Daryamide A
AlkaPlorer ID: AK000749
Synonym: None
IUPAC Name: (2E,4E)-N-[(3S,4R)-3-(3-amino-3-oxopropyl)-3,4-dihydroxy-6-oxocyclohexen-1-yl]-7-methylocta-2,4-dienamide
Structure
SMILES: CC(C)C/C=C/C=C/C(=O)NC1=C[C@@](O)(CCC(N)=O)[C@H](O)CC1=O
InChI: InChI=1S/C18H26N2O5/c1-12(2)6-4-3-5-7-17(24)20-13-11-18(25,9-8-16(19)23)15(22)10-14(13)21/h3-5,7,11-12,15,22,25H,6,8-10H2,1-2H3,(H2,19,23)(H,20,24)/b4-3+,7-5+/t15-,18+/m1/s1
InChIKey: VLZVGRPEASVNDM-HMBRAYOKSA-N
Reference
PubChem CID: 16099480
LOTUS: LTS0033419
SuperNatural Ⅲ: SN0393899-01
NPASS: NPC133729
{NPAtlas: NPA009166
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
| None | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 350.4150000000001
TPSA？: 129.72
MolLogP？: 0.4752999999999992
Number of H-Donors: 4
Number of H-Acceptors: 5
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Candida albicans | Candida albicans | MIC | 62.5 | ug.mL-1 | 10.1021/np0603828 |
| Homo sapiens | HCT-116 | IC50 | 3.15 | ug.mL-1 | 10.1021/np0603828 |
| Staphylococcus aureus | Staphylococcus aureus | Activity | nan | None | 10.1021/np0603828 |