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name Structure Reference Source Properties Activities Metabolism

Galantamine

AlkaPlorer ID: AK001048

Synonym: None

IUPAC Name: (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol

Structure

SMILES: COC1=CC=C2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3OC1=C24

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InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

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InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Zephyranthes candida Zephyranthes Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Reticularia lycoperdon Reticularia Reticulariaceae Liceales Eumycetozoa Evosea None Eukaryota
Salvia yunnanensis Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Crinum asiaticum Crinum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Magnolia x soulangeana Magnolia Magnoliaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pittosporum eugenioides Pittosporum Pittosporaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hippeastrum argentinum Hippeastrum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Leucojum aestivum Leucojum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Narcissus tazetta Narcissus Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stachys aegyptiaca Stachys Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ferula persica Ferula Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pteroxygonum giraldii Pteroxygonum Polygonaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Halocarpus bidwillii Halocarpus Podocarpaceae Araucariales Pinopsida Streptophyta Viridiplantae Eukaryota
Crotalaria crispata Crotalaria Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Atriplex parvifolia Atriplex Chenopodiaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Vateria copallifera Vateria Dipterocarpaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hesperocyparis arizonica Hesperocyparis Cupressaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Corydalis mucronifera Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Actaea heracleifolia Actaea Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Zephyranthes carinata Zephyranthes Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ligularia przewalskii Ligularia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Neorautanenia mitis Neorautanenia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pancratium maritimum Pancratium Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cortinarius infractus Cortinarius Cortinariaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
None None Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Flindersia bourjotiana Flindersia Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stereocaulon dactylophyllum Stereocaulon Stereocaulaceae Lecanorales Lecanoromycetes Ascomycota Fungi Eukaryota
Glycyrrhiza uralensis Glycyrrhiza Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Erythropodium caribaeorum Erythropodium Alcyoniidae Malacalcyonacea Anthozoa Cnidaria Metazoa Eukaryota
Berberis vulgaris Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chrysobalanus icaco Chrysobalanus Chrysobalanaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artemisia juncea Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Viburnum lantana Viburnum Adoxaceae Dipsacales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Jasminum laurifolium Jasminum Oleaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stemona aphylla Stemona Stemonaceae Pandanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces phaeochromogenes Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Commiphora wightii Commiphora Burseraceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 287.35900000000004

TPSA？: 41.93000000000001

MolLogP？: 1.8503

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis IZ 2.25 mm 10.1016/j.ejmech.2009.09.045
Bacillus subtilis Bacillus subtilis IZ 2.73 mm 10.1016/j.ejmech.2009.09.045
Bacillus subtilis Bacillus subtilis MIC 0.18 ug.mL-1 10.1016/j.ejmech.2009.09.045
Bos taurus Acetylcholinesterase IC50 8700.0 nM 10.1016/j.bmc.2010.01.074
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Electrophorus electricus Acetylcholinesterase IC50 0.45 ug.mL-1 10.1016/j.ejmech.2015.11.002
Electrophorus electricus Acetylcholinesterase IC50 150.0 nM 10.1016/j.ejmech.2022.114616
Electrophorus electricus Acetylcholinesterase IC50 250.0 nM 10.1016/j.ejmech.2017.05.019
Electrophorus electricus Acetylcholinesterase IC50 360.0 nM 10.1016/s0960-894x(00)00059-7
Electrophorus electricus Acetylcholinesterase IC50 360.0 nM 10.1021/jm070536w
Electrophorus electricus Acetylcholinesterase IC50 480.0 nM 10.1021/acs.jnatprod.5b00785
Electrophorus electricus Acetylcholinesterase IC50 500.0 nM 10.1007/s00044-011-9754-6
Electrophorus electricus Acetylcholinesterase IC50 500.0 nM 10.1016/j.bmcl.2005.10.042
Electrophorus electricus Acetylcholinesterase IC50 550.0 nM 10.1016/j.bmcl.2007.04.015
Electrophorus electricus Acetylcholinesterase IC50 550.0 nM 10.1016/j.ejmech.2009.01.021
Electrophorus electricus Acetylcholinesterase IC50 560.0 nM 10.1016/j.ejmech.2016.09.037
Electrophorus electricus Acetylcholinesterase IC50 560.0 nM 10.1016/j.ejmech.2019.05.062
Electrophorus electricus Acetylcholinesterase IC50 560.0 nM 10.1021/jm901902w
Electrophorus electricus Acetylcholinesterase IC50 600.0 nM 10.1016/j.bmcl.2012.02.057
Electrophorus electricus Acetylcholinesterase IC50 610.0 nM 10.1016/j.ejmech.2016.06.036
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmc.2009.12.035
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmc.2010.04.063
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmc.2011.02.025
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmc.2011.09.040
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmc.2017.02.048
Electrophorus electricus Acetylcholinesterase IC50 623.0 nM 10.1016/j.bmcl.2012.04.029
Electrophorus electricus Acetylcholinesterase IC50 635.33 nM 10.1016/j.bmc.2008.02.083
Electrophorus electricus Acetylcholinesterase IC50 635.33 nM 10.1016/j.bmc.2010.12.034
Electrophorus electricus Acetylcholinesterase IC50 635.33 nM 10.1016/j.bmcl.2010.03.011
Electrophorus electricus Acetylcholinesterase IC50 635.33 nM 10.1021/jm060682m
Electrophorus electricus Acetylcholinesterase IC50 635.33 nM 10.1021/jm1000024
Electrophorus electricus Acetylcholinesterase IC50 636.0 nM 10.1021/jm1000024
Electrophorus electricus Acetylcholinesterase IC50 640.0 nM 10.1016/j.bmc.2008.02.083
Electrophorus electricus Acetylcholinesterase IC50 640.0 nM 10.1016/j.bmc.2010.12.034
Electrophorus electricus Acetylcholinesterase IC50 640.0 nM 10.1016/j.bmcl.2010.03.011
Electrophorus electricus Acetylcholinesterase IC50 640.0 nM 10.1016/j.ejmech.2011.04.025
Electrophorus electricus Acetylcholinesterase IC50 640.0 nM 10.1021/jm060682m
Electrophorus electricus Acetylcholinesterase IC50 665.0 nM 10.1016/j.ejmech.2015.10.046
Electrophorus electricus Acetylcholinesterase IC50 1000.0 nM 10.1021/acs.jnatprod.2c01150
Electrophorus electricus Acetylcholinesterase IC50 1020.0 nM 10.1016/j.ejmech.2016.10.057
Electrophorus electricus Acetylcholinesterase IC50 1280.0 nM 10.1016/j.bmcl.2019.03.050
Electrophorus electricus Acetylcholinesterase IC50 1290.0 nM 10.1016/j.bmc.2022.116807
Electrophorus electricus Acetylcholinesterase IC50 1450.0 nM 10.1016/j.bmcl.2013.03.069
Electrophorus electricus Acetylcholinesterase IC50 1450.0 nM 10.1016/j.ejmech.2017.10.019
Electrophorus electricus Acetylcholinesterase IC50 1670.0 nM 10.1016/j.bmc.2018.01.029
Electrophorus electricus Acetylcholinesterase IC50 1700.0 nM 10.1016/j.bmc.2018.08.035
Electrophorus electricus Acetylcholinesterase IC50 1820.0 nM 10.1016/j.bmcl.2008.03.008
Electrophorus electricus Acetylcholinesterase IC50 2000.0 nM 10.1021/np100247r
Electrophorus electricus Acetylcholinesterase IC50 2050.0 nM 10.1016/j.bmc.2016.12.037
Electrophorus electricus Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmc.2013.03.058
Electrophorus electricus Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmc.2013.11.020
Electrophorus electricus Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmc.2019.03.058
Electrophorus electricus Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmcl.2014.02.019
Electrophorus electricus Acetylcholinesterase IC50 2090.0 nM 10.1016/j.ejmech.2013.06.054
Electrophorus electricus Acetylcholinesterase IC50 2200.0 nM 10.1021/jm0508639
Electrophorus electricus Acetylcholinesterase IC50 2400.0 nM 10.1021/np401003p
Electrophorus electricus Acetylcholinesterase IC50 2410.0 nM 10.1016/j.bmc.2018.05.042
Electrophorus electricus Acetylcholinesterase IC50 2410.0 nM 10.1016/j.ejmech.2015.07.005
Electrophorus electricus Acetylcholinesterase IC50 2670.0 nM 10.1016/j.bmc.2014.08.035
Electrophorus electricus Acetylcholinesterase IC50 2670.0 nM 10.1016/j.bmcl.2013.02.095
Electrophorus electricus Acetylcholinesterase IC50 2670.0 nM 10.1016/j.bmcl.2014.03.058
Electrophorus electricus Acetylcholinesterase IC50 2670.0 nM 10.1016/j.ejmech.2013.03.051
Electrophorus electricus Acetylcholinesterase IC50 2670.0 nM 10.1016/j.ejmech.2013.09.024
Electrophorus electricus Acetylcholinesterase IC50 2700.0 nM 10.1021/acsmedchemlett.1c00344
Electrophorus electricus Acetylcholinesterase IC50 2770.0 nM 10.1039/C3MD00376K
Electrophorus electricus Acetylcholinesterase IC50 2800.0 nM 10.1016/j.ejmech.2017.06.007
Electrophorus electricus Acetylcholinesterase IC50 3120.0 nM 10.1016/j.ejmech.2016.04.053
Electrophorus electricus Acetylcholinesterase IC50 3180.0 nM 10.1016/j.bmc.2006.10.026
Electrophorus electricus Acetylcholinesterase IC50 3200.0 nM 10.1016/j.bmc.2010.05.071
Electrophorus electricus Acetylcholinesterase IC50 3200.0 nM 10.1016/j.bmcl.2010.08.123
Electrophorus electricus Acetylcholinesterase IC50 3200.0 nM 10.1021/np060268p
Electrophorus electricus Acetylcholinesterase IC50 3560.0 nM 10.1016/j.bmcl.2016.07.017
Electrophorus electricus Acetylcholinesterase IC50 3570.0 nM 10.1016/j.ejmech.2016.10.036
Electrophorus electricus Acetylcholinesterase IC50 3580.0 nM 10.1016/j.ejmech.2019.06.088
Electrophorus electricus Acetylcholinesterase IC50 4000.0 nM 10.1016/j.bmc.2013.01.052
Electrophorus electricus Acetylcholinesterase IC50 4000.0 nM 10.1021/acs.jnatprod.5b00191
Electrophorus electricus Acetylcholinesterase IC50 4480.0 nM 10.1016/j.ejmech.2016.08.037
Electrophorus electricus Acetylcholinesterase IC50 7440.0 nM 10.1021/jm301732a
Electrophorus electricus Acetylcholinesterase IC50 8000.0 nM 10.1016/j.bmc.2017.04.022
Electrophorus electricus Acetylcholinesterase IC50 8500.0 nM 10.1016/j.bmc.2016.01.010
Electrophorus electricus Acetylcholinesterase IC50 10530.0 nM 10.1016/j.ejmech.2014.02.035
Electrophorus electricus Acetylcholinesterase IC50 12730.0 nM 10.1016/j.bmc.2016.09.031
Electrophorus electricus Acetylcholinesterase IC50 21820.0 nM 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase IC50 35000.0 nM 10.1016/s0960-894x(03)00397-4
Electrophorus electricus Acetylcholinesterase Inhibition 0.6 % 10.1007/s00044-008-9122-3
Electrophorus electricus Acetylcholinesterase Inhibition 6.197 % 10.1016/j.ejmech.2011.04.025
Electrophorus electricus Acetylcholinesterase Inhibition 13.44 % 10.1016/j.ejmech.2017.10.050
Electrophorus electricus Acetylcholinesterase Inhibition 35.9 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 43.77 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 50.0 % 10.1016/j.bmcl.2016.11.067
Electrophorus electricus Acetylcholinesterase Inhibition 68.5 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 77.0 % 10.1016/j.ejmech.2021.114031
Electrophorus electricus Acetylcholinesterase Inhibition 80.69 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 85.78 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 90.1 % 10.1016/j.ejmech.2022.114616
Electrophorus electricus Acetylcholinesterase Inhibition 91.8 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 94.77 % 10.1016/j.bmcl.2018.05.063
Electrophorus electricus Acetylcholinesterase Inhibition 100.0 % 10.1016/j.bmcl.2012.02.057
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.bmc.2018.01.029
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1016/j.ejmech.2015.11.002
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1021/acs.jnatprod.5b00681
Electrophorus electricus Acetylcholinesterase Ki 428.0 nM 10.1016/j.bmc.2010.06.095
Electrophorus electricus Acetylcholinesterase Ki 440.0 nM 10.1016/j.bmcl.2005.10.042
Electrophorus electricus Acetylcholinesterase Ki 500.0 nM 10.1039/D1MD00217A
Electrophorus electricus Acetylcholinesterase Ki 1060.0 nM 10.1021/jm301732a
Electrophorus electricus Acetylcholinesterase Ki 1560.0 nM 10.1021/jm0508639
Electrophorus electricus Acetylcholinesterase Ki 3000.0 nM 10.1016/j.ejmech.2019.07.053
Equus caballus Butyrylcholinesterase IC50 8394.6 nM 10.1016/j.bmc.2008.02.083
Equus caballus Butyrylcholinesterase IC50 8394.6 nM 10.1021/jm060682m
Equus caballus Butyrylcholinesterase IC50 8400.0 nM 10.1016/j.bmc.2008.02.083
Equus caballus Butyrylcholinesterase IC50 8400.0 nM 10.1021/jm060682m
Equus caballus Butyrylcholinesterase IC50 8500.0 nM 10.1016/j.bmcl.2005.10.042
Equus caballus Butyrylcholinesterase IC50 14400.0 nM 10.1016/j.bmcl.2007.04.015
Equus caballus Butyrylcholinesterase IC50 15240.0 nM 10.1016/j.bmcl.2007.01.091
Equus caballus Butyrylcholinesterase IC50 15700.0 nM 10.1016/j.bmc.2011.02.025
Equus caballus Butyrylcholinesterase IC50 15700.0 nM 10.1016/j.bmc.2011.09.040
Equus caballus Butyrylcholinesterase IC50 nan None 10.1016/j.bmc.2011.09.040
Equus caballus Butyrylcholinesterase Ki 8000.0 nM 10.1016/j.bmcl.2005.10.042
Equus caballus Cholinesterase IC50 3200.0 nM 10.1021/np100531x
Equus caballus Cholinesterase IC50 3310.0 nM 10.1016/j.bmc.2018.01.029
Equus caballus Cholinesterase IC50 3900.0 nM 10.1021/acsmedchemlett.1c00344
Equus caballus Cholinesterase IC50 5470.0 nM 10.1016/j.bmc.2022.116807
Equus caballus Cholinesterase IC50 7900.0 nM 10.1016/j.ejmech.2022.114616
Equus caballus Cholinesterase IC50 7960.0 nM 10.1016/j.bmc.2013.01.052
Equus caballus Cholinesterase IC50 8394.6 nM 10.1016/j.bmc.2010.12.034
Equus caballus Cholinesterase IC50 8394.6 nM 10.1016/j.bmcl.2010.03.011
Equus caballus Cholinesterase IC50 8394.6 nM 10.1016/j.ejmech.2011.04.025
Equus caballus Cholinesterase IC50 8394.6 nM 10.1021/jm1000024
Equus caballus Cholinesterase IC50 8400.0 nM 10.1016/j.bmc.2010.12.034
Equus caballus Cholinesterase IC50 8400.0 nM 10.1016/j.bmcl.2010.03.011
Equus caballus Cholinesterase IC50 8400.0 nM 10.1016/j.ejmech.2011.04.025
Equus caballus Cholinesterase IC50 8404.0 nM 10.1021/jm1000024
Equus caballus Cholinesterase IC50 9400.0 nM 10.1016/j.bmc.2018.08.035
Equus caballus Cholinesterase IC50 11900.0 nM 10.1016/j.ejmech.2016.09.037
Equus caballus Cholinesterase IC50 12000.0 nM 10.1016/j.bmc.2017.04.022
Equus caballus Cholinesterase IC50 12000.0 nM 10.1016/j.ejmech.2019.05.062
Equus caballus Cholinesterase IC50 12000.0 nM 10.1021/jm901902w
Equus caballus Cholinesterase IC50 12600.0 nM 10.1016/j.bmcl.2012.05.077
Equus caballus Cholinesterase IC50 12700.0 nM 10.1016/j.bmc.2014.08.035
Equus caballus Cholinesterase IC50 12700.0 nM 10.1016/j.bmcl.2013.02.095
Equus caballus Cholinesterase IC50 12700.0 nM 10.1016/j.bmcl.2014.03.058
Equus caballus Cholinesterase IC50 12700.0 nM 10.1016/j.ejmech.2013.03.051
Equus caballus Cholinesterase IC50 12700.0 nM 10.1016/j.ejmech.2013.09.024
Equus caballus Cholinesterase IC50 13610.0 nM 10.1039/C3MD00376K
Equus caballus Cholinesterase IC50 14400.0 nM 10.1016/j.ejmech.2009.01.021
Equus caballus Cholinesterase IC50 15700.0 nM 10.1016/j.bmc.2009.12.035
Equus caballus Cholinesterase IC50 15700.0 nM 10.1016/j.bmc.2010.04.063
Equus caballus Cholinesterase IC50 15700.0 nM 10.1016/j.bmc.2017.02.048
Equus caballus Cholinesterase IC50 15700.0 nM 10.1016/j.bmcl.2012.04.029
Equus caballus Cholinesterase IC50 15800.0 nM 10.1016/j.ejmech.2016.04.053
Equus caballus Cholinesterase IC50 16320.0 nM 10.1016/j.bmcl.2016.07.017
Equus caballus Cholinesterase IC50 17380.0 nM 10.1016/j.bmc.2018.05.042
Equus caballus Cholinesterase IC50 17380.0 nM 10.1016/j.ejmech.2015.07.005
Equus caballus Cholinesterase IC50 18130.0 nM 10.1016/j.bmc.2016.12.037
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmc.2013.01.066
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmc.2013.03.058
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmc.2013.11.020
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmc.2014.01.002
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmc.2019.03.058
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmcl.2013.03.027
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.bmcl.2014.02.019
Equus caballus Cholinesterase IC50 19340.0 nM 10.1016/j.ejmech.2013.06.054
Equus caballus Cholinesterase IC50 19780.0 nM 10.1016/j.ejmech.2015.10.046
Equus caballus Cholinesterase IC50 21850.0 nM 10.1016/j.ejmech.2017.06.007
Equus caballus Cholinesterase IC50 22390.0 nM 10.1021/acs.jnatprod.5b00785
Equus caballus Cholinesterase IC50 24400.0 nM 10.1016/j.bmc.2010.01.074
Equus caballus Cholinesterase IC50 24410.0 nM 10.1016/j.bmcl.2019.03.050
Equus caballus Cholinesterase IC50 28100.0 nM 10.1016/j.bmc.2016.01.010
Equus caballus Cholinesterase IC50 28300.0 nM 10.1016/j.bmcl.2016.03.039
Equus caballus Cholinesterase IC50 39030.0 nM 10.1016/j.ejmech.2014.02.035
Equus caballus Cholinesterase IC50 40720.0 nM 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase IC50 46030.0 nM 10.1016/j.ejmech.2016.08.037
Equus caballus Cholinesterase IC50 nan None 10.1021/np060268p
Equus caballus Cholinesterase Inhibition 11.13 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 13.62 % 10.1016/j.ejmech.2017.10.050
Equus caballus Cholinesterase Inhibition 21.02 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 55.22 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 63.87 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 78.85 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 80.3 % 10.1016/j.ejmech.2017.05.019
Equus caballus Cholinesterase Inhibition 80.77 % 10.1016/j.bmc.2018.01.029
Equus caballus Cholinesterase Inhibition 85.71 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Inhibition 90.0 % 10.1016/j.ejmech.2022.114616
Equus caballus Cholinesterase Inhibition 96.98 % 10.1016/j.bmcl.2018.05.063
Equus caballus Cholinesterase Ki 7700.0 nM 10.1016/j.ejmech.2019.07.053
Escherichia coli Escherichia coli IZ 1.62 mm 10.1016/j.ejmech.2009.09.045
Escherichia coli Escherichia coli IZ 2.02 mm 10.1016/j.ejmech.2009.09.045
Escherichia coli Escherichia coli MIC 0.7 ug.mL-1 10.1016/j.ejmech.2009.09.045
Escherichia coli Escherichia coli MIC 2048.0 ug.mL-1 10.1016/j.bmcl.2017.09.052
Felis catus Felis catus ED50 nan umol.kg-1 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus HR nan None 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus MAP nan None 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Max rev nan None 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Vagus nan None 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholine receptor protein epsilon chain IC50 0.767 ug.mL-1 10.1016/j.ejmech.2019.07.059
Homo sapiens Acetylcholinesterase AC50 557.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase AC50 570.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase Activity 0.01 ug 10.1021/np058123q
Homo sapiens Acetylcholinesterase EC50 1100.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase IC50 100.0 nM 10.1016/0960-894X(96)00102-3
Homo sapiens Acetylcholinesterase IC50 300.0 nM 10.1016/j.bmc.2012.10.045
Homo sapiens Acetylcholinesterase IC50 300.0 nM 10.1016/j.bmcl.2012.02.057
Homo sapiens Acetylcholinesterase IC50 300.0 nM 10.1016/j.ejmech.2018.07.033
Homo sapiens Acetylcholinesterase IC50 300.0 nM 10.1021/acs.jnatprod.5b00877
Homo sapiens Acetylcholinesterase IC50 350.0 nM 10.1016/j.bmc.2021.116270
Homo sapiens Acetylcholinesterase IC50 350.0 nM 10.1016/j.bmc.2023.117256
Homo sapiens Acetylcholinesterase IC50 350.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Acetylcholinesterase IC50 350.0 nM 10.1016/j.bmcl.2015.06.047
Homo sapiens Acetylcholinesterase IC50 350.0 nM 10.1021/jm701253t
Homo sapiens Acetylcholinesterase IC50 355.0 nM 10.1021/acs.jmedchem.7b01086
Homo sapiens Acetylcholinesterase IC50 500.0 nM 10.1007/s00044-011-9804-0
Homo sapiens Acetylcholinesterase IC50 500.0 nM 10.1016/j.bmc.2008.07.009
Homo sapiens Acetylcholinesterase IC50 500.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase IC50 500.0 nM 10.1021/np800305b
Homo sapiens Acetylcholinesterase IC50 530.0 nM 10.1021/np100494u
Homo sapiens Acetylcholinesterase IC50 550.0 nM 10.1021/np400978x
Homo sapiens Acetylcholinesterase IC50 590.0 nM 10.1016/j.bmcl.2006.01.067
Homo sapiens Acetylcholinesterase IC50 600.0 nM 10.1016/j.bmc.2017.02.017
Homo sapiens Acetylcholinesterase IC50 600.0 nM 10.1016/j.bmcl.2006.08.067
Homo sapiens Acetylcholinesterase IC50 600.0 nM 10.1021/jm901902w
Homo sapiens Acetylcholinesterase IC50 635.33 nM 10.1016/j.bmcl.2006.08.067
Homo sapiens Acetylcholinesterase IC50 700.0 nM 10.1016/j.bmc.2014.08.016
Homo sapiens Acetylcholinesterase IC50 790.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Acetylcholinesterase IC50 800.0 nM 10.1016/j.ejmech.2011.02.071
Homo sapiens Acetylcholinesterase IC50 800.0 nM 10.1021/jm010491d
Homo sapiens Acetylcholinesterase IC50 800.0 nM 10.1021/jm049309+
Homo sapiens Acetylcholinesterase IC50 800.0 nM 10.1021/jm050578p
Homo sapiens Acetylcholinesterase IC50 980.0 nM 10.1021/np9905719
Homo sapiens Acetylcholinesterase IC50 1000.0 nM 10.1016/j.ejmech.2020.112792
Homo sapiens Acetylcholinesterase IC50 1000.0 nM 10.1021/np2009626
Homo sapiens Acetylcholinesterase IC50 1070.0 nM 10.1016/j.ejmech.2017.05.019
Homo sapiens Acetylcholinesterase IC50 1070.0 nM 10.1021/np0702077
Homo sapiens Acetylcholinesterase IC50 1100.0 nM 10.1016/j.ejmech.2014.03.067
Homo sapiens Acetylcholinesterase IC50 1156.0 nM None
Homo sapiens Acetylcholinesterase IC50 1170.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Acetylcholinesterase IC50 1180.0 nM 10.1021/np060268p
Homo sapiens Acetylcholinesterase IC50 1270.0 nM 10.1021/acs.jnatprod.7b00301
Homo sapiens Acetylcholinesterase IC50 1300.0 nM 10.1016/j.bmcl.2016.11.065
Homo sapiens Acetylcholinesterase IC50 1600.0 nM 10.1016/j.bmcl.2019.03.024
Homo sapiens Acetylcholinesterase IC50 1700.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Acetylcholinesterase IC50 1700.0 nM 10.1021/acs.jnatprod.9b00561
Homo sapiens Acetylcholinesterase IC50 1900.0 nM 10.1021/acs.jnatprod.7b00847
Homo sapiens Acetylcholinesterase IC50 2000.0 nM 10.1016/j.bmcl.2013.02.103
Homo sapiens Acetylcholinesterase IC50 2000.0 nM 10.1016/j.bmcl.2014.12.006
Homo sapiens Acetylcholinesterase IC50 2010.0 nM 10.1016/j.bmcl.2021.128374
Homo sapiens Acetylcholinesterase IC50 2010.0 nM 10.1016/j.ejmech.2015.12.024
Homo sapiens Acetylcholinesterase IC50 2010.0 nM 10.1021/jm070559a
Homo sapiens Acetylcholinesterase IC50 2010.0 nM 10.1021/jm400990p
Homo sapiens Acetylcholinesterase IC50 2010.0 nM 10.1021/jm8009684
Homo sapiens Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmc.2013.01.066
Homo sapiens Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmc.2014.01.002
Homo sapiens Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmcl.2013.03.027
Homo sapiens Acetylcholinesterase IC50 2090.0 nM 10.1016/j.bmcl.2019.126789
Homo sapiens Acetylcholinesterase IC50 2090.0 nM 10.1016/j.ejmech.2020.113102
Homo sapiens Acetylcholinesterase IC50 2100.0 nM 10.1021/jm901296p
Homo sapiens Acetylcholinesterase IC50 2600.0 nM 10.1021/np100416v
Homo sapiens Acetylcholinesterase IC50 2600.0 nM 10.1039/C5MD00274E
Homo sapiens Acetylcholinesterase IC50 2670.0 nM 10.1016/j.bmc.2014.05.032
Homo sapiens Acetylcholinesterase IC50 2770.0 nM 10.1016/j.ejmech.2019.05.080
Homo sapiens Acetylcholinesterase IC50 2900.0 nM 10.1016/j.bmc.2021.116269
Homo sapiens Acetylcholinesterase IC50 3000.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Acetylcholinesterase IC50 3030.0 nM 10.1016/j.ejmech.2019.06.041
Homo sapiens Acetylcholinesterase IC50 3200.0 nM 10.1016/j.bmc.2014.01.010
Homo sapiens Acetylcholinesterase IC50 3200.0 nM 10.1016/j.bmcl.2012.05.077
Homo sapiens Acetylcholinesterase IC50 3200.0 nM 10.1021/jm049655r
Homo sapiens Acetylcholinesterase IC50 3800.0 nM 10.1016/j.bmc.2019.01.025
Homo sapiens Acetylcholinesterase IC50 6400.0 nM 10.1016/j.bmc.2020.115820
Homo sapiens Acetylcholinesterase IC50 7300.0 nM 10.1016/j.ejmech.2011.02.071
Homo sapiens Acetylcholinesterase IC50 8400.0 nM 10.1021/acs.jmedchem.2c01003
Homo sapiens Acetylcholinesterase IC50 13900.0 nM 10.1021/acs.jnatprod.7b00892
Homo sapiens Acetylcholinesterase IC50 17100.0 nM 10.1039/d0md00009d
Homo sapiens Acetylcholinesterase IC50 73900.0 nM 10.1021/np800671p
Homo sapiens Acetylcholinesterase IC50 90000.0 nM 10.1016/j.bmc.2015.06.005
Homo sapiens Acetylcholinesterase IC50 1725000.0 nM 10.1039/d2md00262k
Homo sapiens Acetylcholinesterase Inhibition 17.9 % 10.1021/jm070559a
Homo sapiens Acetylcholinesterase Inhibition 17.9 % 10.1021/jm8009684
Homo sapiens Acetylcholinesterase Inhibition 54.0 % 10.1016/j.bmcl.2014.12.006
Homo sapiens Acetylcholinesterase Inhibition 61.44 % 10.1021/np4009255
Homo sapiens Acetylcholinesterase Inhibition 71.2 % 10.1016/j.ejmech.2019.06.041
Homo sapiens Acetylcholinesterase Inhibition 81.4 % 10.1016/j.ejmech.2020.112415
Homo sapiens Acetylcholinesterase Inhibition 90.0 % 10.1016/j.ejmech.2019.05.080
Homo sapiens Acetylcholinesterase Inhibition 90.0 % 10.1021/acs.jnatprod.5b00877
Homo sapiens Acetylcholinesterase Inhibition 96.82 % 10.1021/np070690l
Homo sapiens Acetylcholinesterase Inhibition 97.66 % 10.1021/np060268p
Homo sapiens Acetylcholinesterase Inhibition 98.89 % 10.1016/j.bmcl.2019.03.024
Homo sapiens Acetylcholinesterase Inhibition 99.7 % 10.1021/np020169l
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.bmcl.2012.05.077
Homo sapiens Acetylcholinesterase Inhibition nan % 10.1016/j.bmcl.2013.02.103
Homo sapiens Acetylcholinesterase Ki 61.9 nM 10.1016/j.bmc.2014.06.057
Homo sapiens Acetylcholinesterase Ki 61.96 nM 10.1016/j.bmc.2012.09.016
Homo sapiens Acetylcholinesterase Ki 250.0 nM 10.1016/j.bmc.2015.04.019
Homo sapiens Acetylcholinesterase Ki 300.0 nM 10.1016/j.bmcl.2010.06.130
Homo sapiens Acetylcholinesterase Ki 500.0 nM 10.1039/D1MD00217A
Homo sapiens Acetylcholinesterase Ki 540.0 nM 10.1039/D1MD00217A
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Acetylcholinesterase MIC 0.003 nM 10.1021/np100474y
Homo sapiens Acetylcholinesterase MIC 0.004 ug 10.1021/np4009255
Homo sapiens Acetylcholinesterase MIC 0.01 ug 10.1021/np800318m
Homo sapiens Acetylcholinesterase MIC 1.0 ng 10.1021/np100474y
Homo sapiens Acetylcholinesterase MIC 1.0 ng 10.1021/np100668s
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 15848.9 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1021/jm070559a
Homo sapiens Amyloid-beta A4 protein Inhibition 5.0 % 10.1021/jm8009684
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2014.02.035
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2017.10.017
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1039/C3MD00376K
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Beta-secretase 1 IC50 nan None 10.1016/j.bmcl.2012.05.077
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens BJ IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Butyrylcholinesterase IC50 0.38 ug.mL-1 10.1016/j.bmcl.2015.03.028
Homo sapiens Butyrylcholinesterase IC50 6.34 ug.mL-1 10.1016/j.ejmech.2015.11.002
Homo sapiens Butyrylcholinesterase IC50 170.0 nM 10.1007/s00044-011-9804-0
Homo sapiens Butyrylcholinesterase IC50 575.0 nM 10.1016/j.bmc.2019.01.025
Homo sapiens Butyrylcholinesterase IC50 1200.0 nM 10.1016/j.bmc.2017.02.017
Homo sapiens Butyrylcholinesterase IC50 2000.0 nM 10.1021/acs.jnatprod.7b00892
Homo sapiens Butyrylcholinesterase IC50 2015.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Butyrylcholinesterase IC50 3720.0 nM 10.1016/j.ejmech.2017.10.019
Homo sapiens Butyrylcholinesterase IC50 7000.0 nM 10.1016/j.bmc.2012.10.045
Homo sapiens Butyrylcholinesterase IC50 7000.0 nM 10.1016/j.ejmech.2018.07.033
Homo sapiens Butyrylcholinesterase IC50 7300.0 nM 10.1021/jm010491d
Homo sapiens Butyrylcholinesterase IC50 7300.0 nM 10.1021/jm049309+
Homo sapiens Butyrylcholinesterase IC50 7300.0 nM 10.1021/jm050578p
Homo sapiens Butyrylcholinesterase IC50 8000.0 nM 10.1007/s00044-011-9754-6
Homo sapiens Butyrylcholinesterase IC50 8000.0 nM 10.1016/j.bmc.2008.07.009
Homo sapiens Butyrylcholinesterase IC50 8394.6 nM 10.1016/j.bmcl.2006.08.067
Homo sapiens Butyrylcholinesterase IC50 8400.0 nM 10.1016/j.bmcl.2006.08.067
Homo sapiens Butyrylcholinesterase IC50 8500.0 nM 10.1021/np800305b
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1016/j.bmcl.2013.02.103
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1016/j.bmcl.2016.11.067
Homo sapiens Butyrylcholinesterase IC50 10000.0 nM 10.1021/jm070536w
Homo sapiens Butyrylcholinesterase IC50 10600.0 nM 10.1016/j.bmc.2021.116269
Homo sapiens Butyrylcholinesterase IC50 12700.0 nM 10.1016/j.bmc.2014.05.032
Homo sapiens Butyrylcholinesterase IC50 13180.0 nM 10.1016/j.bmcl.2019.03.024
Homo sapiens Butyrylcholinesterase IC50 13700.0 nM 10.1016/j.ejmech.2020.112415
Homo sapiens Butyrylcholinesterase IC50 15800.0 nM 10.1016/j.ejmech.2014.01.020
Homo sapiens Butyrylcholinesterase IC50 16500.0 nM 10.1016/j.ejmech.2019.06.041
Homo sapiens Butyrylcholinesterase IC50 18000.0 nM 10.1016/s0960-894x(03)00397-4
Homo sapiens Butyrylcholinesterase IC50 18600.0 nM 10.1016/j.bmc.2021.116270
Homo sapiens Butyrylcholinesterase IC50 18600.0 nM 10.1016/j.bmcl.2010.12.041
Homo sapiens Butyrylcholinesterase IC50 19100.0 nM 10.1016/j.bmc.2023.117256
Homo sapiens Butyrylcholinesterase IC50 19100.0 nM 10.1021/acs.jmedchem.7b01086
Homo sapiens Butyrylcholinesterase IC50 19270.0 nM 10.1016/j.ejmech.2020.113102
Homo sapiens Butyrylcholinesterase IC50 19340.0 nM 10.1016/j.bmcl.2019.126789
Homo sapiens Butyrylcholinesterase IC50 19710.0 nM 10.1021/acs.jmedchem.2c01003
Homo sapiens Butyrylcholinesterase IC50 20700.0 nM 10.1016/j.ejmech.2019.05.080
Homo sapiens Butyrylcholinesterase IC50 20700.0 nM 10.1021/jm070559a
Homo sapiens Butyrylcholinesterase IC50 20700.0 nM 10.1021/jm8009684
Homo sapiens Butyrylcholinesterase IC50 21900.0 nM 10.1016/j.bmc.2014.08.016
Homo sapiens Butyrylcholinesterase IC50 29310.0 nM 10.1016/j.bmcl.2021.128374
Homo sapiens Butyrylcholinesterase IC50 31600.0 nM 10.1016/j.ejmech.2020.112140
Homo sapiens Butyrylcholinesterase IC50 42000.0 nM 10.1021/acs.jnatprod.9b00561
Homo sapiens Butyrylcholinesterase IC50 42300.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Butyrylcholinesterase IC50 50900.0 nM 10.1021/np800671p
Homo sapiens Butyrylcholinesterase IC50 66500.0 nM 10.1039/C5MD00274E
Homo sapiens Butyrylcholinesterase IC50 9400000.0 nM 10.1016/j.ejmech.2019.07.059
Homo sapiens Butyrylcholinesterase IC50 18600000.0 nM 10.1021/jm701253t
Homo sapiens Butyrylcholinesterase Inhibition 29.0 % 10.1016/j.bmcl.2016.11.067
Homo sapiens Butyrylcholinesterase Inhibition 38.3 % 10.1016/j.ejmech.2019.06.041
Homo sapiens Butyrylcholinesterase Inhibition 40.0 % 10.1016/j.bmcl.2014.12.006
Homo sapiens Butyrylcholinesterase Inhibition 54.2 % 10.1016/j.ejmech.2019.05.080
Homo sapiens Butyrylcholinesterase Inhibition 68.2 % 10.1016/j.bmcl.2021.128374
Homo sapiens Butyrylcholinesterase Inhibition 94.6 % 10.1016/j.bmcl.2019.03.024
Homo sapiens Butyrylcholinesterase Inhibition nan % 10.1016/j.bmcl.2013.02.103
Homo sapiens Butyrylcholinesterase Inhibition nan % 10.1016/j.ejmech.2015.11.002
Homo sapiens Butyrylcholinesterase Ki 192.47 nM 10.1016/j.bmc.2012.09.016
Homo sapiens Butyrylcholinesterase Ki 192.5 nM 10.1016/j.bmc.2014.06.057
Homo sapiens Butyrylcholinesterase Ki 9370.0 nM 10.1039/D1MD00217A
Homo sapiens Butyrylcholinesterase Ki 9400.0 nM 10.1039/D1MD00217A
Homo sapiens Butyrylcholinesterase Ki 28290.0 nM 10.1016/j.bmc.2016.07.043
Homo sapiens Butyrylcholinesterase Selectivity 53.0 None 10.1016/s0960-894x(03)00397-4
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholinesterases; ACHE & BCHE Ratio 11.48 None 10.1016/j.bmc.2012.09.016
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 0.11 None 10.1016/j.bmcl.2019.126789
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 0.12 None 10.1016/j.bmcl.2019.03.024
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 9.0 None 10.1021/jm050578p
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 9.25 None 10.1016/j.bmcl.2019.126789
Homo sapiens Cholinesterases; ACHE & BCHE Ratio IC50 14.0 None 10.1016/j.bmcl.2006.08.067
Homo sapiens Cholinesterases; ACHE & BCHE Ratio Ki 3.1 None 10.1016/j.bmc.2012.09.016
Homo sapiens Cholinesterases; ACHE & BCHE Ratio Ki 3.11 None 10.1016/j.bmc.2014.06.057
Homo sapiens Cholinesterases; ACHE & BCHE Selectivity 9.0 None 10.1021/jm010491d
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None 10.1016/j.bmcl.2009.04.086
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Inhibition nan % 10.1021/jm301034u
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens G-361 IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gamma-secretase Ke 25.7 uM 10.1016/j.bmc.2021.116270
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A Activity 96.8 % 10.1021/jm1000024
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A IC50 nan None 10.1021/jm1000024
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B Activity 93.7 % 10.1021/jm1000024
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 nan None 10.1021/jm1000024
Homo sapiens Glycogen synthase kinase-3 beta Inhibition nan % 10.1021/acs.jnatprod.8b00592
Homo sapiens HeLa IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -31.78 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.81 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 5.6 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 1.57 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 IC50 50000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 7962.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prolyl endopeptidase IC50 200000.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SH-SY5Y Activity 0.0 % 10.1021/jm901902w
Homo sapiens SH-SY5Y Activity 36.0 % 10.1016/j.ejmech.2011.03.003
Homo sapiens SH-SY5Y Activity 44.0 % 10.1021/acs.jnatprod.2c01150
Homo sapiens SH-SY5Y IC50 747.0 nM 10.1021/jm3009458
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vitamin D receptor Potency 89125.1 nM None
Klebsiella pneumoniae Klebsiella pneumoniae IZ 1.83 mm 10.1016/j.ejmech.2009.09.045
Klebsiella pneumoniae Klebsiella pneumoniae IZ 2.21 mm 10.1016/j.ejmech.2009.09.045
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.62 ug.mL-1 10.1016/j.ejmech.2009.09.045
Leishmania donovani Leishmania donovani IC50 30.0 ug.mL-1 10.1016/j.bmcl.2019.126642
Mus musculus Acetylcholinesterase IC50 2080.0 nM 10.1016/j.bmc.2014.11.004
Mus musculus Acetylcholinesterase IC50 2500.0 nM 10.1016/j.bmc.2014.01.010
Mus musculus Acetylcholinesterase Inhibition 91.94 % 10.1016/j.bmc.2014.01.010
Mus musculus Dual specificity protein kinase CLK1 Inhibition nan % 10.1021/jm301034u
Mus musculus Dual specificity protein kinase CLK3 Inhibition nan % 10.1021/jm301034u
Mus musculus Mus musculus Active dose 0.63 mg kg-1 10.1021/jm00018a025
Mus musculus Mus musculus Active dose 1.25 mg kg-1 10.1021/jm00018a025
Mus musculus Mus musculus Active dose 5.0 mg kg-1 10.1021/jm00018a025
Mus musculus Mus musculus Activity 6.6 % 10.1039/d0md00009d
Mus musculus Mus musculus Activity 22.3 % 10.1039/d0md00009d
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2014.01.010
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.2c00944
Mus musculus Mus musculus Activity nan None 10.1039/d0md00009d
Mus musculus Mus musculus ED50 3.0 mg.kg-1 10.1021/jm00031a019
Mus musculus Mus musculus ED50 5.0 mg.kg-1 10.1021/jm00031a019
Mus musculus Mus musculus LD50 10.0 mg.kg-1 10.1021/jm00031a019
Mus musculus Mus musculus TIME 0.03403 hr 10.1039/d0md00009d
Mus musculus Mus musculus TIME 0.05894 hr 10.1016/j.bmc.2014.11.004
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus RAW264.7 Inhibition nan % 10.1021/acs.jnatprod.5b00681
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum IC50 4.38 ug.mL-1 10.1016/j.bmc.2009.02.050
Plasmodium falciparum Plasmodium falciparum Potency 19011.5 nM None
Rattus norvegicus Acetylcholinesterase IC50 538.0 nM 10.1021/jm00015a020
Rattus norvegicus Acetylcholinesterase IC50 630.0 nM 10.1021/jm00018a025
Rattus norvegicus Acetylcholinesterase IC50 750.0 nM 10.1021/jm00031a019
Rattus norvegicus Acetylcholinesterase IC50 920.0 nM 10.1021/np049863m
Rattus norvegicus Acetylcholinesterase IC50 1165.0 nM 10.1016/j.ejmech.2008.04.018
Rattus norvegicus Acetylcholinesterase IC50 1760.0 nM 10.1016/0960-894X(96)00102-3
Rattus norvegicus Acetylcholinesterase IC50 2550.0 nM 10.1021/jm3009458
Rattus norvegicus Acetylcholinesterase IC50 1030000.0 nM 10.1016/S0960-894X(01)81154-9
Rattus norvegicus Acetylcholinesterase ID50 30.0 mg.kg-1 10.1021/jm00031a019
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Ratio IC50 5.06 None 10.1016/j.ejmech.2008.04.018
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Brain Activity 4.69 microg/ml 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Brain Activity 29.37 microg/ml 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Brain Activity 70.68 microg/ml 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Brain Activity 283.44 microg/ml 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Brain EC50 4.21 ug.mL-1 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Brain EC50 4.93 ug.mL-1 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Butyrylcholinesterase IC50 5900.0 nM 10.1016/j.ejmech.2008.04.018
Rattus norvegicus Catalase EC50 5.06 ug.mL-1 10.1016/j.ejmech.2009.09.045
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 2 Ki 100000.0 nM 10.1021/jm3009458
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Rattus norvegicus Activity 1.68 None 10.1021/jm049655r
Rattus norvegicus Rattus norvegicus Activity 1.78 None 10.1021/jm049655r
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2014.02.035
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 356.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 368.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 373.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 378.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 398.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 399.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 401.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 411.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 64.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 74.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 82.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 91.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 93.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 203.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 205.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 603.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 688.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 698.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 706.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 710.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 711.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 763.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 766.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 222.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 247.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 258.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 273.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 312.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 330.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 467.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 541.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Control 142.0 % 10.1021/jm00031a019
Rattus norvegicus Rattus norvegicus Control 171.0 % 10.1021/jm00031a019
Rattus norvegicus Rattus norvegicus Control 328.0 % 10.1021/jm00031a019
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 23.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 31.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 47.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 67.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 71.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1313.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1326.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1418.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1426.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1498.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1516.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1543.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1586.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.28 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.57 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 135.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 153.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 154.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 192.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 252.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 322.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 597.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 653.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10973.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12269.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13451.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14169.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14327.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14943.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15229.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15937.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.1 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.48 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.57 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.6 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.02 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 381300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 388500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 388800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 390000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 392200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 399300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 404300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.82 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.17 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.52 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 32.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 58.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 102.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 124.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 138.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 160.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 201.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 769.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 970.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1084.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1221.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1321.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1323.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1443.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1603.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 124.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 130.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1163330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1211670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1250830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1274000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1277670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1298000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1316670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1366000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.09 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.43 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.58 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.92 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.08 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5450000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5600000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5710000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5760000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5790000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5810000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 140.68 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.22 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.3 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12470.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15780.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16080.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16900.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 17570.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.86 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 19.34 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2532 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.14 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.05 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.53 % 10.21203/rs.3.rs-23951/v1
Staphylococcus aureus Staphylococcus aureus IZ 1.75 mm 10.1016/j.ejmech.2009.09.045
Staphylococcus aureus Staphylococcus aureus IZ 2.66 mm 10.1016/j.ejmech.2009.09.045
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2009.09.045
Staphylococcus aureus Staphylococcus aureus MIC 2048.0 ug.mL-1 10.1016/j.bmcl.2017.09.052
Torpedo californica Acetylcholinesterase IC50 360.0 nM 10.1016/s0960-894x(03)00198-7
Torpedo californica Acetylcholinesterase IC50 550.0 nM 10.1016/j.bmcl.2007.01.091
Torpedo californica Acetylcholinesterase IC50 590.0 nM 10.1016/j.bmc.2008.05.027
Torpedo californica Acetylcholinesterase IC50 652.0 nM 10.1021/jm701253t
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 30.0 ug.mL-1 10.1016/j.bmcl.2019.126642
Trypanosoma cruzi Trypanosoma cruzi IC50 30.0 ug.mL-1 10.1016/j.bmcl.2019.126642
None ADMET CL 5.6 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Fu 0.82 None 10.1021/jm030408h
None ADMET MRT 6.8 hr 10.1124/dmd.108.020479
None ADMET T1/2 5.3 hr 10.1124/dmd.108.020479
None ADMET Vdss 2.3 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 2.46 L.kg-1 10.1021/jm030408h
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Activity 54.4 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 57.1 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 63.5 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 64.1 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 65.3 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 65.4 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 65.9 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 66.5 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 71.7 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2014.02.035
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2016.06.036
None NON-PROTEIN TARGET EC50 1480.0 nM 10.1016/j.ejmech.2016.06.036
None NON-PROTEIN TARGET EC50 1940.0 nM 10.1016/j.ejmech.2016.06.036
None NON-PROTEIN TARGET EC50 2810.0 nM 10.1016/j.ejmech.2016.06.036
None NON-PROTEIN TARGET Fu 0.83 None 10.1124/dmd.108.020479
None No relevant target LogP 1.41 None 10.1016/j.bmc.2013.01.052
None No relevant target Peff nan None 10.1021/acs.jnatprod.9b00561
None No relevant target permeability nan None 10.1021/acs.jnatprod.8b00592
None No relevant target pKa 8.32 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.32 None 10.1021/jm030408h
None No relevant target pKa_B1 8.21 None 10.6019/CHEMBL3301361
None Unchecked Ac50 0.5012 uM None
None Unchecked Ac50 0.5623 uM None
None Unchecked Ac50 0.7079 uM None
None Unchecked AC50 501.2 nM None
None Unchecked AC50 562.3 nM None
None Unchecked AC50 710.0 nM None
None Unchecked Activity 54.23 None 10.1039/d0md00009d
None Unchecked Activity 122.5 None 10.1039/d0md00009d
None Unchecked EC50 3.84 ug.mL-1 10.1016/j.ejmech.2009.09.045
None Unchecked IC50 3120.0 nM 10.1016/j.ejmech.2014.01.020
None Unchecked IC50 8000.0 nM 10.1016/j.ejmech.2014.04.018
None Unchecked IC50 21400.0 nM 10.1021/jm901902w
None Unchecked IC50 nan None None
None Unchecked Inhibition 48.0 % 10.1016/j.bmcl.2012.05.077
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.05.077
None Unchecked Ki 10000.0 nM 10.1021/jm3009458
None Unchecked Ki nan None None
None Unchecked MIC 0.003 nM 10.1021/np100137h
None Unchecked Ratio IC50 0.02 None 10.1021/acs.jnatprod.5b00785
None Unchecked Ratio IC50 0.04 None 10.1021/acs.jnatprod.9b00561
None Unchecked Ratio IC50 0.04 None 10.1039/C5MD00274E
None Unchecked Ratio IC50 0.08 None 10.1016/j.bmc.2008.02.083
None Unchecked Ratio IC50 0.08 None 10.1016/j.bmc.2010.12.034
None Unchecked Ratio IC50 0.08 None 10.1016/j.bmcl.2010.03.011
None Unchecked Ratio IC50 0.08 None 10.1021/jm060682m
None Unchecked Ratio IC50 0.08 None 10.1021/jm300246n
None Unchecked Ratio IC50 0.095 None 10.1016/j.ejmech.2020.112140
None Unchecked Ratio IC50 0.1 None 10.1016/j.ejmech.2019.07.053
None Unchecked Ratio IC50 0.11 None 10.1016/j.bmc.2019.03.058
None Unchecked Ratio IC50 0.11 None 10.1016/j.ejmech.2013.06.054
None Unchecked Ratio IC50 0.18 None 10.1016/j.bmc.2018.08.035
None Unchecked Ratio IC50 0.27 None 10.1016/j.ejmech.2014.02.035
None Unchecked Ratio IC50 0.28 None 10.1016/j.bmc.2013.01.066
None Unchecked Ratio IC50 0.28 None 10.1016/j.bmc.2013.03.058
None Unchecked Ratio IC50 0.28 None 10.1016/j.bmc.2013.11.020
None Unchecked Ratio IC50 0.28 None 10.1016/j.bmc.2014.01.002
None Unchecked Ratio IC50 0.28 None 10.1016/j.bmcl.2014.02.019
None Unchecked Ratio IC50 0.3 None 10.1016/j.bmcl.2012.05.077
None Unchecked Ratio IC50 0.533 None 10.1016/j.bmc.2017.02.017
None Unchecked Ratio IC50 1.87 None 10.1016/j.bmcl.2018.05.063
None Unchecked Ratio IC50 1.875 None 10.1016/j.bmc.2017.02.017
None Unchecked Ratio IC50 2.76 None 10.1016/j.bmcl.2014.03.058
None Unchecked Ratio IC50 2.8 None 10.1016/j.bmc.2010.01.074
None Unchecked Ratio IC50 3.47 None 10.1016/j.bmc.2013.01.066
None Unchecked Ratio IC50 3.47 None 10.1016/j.bmc.2013.03.058
None Unchecked Ratio IC50 3.47 None 10.1016/j.bmc.2013.11.020
None Unchecked Ratio IC50 3.47 None 10.1016/j.bmc.2014.01.002
None Unchecked Ratio IC50 3.47 None 10.1016/j.bmcl.2014.02.019
None Unchecked Ratio IC50 4.6 None 10.1016/j.bmcl.2016.07.017
None Unchecked Ratio IC50 4.76 None 10.1016/j.bmc.2014.08.035
None Unchecked Ratio IC50 4.76 None 10.1016/j.ejmech.2013.03.051
None Unchecked Ratio IC50 4.76 None 10.1016/j.ejmech.2013.09.024
None Unchecked Ratio IC50 4.8 None 10.1016/j.bmcl.2013.02.095
None Unchecked Ratio IC50 4.91 None 10.1039/C3MD00376K
None Unchecked Ratio IC50 5.1 None 10.1016/j.ejmech.2014.01.020
None Unchecked Ratio IC50 5.1 None 10.1016/j.ejmech.2016.04.053
None Unchecked Ratio IC50 7.21 None 10.1016/j.ejmech.2015.07.005
None Unchecked Ratio IC50 7.8 None 10.1016/j.ejmech.2017.06.007
None Unchecked Ratio IC50 9.09 None 10.1021/acs.jmedchem.6b00356
None Unchecked Ratio IC50 9.25 None 10.1016/j.bmc.2019.03.058
None Unchecked Ratio IC50 9.25 None 10.1016/j.ejmech.2013.06.054
None Unchecked Ratio IC50 13.2 None 10.1021/jm1000024
None Unchecked Ratio IC50 19.07 None 10.1016/j.bmcl.2019.03.050
None Unchecked Ratio IC50 25.0 None 10.1021/acs.jnatprod.8b00592
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmc.2009.12.035
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmc.2010.04.063
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmc.2011.02.025
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmc.2011.09.040
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmc.2017.02.048
None Unchecked Ratio IC50 25.3 None 10.1016/j.bmcl.2012.04.029
None Unchecked Ratio IC50 26.0 None 10.1016/j.bmcl.2007.04.015
None Unchecked Ratio IC50 26.0 None 10.1016/j.ejmech.2009.01.021
None Unchecked Ratio IC50 27.7 None 10.1016/j.bmcl.2007.01.091
None Unchecked Ratio IC50 29.74 None 10.1016/j.ejmech.2015.10.046
None Unchecked Ratio IC50 31.0 None 10.1016/j.bmc.2014.08.016
None Unchecked Selectivity Index 0.07 None 10.1016/j.bmcl.2021.128374
None Unchecked Selectivity Index 14.6 None 10.1016/j.bmcl.2021.128374
None Unchecked Selectivity Index 18.0 None 10.1016/j.ejmech.2020.112415

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011916 COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CCNC2.C[SAH]>>COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CCN(C)C2 RXN-18125