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name Structure Reference Source Properties Activities Metabolism

Berberine Chloride

AlkaPlorer ID: AK000522

Synonym: None

IUPAC Name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride

Structure

SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

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InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

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InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Coptis chinensis Coptis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 371.82000000000016

TPSA？: 40.8

MolLogP？: 0.10029999999999939

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agrostis stolonifera var. palustris Agrostis stolonifera var. palustris Activity 0.0 % 10.1271/bbb.64.1998
Alternaria alternata Alternaria alternata MIC 125.0 ug.mL-1 10.1021/np0504863
Artemia Artemia LD50 66.9 uM 10.1021/np068005i
Artemia Artemia LD50 67.0 uM 10.1021/np030065q
Aspergillus flavus Aspergillus flavus MIC80 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Aspergillus fumigatus Aspergillus fumigatus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Aspergillus terreus Aspergillus terreus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Bacillus anthracis Anthrax lethal factor Potency 19952.6 nM None
Bacillus pumilus Bacillus pumilus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Bacillus subtilis Bacillus subtilis INH 100.0 ug ml-1 10.1021/acs.jmedchem.5b01098
Bacillus subtilis Bacillus subtilis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Bacillus subtilis Bacillus subtilis MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Bacillus subtilis Bacillus subtilis MIC 512.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Bacillus subtilis Bacillus subtilis MIC 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Bacillus subtilis Bacillus subtilis MIC 1000.0 ug.mL-1 10.1021/np980044+
Blumeria graminis f. sp. tritici Blumeria graminis f. sp. tritici Activity 0.0 % 10.1271/bbb.64.1998
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Bos taurus Serum albumin Kb 3.37 10'3L/mol 10.1021/np400607k
Candida Candida MIC 128.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Candida albicans Candida albicans Activity nan None 10.1016/j.bmc.2020.115697
Candida albicans Candida albicans FICI 0.5 None 10.1021/np0504863
Candida albicans Candida albicans MIC 15.6 ug.mL-1 10.1021/np0504863
Candida albicans Candida albicans MIC 31.3 ug.mL-1 10.1021/np0504863
Candida albicans Candida albicans MIC 100.0 ug.mL-1 10.1021/np9701889
Candida albicans Candida albicans MIC 128.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Candida albicans Candida albicans MIC 500.0 ug.mL-1 10.1021/np980044+
Candida albicans Candida albicans MIC 512.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Candida albicans Candida albicans MIC80 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Candida tropicalis Candida tropicalis MIC 16.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 2222.0 nM None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 370.0 nM None
Clavispora lusitaniae Clavispora lusitaniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Cricetulus griseus CHO-K1 IC50 336000.0 nM 10.1016/j.ejmech.2020.112593
Cryptococcus neoformans Cryptococcus neoformans MIC 31.3 ug.mL-1 10.1021/np0504863
Cryptococcus neoformans Cryptococcus neoformans MIC 64.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Cyberlindnera jadinii Cyberlindnera jadinii MIC80 256.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2009.12.035
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2010.04.063
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2011.02.025
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2011.09.040
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2013.07.011
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmcl.2010.09.013
Electrophorus electricus Acetylcholinesterase IC50 2740.0 nM 10.1016/j.bmc.2012.09.040
Electrophorus electricus Acetylcholinesterase Inhibition 79.03 % 10.1016/j.bmc.2012.09.040
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.bmc.2009.12.035
Electrophorus electricus Acetylcholinesterase Ki 289.0 nM 10.1016/j.bmc.2009.12.035
Entamoeba histolytica Entamoeba histolytica IC50 111000.0 nM 10.1021/np000144r
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/j.bmc.2016.05.003
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Enterococcus faecalis Enterococcus faecalis MIC 650000.0 nM 10.1016/j.bmc.2009.04.028
Enterococcus faecium Enterococcus faecium MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Equus caballus Butyrylcholinesterase IC50 18200.0 nM 10.1016/j.bmc.2011.02.025
Equus caballus Butyrylcholinesterase IC50 18200.0 nM 10.1016/j.bmc.2011.09.040
Equus caballus Butyrylcholinesterase IC50 18200.0 nM 10.1016/j.bmcl.2010.09.013
Equus caballus Butyrylcholinesterase IC50 nan None 10.1016/j.bmc.2011.09.040
Equus caballus Butyrylcholinesterase IC50 nan None 10.1016/j.bmcl.2010.09.013
Equus caballus Cholinesterase IC50 18200.0 nM 10.1016/j.bmc.2009.12.035
Equus caballus Cholinesterase IC50 18200.0 nM 10.1016/j.bmc.2010.04.063
Equus caballus Cholinesterase IC50 18210.0 nM 10.1016/j.bmc.2013.07.011
Equus caballus Cholinesterase IC50 nan None 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition 6.87 % 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition nan % 10.1016/j.bmc.2009.12.035
Equus caballus Cholinesterase Ki 9200.0 nM 10.1016/j.bmc.2009.12.035
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2020.115697
Escherichia coli Escherichia coli INH 400.0 uM 10.1021/acs.jmedchem.5b01098
Escherichia coli Escherichia coli MIC 5.0 ug.mL-1 10.1016/j.bmcl.2005.11.045
Escherichia coli Escherichia coli MIC 31.25 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmc.2016.05.003
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Escherichia coli Escherichia coli MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Escherichia coli Escherichia coli MIC 250.0 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Escherichia coli Escherichia coli MIC 2000.0 ug.mL-1 10.1021/np980044+
Escherichia coli Escherichia coli MIC 325000.0 nM 10.1016/j.bmc.2009.04.028
Escherichia coli Escherichia coli MIC 2600000.0 nM 10.1016/j.bmc.2009.04.028
Escherichia coli K-12 Beta-lactamase AmpC Potency 11220.2 nM None
Escherichia coli K-12 Cell division protein ftsZ IC50 10000.0 nM 10.1016/j.bmc.2016.05.003
Escherichia coli K-12 Cell division protein ftsZ IC50 16000.0 nM 10.1016/j.bmc.2016.05.003
Escherichia coli K-12 Cell division protein ftsZ INH 10.0 uM 10.1021/acs.jmedchem.5b01098
Escherichia coli K-12 Cell division protein ftsZ INH 16.0 uM 10.1021/acs.jmedchem.5b01098
Escherichia coli K-12 Cell division protein ftsZ Kd 23.0 nM 10.1021/acs.jmedchem.5b01098
Exophiala dermatitidis Exophiala dermatitidis MIC 31.3 ug.mL-1 10.1021/np0504863
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 4456.3 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 17740.7 nM None
Homo sapiens 786-0 GI50 49431.07 nM None
Homo sapiens A2780 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens A498 GI50 95940.06 nM None
Homo sapiens A549 GI50 62517.27 nM None
Homo sapiens A549 IC50 6270.0 nM 10.1016/j.bmcl.2010.06.035
Homo sapiens A549 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens Acetylcholinesterase IC50 40.0 nM 10.1016/j.bmcl.2011.04.042
Homo sapiens Acetylcholinesterase IC50 610.0 nM 10.1016/j.bmc.2012.09.040
Homo sapiens Acetylcholinesterase IC50 774.0 nM None
Homo sapiens Acetylcholinesterase IC50 17400.0 nM 10.1016/j.ejmech.2020.112593
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN GI50 100000.0 nM None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 601.0 nM None
Homo sapiens Alpha-2b adrenergic receptor Ki 274.0 nM None
Homo sapiens Alpha-2c adrenergic receptor IC50 2837.0 nM None
Homo sapiens Alpha-2c adrenergic receptor Ki 412.0 nM None
Homo sapiens Amyloid-beta A4 protein Inhibition 32.0 % 10.1016/j.ejmech.2021.113289
Homo sapiens Amyloid-beta A4 protein Inhibition 35.5 % 10.1016/j.bmc.2013.07.011
Homo sapiens Amyloid-beta A4 protein Inhibition 70.5 % 10.1016/j.ejmech.2020.112593
Homo sapiens Androgen Receptor Potency 31622.8 nM None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 231.1 nM None
Homo sapiens Bel-7402 Activity nan None 10.1021/jm801157z
Homo sapiens Bel-7402 IC50 16280.0 nM 10.1007/s00044-013-0796-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens BGC-823 IC50 7040.0 nM 10.1007/s00044-013-0796-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens BT-549 GI50 5382.7 nM None
Homo sapiens Butyrylcholinesterase IC50 18970.0 nM 10.1016/j.bmcl.2011.04.042
Homo sapiens Butyrylcholinesterase IC50 47200.0 nM 10.1016/j.ejmech.2020.112593
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.bmc.2012.09.040
Homo sapiens CAKI-1 GI50 65012.97 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM CC50 2090.0 nM 10.1016/j.ejmech.2011.01.016
Homo sapiens CCRF-CEM GI50 13243.42 nM None
Homo sapiens Cell division control protein 42 homolog Inhibition 8.0 % 10.1016/j.bmcl.2009.08.037
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens COLO 205 GI50 7464.49 nM None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A1 Inhibition 48.0 % 10.1039/C7MD00388A
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 4504.2 nM None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DLD-1 GI50 54200.09 nM None
Homo sapiens DMS-114 GI50 4226.69 nM None
Homo sapiens DMS-273 GI50 10303.86 nM None
Homo sapiens DNA polymerase iota Potency 8912.5 nM None
Homo sapiens DNA polymerase iota Potency 39810.7 nM None
Homo sapiens DNA repair protein RAD52 homolog AC50 2380.0 nM None
Homo sapiens DNA repair protein RAD52 homolog AC50 5690.0 nM None
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor Potency 11.2 nM None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DU-145 GI50 44463.13 nM None
Homo sapiens DU-145 IC50 20000.0 nM 10.1016/j.bmcl.2019.126821
Homo sapiens ECa-109 cell line IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens EKVX GI50 46238.1 nM None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha Activity 51.41 % 10.1016/j.bmcl.2011.11.041
Homo sapiens Estrogen receptor alpha Activity 58.49 % 10.1016/j.bmcl.2011.11.041
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor alpha Potency 11220.2 nM None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Flap endonuclease 1 Potency 19952.6 nM None
Homo sapiens Flap endonuclease 1 Potency 37933.0 nM None
Homo sapiens Flap endonuclease 1 Potency 44668.4 nM None
Homo sapiens G-402 GI50 11870.0 nM 10.1021/np100645d
Homo sapiens Glucagon-like peptide 1 receptor Potency 2238.7 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 2818.4 nM None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucocorticoid receptor Potency 3162.3 nM None
Homo sapiens HCC 2998 GI50 9057.33 nM None
Homo sapiens HCT-116 GI50 15031.42 nM None
Homo sapiens HCT-116 IC50 10000.0 nM 10.1016/j.bmcl.2019.126821
Homo sapiens HCT-116 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens HCT-116 IC50 39950.0 nM 10.1016/j.ejmech.2017.03.027
Homo sapiens HCT-116 IC50 83090.0 nM 10.1021/acs.jmedchem.0c00088
Homo sapiens HCT-15 GI50 216271.85 nM None
Homo sapiens HCT-15 IC50 16590.0 nM 10.1016/j.bmcl.2010.06.035
Homo sapiens HCT-8 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens HEK293 Potency 11582.1 nM None
Homo sapiens HeLa IC50 138400000.0 ug.mL-1 10.1016/j.bmc.2008.02.015
Homo sapiens HepG2 Activity 0.84 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 1.17 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 1.88 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 2.99 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 3.77 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 4.39 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 4.49 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 5.16 % 10.1016/j.bmcl.2019.126709
Homo sapiens HepG2 Activity 5.3 None 10.1016/j.bmcl.2008.07.005
Homo sapiens HepG2 Activity 5.51 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 6.4 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 88.83 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 89.77 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity 89.95 % 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity nan None 10.1016/j.bmc.2012.09.029
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2016.04.070
Homo sapiens HepG2 Activity nan None 10.1021/acs.jmedchem.0c00881
Homo sapiens HepG2 Activity nan None 10.1021/jm801157z
Homo sapiens HepG2 CI 1.0 None 10.1021/acs.jmedchem.0c00881
Homo sapiens HepG2 FC 1.9 None 10.1016/j.bmcl.2009.09.059
Homo sapiens HepG2 FC 2.2 None 10.1021/jm801157z
Homo sapiens HepG2 FC 2.3 None 10.1016/j.bmcl.2009.09.059
Homo sapiens HepG2 FC 2.35 None 10.1016/j.bmc.2012.09.029
Homo sapiens HepG2 IC50 53.91 ug.mL-1 10.1039/C9MD00036D
Homo sapiens HepG2 IC50 8320.0 nM 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 IC50 11220.0 nM 10.1016/j.bmcl.2012.10.098
Homo sapiens HepG2 IC50 49010.0 nM 10.1016/j.ejmech.2017.03.027
Homo sapiens HepG2 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens HepG2 IC50 146200000.0 ug.mL-1 10.1016/j.bmc.2008.02.015
Homo sapiens HepG2 IC50 relative 14400.0 nM 10.6019/EOS300108
Homo sapiens HERG IC50 3100.0 nM 10.1016/j.ejmech.2017.09.012
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens HL-60 Activity nan None 10.1016/j.ejmech.2010.02.028
Homo sapiens HL-60 GI50 13645.83 nM None
Homo sapiens HL-60 IC50 5830.0 nM 10.1007/s00044-013-0796-9
Homo sapiens HL-60 IC50 27420.0 nM 10.1016/j.ejmech.2017.03.027
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity nan None 10.1021/np400607k
Homo sapiens Homo sapiens Cmax 1.7 nM 10.1021/np400607k
Homo sapiens Homo sapiens Cmax 4.0 nM 10.1021/np400607k
Homo sapiens Homo sapiens Cmax 5.6 nM 10.1021/np400607k
Homo sapiens Homo sapiens Cmax 6.7 nM 10.1021/np400607k
Homo sapiens Homo sapiens T1/2 2.94 hr 10.1021/jm801157z
Homo sapiens Homo sapiens Tmax 1.0 hr 10.1021/np400607k
Homo sapiens Homo sapiens Tmax 2.0 hr 10.1021/np400607k
Homo sapiens HOP-18 GI50 105925.37 nM None
Homo sapiens HOP-62 GI50 11246.05 nM None
Homo sapiens HOP-92 GI50 36728.23 nM None
Homo sapiens Hs-578T GI50 10046.16 nM None
Homo sapiens HT-29 GI50 31045.6 nM None
Homo sapiens HT-29 IC50 8450.0 nM 10.1016/j.bmcl.2012.10.098
Homo sapiens HT-29 IC50 10000.0 nM 10.1016/j.bmcl.2019.126821
Homo sapiens HT-29 IC50 20000.0 nM 10.1016/j.bmcl.2012.10.098
Homo sapiens HT-29 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens Huh-7 CC50 100000.0 nM 10.1073/pnas.0802982105
Homo sapiens Huntingtin Potency 10000.0 nM None
Homo sapiens IGROV-1 GI50 40644.33 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 2310.9 nM None
Homo sapiens K562 GI50 16634.13 nM None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB IC50 6030.0 nM 10.1007/s00044-013-0796-9
Homo sapiens KB IC50 7320.0 nM 10.1021/np000144r
Homo sapiens KM12 GI50 7709.03 nM None
Homo sapiens KM12C IC50 76340.0 nM 10.1021/acs.jmedchem.0c00088
Homo sapiens KM12C TGI 33.6 % 10.1021/acs.jmedchem.0c00088
Homo sapiens KM-20L2 GI50 28183.83 nM None
Homo sapiens L02 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens L02 IC50 71550.0 nM 10.1016/j.ejmech.2017.03.027
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LOX IMVI GI50 77090.35 nM None
Homo sapiens LS174T IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens Lymphoblastoid cell Potency 19952.6 nM None
Homo sapiens Lymphoblastoid cell Potency 31622.8 nM None
Homo sapiens Lymphoblastoid cell Potency 39810.7 nM None
Homo sapiens Lymphoblastoid cell Potency 50118.7 nM None
Homo sapiens Lymphoblastoid cell Potency 63095.7 nM None
Homo sapiens Lymphoblastoid cell Potency 79432.8 nM None
Homo sapiens M14 GI50 22803.42 nM None
Homo sapiens M19-MEL GI50 5559.04 nM None
Homo sapiens Malme-3M GI50 6683.44 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 GI50 15066.07 nM None
Homo sapiens MDA-MB-231 GI50 36140.99 nM None
Homo sapiens MDA-MB-231 IC50 20600.0 nM 10.1016/j.bmcl.2019.126821
Homo sapiens MDA-MB-435 GI50 12793.81 nM None
Homo sapiens MDA-N GI50 17660.38 nM None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Microtubule-associated protein tau Potency 17782.8 nM None
Homo sapiens Microtubule-associated protein tau Potency 25118.9 nM None
Homo sapiens MKN-28 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens MOLT-4 GI50 7533.56 nM None
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MRC5 CC50 74000.0 nM 10.1016/j.bmcl.2006.12.085
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 3080.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki 742.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscleblind-like protein 1 Potency 7943.3 nM None
Homo sapiens NAD(+) hydrolase SARM1 IC50 77000.0 nM 10.1016/j.bmc.2020.115644
Homo sapiens NAD(+) hydrolase SARM1 IC50 110000.0 nM 10.1016/j.bmc.2020.115644
Homo sapiens NAD(+) hydrolase SARM1 IC50 140000.0 nM 10.1016/j.bmc.2020.115644
Homo sapiens NAD(+) hydrolase SARM1 Inhibition 70.0 % 10.1016/j.bmc.2020.115644
Homo sapiens NAD(+) hydrolase SARM1 Ki 130000.0 nM 10.1016/j.bmc.2020.115644
Homo sapiens NCI/ADR-RES GI50 323593.66 nM None
Homo sapiens NCI-H226 GI50 15523.87 nM None
Homo sapiens NCI-H23 GI50 7345.14 nM None
Homo sapiens NCI-H322M GI50 36559.48 nM None
Homo sapiens NCI-H460 GI50 12218.0 nM None
Homo sapiens NCI-H522 GI50 2223.31 nM None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 9200.0 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 29092.9 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 33491.5 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 25118.9 nM None
Homo sapiens OVCAR-3 GI50 5284.45 nM None
Homo sapiens OVCAR-4 GI50 9660.51 nM None
Homo sapiens OVCAR-5 GI50 58344.51 nM None
Homo sapiens OVCAR-8 GI50 12676.52 nM None
Homo sapiens P2X purinoceptor 7 Inhibition 7.03 % 10.1016/j.bmcl.2008.11.088
Homo sapiens PANC-1 IC50 50000.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens Parathyroid hormone receptor Potency 39810.7 nM None
Homo sapiens PC-3 Activity nan None 10.1016/j.bmcl.2019.126821
Homo sapiens PC-3 GI50 26853.44 nM None
Homo sapiens PC-3 IC50 14390.0 nM 10.1016/j.bmcl.2019.126821
Homo sapiens PC-3 IC50 31720.0 nM 10.1021/acs.jmedchem.0c00881
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 19952.6 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 44668.4 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/nrd3028
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma Cmax 0.07 nM 10.1021/np400607k
Homo sapiens Plasma Cmax 0.13 nM 10.1021/np400607k
Homo sapiens Plasma Cmax 0.14 nM 10.1021/np400607k
Homo sapiens Plasma Cmax 1.4 nM 10.1021/np400607k
Homo sapiens Plasma Cp 0.15 nM 10.1021/np400607k
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Prelamin-A/C Potency 7079.5 nM None
Homo sapiens Prelamin-A/C Potency 11220.2 nM None
Homo sapiens Prolyl endopeptidase IC50 142000.0 nM 10.1016/j.ejmech.2020.112593
Homo sapiens Prolyl endopeptidase IC50 145000.0 nM 10.1016/j.ejmech.2020.112593
Homo sapiens Prolyl endopeptidase IC50 145000.0 nM 10.1021/jm901104g
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Ras-related C3 botulinum toxin substrate 1 Inhibition 14.0 % 10.1016/j.bmcl.2009.08.037
Homo sapiens Ras-related C3 botulinum toxin substrate 1 Inhibition 23.0 % 10.1016/j.bmcl.2009.08.037
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Retinoid X receptor alpha Activity nan None 10.1021/acs.jmedchem.0c00088
Homo sapiens Retinoid X receptor alpha Kd 24800.0 nM 10.1021/acs.jmedchem.0c00088
Homo sapiens RPMI-8226 GI50 7345.14 nM None
Homo sapiens RXF 393 GI50 68548.82 nM None
Homo sapiens Sentrin-specific protease 8 IC50 7660.0 nM None
Homo sapiens Sentrin-specific protease 8 IC50 100000.0 nM None
Homo sapiens Serine/threonine-protein kinase NEK7 Activity nan None 10.1021/acs.jmedchem.0c01743
Homo sapiens Serine/threonine-protein kinase NEK7 IC50 4200.0 nM 10.1021/acs.jmedchem.0c01743
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 15600.0 nM 10.1021/acs.jmedchem.0c01743
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 3437.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 2187.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-268 GI50 5199.96 nM None
Homo sapiens SF-295 GI50 8452.79 nM None
Homo sapiens SF-539 GI50 35318.32 nM None
Homo sapiens SGC-7901 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens Sigma opioid receptor IC50 1289.0 nM None
Homo sapiens Sigma opioid receptor Ki 542.0 nM None
Homo sapiens Signal transducer and activator of transcription 3 Inhibition nan % 10.1021/acs.jnatprod.0c00175
Homo sapiens SK-MEL-2 GI50 25292.98 nM None
Homo sapiens SK-MEL-2 IC50 13760.0 nM 10.1016/j.bmcl.2010.06.035
Homo sapiens SK-MEL-28 GI50 22181.96 nM None
Homo sapiens SK-MEL-5 GI50 4954.5 nM None
Homo sapiens SK-OV-3 GI50 84527.88 nM None
Homo sapiens SK-OV-3 IC50 16440.0 nM 10.1016/j.bmcl.2010.06.035
Homo sapiens SMMC-7721 IC50 25940.0 nM 10.1016/j.ejmech.2017.03.027
Homo sapiens SN12C GI50 10327.61 nM None
Homo sapiens SN12K1 GI50 3926.45 nM None
Homo sapiens SNB-19 GI50 8375.29 nM None
Homo sapiens SNB-75 GI50 36475.39 nM None
Homo sapiens SNB-78 GI50 53826.98 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 110.43 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 108.45 % 10.1124/mol.112.084152
Homo sapiens SR GI50 30690.22 nM None
Homo sapiens Sulfonylurea receptor 1 Activity 61.0 mg/dl 10.1016/j.bmcl.2005.11.045
Homo sapiens Sulfonylurea receptor 1, Kir6.2 Activity nan None 10.1016/j.bmcl.2005.11.045
Homo sapiens Survival motor neuron protein Potency 4466.8 nM None
Homo sapiens Survival motor neuron protein Potency 6309.6 nM None
Homo sapiens Survival motor neuron protein Potency 7943.3 nM None
Homo sapiens SW-620 GI50 40644.33 nM None
Homo sapiens SW-620 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Homo sapiens SW-620 IC50 126200.0 nM 10.1021/acs.jmedchem.0c00088
Homo sapiens T47D GI50 10256.52 nM None
Homo sapiens THP-1 Activity nan None 10.1021/acs.jnatprod.0c00175
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 7943.3 nM None
Homo sapiens TK-10 GI50 100000.0 nM None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 819.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1032.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1158.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1299.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1333.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1496.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2310.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3662.6 nM None
Homo sapiens U-251 GI50 5767.66 nM None
Homo sapiens UACC-257 GI50 14588.14 nM None
Homo sapiens UACC-62 GI50 29922.65 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 50118.7 nM None
Homo sapiens UO-31 GI50 133967.67 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens XF498 GI50 7816.28 nM None
Human betaherpesvirus 5 Human betaherpesvirus 5 Activity nan None 10.1016/j.bmcl.2006.12.085
Human betaherpesvirus 5 Human betaherpesvirus 5 IC50 680.0 nM 10.1016/j.bmcl.2006.12.085
Human immunodeficiency virus 1 Aberrant vpr protein Potency 3548.1 nM None
Human immunodeficiency virus 1 Aberrant vpr protein Potency 35481.3 nM None
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 130.0 nM 10.1016/j.ejmech.2011.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 66.0 % 10.1016/j.ejmech.2011.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100.0 ug.mL-1 10.1016/j.ejmech.2011.01.016
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100.0 ug.mL-1 10.1021/np50073a012
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition 94.0 % 10.1016/j.ejmech.2011.01.016
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmc.2016.05.003
Klebsiella pneumoniae Klebsiella pneumoniae MIC 100.0 ug.mL-1 10.1021/np9701889
Klebsiella pneumoniae Klebsiella pneumoniae MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Lemna minor Lemna minor Activity 75.0 % 10.1271/bbb.64.1998
Micrococcus luteus Micrococcus luteus MIC 512.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Micrococcus luteus Micrococcus luteus MIC 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Mus musculus 3T3-L1 Activity -2.93 % 10.1016/j.bmcl.2014.02.032
Mus musculus 3T3-L1 Activity 13.27 % 10.1016/j.bmcl.2014.02.032
Mus musculus 3T3-L1 Activity 74.23 % 10.1016/j.bmcl.2014.02.032
Mus musculus BV-2 Activity 25.0 % 10.1016/j.bmc.2018.10.020
Mus musculus CCRF S-180 IC50 25000.0 nM 10.1016/j.bmc.2021.116143
Mus musculus HMG-CoA reductase Inhibition nan % 10.1007/s00044-011-9651-z
Mus musculus L929 Activity 23.57 % 10.1007/s00044-005-0128-9
Mus musculus L929 Activity 41.77 % 10.1007/s00044-005-0128-9
Mus musculus L929 Activity 67.41 % 10.1007/s00044-005-0128-9
Mus musculus L929 Activity 106.45 % 10.1007/s00044-005-0128-9
Mus musculus Mus musculus Activity 0.315 g 10.1016/j.bmc.2020.115697
Mus musculus Mus musculus Activity 8.95 cm 10.1016/j.bmc.2020.115697
Mus musculus Mus musculus Activity 16.7 % 10.1021/jm801157z
Mus musculus Mus musculus Activity 23.9 % 10.1021/jm801157z
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2020.115697
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.0c01743
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.0c00175
Mus musculus Mus musculus FC 1.5 None 10.1021/jm801157z
Mus musculus Mus musculus LD50 763.5 mg.kg-1 10.1007/s00044-011-9651-z
Mus musculus Mus musculus Ratio 28.18 None 10.1016/j.bmc.2020.115697
Mus musculus Mus musculus T-C 0.6 day 10.1021/jm00401a006
Mus musculus Mus musculus T-C 1.0 day 10.1021/jm00401a006
Mus musculus Mus musculus T-C nan None 10.1021/jm00401a006
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 7943.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 15848.9 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus P388 GI50 1874.99 nM None
Mus musculus P388/ADR GI50 101624.87 nM None
Mus musculus RAW264.7 Activity 97.2 % 10.1039/C5MD00577A
Mus musculus RAW264.7 Activity 99.4 % 10.1039/C5MD00577A
Mus musculus RAW264.7 Inhibition 21.1 % 10.1039/C5MD00577A
Mycobacterium intracellulare Mycobacterium intracellulare MIC 0.78 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium intracellulare Mycobacterium intracellulare MIC 200.0 ug.mL-1 10.1021/np9701889
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 200.0 ug.mL-1 10.1021/np9701889
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1016/j.ejmech.2012.03.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.78 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 25.0 ug.mL-1 10.1021/np9701889
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus Activity 0.7 nmol/L 10.1007/s00044-011-9651-z
Oryctolagus cuniculus Oryctolagus cuniculus Activity 2.02 nmol/L 10.1007/s00044-011-9651-z
Oryctolagus cuniculus Oryctolagus cuniculus Activity 3.27 nmol/L 10.1007/s00044-011-9651-z
Oryctolagus cuniculus Oryctolagus cuniculus Activity 7.94 nmol/L 10.1007/s00044-011-9651-z
Parastagonospora nodorum Parastagonospora nodorum Activity 0.0 % 10.1271/bbb.64.1998
Parastagonospora nodorum Parastagonospora nodorum Inhibition 0.0 % 10.1271/bbb.64.1998
Phytophthora infestans Phytophthora infestans Activity 0.0 % 10.1271/bbb.64.1998
Phytophthora infestans Phytophthora infestans Inhibition 0.0 % 10.1271/bbb.64.1998
Pichia kudriavzevii Pichia kudriavzevii MIC 32.0 ug.mL-1 10.1016/j.bmcl.2006.05.033
Plasmodium falciparum Plasmodium falciparum EC50 218.0 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum EC50 442.0 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum IC50 0.141 ug.mL-1 10.1021/jm00401a006
Plasmodium falciparum Plasmodium falciparum IC50 0.148 ug.mL-1 10.1021/jm00401a006
Plasmodium falciparum Plasmodium falciparum IC50 0.36 ug.mL-1 10.1016/S0960-894X(00)80357-1
Plasmodium falciparum Plasmodium falciparum IC50 968.0 nM 10.1021/np000144r
Plasmodium falciparum Plasmodium falciparum Potency 65.7 nM None
Plasmodium falciparum Plasmodium falciparum Potency 147.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 207.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 233.2 nM None
Plasmodium yoelii Plasmodium yoelii Activity nan None 10.1126/science.1211936
Plasmodium yoelii Plasmodium yoelii IC50 548.0 nM 10.1126/science.1211936
Plasmodium yoelii Plasmodium yoelii Schizont size 102.08 um 10.1126/science.1211936
Proteus hauseri Proteus hauseri MIC 256.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Proteus vulgaris Proteus vulgaris MIC 128.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmc.2020.115697
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Puccinia recondita Puccinia recondita Activity 0.0 % 10.1271/bbb.64.1998
Pyricularia oryzae Pyricularia oryzae Inhibition 0.0 % 10.1271/bbb.64.1998
Rattus norvegicus A10 Activity nan None 10.1021/np100645d
Rattus norvegicus A10 GI50 101620.0 nM 10.1021/np100645d
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus C6 Activity nan None 10.1039/C4MD00264D
Rattus norvegicus C6 IC50 20000.0 nM 10.1039/C4MD00264D
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Hepatocyte Activity 49.8 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus Hepatocyte Activity 64.7 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus Hepatocyte Activity 68.8 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus Hepatocyte IC50 26.5 ug.mL-1 10.1016/j.bmc.2008.02.015
Rattus norvegicus Inositol monophosphatase 1 Potency 3981.1 nM None
Rattus norvegicus INS1 AC50 3252.0 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus L6 Activity 21.3 % 10.1016/j.bmcl.2014.02.032
Rattus norvegicus L6 Activity 43.28 % 10.1016/j.bmcl.2014.02.032
Rattus norvegicus L6 Activity 75.0 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus L6 Activity 91.2 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus L6 Activity 91.9 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus L6 Activity 100.3 % 10.1016/j.bmc.2018.02.052
Rattus norvegicus L6 Activity 173.1 % 10.1016/j.ejmech.2017.09.012
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus PC-12 CC50 150000.0 nM 10.1016/j.ejmech.2021.113289
Rattus norvegicus Rattus norvegicus Activity 27.4 % 10.1016/j.bmc.2010.06.106
Rattus norvegicus Rattus norvegicus Activity 27.4 % 10.1021/jm801157z
Rattus norvegicus Rattus norvegicus Activity 31.6 % 10.1021/jm801157z
Rattus norvegicus Rattus norvegicus Activity 38.0 % 10.1016/j.bmc.2010.06.106
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm801157z
Rattus norvegicus Rattus norvegicus FC 1.5 None 10.1021/jm801157z
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 79432.8 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 89125.1 nM None
Rhizoctonia solani Rhizoctonia solani Inhibition 0.0 % 10.1271/bbb.64.1998
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 5.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 78.1 ug.mL-1 10.1021/np0504863
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC80 128.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 500.0 ug.mL-1 10.1021/np980044+
Salmonella enterica subsp. enterica serovar Paratyphi B Salmonella enterica subsp. enterica serovar Paratyphi B Activity nan None 10.1016/j.bmc.2020.115697
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi Activity nan None 10.1016/j.bmc.2020.115697
Scedosporium boydii Scedosporium boydii MIC 62.5 ug.mL-1 10.1021/np0504863
Scheffersomyces shehatae Scheffersomyces shehatae MIC 7.8 ug.mL-1 10.1021/np0504863
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 18.85 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.07 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.59 % 10.21203/rs.3.rs-23951/v1
Shigella dysenteriae Shigella dysenteriae MIC 256.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Staphylococcus aureus Quinolone resistance protein norA Activity nan None 10.1128/aac.01715-09
Staphylococcus aureus Quinolone resistance protein norA Inhibition nan % 10.1128/aac.01715-09
Staphylococcus aureus Sortase A IC50 8.7 ug.mL-1 10.1016/j.bmc.2009.02.008
Staphylococcus aureus Sortase A IC50 8.7 ug.mL-1 10.1016/j.bmcl.2007.08.007
Staphylococcus aureus Sortase A IC50 8.7 ug.mL-1 10.1021/acs.jmedchem.1c00386
Staphylococcus aureus Sortase A IC50 40.6 ug.mL-1 10.1021/acs.jnatprod.5b00867
Staphylococcus aureus Sortase A IC50 102000.0 nM 10.1021/acs.jnatprod.9b00968
Staphylococcus aureus Sortase A IC50 120000.0 nM 10.1016/j.bmc.2019.01.010
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2020.115697
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/np990639k
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.01715-09
Staphylococcus aureus Staphylococcus aureus Drug uptake nan None 10.1128/aac.01715-09
Staphylococcus aureus Staphylococcus aureus FICI 0.25 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI 0.375 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI 1.5 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI50 0.313 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI50 0.5 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI50 2.0 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI90 0.5 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI90 0.75 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus FICI90 2.0 None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus INH 32.0 ug ml-1 10.1021/acs.jmedchem.5b01098
Staphylococcus aureus Staphylococcus aureus MBC 64.0 ug ml-1 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmc.2016.05.003
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1021/np9701889
Staphylococcus aureus Staphylococcus aureus MIC 60.0 ug.mL-1 10.1021/np049868j
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.bmcl.2007.08.007
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Staphylococcus aureus Staphylococcus aureus MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Staphylococcus aureus Staphylococcus aureus MIC 250.0 ug.mL-1 10.1021/np980044+
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.bmc.2013.05.007
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
Staphylococcus aureus Staphylococcus aureus MIC 40000.0 nM 10.1016/j.bmc.2009.04.028
Staphylococcus aureus Staphylococcus aureus MIC 40000.0 nM 10.1128/aac.01715-09
Staphylococcus aureus Staphylococcus aureus MIC 67000.0 nM 10.1016/j.bmcl.2008.06.093
Staphylococcus aureus Staphylococcus aureus MIC 89000.0 nM 10.1021/np058057s
Staphylococcus aureus Staphylococcus aureus MIC 269000.0 nM 10.1016/j.bmcl.2008.06.093
Staphylococcus aureus Staphylococcus aureus MIC 325000.0 nM 10.1016/j.bmc.2009.04.028
Staphylococcus aureus Staphylococcus aureus MIC 325000.0 nM 10.1128/aac.01715-09
Staphylococcus aureus Staphylococcus aureus MIC 372000.0 nM 10.1021/np058057s
Staphylococcus aureus Staphylococcus aureus MIC 650000.0 nM 10.1016/j.bmc.2009.04.028
Staphylococcus aureus Staphylococcus aureus MIC 650000.0 nM 10.1128/aac.01715-09
Staphylococcus aureus Staphylococcus aureus MIC 1488000.0 nM 10.1021/np058057s
Staphylococcus aureus Staphylococcus aureus MIC 2152000.0 nM 10.1016/j.bmcl.2008.06.093
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1016/j.bmc.2020.115697
Streptococcus pyogenes Streptococcus pyogenes Activity nan None 10.1016/j.bmc.2020.115697
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113480
Torpedo californica Acetylcholine receptor protein delta chain Bmax 0.31 uM 10.1016/S0960-894X(96)00429-5
Torpedo californica Acetylcholine receptor protein delta chain Bmax 2.14 uM 10.1016/S0960-894X(96)00429-5
Torpedo californica Acetylcholine receptor protein delta chain Kd1 0.77 uM 10.1016/S0960-894X(96)00429-5
Torpedo californica Acetylcholine receptor protein delta chain Kd1 0.84 uM 10.1016/S0960-894X(96)00429-5
Torpedo californica Acetylcholine receptor protein delta chain Kd2 27.0 uM 10.1016/S0960-894X(96)00429-5
Torpedo californica Acetylcholine receptor protein delta chain Kd2 34.0 uM 10.1016/S0960-894X(96)00429-5
Ustilago maydis Ustilago maydis Inhibition 0.0 % 10.1271/bbb.64.1998
Zymoseptoria tritici Zymoseptoria tritici Inhibition 90.0 % 10.1271/bbb.64.1998
None ADMET Activity 0.26 umol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 0.4 umol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 0.77 mmol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 2.13 mmol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 2.35 mmol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 8.08 mmol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 24.36 umol/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 27.9 U/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 71.28 U/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity 177.86 U/L 10.1021/acs.jmedchem.0c00088
None ADMET Activity nan None 10.1021/acs.jnatprod.0c00175
None ADMET AUC 99.0 ng.hr.mL-1 10.1021/acs.jmedchem.0c00088
None ADMET Cmax 8.601 nM 10.1021/acs.jmedchem.0c00088
None ADMET Drug uptake nan None 10.1039/C4MD00264D
None ADMET F 0.544 % 10.1021/acs.jmedchem.0c00088
None ADMET F 1.0 % 10.1016/j.bmcl.2019.126709
None ADMET MRT 31.51 hr 10.1021/acs.jmedchem.0c00088
None ADMET permeability 0.2 10^-6 cm/s 10.1016/j.ejmech.2020.112593
None ADMET T1/2 28.98 hr 10.1021/acs.jmedchem.0c00088
None ADMET TI 16.07 None 10.1016/j.ejmech.2011.01.016
None ADMET Tmax 2.0 hr 10.1021/acs.jmedchem.0c00088
None NON-PROTEIN TARGET Activity 0.4 equiv 10.1016/j.bmc.2013.07.011
None NON-PROTEIN TARGET Activity nan None 10.1039/C4MD00264D
None NON-PROTEIN TARGET GI50 15880.0 nM 10.1021/np100645d
None NON-PROTEIN TARGET GI50 49600.0 nM 10.1021/np100645d
None NON-PROTEIN TARGET GI50 95100.0 nM 10.1021/np100645d
None NON-PROTEIN TARGET IC50 20000.0 nM 10.1039/C4MD00264D
None NON-PROTEIN TARGET IC50 35000.0 nM 10.1039/C0MD00241K
None NON-PROTEIN TARGET Ratio 0.4 None 10.1016/j.bmc.2011.09.040
None No relevant target Drug degradation 1.8 % 10.1039/C9MD00036D
None No relevant target EC50 5500000.0 nM 10.1016/j.ejmech.2020.112593
None No relevant target LogD -1.2 None 10.1021/np400607k
None No relevant target LogP -1.68 None 10.1039/C4MD00264D
None No relevant target LogP -1.2 None 10.1021/np400607k
None No relevant target LogP -0.92 None 10.1016/j.bmc.2010.06.106
None No relevant target -log(solubility) 3.27 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 3.4 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 3.67 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.47 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) 4.67 None 10.1016/j.bmcl.2015.02.013
None No relevant target -log(solubility) nan None 10.1016/j.bmcl.2015.02.013
None No relevant target pKa 2.47 None 10.1021/np400607k
None No relevant target pKa 15.7 None 10.1021/np400607k
None No relevant target Solubility 1750.0 ug.mL-1 10.1039/C9MD00036D
None No relevant target Solubility 1784000.0 nM 10.1016/j.ejmech.2021.113289
None No relevant target Solubility 7600000.0 nM 10.1021/np400607k
None No relevant target Solubility 8200000.0 nM 10.1021/np400607k
None No relevant target Solubility 9000000.0 nM 10.1021/np400607k
None No relevant target Solubility 9600000.0 nM 10.1021/np400607k
None Nucleic Acid Activity nan None 10.1016/j.bmc.2012.03.006
None Nucleic Acid Cmax/SS 3.55 uM 10.1021/jm049491e
None Nucleic Acid Delta Tm 0.3 degrees C 10.1016/j.bmcl.2012.02.020
None Nucleic Acid Delta Tm 1.0 degrees C 10.1016/j.bmcl.2009.05.030
None Nucleic Acid Delta Tm 1.0 degrees C 10.1016/j.ejmech.2011.02.020
None Nucleic Acid Delta Tm 2.0 degrees C 10.1016/j.ejmech.2011.02.020
None Nucleic Acid Delta Tm 4.0 degrees C 10.1016/j.bmcl.2009.05.030
None Nucleic Acid Delta Tm 9.0 degrees C 10.1016/j.bmc.2012.03.006
None Nucleic Acid Delta Tm 9.7 degrees C 10.1016/j.bmcl.2012.02.020
None Nucleic Acid Delta Tm 23.8 degrees C 10.1016/j.bmcl.2012.02.020
None Nucleic Acid Ka 1.28 10'-5/M 10.1016/j.bmc.2012.03.006
None Nucleic Acid Ka 12400.0 None 10.1016/j.bmcl.2004.10.098
None Nucleic Acid Ka 29300.0 None 10.1016/j.bmcl.2004.10.098
None Nucleic Acid Kb 2000.0 nM 10.1016/j.bmcl.2009.05.030
None Nucleic Acid Ki 36400.0 nM 10.1016/j.bmc.2012.03.006
None Nucleic Acid KSV 90.0 /M 10.1016/j.bmc.2012.03.006
None Nucleic Acid RA 1.0 None 10.1016/j.bmcl.2004.10.098
None Nucleic Acid Selectivity ratio 50.0 None 10.1016/j.bmcl.2009.05.030
None Radical scavenging activity IC50 nan None 10.1021/np030065q
None Unchecked Ac50 2.818 uM None
None Unchecked Ac50 3.162 uM None
None Unchecked AC50 2818.4 nM None
None Unchecked AC50 3162.3 nM None
None Unchecked Activity 57.6 % 10.1016/j.bmc.2018.02.052
None Unchecked Activity 59.2 % 10.1016/j.ejmech.2017.09.012
None Unchecked Activity 63.6 % 10.1016/j.ejmech.2017.09.012
None Unchecked Activity 69.3 % 10.1016/j.ejmech.2017.09.012
None Unchecked Activity 78.9 % 10.1016/j.ejmech.2017.09.012
None Unchecked Activity 84.5 % 10.1016/j.bmc.2018.02.052
None Unchecked Activity 85.8 % 10.1016/j.bmc.2018.02.052
None Unchecked Activity 91.5 % 10.1016/j.bmc.2018.02.052
None Unchecked Activity 227.6 % 10.1016/j.bmc.2018.02.052
None Unchecked Activity nan None 10.1016/j.bmc.2012.09.029
None Unchecked Activity nan None 10.1016/j.bmc.2018.02.052
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c00088
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c01743
None Unchecked Activity nan None 10.1039/C4MD00264D
None Unchecked Delta Tm 1.0 degrees C 10.1016/j.bmc.2008.07.029
None Unchecked Delta Tm 2.0 degrees C 10.1016/j.bmc.2008.07.029
None Unchecked Delta Tm 3.9 degrees C 10.1016/j.bmc.2007.05.050
None Unchecked Delta Tm 13.0 degrees C 10.1039/C3MD00254C
None Unchecked EC50 433.0 nM None
None Unchecked FC 3.2 None 10.1016/j.bmc.2012.09.029
None Unchecked GI50 95140.0 nM 10.1021/np100645d
None Unchecked IC50 8.7 ug.mL-1 10.1021/acs.jmedchem.5b00779
None Unchecked IC50 95.0 nM None
None Unchecked IC50 1278.0 nM None
None Unchecked IC50 2100.0 nM 10.1016/j.bmc.2007.05.050
None Unchecked IC50 2681.5 nM None
None Unchecked IC50 5100.0 nM 10.1021/acs.jmedchem.0c01743
None Unchecked IC50 10000.0 nM None
None Unchecked IC50 13800.0 nM 10.1021/acs.jnatprod.0c00829
None Unchecked IC50 43840.0 nM 10.1016/j.bmc.2012.09.040
None Unchecked IC50 75000.0 nM 10.1016/j.bmc.2007.05.050
None Unchecked IC50 86120.0 nM 10.1016/j.bmcl.2019.126821
None Unchecked IC50 105900.0 nM 10.1016/j.bmc.2012.09.040
None Unchecked IC50 nan None None
None Unchecked IFI 1.84 % 10.1073/pnas.0802982105
None Unchecked Inhibition 25.0 % 10.1016/j.ejmech.2020.112593
None Unchecked Inhibition 36.0 % 10.1016/j.bmc.2012.09.040
None Unchecked Inhibition 36.3 % 10.1016/j.bmc.2011.02.025
None Unchecked Inhibition 36.3 % 10.1016/j.bmc.2011.09.040
None Unchecked Inhibition 72.0 % 10.1021/acs.jmedchem.0c01743
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.0c01743
None Unchecked Ki 59.0 nM None
None Unchecked Ki 852.0 nM None
None Unchecked Ki 1790.0 nM 10.1016/j.bmc.2007.05.050
None Unchecked Ki nan None None
None Unchecked MIC 512.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
None Unchecked MIC80 128.0 ug.mL-1 10.1016/j.bmcl.2016.04.070
None Unchecked Potency 82.0 nM None
None Unchecked Potency 231.1 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 3981.1 nM None
None Unchecked Potency 4109.5 nM None
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 6309.6 nM None
None Unchecked Potency 7079.5 nM None
None Unchecked Potency 7943.3 nM None
None Unchecked Potency 9439.2 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14581.0 nM None
None Unchecked Potency 16360.1 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 21131.7 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 25929.0 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Ratio 9000.0 None 10.1016/j.ejmech.2021.113289
None Unchecked Ratio CC50/IC50 110.0 None 10.1016/j.bmcl.2006.12.085
None Unchecked Ratio IC50 2.7 None 10.1016/j.ejmech.2020.112593
None Unchecked Ratio IC50 6.0 None 10.1016/j.bmcl.2019.126821
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmc.2009.12.035
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmc.2010.04.063
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmc.2011.02.025
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmc.2011.09.040
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmcl.2010.09.013
None Unchecked Ratio IC50 48.82 None 10.1016/j.bmc.2013.07.011
None Unchecked Tm 44.0 degrees C 10.1016/j.bmc.2007.05.050
None Unchecked Tm 55.0 degrees C 10.1016/j.bmc.2008.07.029
None Unchecked Tm 60.0 degrees C 10.1016/j.bmc.2008.07.029

Metabolism Information