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Oliverine

AlkaPlorer ID: AK000871

Synonym: None

IUPAC Name: 13,16-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene;hydrochloride

Structure

SMILES: CN1CCC2=CC3=C(C4=C2C1C(C5=C4C=CC(=C5)OC)OC)OCO3.Cl

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InChI: InChI=1S/C20H21NO4.ClH/c1-21-7-6-11-8-15-20(25-10-24-15)17-13-5-4-12(22-2)9-14(13)19(23-3)18(21)16(11)17;/h4-5,8-9,18-19H,6-7,10H2,1-3H3;1H

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InChIKey: XCRFUDLMWTVMSG-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 375.85200000000015

TPSA？: 40.160000000000004

MolLogP？: 3.742800000000003

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 3639.15 nM None
Homo sapiens A498 GI50 1819.7 nM None
Homo sapiens A549 GI50 2917.43 nM None
Homo sapiens ACHN GI50 1815.52 nM None
Homo sapiens BT-549 GI50 2275.1 nM None
Homo sapiens CAKI-1 GI50 2123.24 nM None
Homo sapiens CCRF-CEM GI50 2238.72 nM None
Homo sapiens COLO 205 GI50 2792.54 nM None
Homo sapiens DU-145 GI50 5407.54 nM None
Homo sapiens EKVX GI50 4335.11 nM None
Homo sapiens HCC 2998 GI50 3404.08 nM None
Homo sapiens HCT-116 GI50 2098.94 nM None
Homo sapiens HCT-15 GI50 2128.14 nM None
Homo sapiens HL-60 GI50 1235.95 nM None
Homo sapiens HOP-62 GI50 2426.61 nM None
Homo sapiens HOP-92 GI50 924.7 nM None
Homo sapiens Hs-578T GI50 1963.36 nM None
Homo sapiens HT-29 GI50 2208.0 nM None
Homo sapiens IGROV-1 GI50 2884.03 nM None
Homo sapiens K562 GI50 3630.78 nM None
Homo sapiens KM12 GI50 4335.11 nM None
Homo sapiens LOX IMVI GI50 2805.43 nM None
Homo sapiens M14 GI50 2642.41 nM None
Homo sapiens Malme-3M GI50 1995.26 nM None
Homo sapiens MCF7 GI50 2666.86 nM None
Homo sapiens MDA-MB-231 GI50 2443.43 nM None
Homo sapiens MDA-MB-435 GI50 3341.95 nM None
Homo sapiens MDA-N GI50 2864.18 nM None
Homo sapiens MOLT-4 GI50 1945.36 nM None
Homo sapiens NCI/ADR-RES GI50 1874.99 nM None
Homo sapiens NCI-H226 GI50 2393.32 nM None
Homo sapiens NCI-H23 GI50 2798.98 nM None
Homo sapiens NCI-H322M GI50 4285.49 nM None
Homo sapiens NCI-H460 GI50 2818.38 nM None
Homo sapiens NCI-H522 GI50 1563.15 nM None
Homo sapiens OVCAR-3 GI50 5807.64 nM None
Homo sapiens OVCAR-4 GI50 2317.39 nM None
Homo sapiens OVCAR-5 GI50 3126.08 nM None
Homo sapiens OVCAR-8 GI50 2500.35 nM None
Homo sapiens PC-3 GI50 2600.16 nM None
Homo sapiens RPMI-8226 GI50 3459.39 nM None
Homo sapiens RXF 393 GI50 2060.63 nM None
Homo sapiens SF-268 GI50 4634.47 nM None
Homo sapiens SF-295 GI50 2382.32 nM None
Homo sapiens SF-539 GI50 2535.13 nM None
Homo sapiens SK-MEL-2 GI50 2728.98 nM None
Homo sapiens SK-MEL-28 GI50 3881.5 nM None
Homo sapiens SK-MEL-5 GI50 2426.61 nM None
Homo sapiens SK-OV-3 GI50 4497.8 nM None
Homo sapiens SN12C GI50 2636.33 nM None
Homo sapiens SNB-19 GI50 3118.89 nM None
Homo sapiens SNB-75 GI50 4045.76 nM None
Homo sapiens SR GI50 2398.83 nM None
Homo sapiens SW-620 GI50 2322.74 nM None
Homo sapiens T47D GI50 6561.45 nM None
Homo sapiens TK-10 GI50 4528.98 nM None
Homo sapiens U-251 GI50 3672.82 nM None
Homo sapiens UACC-257 GI50 3380.65 nM None
Homo sapiens UACC-62 GI50 2108.63 nM None
Homo sapiens UO-31 GI50 1667.25 nM None

Metabolism Information