019/CHEMBL1201861
Homo sapiens NTERA-2-cl-D1 IC50 0.443 nM 10.6019/CHEMBL1201861
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Obg-like ATPase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens OCI-AML2 IC50 500.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens OCI-AML2 IC50 4194.89 nM 10.6019/CHEMBL1201861
Homo sapiens OCI-AML-3 IC50 500.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens OCUB-M IC50 0.00524 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 1950.66 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 1535.69 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 4.15 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 0.6518 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 IC50 237.24 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-5 IC50 10000.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens P30-OHK IC50 4665.81 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 31537.43 nM 10.6019/CHEMBL1201861
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens PBMC Activity 15.0 % 10.1128/aac.01602-06
Homo sapiens PBMC Activity 80.0 % 10.1128/aac.01602-06
Homo sapiens PBMC Activity nan None 10.1128/aac.01015-09
Homo sapiens PBMC Activity nan None 10.1128/aac.01602-06
Homo sapiens PBMC Inhibition 13.1 % 10.1021/jm8000746
Homo sapiens PBMC Inhibition 32.5 % 10.1021/jm8000746
Homo sapiens PBMC Inhibition 34.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 36.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 40.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 56.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 67.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 77.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 94.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 97.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition 100.0 % 10.1128/aac.01015-09
Homo sapiens PBMC Inhibition nan % 10.1128/aac.01015-09
Homo sapiens PC-3 Activity nan None 10.1021/acs.jmedchem.6b00484
Homo sapiens PC-3 Activity nan None 10.1021/jm501942m
Homo sapiens PC-3 EC50 43100.0 nM 10.1016/j.bmcl.2017.07.061
Homo sapiens PC-3 FC 0.401 None 10.1038/nchembio790
Homo sapiens PC-3 IC50 10.0 nM 10.1016/j.bmcl.2011.09.035
Homo sapiens PC-3 IC50 1300.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens PC-3 TGI 66.0 % 10.1021/jm1003842
Homo sapiens PC-3 TGI nan None 10.1021/jm301389h
Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Kd 3.7 nM 10.1021/acs.jmedchem.6b00411
Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Ki 3.0 nM 10.1021/jm400087k
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PF-382 IC50 96.79 nM 10.6019/CHEMBL1201861
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1124/jpet.102.036541
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 IC50 1250.0 nM 10.1124/jpet.102.036541
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylethanolamine-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens PI3-kinase class I Inhibition nan % None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Pregnane X receptor Activity nan None 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor EC50 890.0 nM 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor EC50 10000.0 nM 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor Efficacy 80.7 % 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor Efficacy 93.2 % 10.1124/dmd.110.035105
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Programmed cell death protein 4 EC50 50.0 nM 10.1021/np100918z
Homo sapiens Programmed cell death protein 4 Ratio 6.6 None 10.1021/ml4005039
Homo sapiens Protein kinase C alpha Activity 88.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Inhibition 99.0 % 10.1042/0264-6021:3510095
Homo sapiens Protein kinase C alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C alpha Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C iota Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Activity 92.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C nu Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C theta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C theta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Activity 92.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C zeta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Activity 79.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens PSN1 IC50 242.71 nM 10.6019/CHEMBL1201861
Homo sapiens Putative heat shock protein HSP 90-beta 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 Inhibition 110.0 % 10.1042/0264-6021:3510095
Homo sapiens Pyruvate kinase isozymes M1/M2 IC50 50.0 nM 10.1039/D1MD00045D
Homo sapiens QIMR-WIL IC50 11.85 nM 10.6019/CHEMBL1201861
Homo sapiens Quinone reductase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Raji IC50 89.72 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 1.457 nM 10.6019/CHEMBL1201861
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-27A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-6A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RCC10RGB IC50 1958.17 nM 10.6019/CHEMBL1201861
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens REH IC50 7681.09 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 23786.61 nM 10.6019/CHEMBL1201861
Homo sapiens Rho-associated protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 1 Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 140.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Activity 103.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Activity 106.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 109.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 147.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 104.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens RKO IC50 50.29 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 20387.97 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 0.1073 nM 10.6019/CHEMBL1201861
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RPMI-6666 IC50 24.42 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 1.191 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 21.77 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 26742.04 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 6258.97 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 IC50 416.45 nM 10.6019/CHEMBL1201861
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SBC-1 IC50 107.75 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 16386.86 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 1034.14 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 1585.82 nM 10.6019/CHEMBL1201861
Homo sapiens Septin-9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 149.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Activity nan None None
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 91.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 102.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 88.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 137.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 360.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 148.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 146.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase mTOR AC50 nan None 10.1073/pnas.0709695104
Homo sapiens Serine/threonine-protein kinase mTOR Activity nan None 10.1021/jm9012642
Homo sapiens Serine/threonine-protein kinase mTOR Activity nan None 10.1073/pnas.0700816104
Homo sapiens Serine/threonine-protein kinase mTOR IC50 0.1 nM 10.1016/j.ejmech.2020.112391
Homo sapiens Serine/threonine-protein kinase mTOR IC50 0.1 nM 10.1021/acs.jmedchem.9b02038
Homo sapiens Serine/threonine-protein kinase mTOR IC50 0.1 nM 10.1074/jbc.m700498200
Homo sapiens Serine/threonine-protein kinase mTOR IC50 0.45 nM 10.1021/jm050524f
Homo sapiens Serine/threonine-protein kinase mTOR IC50 0.8 nM 10.1016/j.ejmech.2021.113424
Homo sapiens Serine/threonine-protein kinase mTOR IC50 1.6 nM 10.1016/j.bmcl.2005.06.106
Homo sapiens Serine/threonine-protein kinase mTOR IC50 3.467 nM 10.1016/s0960-894x(00)00104-9
Homo sapiens Serine/threonine-protein kinase mTOR IC50 10.0 nM 10.1016/j.bmcl.2011.09.035
Homo sapiens Serine/threonine-protein kinase mTOR IC50 430.0 nM 10.1016/j.ejmech.2018.07.004
Homo sapiens Serine/threonine-protein kinase mTOR IC50 10000.0 nM 10.1016/j.bmcl.2011.09.035
Homo sapiens Serine/threonine-protein kinase mTOR Inhibition 94.88 % 10.1016/j.ejmech.2018.07.004
Homo sapiens Serine/threonine-protein kinase mTOR Inhibition nan % 10.1016/j.ejmech.2017.11.097
Homo sapiens Serine/threonine-protein kinase mTOR Inhibition nan % 10.1021/acs.jmedchem.8b01825
Homo sapiens Serine/threonine-protein kinase mTOR Kd 0.6 nM 10.1021/acs.jmedchem.8b01262
Homo sapiens Serine/threonine-protein kinase mTOR Ratio 1.59 None 10.1016/j.bmcl.2013.06.001
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity -17.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase N3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 82.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 102.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 149.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 136.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 141.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 117.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 142.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 88.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 108.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 213.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 149.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 148.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 253.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-126 IC50 30.38 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 IC50 2700.0 nM 10.1016/j.ejmech.2022.114498
Homo sapiens SF-268 IC50 3715.54 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 IC50 0.0116 nM 10.6019/CHEMBL1201861
Homo sapiens SH-4 IC50 4.34 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 10406.97 nM 10.6019/CHEMBL1201861
Homo sapiens SIG-M5 IC50 17.25 nM 10.6019/CHEMBL1201861
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SiHa Activity nan None 10.1021/acs.jmedchem.7b01402
Homo sapiens SiHa IC50 1756.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens SIMA IC50 16480.24 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 271.46 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 2.495 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 9859.63 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 5290.44 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 IC50 4869.55 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MM-2 IC50 8260.65 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 2132.74 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 8.788 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 27381.13 nM 10.6019/CHEMBL1201861
Homo sapiens SK-OV-3 Activity nan None 10.1021/acs.jmedchem.8b01262
Homo sapiens SK-OV-3 IC50 10000.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens SK-PN-DW IC50 20.23 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 16.81 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 IC50 119.69 nM 10.6019/CHEMBL1201861
Homo sapiens SNU1 IC50 11021.72 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 5640.74 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 690.01 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 7981.92 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 6409.69 nM 10.6019/CHEMBL1201861
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 1100.0 nM 10.1007/s00210-003-0814-4
Homo sapiens SR IC50 11.45 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 296.14 nM 10.6019/CHEMBL1201861
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Stem cell growth factor receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Structural maintenance of chromosomes protein 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SU-DHL-1 IC50 1328.01 nM 10.6019/CHEMBL1201861
Homo sapiens SUM185PE GI50 0.04 nM 10.1021/acs.jnatprod.0c00404
Homo sapiens SUP-T1 IC50 14413.03 nM 10.6019/CHEMBL1201861
Homo sapiens SW684 IC50 1960.99 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 0.8464 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 2477.79 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 748.44 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 314.75 nM 10.6019/CHEMBL1201861
Homo sapiens T47D Activity 0.36 g 10.1021/acs.jmedchem.7b01402
Homo sapiens T47D Activity nan None 10.1016/j.bmc.2023.117235
Homo sapiens T47D Activity nan None 10.1021/acs.jmedchem.7b01402
Homo sapiens T47D IC50 1576.0 nM 10.1021/acs.jmedchem.7b01402
Homo sapiens T47D TGI 72.4 % 10.1021/acs.jmedchem.7b01402
Homo sapiens TALL-1 IC50 6146.88 nM 10.6019/CHEMBL1201861
Homo sapiens TC-YIK IC50 4979.42 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 646.12 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 3.296 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 77.17 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 434.26 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 1.363 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 5278.2 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 883.56 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 2.766 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 2055.59 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 4175.82 nM 10.6019/CHEMBL1201861
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens TGBC1TKB IC50 2.687 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 5.508 nM 10.6019/CHEMBL1201861
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type I Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGW IC50 1639.75 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 9969.18 nM 10.6019/CHEMBL1201861
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid hormone receptor-associated protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TK-10 IC50 916.03 nM 10.6019/CHEMBL1201861
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TUR IC50 363.95 nM 10.6019/CHEMBL1201861
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 139.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Activity 83.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FES Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 160.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Inhibition 102.0 % 10.1042/0264-6021:3510095
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 131.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TYK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4466.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8912.5 nM None
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-266 IC50 5982.02 nM 10.6019/CHEMBL1201861
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-698-M IC50 7843.15 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 5094.66 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 IC50 4395.34 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-812 IC50 4691.61 nM 10.6019/CHEMBL1201861
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 35481.3 nM None
Homo sapiens UMP-CMP kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized protein FLJ45252 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens VA-ES-BJ IC50 0.7231 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens WSU-NHL IC50 5951.74 nM 10.6019/CHEMBL1201861
Homo sapiens YT IC50 8624.27 nM 10.6019/CHEMBL1201861
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 0.34 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 0.66 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 0.78 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 0.85 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 0.92 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.1 nM 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.15 nM 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.18 nM 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.3 nM 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.5 nM 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.1 None 10.1128/aac.01602-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.5 None 10.1128/aac.01602-06
Klebsiella pneumoniae Klebsiella pneumoniae MIC 10000.0 nM 10.6019/CHEMBL4296183
Legionella pneumophila Legionella pneumophila Activity nan None 10.1021/jm101156y
Lichtheimia corymbifera Lichtheimia corymbifera MIC 4.0 ug.mL-1 10.1128/aac.00184-09
Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus Inhibition 40.0 % 10.1021/acs.jmedchem.1c00335
Mucor circinelloides Mucor circinelloides MIC 0.25 ug.mL-1 10.1128/aac.00184-09
Mus musculus Blood Drug uptake 38.0 ng/ml 10.1128/aac.01015-09
Mus musculus Blood Drug uptake 492.0 ng/ml 10.1128/aac.01015-09
Mus musculus Blood Drug uptake 622.0 ng/ml 10.1128/aac.01015-09
Mus musculus MEF Activity nan None 10.1016/j.bmcl.2007.03.012
Mus musculus Mus musculus Activity 10.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity 20.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity 56.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity 65.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity 80.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity 100.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.7b00665
Mus musculus Mus musculus Activity nan None 10.1128/aac.01015-09
Mus musculus Mus musculus IC50 1.0 nM 10.1016/S0960-894X(01)80998-7
Mus musculus Mus musculus IC50 3.0 nM 10.1016/s0960-894x(98)00735-5
Mus musculus Mus musculus Inhibition 8.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Inhibition 80.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Inhibition 90.0 % 10.1128/aac.01015-09
Mus musculus Mus musculus Inhibition nan % 10.1021/jm301389h
Mus musculus Mus musculus Inhibition nan % 10.1128/aac.01015-09
Mus musculus Mus musculus MST 12.01 day 10.1016/0960-894X(95)00223-G
Mus musculus Mus musculus Skin Graft Survival 12.0 None 10.1016/s0960-894x(98)00735-5
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 31622.8 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus Peptidyl-prolyl cis-trans isomerase FKBP1A IC50 1.0 nM 10.1039/C7MD00474E
Mus musculus Phosphatidylinositol 3-kinase Inhibition nan % None
Mus musculus RAC-alpha serine/threonine-protein kinase Activity nan None 10.1074/jbc.m704741200
Mus musculus RAC-alpha serine/threonine-protein kinase Activity nan None None
Mus musculus Serine/threonine-protein kinase mTOR IC50 0.05 nM 10.1021/acsmedchemlett.9b00215
Mus musculus Tyrosine-protein kinase LCK Activity 79.0 % 10.1042/bj20070797
Nakaseomyces glabratus Nakaseomyces glabratus MIC 0.1 ug.mL-1 10.1016/s0960-894x(00)00184-0
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Sarcoplasmic/endoplasmic reticulum calcium ATP-ase IC50 77000.0 nM 10.1021/acs.jmedchem.9b01509
Pichia kudriavzevii Pichia kudriavzevii MIC 0.78 ug.mL-1 10.1016/s0960-894x(00)00184-0
Plasmodium falciparum Plasmodium falciparum IC50 2600.0 nM 10.1021/acsmedchemlett.0c00272
Plasmodium falciparum Plasmodium falciparum Potency 1510.1 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4296183
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 11910.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Activity nan None 10.1124/dmd.110.035105
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 271.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 311.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 328.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 356.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 361.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 398.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 92.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 82.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 93.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 142.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 559.0 ng.hr.mL-1 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 173.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 183.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 205.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 206.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 666.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 688.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 698.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 793.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 816.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 843.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 205.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 312.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 323.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 467.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 479.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 1089.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cmax 55.57 nM 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus CO2 20330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ED50 0.2 mg.kg-1 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus ED50 0.3 mg.kg-1 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus ED50 0.5 mg.kg-1 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus ED50 2.1 mpk/d 10.1021/jm960066y
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 31.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 47.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 267.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 43.2 % 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus GLUC 1498.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1516.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1620.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1920.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 2023.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 2513.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.87 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 39.93 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 155700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 157700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 111.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 201.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 231.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 322.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 597.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 725.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6680.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11212.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12718.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13791.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14327.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15937.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.87 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.48 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.5 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.6 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.73 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.33 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 380000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 388800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 390000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 392200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 407700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.2 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.5 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 49.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 96.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 102.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 138.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 245.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 267.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 775.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1321.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1443.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1575.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1619.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 104.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 140.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 709330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1112000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1156000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1211670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1286330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1298000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 4.97 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.46 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.43 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.49 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 54300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5450000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5630000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5790000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6320000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6630000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 140.68 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.93 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.47 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.27 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 14.0 hr 10.1039/C7MD00474E
Rattus norvegicus Rattus norvegicus T1/2 33.4 hr 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus T1/2 33.4 hr 10.1039/C7MD00474E
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tmax 0.5 hr 10.1016/j.bmcl.2005.06.106
Rattus norvegicus Rattus norvegicus URATE 12.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 22.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 7400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15780.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17570.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rho-associated protein kinase 2 Inhibition 92.0 % 10.1042/0264-6021:3510095
Rattus norvegicus Serine/threonine-protein kinase mTOR FC 2.0 None 10.1021/acs.jmedchem.7b01199
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Synaptic vesicular amine transporter AC50 23000.1 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 0.00043 ug 10.1021/np9701438
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 0.00044 ug 10.1021/np9701438
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 0.00057 ug 10.1021/np9701438
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 0.00074 ug 10.1021/np9701438
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -5.1 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -3.2 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -3.1 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -2.5 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -2.3 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC -2.1 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC 2.9 None 10.1038/nchembio762
Saccharomyces cerevisiae Saccharomyces cerevisiae FC 5.0 None 10.1038/nchembio762
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.54 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 19.32 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Activity nan None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 AUC 237.6 None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.6828 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 26302.68 nM 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.12 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.5 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 49.65 % 10.21203/rs.3.rs-23951/v1
Staphylococcus aureus Staphylococcus aureus MIC 10000.0 nM 10.6019/CHEMBL4296183
Trypanosoma brucei Trypanosoma brucei Activity nan None 10.1128/aac.00423-07
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01825
None ADMET AUC Ratio 0.68 None 10.1038/s41586-020-2286-9
None ADMET CL 50.12 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 150.0 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET T1/2 13.0 hr 10.1016/s0960-894x(98)00735-5
None ADMET T1/2 40.0 hr 10.1016/j.ejmech.2020.112391
None BC1 cell line IC50 31.26 nM 10.6019/CHEMBL1201861
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 3.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Molecular identity unknown FC -8.1 None 10.1038/nchembio762
None Molecular identity unknown FC -7.2 None 10.1038/nchembio762
None Molecular identity unknown FC -6.4 None 10.1038/nchembio762
None Molecular identity unknown FC -5.9 None 10.1038/nchembio762
None Molecular identity unknown FC -5.8 None 10.1038/nchembio762
None Molecular identity unknown FC -5.7 None 10.1038/nchembio762
None Molecular identity unknown FC -5.6 None 10.1038/nchembio762
None Molecular identity unknown FC -5.2 None 10.1038/nchembio762
None Molecular identity unknown FC -5.1 None 10.1038/nchembio762
None Molecular identity unknown FC -4.9 None 10.1038/nchembio762
None Molecular identity unknown FC -4.5 None 10.1038/nchembio762
None Molecular identity unknown FC -4.4 None 10.1038/nchembio762
None Molecular identity unknown FC -4.2 None 10.1038/nchembio762
None Molecular identity unknown FC -4.1 None 10.1038/nchembio762
None Molecular identity unknown FC -4.0 None 10.1038/nchembio762
None Molecular identity unknown FC -3.9 None 10.1038/nchembio762
None Molecular identity unknown FC -3.8 None 10.1038/nchembio762
None Molecular identity unknown FC -3.7 None 10.1038/nchembio762
None Molecular identity unknown FC -3.6 None 10.1038/nchembio762
None Molecular identity unknown FC -3.4 None 10.1038/nchembio762
None Molecular identity unknown FC -3.3 None 10.1038/nchembio762
None Molecular identity unknown FC -3.2 None 10.1038/nchembio762
None Molecular identity unknown FC -3.1 None 10.1038/nchembio762
None Molecular identity unknown FC -3.0 None 10.1038/nchembio762
None Molecular identity unknown FC -2.9 None 10.1038/nchembio762
None Molecular identity unknown FC -2.8 None 10.1038/nchembio762
None Molecular identity unknown FC -2.7 None 10.1038/nchembio762
None Molecular identity unknown FC -2.6 None 10.1038/nchembio762
None Molecular identity unknown FC -2.5 None 10.1038/nchembio762
None Molecular identity unknown FC -2.4 None 10.1038/nchembio762
None Molecular identity unknown FC -2.3 None 10.1038/nchembio762
None Molecular identity unknown FC -2.2 None 10.1038/nchembio762
None Molecular identity unknown FC -2.1 None 10.1038/nchembio762
None Molecular identity unknown FC -2.0 None 10.1038/nchembio762
None Molecular identity unknown FC 2.0 None 10.1038/nchembio762
None Molecular identity unknown FC 2.1 None 10.1038/nchembio762
None Molecular identity unknown FC 2.2 None 10.1038/nchembio762
None Molecular identity unknown FC 2.3 None 10.1038/nchembio762
None Molecular identity unknown FC 2.4 None 10.1038/nchembio762
None Molecular identity unknown FC 2.5 None 10.1038/nchembio762
None Molecular identity unknown FC 2.6 None 10.1038/nchembio762
None Molecular identity unknown FC 2.7 None 10.1038/nchembio762
None Molecular identity unknown FC 2.8 None 10.1038/nchembio762
None Molecular identity unknown FC 2.9 None 10.1038/nchembio762
None Molecular identity unknown FC 3.0 None 10.1038/nchembio762
None Molecular identity unknown FC 3.1 None 10.1038/nchembio762
None Molecular identity unknown FC 3.2 None 10.1038/nchembio762
None Molecular identity unknown FC 3.3 None 10.1038/nchembio762
None Molecular identity unknown FC 3.4 None 10.1038/nchembio762
None Molecular identity unknown FC 3.5 None 10.1038/nchembio762
None Molecular identity unknown FC 3.6 None 10.1038/nchembio762
None Molecular identity unknown FC 3.8 None 10.1038/nchembio762
None Molecular identity unknown FC 3.9 None 10.1038/nchembio762
None Molecular identity unknown FC 4.1 None 10.1038/nchembio762
None Molecular identity unknown FC 4.2 None 10.1038/nchembio762
None Molecular identity unknown FC 4.4 None 10.1038/nchembio762
None Molecular identity unknown FC 4.5 None 10.1038/nchembio762
None Molecular identity unknown FC 4.6 None 10.1038/nchembio762
None Molecular identity unknown FC 4.7 None 10.1038/nchembio762
None Molecular identity unknown FC 4.9 None 10.1038/nchembio762
None Molecular identity unknown FC 5.0 None 10.1038/nchembio762
None Molecular identity unknown FC 5.3 None 10.1038/nchembio762
None Molecular identity unknown FC 5.4 None 10.1038/nchembio762
None Molecular identity unknown FC 5.7 None 10.1038/nchembio762
None Molecular identity unknown FC 5.9 None 10.1038/nchembio762
None Molecular identity unknown FC 6.2 None 10.1038/nchembio762
None Molecular identity unknown FC 6.3 None 10.1038/nchembio762
None Molecular identity unknown FC 6.4 None 10.1038/nchembio762
None Molecular identity unknown FC 6.5 None 10.1038/nchembio762
None Molecular identity unknown FC 6.9 None 10.1038/nchembio762
None Molecular identity unknown FC 7.0 None 10.1038/nchembio762
None Molecular identity unknown FC 7.1 None 10.1038/nchembio762
None Molecular identity unknown FC 7.2 None 10.1038/nchembio762
None Molecular identity unknown FC 7.4 None 10.1038/nchembio762
None Molecular identity unknown FC 8.3 None 10.1038/nchembio762
None Molecular identity unknown FC 8.4 None 10.1038/nchembio762
None Molecular identity unknown FC 9.8 None 10.1038/nchembio762
None Molecular identity unknown FC 10.4 None 10.1038/nchembio762
None Molecular identity unknown FC 11.4 None 10.1038/nchembio762
None Molecular identity unknown FC 13.6 None 10.1038/nchembio762
None Molecular identity unknown FC 13.7 None 10.1038/nchembio762
None Molecular identity unknown FC 14.4 None 10.1038/nchembio762
None Molecular identity unknown FC 14.5 None 10.1038/nchembio762
None Molecular identity unknown FC 24.4 None 10.1038/nchembio762
None NON-PROTEIN TARGET Activity 57.0 % 10.1074/jbc.m704741200
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2016.05.011
None NON-PROTEIN TARGET Activity nan None 10.1021/jm901427g
None NON-PROTEIN TARGET Activity nan None 10.1073/pnas.0700816104
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00184-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00184-09
None No relevant target solubility nan None 10.1021/jm901427g
None No relevant target Solubility 2.6 ug.mL-1 10.1016/j.ejmech.2022.114498
None T-cell IC50 1.6 nM 10.1016/j.bmcl.2005.06.106
None T-cell IC50 9.8 nM 10.1016/0960-894X(95)00223-G
None T-cell IC50 2600.0 nM 10.1016/j.bmcl.2005.06.106
None Unchecked Activity 17.0 % 10.1021/acs.jnatprod.9b00451
None Unchecked Activity 58.3 % 10.1016/j.bmcl.2017.07.061
None Unchecked Activity 87.0 % 10.1042/bj20070797
None Unchecked Activity 95.0 % 10.1042/bj20070797
None Unchecked Activity nan None 10.1016/j.bmcl.2020.127715
None Unchecked Activity nan None 10.1038/nchembio832
None Unchecked FC 0.26 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 0.79 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 1.14 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 1.26 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 1.3 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 1.69 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 2.17 None 10.1016/j.bmcl.2020.127715
None Unchecked FC 16.57 None 10.1016/j.bmcl.2020.127715
None Unchecked IC12 7.0 nM 10.1039/C7MD00474E
None Unchecked IC50 1.0 nM 10.1016/s0960-894x(99)00007-4
None Unchecked IC50 7.9 nM 10.1021/acs.jmedchem.0c00911
None Unchecked IC50 15.0 nM 10.1016/s0960-894x(98)00735-5
None Unchecked IC50 15.8 nM 10.1021/acs.jmedchem.0c00911
None Unchecked IC50 34.0 nM 10.1021/acsmedchemlett.0c00272
None Unchecked IC50 50.0 nM 10.1021/acs.jmedchem.1c00981
None Unchecked IC50 1084.8 nM None
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2022.114498
None Unchecked IC50 57000.0 nM 10.1021/acs.jnatprod.9b00451
None Unchecked IC50 77000.0 nM 10.1021/acs.jmedchem.9b01509
None Unchecked IC50 nan None None
None Unchecked Inhibition 7.24 % 10.1016/j.bmcl.2017.07.061
None Unchecked Inhibition 28.94 % 10.1016/j.bmcl.2017.07.061
None Unchecked Inhibition 40.0 % 10.1016/j.bmcl.2011.01.139
None Unchecked Inhibition 76.0 % 10.1038/nchembio859
None Unchecked Inhibition 80.0 % 10.1021/acs.jmedchem.9b01509
None Unchecked Inhibition 95.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 99.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 103.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 104.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 106.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition nan % 10.1016/j.bmc.2015.11.003
None Unchecked Inhibition nan % 10.1016/j.bmcl.2011.01.139
None Unchecked Inhibition nan % 10.1016/j.bmcl.2016.05.011
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368
None Unchecked Ki 0.5 nM 10.1016/S0960-894X(01)80998-7
None Unchecked Ki 1.0 nM 10.1021/acs.jmedchem.8b01732
None Unchecked Ki 371.1 nM None
None Unchecked Ki 1000.0 nM 10.1016/S0960-894X(01)80135-9
None Unchecked Ki nan None None
None Unchecked Potency 25.6 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio 3.0 None 10.1016/s0960-894x(98)00735-5
None Unchecked Ratio 6.0 None 10.1038/nchembio832
None Unchecked Ratio 15.0 None 10.1038/nchembio832
None Unchecked Ratio 22.0 None 10.1038/nchembio832
None Unchecked Ratio 50.0 None 10.1038/nchembio832
None Unchecked Ratio 75.0 None 10.1038/nchembio832
None Unchecked Selectivity Index 2.32 None 10.1016/j.bmcl.2017.07.061

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011310 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OP(=O)(O)O)[C@H](OC)C2)CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C1C.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT011311 CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C>>CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OP(=O)(O)O)[C@H](OC)C2)CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C1C enzymemap_45721