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name Structure Reference Source Properties Activities Metabolism

Minocycline

AlkaPlorer ID: AK000609

Synonym: None

IUPAC Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Structure

SMILES: CN(C)C1=C2C[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(=N)O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C(O)C=C1

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InChI: InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1

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InChIKey: DYKFCLLONBREIL-KVUCHLLUSA-N

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Properties Information

Molecule Weight: 457.4830000000002

TPSA？: 165.62

MolLogP？: 1.2365700000000004

Number of H-Donors: 6

Number of H-Acceptors: 9

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 1.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter Acinetobacter MIC nan None 10.1128/aac.01115-07
Acinetobacter baumannii Acinetobacter baumannii Activity 18.0 % 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii Activity 49.4 % 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii Activity 77.0 % 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii Activity 78.0 % 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii EC50 50.0 nM 10.1016/j.bmcl.2016.04.089
Acinetobacter baumannii Acinetobacter baumannii MIC 0.031 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 0.047 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.06 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.06 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.0625 ug.mL-1 10.1021/jm1015395
Acinetobacter baumannii Acinetobacter baumannii MIC 0.064 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.064 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.19 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.25 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.9b00876
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 0.5 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 0.75 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 0.75 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1016/j.bmcl.2021.128192
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1039/C5MD00377F
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01037-09
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 12.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01198-06
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1128/aac.01259-06
Acinetobacter baumannii Acinetobacter baumannii MIC 250.0 nM 10.1021/acs.jmedchem.9b00288
Acinetobacter baumannii Acinetobacter baumannii MIC50 0.5 ug.mL-1 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii MIC50 2.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC50 4.0 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC50 8.0 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC>90 0.2 ug ml-1 10.1021/np400145u
Acinetobacter baumannii Acinetobacter baumannii MIC90 8.0 ug.mL-1 10.1128/aac.01097-08
Acinetobacter baumannii Acinetobacter baumannii MIC90 8.0 ug.mL-1 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii MIC90 8.0 ug.mL-1 10.1128/aac.01581-07
Acinetobacter baumannii Acinetobacter baumannii MIC90 16.0 ug.mL-1 10.1128/aac.01097-08
Brugia malayi Brugia malayi Activity 98.2 % 10.1021/acs.jmedchem.8b01854
Burkholderia cepacia Burkholderia cepacia Activity 37.0 % 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia Activity 38.0 % 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia MIC50 8.0 ug.mL-1 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia MIC90 32.0 ug.mL-1 10.1128/aac.00954-06
Candida parapsilosis Candida parapsilosis CFU/ml 138.0 None 10.1128/aac.00154-06
Candida parapsilosis Candida parapsilosis CFU/ml 500.0 None 10.1128/aac.00154-06
Candida parapsilosis Candida parapsilosis CFU/ml 5000.0 None 10.1128/aac.00154-06
Clostridium perfringens Clostridium perfringens MIC 0.063 ug.mL-1 10.1021/jm8000136
Corynebacterium amycolatum Corynebacterium amycolatum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC90 0.25 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC90 0.25 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC50 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC90 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium sp. Corynebacterium sp. Activity nan None 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC 0.06 ug.mL-1 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC50 2.0 ug.mL-1 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC90 16.0 ug.mL-1 10.1128/aac.00845-09
Corynebacterium striatum Corynebacterium striatum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC50 4.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC90 8.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC90 0.5 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC50 0.25 ug.mL-1 10.1128/aac.01129-07
Cutibacterium acnes Cutibacterium acnes MIC 0.125 ug.mL-1 10.1021/jm8000136
Electrophorus electricus Acetylcholinesterase Inhibition -0.24 % 10.1016/j.bmc.2012.09.040
Enterobacter cloacae Enterobacter cloacae EC50 1500.0 nM 10.1016/j.bmcl.2016.04.089
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1021/jm1015395
Enterobacter cloacae Enterobacter cloacae MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Enterococcus Enterococcus MIC 4.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Enterococcus faecalis Enterococcus faecalis MBC50 16.0 mg/L 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MBC90 64.0 mg/L 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC 0.098 ug.mL-1 10.1016/s0960-894x(02)00369-4
Enterococcus faecalis Enterococcus faecalis MIC 0.12 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1021/jm00027a023
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1021/jm1015395
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1021/jm8000136
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1128/aac.00603-06
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1021/jm1015395
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC50 8.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC50 16.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC90 16.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecalis Enterococcus faecalis MIC90 32.0 ug.mL-1 10.1128/aac.00666-06
Enterococcus faecium Enterococcus faecium EC50 50.0 nM 10.1016/j.bmcl.2016.04.089
Enterococcus faecium Enterococcus faecium MIC 0.063 ug.mL-1 10.1021/jm8000136
Enterococcus faecium Enterococcus faecium MIC 16.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecium Enterococcus faecium MIC 32.0 ug.mL-1 10.1128/aac.00576-06
Equus caballus Cholinesterase Inhibition -8.62 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli Activity 30.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 32.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 35.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 38.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 40.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 50.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 65.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 75.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity 125.0 % 10.1128/aac.01420-09
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm1015395
Escherichia coli Escherichia coli MIC 0.625 ug.mL-1 10.1128/aac.00475-08
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.00993-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm00027a023
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00899-09
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 2.4 ug.mL-1 10.1128/aac.01420-09
Escherichia coli Escherichia coli MIC 3.3 ug.mL-1 10.1128/aac.01420-09
Escherichia coli Escherichia coli MIC 4.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm00027a023
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 4.9 ug.mL-1 10.1128/aac.01420-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm00027a023
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm1015389
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm1015395
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00993-09
Escherichia coli Escherichia coli MIC 16.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/jm00027a023
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00143-07
Escherichia coli Escherichia coli MIC 32.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/jm00027a023
Escherichia coli Escherichia coli MIC 1000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 64000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC50 1.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 2.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC50 8.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC50 16.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 2.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 4.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 8.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC90 32.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 32.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.00625-07
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.00883-08
Escherichia coli Escherichia coli Ratio 2.0 None 10.1128/aac.01420-09
Escherichia coli Escherichia coli Ratio 4.0 None 10.1128/aac.00921-08
Escherichia coli K-12 Multidrug translocase mdfA IC50 2600.0 nM 10.1021/jm00055a008
Finegoldia magna Finegoldia magna MIC 0.125 ug.mL-1 10.1021/jm8000136
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1021/jm8000136
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adrenergic receptor beta Activity -9.15 None 10.1016/S0960-894X(97)00046-2
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 83000.4 nM 10.1038/s41467-023-40064-9
Homo sapiens CCRF-CEM CC50 52100.0 nM 10.1016/j.bmcl.2006.11.055
Homo sapiens Cyclooxygenase-1 AC50 2503.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2J2 IC50 50000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 15848.9 nM None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens CL 1.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 1.2 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 97.5 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens F 100.0 % 10.1021/jm901421c
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.05 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.95 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 1.6 L.kg-1 10.1021/jm901371v
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Matrix metalloproteinase 3 IC50 290000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 7 IC50 125000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 9 IC50 180000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens microRNA 21 IC50 305000.0 nM 10.1021/acsmedchemlett.9b00091
Homo sapiens microRNA 21 Inhibition 40.0 % 10.1021/acsmedchemlett.9b00091
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens N9 IC50 19890.0 nM 10.1016/j.bmcl.2016.12.075
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Poly [ADP-ribose] polymerase 14 Inhibition nan % None
Homo sapiens Poly [ADP-ribose] polymerase 15 IC50 15000.0 nM None
Homo sapiens Poly [ADP-ribose] polymerase 15 pIC50 nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein-arginine deiminase type-4 IC50 620000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Protein-arginine deiminase type-4 Ki 180000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Protein-arginine deiminase type-4 Ki 540000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Proteinase-activated receptor 2 Activity nan None 10.1128/aac.01540-08
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum Cmax 1311.53 nM 10.1128/aac.00922-07
Homo sapiens Serum fAUC 0.6 mg/L 10.1128/aac.00922-07
Homo sapiens Serum T1/2 12.0 hr 10.1128/aac.00922-07
Homo sapiens Serum Tmax 2.3 hr 10.1128/aac.00922-07
Homo sapiens Serum albumin Kd 12000.0 nM 10.1128/aac.00971-08
Homo sapiens Serum albumin Log K' 0.21 None 10.1021/jm010960b
Homo sapiens Serum albumin Ratio 0.5 None 10.1128/aac.00971-08
Homo sapiens Serum albumin Ratio 1.0 None 10.1128/aac.00971-08
Homo sapiens Solute carrier family 22 member 11 Activity nan None 10.1254/jjp.88.69
Homo sapiens Solute carrier family 22 member 6 Activity nan None 10.1254/jjp.88.69
Homo sapiens Solute carrier family 22 member 7 Activity nan None 10.1254/jjp.88.69
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1254/jjp.88.69
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23715.0 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 52100.0 nM 10.1016/j.bmcl.2006.11.055
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 nan None 10.1016/j.bmcl.2006.11.055
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm1015389
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm1015395
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1021/jm1015395
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00883-08
Klebsiella pneumoniae subsp. pneumoniae Klebsiella pneumoniae subsp. pneumoniae EC50 700.0 nM 10.1016/j.bmcl.2016.04.089
Leishmania donovani Leishmania donovani IC50 21860.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 45680.0 nM 10.6019/CHEMBL3392926
Listeria monocytogenes Listeria monocytogenes Activity nan None 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC 8.0 ug.mL-1 10.1128/aac.01557-09
Listeria monocytogenes Listeria monocytogenes MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC90 0.06 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC90 16.0 ug.mL-1 10.1128/aac.00845-09
Metamycoplasma hominis Metamycoplasma hominis MIC 32.0 ug.mL-1 10.1128/aac.00960-07
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1021/jm8000136
Mus musculus BV-2 Activity nan None 10.1021/acs.jnatprod.2c00376
Mus musculus BV-2 IC50 4900.0 nM 10.1021/acs.jnatprod.8b00585
Mus musculus BV-2 IC50 9070.0 nM 10.1016/j.bmcl.2017.08.047
Mus musculus BV-2 IC50 15000.0 nM 10.1021/acs.jnatprod.1c00055
Mus musculus BV-2 IC50 17500.0 nM 10.1021/acs.jnatprod.9b00483
Mus musculus BV-2 IC50 18500.0 nM 10.1021/acs.jnatprod.9b00877
Mus musculus BV-2 IC50 27200.0 nM 10.1021/acs.jnatprod.9b00291
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus Survival 6.0 % 10.1016/j.ejmech.2016.06.017
Mus musculus Mus musculus Survival 14.0 % 10.1021/jm400161p
Mus musculus RAW264.7 Activity 100.06 % 10.1016/j.bmcl.2012.12.086
Mus musculus RAW264.7 Activity 100.23 % 10.1016/j.bmcl.2011.12.122
Mus musculus RAW264.7 IC50 31280.0 nM 10.1016/j.bmcl.2018.05.039
Mus musculus RAW264.7 IC50 34810.0 nM 10.1016/j.bmcl.2012.12.086
Mus musculus RAW264.7 IC50 34850.0 nM 10.1016/j.bmcl.2011.12.122
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.bmcl.2006.11.055
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 7100.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 7200.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 38400.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 53500.0 nM 10.1128/aac.00055-06
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 5020.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 6770.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 7230.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 12500.0 nM 10.1128/aac.00803-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.007 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.0313 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.0625 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.00582-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.25 ug.mL-1 10.1021/jm8000136
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.00582-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01561-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.5 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.125 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.00779-07
Neisseria meningitidis Neisseria meningitidis Activity 0.0 % 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis Activity 100.0 % 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC 0.015 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC50 0.12 ug.mL-1 10.1128/aac.01315-06
Neisseria meningitidis Neisseria meningitidis MIC50 0.12 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC90 0.12 ug.mL-1 10.1128/aac.01315-06
Neisseria meningitidis Neisseria meningitidis MIC90 0.25 ug.mL-1 10.1128/aac.01812-09
Nocardia brasiliensis Nocardia brasiliensis MIC 0.001 ug.mL-1 10.1128/aac.01102-06
Nocardia carnea Nocardia carnea MIC 0.0005 ug.mL-1 10.1128/aac.01102-06
Nocardia cyriacigeorgica Nocardia cyriacigeorgica MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
Nocardia farcinica Nocardia farcinica MIC 0.001 ug.mL-1 10.1128/aac.01102-06
Nocardia nova Nocardia nova MIC 0.001 ug.mL-1 10.1128/aac.01102-06
Nocardia otitidiscaviarum Nocardia otitidiscaviarum MIC 0.0005 ug.mL-1 10.1128/aac.01102-06
Nocardia sp. Nocardia sp. MIC 0.00025 ug.mL-1 10.1128/aac.01102-06
Nocardia transvalensis Nocardia transvalensis MIC 0.001 ug.mL-1 10.1128/aac.01102-06
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC 16.0 ug.mL-1 10.1021/jm8000136
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC 0.032 ug.mL-1 10.1021/jm8000136
Plasmodium falciparum Plasmodium falciparum IC50 3000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 3580.0 nM 10.6019/CHEMBL3392926
Prescottella equi Prescottella equi MIC 0.06 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC50 0.25 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC90 0.25 ug.mL-1 10.1128/aac.01129-07
Proteus mirabilis Proteus mirabilis MIC 16.0 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC50 64.0 ug.mL-1 10.1128/aac.00883-08
Proteus mirabilis Proteus mirabilis MIC90 64.0 ug.mL-1 10.1128/aac.00883-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 100.0 % 10.1021/acs.jmedchem.7b00156
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa EC50 2400.0 nM 10.1016/j.bmcl.2016.04.089
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/jm1015395
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1128/aac.00899-09
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 nM 10.1021/acs.jmedchem.9b00288
Pseudomonas aeruginosa Pseudomonas aeruginosa mortality 100.0 % 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 16.0 None 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 16.0 None 10.1021/acs.jmedchem.7b00156
Rattus norvegicus Interferon regulatory factor 1 Activity nan None 10.1074/jbc.m611907200
Rattus norvegicus Protein kinase C alpha Activity nan None 10.1074/jbc.m611907200
Rattus norvegicus Rattus norvegicus Activity 24.0 % 10.1074/jbc.m611907200
Rattus norvegicus Rattus norvegicus Activity 42.0 % 10.1074/jbc.m611907200
Rattus norvegicus Rattus norvegicus Activity nan None 10.1074/jbc.m611907200
Rattus norvegicus Signal transducer and activator of transcription 1 Activity nan None 10.1074/jbc.m611907200
Salmonella enterica Salmonella enterica MIC nan None 10.1128/aac.00993-09
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 8000.0 nM 10.1021/acs.jmedchem.9b00288
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.178 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Staphylococcus Staphylococcus Activity 96.0 % 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC50 0.5 ug.mL-1 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC90 2.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 92.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 96.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00350-06
Staphylococcus aureus Staphylococcus aureus CFU/g 5.3 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus CFU/ml 308.0 None 10.1128/aac.00154-06
Staphylococcus aureus Staphylococcus aureus CFU/ml 324.0 None 10.1128/aac.00154-06
Staphylococcus aureus Staphylococcus aureus CFU/ml 5000.0 None 10.1128/aac.00154-06
Staphylococcus aureus Staphylococcus aureus EC50 50.0 nM 10.1016/j.bmcl.2016.04.089
Staphylococcus aureus Staphylococcus aureus EC50 350.0 nM 10.1016/j.bmcl.2016.04.089
Staphylococcus aureus Staphylococcus aureus ED50 0.515 mg.kg-1 10.1021/jm8000136
Staphylococcus aureus Staphylococcus aureus ED50 50.0 mg.kg-1 10.1021/jm8000136
Staphylococcus aureus Staphylococcus aureus FC 0.1 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 0.2 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 0.5 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 0.8 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 1.4 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 1.5 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 1.6 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 1.9 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 77.2 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 77.6 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 79.7 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 98.4 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FIC 0.5 None 10.1021/acs.jnatprod.2c00621
Staphylococcus aureus Staphylococcus aureus log10cfu 0.7 None 10.1128/aac.00237-08
Staphylococcus aureus Staphylococcus aureus log10cfu 2.04 None 10.1128/aac.00237-08
Staphylococcus aureus Staphylococcus aureus MBC50 8.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MBC90 32.0 mg/L 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC 0.008 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.01 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.012 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.016 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.024 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.0313 ug.mL-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.0625 ug.mL-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus MIC 0.063 ug.mL-1 10.1021/jm8000136
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1021/jm00027a023
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.bmcl.2007.09.077
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.12.060
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.ejmech.2019.04.067
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c00621
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.19 ug.mL-1 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus MIC 0.195 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.1c00578
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.2c00621
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00027a023
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.75 ug.mL-1 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 3.12 ug.mL-1 10.1016/s0960-894x(02)00369-4
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/jm00027a023
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/jm8000136
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00237-08
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00971-08
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/s0960-894x(02)00369-4
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2005.09.078
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/jm1015395
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug mg-1 10.1016/s0960-894x(99)00216-4
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/jm1015389
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/jm8000136
Staphylococcus aureus Staphylococcus aureus MIC 250.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC50 0.125 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC50 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC90 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.25 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 0.5 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 4.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.00666-06
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1021/jm960294s
Staphylococcus aureus Staphylococcus aureus RatioAUC/MIC 1.6 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus RatioAUC/MIC 1.7 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus RatioAUC/MIC 2.1 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus RatioAUC/MIC 200.0 None 10.1128/aac.00922-07
Staphylococcus epidermidis Staphylococcus epidermidis log10cfu -0.18 None 10.1128/aac.00237-08
Staphylococcus epidermidis Staphylococcus epidermidis log10cfu 3.32 None 10.1128/aac.00237-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1021/jm8000136
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.125 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1128/aac.00237-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 250.0 nM 10.1021/acs.jmedchem.9b00288
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 2.0 ug.mL-1 10.1016/j.bmcl.2021.128192
Streptococcus equinus Streptococcus equinus MIC nan None 10.1128/aac.00603-06
Streptococcus intermedius Streptococcus intermedius MIC 0.25 ug.mL-1 10.1021/jm8000136
Streptococcus mitis Streptococcus mitis MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus mitis Streptococcus mitis MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus pasteurianus Streptococcus pasteurianus MIC 0.12 ug.mL-1 10.1128/aac.00603-06
Streptococcus pasteurianus Streptococcus pasteurianus MIC 8.0 ug.mL-1 10.1128/aac.00603-06
Streptococcus pasteurianus Streptococcus pasteurianus MIC 16.0 ug.mL-1 10.1128/aac.00603-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 24.4 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 38.8 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 93.0 % 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae ED50 0.968 mg.kg-1 10.1021/jm8000136
Streptococcus pneumoniae Streptococcus pneumoniae ED50 50.0 mg.kg-1 10.1021/jm8000136
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.0156 ug.mL-1 10.1021/jm1015395
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1021/jm1015389
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.032 ug.mL-1 10.1021/jm8000136
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmc.2016.07.029
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1021/jm1015395
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1021/jm1015389
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1021/jm8000136
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae PD50 3.44 mg kg-1 10.1016/j.bmc.2016.07.029
Streptococcus pyogenes Streptococcus pyogenes MBC50 8.0 mg/L 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MBC90 16.0 mg/L 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MIC 0.063 ug.mL-1 10.1021/jm8000136
Streptococcus pyogenes Streptococcus pyogenes MIC50 4.0 ug.mL-1 10.1128/aac.00666-06
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.00666-06
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Activity 100.0 % 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.12 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Activity 29.0 % 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC50 16.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC90 32.0 ug.mL-1 10.1128/aac.00845-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 36550.0 nM 10.6019/CHEMBL3392926
Trypanosoma cruzi Trypanosoma cruzi IC50 22300.0 nM 10.6019/CHEMBL3392926
Ureaplasma Ureaplasma MIC 32.0 ug.mL-1 10.1128/aac.00960-07
None ADMET Activity nan None 10.1128/aac.01540-08
None ADMET CL 1.2 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET MRT 22.0 hr 10.1124/dmd.108.020479
None ADMET permeability 50.0 10'-6 cm/s 10.1021/jm901421c
None ADMET PPB 54.0 % 10.1128/aac.00971-08
None ADMET Ratio 1.0 None 10.1128/aac.00971-08
None ADMET T1/2 17.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.6 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 2.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports nan None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 2.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Macrophage Activity nan None 10.1074/jbc.m611907200
None Molecular identity unknown Activity 55.0 % 10.1074/jbc.m611907200
None Molecular identity unknown Activity nan None 10.1074/jbc.m611907200
None NON-PROTEIN TARGET Activity 75.0 % 10.1128/aac.00845-09
None NON-PROTEIN TARGET Activity 84.0 % 10.1128/aac.00845-09
None NON-PROTEIN TARGET Activity 92.6 % 10.1128/aac.01173-09
None NON-PROTEIN TARGET fT>MIC 100.0 % 10.1128/aac.00922-07
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 17.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 41.7 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 9420.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 21860.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 35820.0 nM 10.1016/j.bmcl.2016.11.069
None NON-PROTEIN TARGET IC50 37040.0 nM 10.1016/j.bmcl.2016.08.094
None NON-PROTEIN TARGET IC50 55100.0 nM 10.1016/j.bmcl.2016.10.012
None NON-PROTEIN TARGET Inhibition 15.6 % 10.1016/j.bmcl.2016.10.012
None NON-PROTEIN TARGET Inhibition 22.7 % 10.1016/j.bmcl.2016.10.012
None NON-PROTEIN TARGET Inhibition 51.8 % 10.1016/j.bmcl.2016.10.012
None NON-PROTEIN TARGET Inhibition 59.7 % 10.1016/j.bmcl.2016.10.012
None NON-PROTEIN TARGET MIC 3.1e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 6e-05 ug.mL-1 10.1128/aac.01102-06
None NON-PROTEIN TARGET MIC 6.3e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 0.001 ug.mL-1 10.1128/aac.01102-06
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC 0.12 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1021/jm8000136
None NON-PROTEIN TARGET MIC 0.19 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1021/jm8000136
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 0.4 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 3.0 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.00899-09
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00993-09
None NON-PROTEIN TARGET MIC nan None 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC nan None 10.1128/aac.00993-09
None NON-PROTEIN TARGET MIC50 0.000125 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 0.03 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 6.0 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC50 nan None 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 0.00025 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC90 16.0 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC90 24.0 ug.mL-1 10.1128/aac.00630-09
None NON-PROTEIN TARGET MIC90 nan None 10.1128/aac.00724-09
None Unchecked Activity 45.0 % 10.1074/jbc.m611907200
None Unchecked Activity 47.0 % 10.1074/jbc.m611907200
None Unchecked Activity 91.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Activity nan None 10.1016/j.bmcl.2009.07.082
None Unchecked Activity nan None 10.1074/jbc.m611907200
None Unchecked Hepatotoxicity (acute) 48.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 11.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 36.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 8.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 129000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 327000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 369000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 397000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 437000.0 nM 10.1021/acsmedchemlett.9b00091
None Unchecked Inhibition 30.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Inhibition 45.0 % 10.1128/aac.00620-10
None Unchecked Inhibition nan % 10.1016/j.bmc.2015.07.062
None Unchecked Kd 597.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 612.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 651.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1450.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1980.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Potency 10000.0 nM None
None Unchecked Ratio 2.4 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio 3.2 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio 64.0 None 10.1021/acs.jmedchem.9b00288
None Unchecked TIME 0.05556 hr 10.1128/aac.00620-10

Metabolism Information