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name Structure Reference Source Properties Activities Metabolism

Methicillin

AlkaPlorer ID: AK000802

Synonym: None

IUPAC Name: (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Structure

SMILES: COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O

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InChI: InChI=1S/C17H20N2O6S/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23)/t11-,12+,15-/m1/s1

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InChIKey: RJQXTJLFIWVMTO-TYNCELHUSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Psorothamnus fremontii Psorothamnus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 380.42200000000014

TPSA？: 105.17

MolLogP？: 0.9490999999999996

Number of H-Donors: 2

Number of H-Acceptors: 6

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus IC50 300.0 nM 10.1021/acs.jnatprod.9b00187
Bacillus subtilis Bacillus subtilis MBC 6.25 ug ml-1 10.1016/j.ejmech.2020.112609
Bacillus subtilis Bacillus subtilis MIC 0.5 ug.mL-1 10.1016/j.ejmech.2017.04.018
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1021/np5007235
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.ejmech.2020.112609
Bacillus subtilis Bacillus subtilis MIC 100.0 ug.mL-1 10.1021/np970182j
Bacillus subtilis Bacillus subtilis MIC 128.0 ug.mL-1 10.1021/np960006v
Bacillus subtilis Bacillus subtilis MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Bacillus subtilis Bacillus subtilis MIC nan None 10.1016/j.ejmech.2016.07.074
Bacillus subtilis Bacillus subtilis MIC=>90 0.5 ug ml-1 10.1016/j.ejmech.2018.10.039
Bacillus subtilis Bacillus subtilis MIC=>90 1.0 ug ml-1 10.1039/C7MD00387K
Candida albicans Candida albicans IC50 300.0 nM 10.1021/acs.jnatprod.9b00187
Candida albicans Candida albicans MIC 100.0 ug.mL-1 10.1021/np970182j
Candida albicans Candida albicans MIC 512.0 ug.mL-1 10.1021/np960006v
Canis lupus familiaris MDCK EC50 nan None 10.1039/C9MD00329K
Chlorocebus sabaeus Vero CC50 200000.0 nM 10.1016/j.bmcl.2016.03.089
Corynebacterium ammoniagenes Corynebacterium ammoniagenes MBC 25.0 ug ml-1 10.1016/j.ejmech.2020.112609
Corynebacterium ammoniagenes Corynebacterium ammoniagenes MIC 25.0 ug.mL-1 10.1016/j.ejmech.2020.112609
Cryptococcus neoformans Cryptococcus neoformans IC50 300.0 nM 10.1021/acs.jnatprod.9b00187
Enterobacter cloacae Enterobacter cloacae MIC 128.0 ug.mL-1 10.1021/jm00066a006
Enterococcus faecalis Enterococcus faecalis IC50 14.2 ug.mL-1 10.1021/np500911k
Enterococcus faecalis Enterococcus faecalis IC50 15.3 ug.mL-1 10.1021/np500911k
Enterococcus faecalis Enterococcus faecalis IC50 nan None 10.1021/acs.jnatprod.5b00721
Enterococcus faecalis Enterococcus faecalis MBC 50.0 ug ml-1 10.1021/np500911k
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112072
Enterococcus faecalis Enterococcus faecalis MIC 25.0 ug.mL-1 10.1021/np500911k
Enterococcus faecalis Enterococcus faecalis MIC 50.0 ug.mL-1 10.1021/np500911k
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1016/j.ejmech.2015.06.047
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1016/j.ejmech.2018.06.023
Enterococcus faecalis Enterococcus faecalis MIC=>90 0.75 ug ml-1 10.1039/C7MD00387K
Enterococcus faecalis Enterococcus faecalis MIC=>90 6.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Enterococcus faecium Enterococcus faecium Activity nan None 10.1021/np500911k
Enterococcus faecium Enterococcus faecium GI nan None 10.1021/np500911k
Enterococcus faecium Enterococcus faecium MIC 4.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Enterococcus faecium Enterococcus faecium MIC 6.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Enterococcus faecium Enterococcus faecium MIC=>90 1.5 ug ml-1 10.1039/C7MD00387K
Enterococcus faecium Enterococcus faecium MIC=>90 4.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Escherichia coli Escherichia coli IC50 300.0 nM 10.1021/acs.jnatprod.9b00187
Escherichia coli Escherichia coli IC50 1000.0 ug.mL-1 10.1016/j.bmcl.2015.10.022
Escherichia coli Escherichia coli MIC 1.6 ug.mL-1 10.1021/np970182j
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/np960006v
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/j.bmcl.2014.02.044
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/j.ejmech.2014.06.048
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1021/np970182j
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/S0960-894X(96)00285-5
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1021/jm00066a006
Escherichia coli Escherichia coli MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1021/np960006v
Escherichia coli Escherichia coli MIC 1000.0 ug.mL-1 10.1016/j.bmcl.2015.10.022
Escherichia coli Escherichia coli MIC 200000.0 nM 10.1007/s00044-012-0363-9
Escherichia coli Escherichia coli MIC 200000.0 nM 10.1016/j.bmcl.2016.03.089
Escherichia coli Escherichia coli MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Escherichia coli Escherichia coli MIC nan None 10.1016/j.ejmech.2016.07.074
Escherichia coli Escherichia coli MIC=>90 3.0 ug ml-1 10.1039/C7MD00387K
Escherichia coli Escherichia coli MIC=>90 4.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1021/jm00066a006
Homo sapiens A549 EC50 nan None 10.1039/C9MD00329K
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 18505.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 18930.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -14.46 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 8.98 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens CL 6.6 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 4.2 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 2807.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella Klebsiella MIC 32.0 ug.mL-1 10.1021/jm00066a006
Klebsiella aerogenes Beta-lactamase OXA-9 Relative inhibition 50.0 None 10.1021/jm00186a002
Klebsiella aerogenes Klebsiella aerogenes MIC nan None 10.1016/j.ejmech.2016.07.074
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.25 ug.mL-1 10.1016/j.ejmech.2014.06.048
Klebsiella pneumoniae Klebsiella pneumoniae MIC 50.0 ug.mL-1 10.1016/j.bmcl.2014.02.044
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1016/S0960-894X(96)00285-5
Klebsiella pneumoniae Klebsiella pneumoniae MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Klebsiella pneumoniae Klebsiella pneumoniae MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Klebsiella pneumoniae Klebsiella pneumoniae MIC nan None 10.1016/j.ejmech.2015.06.047
Klebsiella pneumoniae Klebsiella pneumoniae MIC nan None 10.1016/j.ejmech.2016.07.074
Klebsiella pneumoniae Klebsiella pneumoniae MIC=>90 256.0 ug ml-1 10.1039/C7MD00387K
Listeria monocytogenes Listeria monocytogenes IZ 25.6 mm 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes IZ 26.7 mm 10.1128/aac.00290-10
Listeria monocytogenes Listeria monocytogenes MIC nan None 10.1016/j.ejmech.2018.06.023
Micrococcus luteus Micrococcus luteus MBC 6.25 ug ml-1 10.1016/j.ejmech.2020.112609
Micrococcus luteus Micrococcus luteus MIC 6.25 ug.mL-1 10.1016/j.ejmech.2020.112609
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Solute carrier family 22 member 6 Inhibition nan % 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 Drug uptake nan None 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 IC50 116000.0 nM 10.1124/dmd.112.049569
Mus musculus Solute carrier family 22 member 8 Inhibition nan % 10.1124/dmd.112.049569
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 300.0 nM 10.1021/acs.jnatprod.9b00187
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.1 ug.mL-1 10.1021/np970182j
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/np960006v
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 ug.mL-1 10.1016/j.bmcl.2014.02.044
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 ug.mL-1 10.1016/j.ejmech.2014.06.048
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 ug.mL-1 10.1021/np970182j
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/jm00066a006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1021/np960006v
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1016/j.ejmech.2015.06.047
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1016/j.ejmech.2016.07.074
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC=>90 256.0 ug ml-1 10.1039/C7MD00387K
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Salmonella Salmonella MIC 200000.0 nM 10.1007/s00044-012-0363-9
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.05096 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Staphylococcus aureus Cell division protein ftsZ Activity nan None 10.1039/C7MD00387K
Staphylococcus aureus Cell division protein ftsZ Inhibition nan % 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus FC 8.0 None 10.1016/j.ejmech.2019.111686
Staphylococcus aureus Staphylococcus aureus FICI 0.5 None 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus FICI 0.52 None 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus FICI 1.0 None 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus GI nan None 10.1016/j.bmc.2015.04.069
Staphylococcus aureus Staphylococcus aureus GI nan None 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus IC50 0.4 ug.mL-1 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus IC50 0.4 ug.mL-1 10.1021/np900499q
Staphylococcus aureus Staphylococcus aureus IC50 0.5 ug.mL-1 10.1021/acs.jnatprod.5b00721
Staphylococcus aureus Staphylococcus aureus IC50 0.98 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 1.2 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 1.3 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 1.9 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 2.2 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 3.0 ug.mL-1 10.1021/acs.jnatprod.5b00721
Staphylococcus aureus Staphylococcus aureus IC50 3.2 ug.mL-1 10.1021/acs.jnatprod.5b00721
Staphylococcus aureus Staphylococcus aureus IC50 10.1 ug.mL-1 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus IC50 11.8 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus IC50 26.9 ug.mL-1 10.1021/acs.jnatprod.5b00721
Staphylococcus aureus Staphylococcus aureus IC50 30.0 nM 10.1021/acs.jnatprod.9b00187
Staphylococcus aureus Staphylococcus aureus IC50 50.0 ug.mL-1 10.1021/acs.jnatprod.5b00721
Staphylococcus aureus Staphylococcus aureus IC50 10000.0 nM 10.1021/acs.jnatprod.2c00444
Staphylococcus aureus Staphylococcus aureus IC50 nan None 10.1021/np900499q
Staphylococcus aureus Staphylococcus aureus IZ 10.77 mm 10.1016/j.bmcl.2013.10.072
Staphylococcus aureus Staphylococcus aureus MBC 6.25 ug ml-1 10.1016/j.ejmech.2020.112609
Staphylococcus aureus Staphylococcus aureus MBC 12.5 ug ml-1 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus MBC 800.0 ug ml-1 10.1016/s0960-894x(01)00663-1
Staphylococcus aureus Staphylococcus aureus MIC 0.04 ug.mL-1 10.1016/j.ejmech.2014.06.048
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.01264-06
Staphylococcus aureus Staphylococcus aureus MIC 0.256 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2020.112072
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/S0960-894X(96)00285-5
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2019.111686
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2020.112996
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmcl.2014.02.044
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.ejmech.2020.112609
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 1.6 ug.mL-1 10.1021/np970182j
Staphylococcus aureus Staphylococcus aureus MIC 1.9 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus MIC 1.95 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.06.023
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 2.5 ug.mL-1 10.1021/np900499q
Staphylococcus aureus Staphylococcus aureus MIC 3.1 ug.mL-1 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus MIC 3.12 ug.mL-1 10.1016/S0960-894X(01)80919-7
Staphylococcus aureus Staphylococcus aureus MIC 3.12 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmcl.2013.10.072
Staphylococcus aureus Staphylococcus aureus MIC 3.9 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/acsmedchemlett.1c00680
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/np960006v
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/S0960-894X(01)80919-7
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 6.3 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 7.8 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.01264-06
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1039/C9MD00329K
Staphylococcus aureus Staphylococcus aureus MIC 25.0 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 25.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 31.3 ug.mL-1 10.1016/j.bmcl.2015.10.022
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2020.112996
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/S0960-894X(96)00285-5
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/acsmedchemlett.1c00680
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1039/C9MD00329K
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1021/np500911k
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2020.112996
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2022.114360
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/S0960-894X(01)80919-7
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/S0960-894X(01)80927-6
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.06.023
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2022.114360
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01242-06
Staphylococcus aureus Staphylococcus aureus MIC 192.0 ug.mL-1 10.1016/j.ejmech.2017.04.018
Staphylococcus aureus Staphylococcus aureus MIC 200.0 ug.mL-1 10.1016/j.ejmech.2015.06.047
Staphylococcus aureus Staphylococcus aureus MIC 250.0 ug.mL-1 10.1016/j.ejmech.2019.03.023
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2022.114360
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/np960006v
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 400.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 400.0 ug.mL-1 10.1128/aac.00504-07
Staphylococcus aureus Staphylococcus aureus MIC 500.0 ug.mL-1 10.1021/np970182j
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1021/acsmedchemlett.1c00680
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 800.0 ug.mL-1 10.1016/s0960-894x(01)00663-1
Staphylococcus aureus Staphylococcus aureus MIC 800.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1021/jm061349l
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2018.11.052
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2020.112072
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1016/j.ejmech.2022.114360
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1021/acsmedchemlett.1c00680
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1039/d1md00249j
Staphylococcus aureus Staphylococcus aureus MIC 1024.0 ug.mL-1 10.1128/aac.01242-06
Staphylococcus aureus Staphylococcus aureus MIC 1200.0 ug.mL-1 10.1016/j.ejmech.2019.111686
Staphylococcus aureus Staphylococcus aureus MIC 1600.0 ug.mL-1 10.1128/aac.00395-07
Staphylococcus aureus Staphylococcus aureus MIC 3130.0 nM 10.1016/j.bmc.2009.12.003
Staphylococcus aureus Staphylococcus aureus MIC 32000.0 nM 10.1021/jm061349l
Staphylococcus aureus Staphylococcus aureus MIC 37500.0 nM 10.1021/acs.jmedchem.1c00168
Staphylococcus aureus Staphylococcus aureus MIC 65700.0 nM 10.1007/s00044-012-0363-9
Staphylococcus aureus Staphylococcus aureus MIC 100000.0 nM 10.1016/j.bmcl.2016.03.089
Staphylococcus aureus Staphylococcus aureus MIC 200000.0 nM 10.1016/j.ejmech.2016.07.074
Staphylococcus aureus Staphylococcus aureus MIC 400000.0 nM 10.1016/j.bmc.2009.12.003
Staphylococcus aureus Staphylococcus aureus MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.bmc.2009.12.003
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.ejmech.2016.07.074
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.ejmech.2019.01.060
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/np900499q
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1039/C9MD00329K
Staphylococcus aureus Staphylococcus aureus MIC50 32.0 ug.mL-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus MIC50 256.0 ug.mL-1 10.1021/jm1014023
Staphylococcus aureus Staphylococcus aureus MIC=>90 1.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus MIC=>90 1.0 ug ml-1 10.1039/C7MD00387K
Staphylococcus aureus Staphylococcus aureus MIC=>90 6.0 ug ml-1 10.1039/C7MD00387K
Staphylococcus aureus Staphylococcus aureus MIC=>90 64.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus MIC=>90 192.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus MIC=>90 256.0 ug ml-1 10.1039/C7MD00387K
Staphylococcus aureus Staphylococcus aureus MIC=>90 512.0 ug ml-1 10.1039/C7MD00387K
Staphylococcus aureus Staphylococcus aureus MIC=>90 1024.0 ug ml-1 10.1039/C7MD00387K
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1021/jm0310232
Staphylococcus aureus Staphylococcus aureus MIC90 128.0 ug.mL-1 10.1016/j.bmc.2016.09.027
Staphylococcus aureus Staphylococcus aureus MIC90 256.0 ug.mL-1 10.1021/jm1014023
Staphylococcus aureus Staphylococcus aureus Ratio 4.0 None 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus Ratio 8.0 None 10.1016/j.ejmech.2019.111686
Staphylococcus aureus Staphylococcus aureus Ratio 32.0 None 10.1016/j.ejmech.2018.10.039
Staphylococcus epidermidis Staphylococcus epidermidis MBC 200.0 uM 10.1016/j.bmcl.2016.03.089
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1021/jm00066a006
Staphylococcus epidermidis Staphylococcus epidermidis MIC 3130.0 nM 10.1016/j.bmcl.2016.03.089
Staphylococcus epidermidis Staphylococcus epidermidis MIC 5260.0 nM 10.1007/s00044-012-0363-9
Staphylococcus epidermidis Staphylococcus epidermidis MIC 65700.0 nM 10.1007/s00044-012-0363-9
Staphylococcus epidermidis Staphylococcus epidermidis MIC 400000.0 nM 10.1016/j.ejmech.2019.01.060
Staphylococcus epidermidis Staphylococcus epidermidis MIC nan None 10.1016/j.ejmech.2016.07.074
Staphylococcus epidermidis Staphylococcus epidermidis MIC=>90 0.5 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC=>90 0.75 ug ml-1 10.1039/C7MD00387K
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1021/jm00066a006
None ADMET Activity nan None 10.1016/j.bmcl.2016.03.089
None ADMET CL 6.6 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET MRT 0.8 hr 10.1124/dmd.108.020479
None ADMET T1/2 0.64 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.32 L.kg-1 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.43 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 18.7 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MIC90 128.0 ug.mL-1 10.1016/j.bmc.2016.09.027
None NON-PROTEIN TARGET Range 64.0 ug ml-1 10.1021/jm0310232
None No relevant target LogD -1.88 None 10.1021/acs.jmedchem.2c01079
None No relevant target pKa 2.8 None 10.1021/acs.jmedchem.2c01079
None Unchecked Hepatotoxicity (acute) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 456.0 ug.mL-1 10.1021/jm00066a006

Metabolism Information