cytidine
AlkaPlorer ID: AK001150
Synonym: '', '1-beta-D-Ribofuranosylcytosine', '65-46-3', 'CYTARABINE, Cytarabine (Cytosine 1-b-D-arabinofuranoside), CYTIDINE', 'cytidine', 'Zytidin', '1beta-D-ribofuranosylcytosine', '4-amino-1-beta-D-ribofuranosylpyrimidin-2(1H)-one', 'Cytidine', 'Cyd', 'Cytidin', '26524-60-7', 'Cytarabine', 'cytosine-1beta-D-Ribofuranoside', '4-amino-1beta-D-ribofuranosyl-2(1H)-pyrimidinone', 'MLSMR', 'SMR001549941', '1-β-D-Arabinofuranosylcytosine', 'MLS003389283', 'MLS002702869', 'Cytosine riboside', '4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE'
IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Structure
SMILES: NC1=NC(=O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)C=C1
InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
InChIKey: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Reference
Isolation of 1-.BETA.-D-Arabinofuranosylcytosine from the Mushroom Xerocomus nigromaculatus HONGO.
PubChem CID: 6253
CAS: 147-94-4
LOTUS: LTS0190344
SuperNatural Ⅲ: SN0370328-02
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 243.219
TPSA？: 130.83
MolLogP？: -2.562999999999999
Number of H-Donors: 4
Number of H-Acceptors: 8
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Acinetobacter baumannii | Acinetobacter baumannii | Inhibition | 23.86 | % | 10.6019/CHEMBL4513141 |
| Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Potency | 100000.0 | nM | None |
| Bos taurus | Progesterone receptor | IC50 | nan | None | None |
| Bos taurus | Progesterone receptor | Ki | nan | None | None |
| Caenorhabditis elegans | Deoxycytidylate deaminase | Km | 160000.0 | nM | 10.1021/jm00394a039 |
| Caenorhabditis elegans | Deoxycytidylate deaminase | Relative velocity | 0.85 | None | 10.1021/jm00394a039 |
| Candida albicans | Candida albicans | Inhibition | 2.79 | % | 10.6019/CHEMBL4513141 |
| Cavia porcellus | Leukotriene C4 synthase | IC50 | nan | None | None |
| Cavia porcellus | Leukotriene C4 synthase | Ki | nan | None | None |
| Cavia porcellus | Serotonin 4 (5-HT4) receptor | IC50 | nan | None | None |
| Cavia porcellus | Serotonin 4 (5-HT4) receptor | Ki | nan | None | None |
| Chlorocebus aethiops | BSC-1 | Inhibition | 38.28 | % | 10.1021/jm00355a007 |
| Chlorocebus sabaeus | Vero | CC50 | 4.8 | ug.mL-1 | 10.1021/np020234r |
| Chlorocebus sabaeus | Vero | Cytotoxicity | 0.0005 | mM l-1 | 10.1021/jm00382a005 |
| Cricetulus griseus | CHO | Log CR | 0.0 | None | 10.1021/jm00169a014 |
| Cryptococcus neoformans | Cryptococcus neoformans | Inhibition | -8.77 | % | 10.6019/CHEMBL4513141 |
| Cryptosporidium parvum | Cryptosporidium parvum | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Drosophila melanogaster | Deoxynucleoside kinase | IC50 | 5319000.0 | nM | 10.1016/j.bmc.2007.01.049 |
| Drosophila melanogaster | Deoxynucleoside kinase | IC50 | 5319000.0 | nM | 10.1016/s0960-894x(01)00207-4 |
| Entamoeba histolytica | Entamoeba histolytica | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Escherichia coli | Escherichia coli | Inhibition | -2.15 | % | 10.6019/CHEMBL4513141 |
| Escherichia coli | Escherichia coli | MIC | 1000000.0 | nM | 10.1128/aac.00081-07 |
| Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) | Enoyl-[acyl-carrier-protein] reductase [NADH] | IC50 | 59000.0 | nM | 10.1021/jm4001242 |
| Hepacivirus hominis | Hepatitis C virus | EC50 | 160.0 | nM | 10.1016/j.bmcl.2022.128605 |
| Hepacivirus hominis | Hepatitis C virus | IC50 | 20.0 | nM | 10.1021/jm800981y |
| Herpes simplex virus (type 1 / strain 17) | Alpha trans-inducing protein (VP16) | IC50 | 16247.0 | nM | None |
| Herpesviridae sp. | Herpesviridae sp. | ED50 | 0.16 | uM | 10.1021/jm00227a018 |
| Homo sapiens | 143B | IC50 | 2060.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | 143B | IC50 | 16880.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | 143B | Ratio IC50 | 2.42 | None | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | 23132-87 | IC50 | 318.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 5637 | IC50 | 501.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 639-V | IC50 | 27591.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 647-V | IC50 | 1232.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 697 | IC50 | 10.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 769-P | IC50 | 227.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 786-0 | IC50 | 668.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8305C | IC50 | 5466.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8505C | IC50 | 3702.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | 8-MG-BA | IC50 | 340.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A101D | IC50 | 4763.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A 172 | IC50 | 3517.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A204 | IC50 | 310.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2058 | IC50 | 686.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A2780 | IC50 | 162.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-375 | IC50 | 395.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-375 | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | A388 | IC50 | 739.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A3-KAW | IC50 | 844.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-427 | IC50 | 34.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-431 | IC50 | 6264.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A-431 | IC50 | nan | None | 10.1016/j.bmc.2006.09.063 |
| Homo sapiens | A498 | IC50 | 3729.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A4-Fuk | IC50 | 1173.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A549 | GI50 | 200.0 | nM | 10.1021/np200523b |
| Homo sapiens | A549 | IC50 | 49.27 | ug.mL-1 | 10.1016/j.ejmech.2022.114651 |
| Homo sapiens | A549 | IC50 | 49.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A549 | IC50 | 830.0 | nM | 10.1016/j.ejmech.2020.112624 |
| Homo sapiens | A549 | IC50 | 1200.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| Homo sapiens | A549 | IC50 | 1750.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | A549 | IC50 | 1900.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| Homo sapiens | A549 | IC50 | 1900.0 | nM | 10.1021/jm900852b |
| Homo sapiens | A549 | IC50 | 3470.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | A549 | IC50 | 620000.0 | nM | 10.1021/jm0612923 |
| Homo sapiens | A673 | IC50 | 223.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | A704 | IC50 | 6133.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ABC-1 | IC50 | 1520.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Acetylcholinesterase | IC50 | nan | None | None |
| Homo sapiens | Acetylcholinesterase | Ki | nan | None | None |
| Homo sapiens | ACHN | IC50 | 370.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ACN | IC50 | 2794.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Adenosine A1 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Adenosine A1 receptor | IC50 | nan | None | None |
| Homo sapiens | Adenosine A1 receptor | Ki | nan | None | None |
| Homo sapiens | Adenosine A2a receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Adenosine A2a receptor | IC50 | nan | None | None |
| Homo sapiens | Adenosine A2a receptor | Ki | nan | None | None |
| Homo sapiens | Adenosine A3 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Adenosine A3 receptor | IC50 | nan | None | None |
| Homo sapiens | Adenosine A3 receptor | Ki | nan | None | None |
| Homo sapiens | Adrenergic receptor beta | Activity | -5.16 | None | 10.1016/S0960-894X(97)00046-2 |
| Homo sapiens | AGS | IC50 | 917.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ALL-PO | IC50 | 287.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Alpha-1a adrenergic receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Alpha-1a adrenergic receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Alpha-1d adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Alpha-1d adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | Alpha-2a adrenergic receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Alpha-2a adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Alpha-2a adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | Alpha-2b adrenergic receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Alpha-2b adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Alpha-2b adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | Alpha-2c adrenergic receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Alpha-2c adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Alpha-2c adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | AM-38 | IC50 | 1467.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AN3-CA | IC50 | 1840.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Angiotensin II type 2 (AT-2) receptor | IC50 | nan | None | None |
| Homo sapiens | Angiotensin II type 2 (AT-2) receptor | Ki | nan | None | None |
| Homo sapiens | ASPC1 | IC50 | 1392.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ataxin-2 | Potency | 14125.4 | nM | None |
| Homo sapiens | ATN-1 | IC50 | 365.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | AU565 | IC50 | 3470.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BALL-1 | GI50 | 80.0 | nM | 10.1021/np200523b |
| Homo sapiens | BALL-1 | IC50 | 109945.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB30-HNC | IC50 | 90646.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB49-HNC | IC50 | 6495.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BB65-RCC | IC50 | 110.19 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BCPAP | IC50 | 501.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BE-13 | IC50 | 824.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Becker | IC50 | 1096.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Bel-7402 | IC50 | 34200.0 | nM | 10.1016/j.bmc.2010.07.043 |
| Homo sapiens | BEN | IC50 | 5447.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Beta-1 adrenergic receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Beta-1 adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Beta-1 adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | Beta-2 adrenergic receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Beta-2 adrenergic receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Beta-2 adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Beta-2 adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | Beta-3 adrenergic receptor | IC50 | nan | None | None |
| Homo sapiens | Beta-3 adrenergic receptor | Ki | nan | None | None |
| Homo sapiens | BFTC-905 | IC50 | 0.021 | ug.mL-1 | None |
| Homo sapiens | BFTC-905 | IC50 | 0.063 | ug.mL-1 | None |
| Homo sapiens | BFTC-905 | IC50 | 0.086 | ug.mL-1 | None |
| Homo sapiens | BFTC-905 | IC50 | 108.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BFTC-909 | IC50 | 357.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHT-101 | IC50 | 41.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BHY | IC50 | 897.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Bile salt export pump | AC50 | 300000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Bile salt export pump | IC50 | 133000.0 | nM | 10.1093/toxsci/kft176 |
| Homo sapiens | BPH-1 | IC50 | 3642.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Bradykinin B2 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Bradykinin B2 receptor | IC50 | nan | None | None |
| Homo sapiens | Bradykinin B2 receptor | Ki | nan | None | None |
| Homo sapiens | BT-20 | IC50 | 220295.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-474 | IC50 | 49463.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BT-549 | IC50 | 531.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BV-173 | IC50 | 515.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BXPC-3 | IC50 | 4299.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | BXPC-3 | TGI | 23.8 | % | 10.1021/jm3013008 |
| Homo sapiens | C2BBe1 | IC50 | 165.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C32 | IC50 | 13274.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C-33-A | IC50 | 550.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C3A | IC50 | 5234.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | C8166 | IC50 | 40367.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca9-22 | IC50 | 320.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAKI-1 | IC50 | 120.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAKI-1 | IC50 | 5000.0 | nM | 10.1021/jm990417j |
| Homo sapiens | CAL-120 | IC50 | 7076.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-12T | IC50 | 10184.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-27 | IC50 | 1928.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-33 | IC50 | 1176.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-39 | IC50 | 998.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-51 | IC50 | 570.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-54 | IC50 | 940.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-62 | IC50 | 709.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-72 | IC50 | 3145.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAL-85-1 | IC50 | 179748.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calcitonin receptor | IC50 | nan | None | None |
| Homo sapiens | Calcitonin receptor | Ki | nan | None | None |
| Homo sapiens | Calu-3 | IC50 | 5457.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Calu-6 | IC50 | 135815.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CAMA-1 | IC50 | 32163.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Canalicular multispecific organic anion transporter 1 | IC50 | 133000.0 | nM | 10.1093/toxsci/kft176 |
| Homo sapiens | Canalicular multispecific organic anion transporter 2 | IC50 | 133000.0 | nM | 10.1093/toxsci/kft176 |
| Homo sapiens | Cannabinoid CB1 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Cannabinoid CB1 receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Cannabinoid CB1 receptor | IC50 | nan | None | None |
| Homo sapiens | Cannabinoid CB1 receptor | Ki | nan | None | None |
| Homo sapiens | CAPAN-1 | IC50 | 3275.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Capan-2 | IC50 | 8360.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CaR-1 | IC50 | 16662.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Carbonic anhydrase II | IC50 | nan | None | None |
| Homo sapiens | Carbonic anhydrase II | Ki | nan | None | None |
| Homo sapiens | CAS-1 | IC50 | 2642.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ca-Ski | IC50 | 2861.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Caspase-1 | IC50 | nan | None | None |
| Homo sapiens | Caspase-1 | Ki | nan | None | None |
| Homo sapiens | Cathepsin G | IC50 | nan | None | None |
| Homo sapiens | Cathepsin G | Ki | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 2 | IC50 | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 2 | Ki | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 4 | IC50 | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 4 | Ki | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 5 | IC50 | nan | None | None |
| Homo sapiens | C-C chemokine receptor type 5 | Ki | nan | None | None |
| Homo sapiens | CCRF-CEM | EC50 | 5.614 | nM | 10.1021/jm9005059 |
| Homo sapiens | CCRF-CEM | ED50 | 0.005 | uM | 10.1021/jm00106a034 |
| Homo sapiens | CCRF-CEM | ED50 | 0.006 | uM | 10.1021/jm00112a040 |
| Homo sapiens | CCRF-CEM | ED50 | 120.0 | uM | 10.1021/jm00112a040 |
| Homo sapiens | CCRF-CEM | GI50 | 90.0 | nM | 10.1016/s0960-894x(01)00513-3 |
| Homo sapiens | CCRF-CEM | GI50 | 99.8 | nM | 10.1016/s0960-894x(01)00513-3 |
| Homo sapiens | CCRF-CEM | IC50 | 0.065 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | CCRF-CEM | IC50 | 0.065 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | CCRF-CEM | IC50 | 0.32 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | CCRF-CEM | IC50 | 1.0 | nM | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | CCRF-CEM | IC50 | 6.0 | nM | 10.1021/jm300515q |
| Homo sapiens | CCRF-CEM | IC50 | 20.0 | nM | 10.1021/jm00356a032 |
| Homo sapiens | CCRF-CEM | IC50 | 24.0 | nM | 10.1016/j.ejmech.2009.10.032 |
| Homo sapiens | CCRF-CEM | IC50 | 24.0 | nM | 10.1021/jm901590f |
| Homo sapiens | CCRF-CEM | IC50 | 90.0 | nM | 10.1021/jm9603680 |
| Homo sapiens | CCRF-CEM | IC50 | 32121.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CCRF-CEM | Ratio IC50 | 0.88 | None | 10.1021/jm200764t |
| Homo sapiens | CCRF-CEM | Ratio IC50 | 1.0 | None | 10.1021/jm300515q |
| Homo sapiens | CCRF-CEM | Ratio IC50 | 4.1 | None | 10.1021/jm300515q |
| Homo sapiens | CCRF-CEM | Ratio IC50 | 6.5 | None | 10.1021/jm300515q |
| Homo sapiens | CCRF-CEM | Ratio IC50 | 100000.0 | None | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | CCRF-CEM/ara-C | IC50 | 100000.0 | nM | 10.1021/jm00356a032 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 0.0086 | ug.mL-1 | 10.1021/jm9701536 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 0.017 | ug.mL-1 | 10.1016/j.bmc.2008.07.089 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 0.017 | ug.mL-1 | 10.1016/j.bmc.2008.09.022 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 0.047 | ug.mL-1 | 10.1016/j.bmc.2007.06.058 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 0.047 | ug.mL-1 | 10.1016/j.bmc.2007.10.014 |
| Homo sapiens | CCRF-HSB-2 | IC50 | 150.0 | nM | 10.1016/j.bmc.2006.09.063 |
| Homo sapiens | CFPAC-1 | IC50 | 1055.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CGTH-W-1 | IC50 | 181.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ChaGo-K-1 | IC50 | 33700.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CHL-1 | IC50 | 1043.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Cholecystokinin A receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Cholecystokinin A receptor | IC50 | nan | None | None |
| Homo sapiens | Cholecystokinin A receptor | Ki | nan | None | None |
| Homo sapiens | CHP-212 | IC50 | 33.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 28183.8 | nM | None |
| Homo sapiens | COLO 320 | IC50 | 40.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | COLO-320-HSR | IC50 | 32429.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-668 | IC50 | 809.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-678 | IC50 | 93504.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-679 | IC50 | 125505.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-680N | IC50 | 45239.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-684 | IC50 | 12989.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-741 | IC50 | 2325.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-792 | IC50 | 1053.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-800 | IC50 | 424.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-824 | IC50 | 9832.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COLO-829 | IC50 | 1864.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L105 | IC50 | 160.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L23 | IC50 | 796.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | COR-L88 | IC50 | 60358.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP50-MEL-B | IC50 | 5595.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CP66-MEL | IC50 | 11980.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTB-1 | IC50 | 34.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CTV-1 | IC50 | 84.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CW-2 | IC50 | 612.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | CWR22R | IC50 | 2758.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Cyclooxygenase-1 | IC50 | nan | None | None |
| Homo sapiens | Cyclooxygenase-1 | Ki | nan | None | None |
| Homo sapiens | Cyclooxygenase-2 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Cyclooxygenase-2 | IC50 | nan | None | None |
| Homo sapiens | Cyclooxygenase-2 | Ki | nan | None | None |
| Homo sapiens | Cysteinyl leukotriene receptor 1 | IC50 | nan | None | None |
| Homo sapiens | Cysteinyl leukotriene receptor 1 | Ki | nan | None | None |
| Homo sapiens | Cytidine deaminase | CL | 340.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | CL | 740.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | CL | 830.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Ki | 190000.0 | nM | 10.1021/jm00112a040 |
| Homo sapiens | Cytidine deaminase | Km | 56000.0 | nM | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Km | 138000.0 | nM | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Km | 160000.0 | nM | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Vmax | 19.0 | nmol/min/mg | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Vmax | 114.0 | nmol/min/mg | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytidine deaminase | Vmax | 119.0 | nmol/min/mg | 10.1124/dmd.112.048769 |
| Homo sapiens | Cytochrome P450 1A2 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 1A2 | Inhibition | nan | % | 10.1021/tx300075j |
| Homo sapiens | Cytochrome P450 1A2 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 2A6 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 2A6 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 2C19 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 2C19 | Inhibition | nan | % | 10.1021/tx300075j |
| Homo sapiens | Cytochrome P450 2C19 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 2C9 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 2C9 | Inhibition | nan | % | 10.1021/tx300075j |
| Homo sapiens | Cytochrome P450 2C9 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 2D6 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 2D6 | Inhibition | nan | % | 10.1021/tx300075j |
| Homo sapiens | Cytochrome P450 2D6 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 2E1 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 2E1 | Ki | nan | None | None |
| Homo sapiens | Cytochrome P450 3A4 | IC50 | nan | None | None |
| Homo sapiens | Cytochrome P450 3A4 | Inhibition | nan | % | 10.1021/tx300075j |
| Homo sapiens | Cytochrome P450 3A4 | Ki | nan | None | None |
| Homo sapiens | D-247MG | IC50 | 1089.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-263MG | IC50 | 1171.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D283 Med | IC50 | 360.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-336MG | IC50 | 804.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-392MG | IC50 | 3403.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-423MG | IC50 | 298.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-502MG | IC50 | 5490.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-542MG | IC50 | 172143.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | D-566MG | IC50 | 269.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Daoy | IC50 | 532.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DB | IC50 | 245.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DBTRG-05MG | IC50 | 2619.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DEL | IC50 | 874.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Delta opioid receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Delta opioid receptor | IC50 | nan | None | None |
| Homo sapiens | Delta opioid receptor | Ki | nan | None | None |
| Homo sapiens | Deoxycytidine kinase | CL | 231400.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| Homo sapiens | Deoxycytidine kinase | Km | 3040.0 | nM | 10.1124/dmd.112.048769 |
| Homo sapiens | Deoxycytidine kinase | Vmax | 706.5 | nmol/min/mg | 10.1124/dmd.112.048769 |
| Homo sapiens | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Activity | nan | None | None |
| Homo sapiens | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Ratio | 20.0 | None | None |
| Homo sapiens | Detroit 562 | IC50 | 2062.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DJM-1 | IC50 | 17169.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DK-MG | IC50 | 5390.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DLD-1 | IC50 | 5000.0 | nM | 10.1021/jm990417j |
| Homo sapiens | DMS-114 | IC50 | 1681.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-273 | IC50 | 1456.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DMS-79 | IC50 | 41158.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 3162.3 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 89125.1 | nM | None |
| Homo sapiens | DOHH-2 | IC50 | 1378.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DOK | IC50 | 904.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Dopamine D1 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Dopamine D1 receptor | IC50 | nan | None | None |
| Homo sapiens | Dopamine D1 receptor | Ki | nan | None | None |
| Homo sapiens | Dopamine D2 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Dopamine D2 receptor | IC50 | nan | None | None |
| Homo sapiens | Dopamine D2 receptor | Ki | nan | None | None |
| Homo sapiens | Dopamine D3 receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Dopamine D3 receptor | IC50 | nan | None | None |
| Homo sapiens | Dopamine D3 receptor | Ki | nan | None | None |
| Homo sapiens | Dopamine D4 receptor | IC50 | nan | None | None |
| Homo sapiens | Dopamine D4 receptor | Ki | nan | None | None |
| Homo sapiens | Dopamine transporter | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Dopamine transporter | IC50 | nan | None | None |
| Homo sapiens | Dopamine transporter | Ki | nan | None | None |
| Homo sapiens | DoTc2-4510 | IC50 | 1598.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DSH1 | IC50 | 3408.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DU-145 | IC50 | 52125.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | DU-4475 | IC50 | 575.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ECC10 | IC50 | 15173.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EC-GI-10 | IC50 | 556.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFM-19 | IC50 | 2980.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-21 | IC50 | 1549.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EFO-27 | IC50 | 1939.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EGI-1 | IC50 | 1109.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EKVX | IC50 | 217094.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EM-2 | IC50 | 211.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Endothelin receptor ET-A | IC50 | nan | None | None |
| Homo sapiens | Endothelin receptor ET-A | Ki | nan | None | None |
| Homo sapiens | EOL1 | IC50 | 803.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | IC50 | nan | None | None |
| Homo sapiens | Epidermal growth factor receptor erbB1 | Ki | nan | None | None |
| Homo sapiens | EPLC-272H | IC50 | 1449.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Equilibrative nucleoside transporter 1 | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | ES1 | IC50 | 12.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES3 | IC50 | 198.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES4 | IC50 | 214.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES5 | IC50 | 242.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES6 | IC50 | 721.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES7 | IC50 | 257.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ES8 | IC50 | 123.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ESS-1 | IC50 | 5478.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Estrogen receptor alpha | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Estrogen receptor alpha | IC50 | nan | None | None |
| Homo sapiens | Estrogen receptor alpha | Ki | nan | None | None |
| Homo sapiens | Estrogen receptor beta | IC50 | nan | None | None |
| Homo sapiens | Estrogen receptor beta | Ki | nan | None | None |
| Homo sapiens | ETK-1 | IC50 | 2304.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-1 | IC50 | 138.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-11 | IC50 | 1213.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-13 | IC50 | 1981.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-16 | IC50 | 265.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-18 | IC50 | 112132.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-22 | IC50 | 667.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-24 | IC50 | 793.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | EW-3 | IC50 | 829.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | FaDu | IC50 | 2169.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | FTC-133 | IC50 | 1385.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-361 | IC50 | 110525.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-401 | Cell number | 0.0 | None | 10.1021/jm00047a024 |
| Homo sapiens | G-401 | Cell number | 55.0 | None | 10.1021/jm00047a024 |
| Homo sapiens | G-401 | IC50 | 758.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | G-402 | IC50 | 649.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAK | IC50 | 6840.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GAMG | IC50 | 393.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GB-1 | IC50 | 6141.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCIY | IC50 | 2802.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GCT | IC50 | 855.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Geminin | Potency | 167.9 | nM | None |
| Homo sapiens | Geminin | Potency | 183.6 | nM | None |
| Homo sapiens | Geminin | Potency | 29092.9 | nM | None |
| Homo sapiens | Ghrelin receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | GI-1 | IC50 | 338.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GI-ME-N | IC50 | 1659.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 1258.9 | nM | None |
| Homo sapiens | Glucocorticoid receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Glucocorticoid receptor | IC50 | nan | None | None |
| Homo sapiens | Glucocorticoid receptor | Ki | nan | None | None |
| Homo sapiens | GMS-10 | IC50 | 395.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GOTO | IC50 | 424.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GP5d | IC50 | 102.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GR-ST | IC50 | 384.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | GT3TKB | IC50 | 340.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | H4 | IC50 | 274.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | H9 | IC50 | 391.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HAL-01 | IC50 | 327.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HC-1 | IC50 | 1077.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1187 | IC50 | 28654.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1395 | IC50 | 3007.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1419 | IC50 | 4262.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1569 | IC50 | 21999.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1806 | IC50 | 191.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1937 | IC50 | 27539.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC1954 | IC50 | 30393.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC2218 | IC50 | 107312.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC 2998 | IC50 | 2578.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC38 | IC50 | 1879.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCC70 | IC50 | 3624.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-4 | IC50 | 277.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCE-T | IC50 | 62658.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-116 | GI50 | 120.0 | nM | 10.1021/np200523b |
| Homo sapiens | HCT-116 | IC50 | 100.0 | nM | 10.1016/j.bmc.2010.02.023 |
| Homo sapiens | HCT-116 | IC50 | 244.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HCT-116 | IC50 | 2420.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| Homo sapiens | HCT-116 | IC50 | 4400.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | HCT-116 | IC50 | 5300.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| Homo sapiens | HCT-116 | IC50 | 5300.0 | nM | 10.1021/jm900852b |
| Homo sapiens | HCT-116 | IC50 | nan | None | 10.1016/j.bmc.2006.09.063 |
| Homo sapiens | HCT-15 | IC50 | 8123.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HDLM-2 | IC50 | 61413.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HD-MY-Z | IC50 | 744.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HEC-1 | IC50 | 1787.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HEK293 | AC50 | 4970.0 | nM | None |
| Homo sapiens | HEK293 | Potency | 2058.8 | nM | None |
| Homo sapiens | HEL | Activity | nan | None | None |
| Homo sapiens | HEL | IC50 | 0.0007 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.0024 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.0073 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.0087 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.0384 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.166 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 0.1675 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 1.067 | ug.mL-1 | None |
| Homo sapiens | HEL | IC50 | 20.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HeLa | ED50 | 0.05 | ug ml-1 | 10.1021/jm00227a018 |
| Homo sapiens | HeLa | GI50 | 180.0 | nM | 10.1021/np200523b |
| Homo sapiens | HeLa | IC50 | 0.23 | ug.mL-1 | 10.1021/np9805185 |
| Homo sapiens | HeLa | IC50 | 260.0 | nM | 10.1021/jm901590f |
| Homo sapiens | HeLa | IC50 | 950.0 | nM | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | HeLa | IC50 | 3540.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | HeLa | IC50 | 3540.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | HeLa | IC50 | 3540.0 | nM | 10.1016/j.ejmech.2013.06.047 |
| Homo sapiens | HeLa | IC50 | 3540.0 | nM | 10.1021/acs.jmedchem.6b00764 |
| Homo sapiens | HeLa | IC50 | 464433.0 | nM | 10.1016/j.ejmech.2009.02.028 |
| Homo sapiens | HeLa | ID50 | 0.1 | uM | 10.1021/jm00392a029 |
| Homo sapiens | HeLa | ID50 | 0.6 | uM | 10.1021/jm00392a029 |
| Homo sapiens | HeLa | Ratio IC50 | 1.41 | None | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | H-EMC-SS | IC50 | 145.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HepG2 | IC50 | 200.0 | nM | 10.1016/j.bmc.2010.07.043 |
| Homo sapiens | HepG2 | IC50 | 2860.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | HepG2 | IC50 | 2860.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | HepG2 | IC50 | 2860.0 | nM | 10.1021/acs.jmedchem.6b00764 |
| Homo sapiens | HepG2 | IC50 | 26230.0 | nM | 10.1016/j.ejmech.2011.05.004 |
| Homo sapiens | HepG2 | IC50 | 38100.0 | nM | 10.1039/C0MD00208A |
| Homo sapiens | HepG2 | Potency | 1258.9 | nM | None |
| Homo sapiens | HepG2 | Ratio IC50 | 1.75 | None | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | HERG | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | HERG | IC50 | nan | None | None |
| Homo sapiens | HERG | Ki | nan | None | None |
| Homo sapiens | HGC-27 | IC50 | 455.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HH | IC50 | 2640.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Histamine H1 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Histamine H1 receptor | IC50 | nan | None | None |
| Homo sapiens | Histamine H1 receptor | Ki | nan | None | None |
| Homo sapiens | Histamine H2 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Histamine H2 receptor | IC50 | nan | None | None |
| Homo sapiens | Histamine H2 receptor | Ki | nan | None | None |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 11220.2 | nM | None |
| Homo sapiens | HL-60 | AC50 | 150.0 | nM | 10.1021/jm030785u |
| Homo sapiens | HL-60 | AC50 | 8000.0 | nM | 10.1021/jm030785u |
| Homo sapiens | HL-60 | Activity | nan | None | None |
| Homo sapiens | HL-60 | EC50 | 657.2 | nM | 10.1021/jm9005059 |
| Homo sapiens | HL-60 | ED50 | 0.047 | uM | 10.1021/jm00157a031 |
| Homo sapiens | HL-60 | ED50 | 30.0 | uM | 10.1021/jm00157a031 |
| Homo sapiens | HL-60 | IC50 | 0.029 | ug.mL-1 | 10.1021/jm9602322 |
| Homo sapiens | HL-60 | IC50 | 0.1 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | HL-60 | IC50 | 0.1 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | HL-60 | IC50 | 49.0 | nM | 10.1021/jm300515q |
| Homo sapiens | HL-60 | IC50 | 80.0 | nM | 10.1021/jm030785u |
| Homo sapiens | HL-60 | IC50 | 118.0 | nM | 10.1016/j.ejmech.2009.02.028 |
| Homo sapiens | HL-60 | IC50 | 130.0 | nM | 10.1021/jm00160a041 |
| Homo sapiens | HL-60 | IC50 | 185.0 | nM | 10.1016/j.ejmech.2018.08.023 |
| Homo sapiens | HL-60 | IC50 | 350.0 | nM | 10.1021/jm030785u |
| Homo sapiens | HL-60 | IC50 | 760.0 | nM | 10.1021/jm020571x |
| Homo sapiens | HL-60 | IC50 | 2444.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HL-60 | Inhibition | 43.28 | % | 10.1021/acs.jmedchem.8b00241 |
| Homo sapiens | HL-60 | Inhibition | 44.04 | % | 10.1021/acs.jmedchem.8b00241 |
| Homo sapiens | HL-60 | NBT positive cells | 5.0 | % | 10.1021/jm9602322 |
| Homo sapiens | HL-60 | NBT positive cells | 8.0 | % | 10.1021/jm9602322 |
| Homo sapiens | HL-60 | NBT positive cells | 20.0 | % | 10.1021/jm9602322 |
| Homo sapiens | HL-60 | Ratio IC50 | 0.1 | None | 10.1021/jm300515q |
| Homo sapiens | HL-60 | Ratio IC50 | 0.4 | None | 10.1021/jm300515q |
| Homo sapiens | HL-60 | Ratio IC50 | 1.3 | None | 10.1021/jm200764t |
| Homo sapiens | HL-60 | Ratio IC50 | 1.3 | None | 10.1021/jm300515q |
| Homo sapiens | HL-60 | Ratio IC50 | 7.5 | None | 10.1021/jm300515q |
| Homo sapiens | HLE | IC50 | 1591.75 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HMG-CoA reductase | IC50 | nan | None | None |
| Homo sapiens | HMG-CoA reductase | Ki | nan | None | None |
| Homo sapiens | HMV-2 cell line | IC50 | 123.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HN | IC50 | 220.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HO-1-N-1 | IC50 | 690.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Homo sapiens | CL | 0.014 | L/hr | 10.1021/acsmedchemlett.7b00462 |
| Homo sapiens | Homo sapiens | DILI_Concern | nan | None | 10.1016/j.drudis.2016.02.015 |
| Homo sapiens | Homo sapiens | DILI_severity_class | 3.0 | None | 10.1016/j.drudis.2016.02.015 |
| Homo sapiens | Homo sapiens | T1/2 | 0.2 | hr | 10.1021/jm00227a016 |
| Homo sapiens | Homo sapiens | T1/2 | 0.2 | hr | 10.1021/jm00227a018 |
| Homo sapiens | Homo sapiens | Vdss | 0.67 | L.kg-1 | 10.1021/jm9004658 |
| Homo sapiens | HOP-62 | IC50 | 16601.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOP-92 | IC50 | 354.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOS | IC50 | 518.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HOS | Inhibition | 45.4 | % | 10.1021/jm00107a018 |
| Homo sapiens | HOS-TE85 | IC50 | 2.6 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | HOS-TE85 | IC50 | 10700.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | HPAF-II | IC50 | 8771.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Hs-578T | IC50 | 838.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-2 | IC50 | 1456.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-3 | IC50 | 399.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HSC-4 | IC50 | 467.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT | IC50 | 90721.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1080 | IC50 | 0.13 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | HT-1080 | IC50 | 114.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1080 | IC50 | 530.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | HT1197 | IC50 | 4313.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-1376 | IC50 | 1681.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-144 | IC50 | 1231.01 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-29 | Activity | nan | None | 10.1021/np50063a010 |
| Homo sapiens | HT-29 | IC50 | 66.0 | nM | 10.1021/np50063a010 |
| Homo sapiens | HT-29 | IC50 | 3524.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT-3 | IC50 | 1381.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HT55 | IC50 | 3289.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HTC-C3 | IC50 | 459.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuCCT-1 | IC50 | 2936.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Huh-7 | IC50 | 24614.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuO-3N1 | IC50 | 1326.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuO9 | IC50 | 3853.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T3 | IC50 | 855.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuP-T4 | IC50 | 236.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HuTu80 | IC50 | 561.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | HUVEC | GI50 | 230.0 | nM | 10.1021/np200523b |
| Homo sapiens | IA-LM | IC50 | 10444.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGR-1 | IC50 | 1782.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IGROV-1 | IC50 | 1789.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Interleukin-8 receptor A | IC50 | nan | None | None |
| Homo sapiens | Interleukin-8 receptor A | Ki | nan | None | None |
| Homo sapiens | Interleukin-8 receptor B | IC50 | nan | None | None |
| Homo sapiens | Interleukin-8 receptor B | Ki | nan | None | None |
| Homo sapiens | IST-MEL1 | IC50 | 380.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-MES1 | IC50 | 3554.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | IST-SL1 | IC50 | 2201.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J82 | IC50 | 1618.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JAR | IC50 | 337.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JEG-3 | IC50 | 431.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | J-RT3-T3-5 | IC50 | 68.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Jurkat | IC50 | 45800.0 | nM | None |
| Homo sapiens | Jurkat E6.1 | IC50 | 18.0 | nM | 10.1016/j.ejmech.2018.08.023 |
| Homo sapiens | JVM-2 | IC50 | 162408.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | JVM-3 | IC50 | 1454.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K5 | IC50 | 43.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K562 | Activity | 22.0 | % | 10.1016/j.ejmech.2008.05.001 |
| Homo sapiens | K562 | Activity | 78.0 | % | 10.1016/j.ejmech.2008.05.001 |
| Homo sapiens | K562 | Activity | 78.3 | % | 10.1021/jm800982q |
| Homo sapiens | K562 | Erythroid induction | 45.0 | % | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | Erythroid induction | 61.5 | % | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | Erythroid induction | 84.5 | % | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | Erythroid induction | 93.2 | % | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | Erythroid induction | 95.0 | % | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | GI | 39.88 | % | 10.1007/s00044-012-0001-6 |
| Homo sapiens | K562 | GI | 65.08 | % | 10.1007/s00044-012-0001-6 |
| Homo sapiens | K562 | IC50 | 3.2 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | K562 | IC50 | 3.2 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | K562 | IC50 | 50.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| Homo sapiens | K562 | IC50 | 50.0 | nM | 10.1021/jm900852b |
| Homo sapiens | K562 | IC50 | 500.0 | nM | 10.1016/s0960-894x(99)00547-8 |
| Homo sapiens | K562 | IC50 | 14000.0 | nM | 10.1021/jm300515q |
| Homo sapiens | K562 | IC50 | 24290.0 | nM | 10.1016/j.ejmech.2011.05.004 |
| Homo sapiens | K562 | IC50 | 33500.0 | nM | 10.1016/j.bmc.2010.07.043 |
| Homo sapiens | K562 | IC50 | 43610.0 | nM | 10.1039/C0MD00208A |
| Homo sapiens | K562 | IC50 | 103485.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | K562 | IC50 | 500000000.0 | nM | 10.1016/j.ejmech.2008.05.001 |
| Homo sapiens | K562 | Ratio IC50 | 1.5 | None | 10.1021/jm300515q |
| Homo sapiens | K562 | Ratio IC50 | 2.2 | None | 10.1021/jm200764t |
| Homo sapiens | K562 | Ratio IC50 | 7.0 | None | 10.1021/jm300515q |
| Homo sapiens | KALS-1 | IC50 | 33392.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Kappa opioid receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Kappa opioid receptor | IC50 | nan | None | None |
| Homo sapiens | Kappa opioid receptor | Ki | nan | None | None |
| Homo sapiens | KARPAS-299 | IC50 | 180907.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KARPAS-45 | IC50 | 3609.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Kasumi 1 | IC50 | 2162.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KATO III stomach cancer cell line | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | KATO III stomach cancer cell line | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | KATO III stomach cancer cell line | IC50 | 300.0 | nM | 10.1021/jm00078a007 |
| Homo sapiens | KATO III stomach cancer cell line | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | KB | ED50 | 0.99 | ug ml-1 | 10.1016/j.bmcl.2010.11.127 |
| Homo sapiens | KB | ED50 | 2.84 | ug ml-1 | 10.1021/np50077a010 |
| Homo sapiens | KB | IC50 | 0.14 | ug.mL-1 | 10.1016/j.ejmech.2007.10.011 |
| Homo sapiens | KB | IC50 | 0.23 | ug.mL-1 | 10.1016/j.bmc.2007.06.058 |
| Homo sapiens | KB | IC50 | 0.23 | ug.mL-1 | 10.1016/j.bmc.2007.10.014 |
| Homo sapiens | KB | IC50 | 0.42 | ug.mL-1 | 10.1016/j.bmc.2008.09.022 |
| Homo sapiens | KB | IC50 | 0.73 | ug.mL-1 | 10.1016/j.bmc.2008.07.089 |
| Homo sapiens | KB | IC50 | 0.81 | ug.mL-1 | 10.1021/np9805185 |
| Homo sapiens | KB | IC50 | 0.99 | ug.mL-1 | 10.1016/j.bmc.2011.08.069 |
| Homo sapiens | KB | IC50 | 30.5 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | KB | IC50 | 640.0 | nM | 10.1021/jm00078a007 |
| Homo sapiens | KB | IC50 | 700.0 | nM | 10.1016/j.bmc.2006.09.063 |
| Homo sapiens | KB | IC50 | 4070.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | KB | IC50 | 4070.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | KB | IC50 | 4070.0 | nM | 10.1016/j.ejmech.2013.06.047 |
| Homo sapiens | KB | IC50 | 4070.0 | nM | 10.1021/acs.jmedchem.6b00764 |
| Homo sapiens | KB | ID50 | 1.0 | uM | 10.1021/jm00392a029 |
| Homo sapiens | KB | ID50 | 1.1 | uM | 10.1021/jm00392a029 |
| Homo sapiens | KB | Inhibition | nan | % | 10.1021/jm00191a011 |
| Homo sapiens | KE-37 | IC50 | 110.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KG-1 | IC50 | 1156.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KGN | IC50 | 73349.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KHOS-321H | IC50 | 0.27 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | KINGS-1 | IC50 | 4052.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KKLS | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | KLE | IC50 | 13392.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM12 | IC50 | 10277.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KM-H2 | IC50 | 126686.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KMOE-2 | IC50 | 943.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-42 | IC50 | 32244.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-62 | IC50 | 2075.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KNS-81-FD | IC50 | 9197.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KOSC-2 | IC50 | 643.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-4 | IC50 | 535.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YN | IC50 | 61855.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KP-N-YS | IC50 | 142173.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KS-1 | IC50 | 4344.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KU-19-19 | IC50 | 0.0039 | ug.mL-1 | None |
| Homo sapiens | KU-19-19 | IC50 | 0.0145 | ug.mL-1 | None |
| Homo sapiens | KU-19-19 | IC50 | 0.0151 | ug.mL-1 | None |
| Homo sapiens | KU-19-19 | IC50 | 4428.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KU812 cell line | IC50 | 2357.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KURAMOCHI | IC50 | 121437.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KY821 | IC50 | 17200.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-140 | IC50 | 2752.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-150 cell line | IC50 | 115088.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-180 | IC50 | 564.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-270 | IC50 | 848.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-410 | IC50 | 2191.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-450 | IC50 | 1090.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-510 | IC50 | 306.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-520 cell line | IC50 | 2541.59 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | KYSE-70 cell line | IC50 | 1857.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L02 | GI | -1.76 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | GI | 3.02 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | GI | 13.31 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | GI | 18.81 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | GI | 25.44 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | IC50 | 170.0 | nM | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | L02 | IC50 | 210.0 | nM | 10.1016/j.ejmech.2019.02.071 |
| Homo sapiens | L-363 | IC50 | 1339.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | L-428 | IC50 | 133636.04 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAMA-84 | IC50 | 334.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LAN-6 | IC50 | 12474.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB1047-RCC | IC50 | 108.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2241-RCC | IC50 | 55.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB2518-MEL | IC50 | 3207.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB373-MEL-D | IC50 | 14380.05 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB771-HNC | IC50 | 11198.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LB831-BLC | IC50 | 4585.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LC-2-ad | IC50 | 229.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-103H cell line | IC50 | 24520.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LCLC-97TM1 | IC50 | 477.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Leukocyte common antigen | IC50 | nan | None | None |
| Homo sapiens | Leukocyte common antigen | Ki | nan | None | None |
| Homo sapiens | Leukocyte elastase | IC50 | nan | None | None |
| Homo sapiens | Leukocyte elastase | Ki | nan | None | None |
| Homo sapiens | Liver microsomes | Activity | nan | None | 10.1021/tx300075j |
| Homo sapiens | Liver microsomes | Stability | nan | % | 10.1021/tx300075j |
| Homo sapiens | LK-2 | IC50 | 460.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LN-405 | IC50 | 17148.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LNCaP-Clone-FGC | IC50 | 1311.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LoVo | IC50 | 671.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LOX IMVI | IC50 | 290.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-1034 | IC50 | 179759.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-123 | IC50 | 87176.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-411N | IC50 | 695.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LS-513 | IC50 | 379.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-134-A | IC50 | 2724.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-135 | IC50 | 26593.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-139 | IC50 | 22440.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Lu-65 | IC50 | 93665.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LU-99A | IC50 | 266.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | LXF-289 cell line | IC50 | 251.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M059J | IC50 | 1822.97 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | M14 | IC50 | 632.24 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MAP kinase ERK1 | IC50 | nan | None | None |
| Homo sapiens | MAP kinase ERK1 | Ki | nan | None | None |
| Homo sapiens | MAP kinase ERK2 | IC50 | nan | None | None |
| Homo sapiens | MAP kinase ERK2 | Ki | nan | None | None |
| Homo sapiens | MAP kinase p38 alpha | IC50 | nan | None | None |
| Homo sapiens | MAP kinase p38 alpha | Ki | nan | None | None |
| Homo sapiens | Matrix metalloproteinase-1 | IC50 | nan | None | None |
| Homo sapiens | Matrix metalloproteinase-1 | Ki | nan | None | None |
| Homo sapiens | Matrix metalloproteinase 9 | IC50 | nan | None | None |
| Homo sapiens | Matrix metalloproteinase 9 | Ki | nan | None | None |
| Homo sapiens | MC116 | IC50 | 1283.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MCF7 | IC50 | 0.93 | ug.mL-1 | 10.1016/j.bmc.2011.08.069 |
| Homo sapiens | MCF7 | IC50 | 4.0 | nM | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | MCF7 | IC50 | 40.0 | nM | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | MCF7 | IC50 | 620.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | MCF7 | IC50 | 1030.0 | nM | 10.1021/jm0004446 |
| Homo sapiens | MCF7 | IC50 | 2002.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MCF7 | IC50 | 3820.0 | nM | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | MCF7 | IC50 | 3820.0 | nM | 10.1016/j.ejmech.2013.06.047 |
| Homo sapiens | MCF7 | IC50 | 3820.0 | nM | 10.1021/acs.jmedchem.6b00764 |
| Homo sapiens | MCF7 | IC50 | 20000.0 | nM | 10.1016/j.ejmech.2022.114494 |
| Homo sapiens | MCF7 | IC50 | 100000.0 | nM | 10.1016/j.bmc.2010.02.023 |
| Homo sapiens | MCF7 | Ratio IC50 | 1.31 | None | 10.1016/j.bmc.2016.04.003 |
| Homo sapiens | MCF7 | Ratio IC50 | 10.0 | None | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | MC-IXC | IC50 | 41.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-157 | IC50 | 1389.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-175-VII | IC50 | 1991.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-231 | IC50 | 1370.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| Homo sapiens | MDA-MB-231 | IC50 | 8823.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-231 | IC50 | 10490.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | MDA-MB-361 | IC50 | 4227.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-415 | IC50 | 2958.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MDA-MB-453 | IC50 | 2107.39 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ME-180 | IC50 | 5485.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEG-01 | IC50 | 2389.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Melanocortin receptor 3 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Melanocortin receptor 3 | IC50 | nan | None | None |
| Homo sapiens | Melanocortin receptor 3 | Ki | nan | None | None |
| Homo sapiens | Melanocortin receptor 4 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Melanocortin receptor 4 | IC50 | nan | None | None |
| Homo sapiens | Melanocortin receptor 4 | Ki | nan | None | None |
| Homo sapiens | Melanocortin receptor 5 | IC50 | nan | None | None |
| Homo sapiens | Melanocortin receptor 5 | Ki | nan | None | None |
| Homo sapiens | MEL-HO | IC50 | 9317.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MEL-JUSO | IC50 | 85.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MES-SA | Ratio IC50 | 3725.0 | None | 10.1016/j.bmc.2009.07.038 |
| Homo sapiens | MeWo | IC50 | 1239.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFE-280 | IC50 | 80427.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFH-ino | IC50 | 2956.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MFH-ST | Inhibition | 47.9 | % | 10.1021/jm00107a018 |
| Homo sapiens | MFM-223 | IC50 | 34024.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MG-63 | IC50 | 2559.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MG-63 | Inhibition | 29.5 | % | 10.1021/jm00107a018 |
| Homo sapiens | MHH-ES-1 | IC50 | 323.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-NB-11 | IC50 | 727.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MHH-PREB-1 | IC50 | 533.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MIA PaCa-2 | IC50 | 1488.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-1 | IC50 | 1739.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-28 | IC50 | 4.5 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | MKN-28 | IC50 | 2419.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-45 | IC50 | 1648.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MKN-45 | IC50 | 57600.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | MKN-7 | IC50 | 20331.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ML-2 | IC50 | 269.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MLMA | IC50 | 55.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MMAC-SF | IC50 | 11952.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MN-60 | IC50 | 934.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Mo | IC50 | 58741.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLM-13 | Activity | nan | None | None |
| Homo sapiens | MOLT-13 | IC50 | 58554.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-16 | IC50 | 36.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-4 | IC50 | 0.056 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | MOLT-4 | IC50 | 0.056 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | MOLT-4 | IC50 | 0.056 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | MOLT-4 | IC50 | 10.0 | nM | 10.1021/jm00356a032 |
| Homo sapiens | MOLT-4 | IC50 | 89.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MOLT-4 | IC50 | 1000.0 | nM | 10.1016/j.bmc.2010.02.023 |
| Homo sapiens | Monoamine oxidase A | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Monoamine oxidase A | IC50 | nan | None | None |
| Homo sapiens | Monoamine oxidase A | Ki | nan | None | None |
| Homo sapiens | Motilin receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | MPP-89 | IC50 | 1313.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MS-1 | IC50 | 2768.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MSTO-211H | IC50 | 323.88 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Multidrug resistance-associated protein 4 | IC50 | 133000.0 | nM | 10.1093/toxsci/kft176 |
| Homo sapiens | Mu opioid receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Mu opioid receptor | IC50 | nan | None | None |
| Homo sapiens | Mu opioid receptor | Ki | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M1 | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Muscarinic acetylcholine receptor M1 | IC50 | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M1 | Ki | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M2 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Muscarinic acetylcholine receptor M2 | IC50 | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M2 | Ki | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M3 | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Muscarinic acetylcholine receptor M3 | IC50 | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M3 | Ki | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M4 | IC50 | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M4 | Ki | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M5 | IC50 | nan | None | None |
| Homo sapiens | Muscarinic acetylcholine receptor M5 | Ki | nan | None | None |
| Homo sapiens | MV4-11 | Activity | 0.26 | g | 10.1016/j.ejmech.2020.112424 |
| Homo sapiens | MV4-11 | Activity | nan | None | 10.1016/j.ejmech.2021.113677 |
| Homo sapiens | MV4-11 | IC50 | 1846.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MV4-11 | IC50 | 3360.0 | nM | 10.1016/j.bmcl.2010.01.039 |
| Homo sapiens | MV4-11 | Inhibition | 50.62 | % | 10.1021/acs.jmedchem.1c01196 |
| Homo sapiens | MV4-11 | TGI | 61.94 | % | 10.1021/acs.jmedchem.7b01261 |
| Homo sapiens | MV4-11 | TGI | 65.96 | % | 10.1021/acs.jmedchem.1c01196 |
| Homo sapiens | MZ1-PC | IC50 | 1803.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ2-MEL | IC50 | 1434.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | MZ7-mel | IC50 | 416.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB10 | IC50 | 188.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB12 | IC50 | 8657.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB13 | IC50 | 22504.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB14 | IC50 | 309.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB17 | IC50 | 6440.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB5 | IC50 | 452.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB6 | IC50 | 20285.29 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB69 | IC50 | 79.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NB7 | IC50 | 1515.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NBsusSR | IC50 | 335.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCC | IC50 | 0.13 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | NCI-H1048 | IC50 | 388.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1092 | IC50 | 11729.07 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1155 | IC50 | 396.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1299 | IC50 | 671.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1304 | IC50 | 80461.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1355 | IC50 | 555.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1395 | IC50 | 3247.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1437 | IC50 | 798.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1563 | IC50 | 9216.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1573 | IC50 | 6708.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1581 | IC50 | 1769.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1623 | IC50 | 536.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1648 | IC50 | 13682.86 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1650 | IC50 | 4132.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1651 | IC50 | 4984.74 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1666 | IC50 | 1576.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1693 | IC50 | 9579.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1703 | IC50 | 49.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1755 | IC50 | 2419.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1770 | IC50 | 128666.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1792 | IC50 | 1424.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1793 | IC50 | 26609.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1838 | IC50 | 19905.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1975 | IC50 | 23880.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H1993 | IC50 | 130486.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2009 | IC50 | 2252.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2029 | IC50 | 40972.78 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2030 | IC50 | 1049.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2052 | IC50 | 4056.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2087 | IC50 | 4805.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H209 | IC50 | 68973.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2122 | IC50 | 429.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2126 | IC50 | 9328.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2170 | IC50 | 3356.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2228 | IC50 | 596.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H226 | IC50 | 2520.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2291 | IC50 | 11355.35 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H23 | IC50 | 1000.0 | nM | 10.1021/jm990417j |
| Homo sapiens | NCI-H23 | IC50 | 1195.72 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2342 | IC50 | 8677.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2347 | IC50 | 4636.98 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2405 | IC50 | 3004.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H2452 | IC50 | 3122.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H28 | IC50 | 1822.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H292 | IC50 | 114.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H358 | IC50 | 6191.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H441 | IC50 | 14739.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H446 | IC50 | 3905.4 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H460 | IC50 | 100.0 | nM | 10.1016/j.bmc.2010.02.023 |
| Homo sapiens | NCI-H460 | IC50 | 9640.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H460 | IC50 | nan | None | 10.1016/j.bmc.2006.09.063 |
| Homo sapiens | NCI-H510A | IC50 | 68.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H520 | IC50 | 43476.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H526 | IC50 | 4333.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H596 | IC50 | 66338.94 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H630 | IC50 | 5348.12 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H650 | IC50 | 4353.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H661 | IC50 | 1734.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H69 | IC50 | 141206.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H720 | IC50 | 13189.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H727 | IC50 | 69412.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H747 | IC50 | 3297.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H810 | IC50 | 5677.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-H82 | IC50 | 53210.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NCI-N87 | IC50 | 2676.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NEC8 | IC50 | 134.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Neurokinin 1 receptor | IC50 | nan | None | None |
| Homo sapiens | Neurokinin 1 receptor | Ki | nan | None | None |
| Homo sapiens | Neurokinin 2 receptor | IC50 | nan | None | None |
| Homo sapiens | Neurokinin 2 receptor | Ki | nan | None | None |
| Homo sapiens | Neuronal acetylcholine receptor protein alpha-4 subunit | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Neuropeptide Y receptor type 1 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Neuropeptide Y receptor type 1 | IC50 | nan | None | None |
| Homo sapiens | Neuropeptide Y receptor type 1 | Ki | nan | None | None |
| Homo sapiens | Neuropeptide Y receptor type 2 | IC50 | nan | None | None |
| Homo sapiens | Neuropeptide Y receptor type 2 | Ki | nan | None | None |
| Homo sapiens | NH-12 | IC50 | 1162.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NHDF | IC50 | 4990.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | NHDF | IC50 | 4990.0 | nM | 10.1021/acs.jmedchem.6b00764 |
| Homo sapiens | NKM-1 | IC50 | 1064.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NMC-G1 | IC50 | 1957.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-10 | IC50 | 29884.44 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | no-11 | IC50 | 5810.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NOMO-1 | IC50 | 2332.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Norepinephrine transporter | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Norepinephrine transporter | IC50 | nan | None | None |
| Homo sapiens | Norepinephrine transporter | Ki | nan | None | None |
| Homo sapiens | NOS-1 | IC50 | 1907.64 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NTERA-2-cl-D1 | IC50 | 159.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 115.8 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 231.1 | nM | None |
| Homo sapiens | Nuclear receptor coactivator 1 | IC50 | 25587.0 | nM | None |
| Homo sapiens | Nuclear receptor coactivator 3 | IC50 | 7533.0 | nM | None |
| Homo sapiens | NUGC-3 | GI50 | 250.0 | nM | 10.1021/np200523b |
| Homo sapiens | NUGC-3 | IC50 | 588.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | NUGC-4 | Inhibition | 49.9 | % | 10.1021/jm00107a018 |
| Homo sapiens | NY | IC50 | 57433.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-28 | IC50 | 5664.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OAW-42 | IC50 | 1249.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OC-314 | IC50 | 398.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCI-AML2 | IC50 | 545.02 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OCI-AML-3 | IC50 | 0.00077 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.00098 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.00099 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.001 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.0014 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.0015 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.0072 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | IC50 | 0.1102 | ug.mL-1 | None |
| Homo sapiens | OCI-AML-3 | Ratio IC50 | 6.0 | None | None |
| Homo sapiens | OCUB-M | IC50 | 4284.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE19 | IC50 | 22440.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OE33 | IC50 | 1802.43 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OMC-1 | IC50 | 832.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | ONS-76 | IC50 | 390.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OS-RC-2 | IC50 | 1582.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OST | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | OST | Inhibition | 48.0 | % | 10.1021/jm00107a018 |
| Homo sapiens | OVCAR-3 | IC50 | 20315.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-4 | IC50 | 6074.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-5 | IC50 | 219.63 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | OVCAR-8 | IC50 | 210.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P12-Ichikawa | IC50 | 5.537 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | P30-OHK | IC50 | 56.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | p53-binding protein Mdm-2 | IC50 | 20.0 | nM | 10.1016/j.ejmech.2018.09.044 |
| Homo sapiens | PA-1 | IC50 | 186.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-03-27 | IC50 | 896.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PANC-08-13 | IC50 | 7781.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Panc1005 | IC50 | 801.76 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Panel NCI-60 (60 carcinoma cell lines) | GI50 | 5.0 | None | 10.1021/jm051029m |
| Homo sapiens | PC10 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | PC10 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | PC10 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | PC-13 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | PC-13 | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | PC-13 | Inhibition | 40.0 | % | 10.1021/jm00107a018 |
| Homo sapiens | PC-14 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | PC-14 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | PC-14 | IC50 | 609.5 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-3 | IC50 | 810.0 | nM | 10.1016/j.ejmech.2020.112624 |
| Homo sapiens | PC-3 | IC50 | 1276.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | PC-3 | IC50 | 48400.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | PC-3 | IC50 | 50510.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| Homo sapiens | PC-3 | IC50 | 55900.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| Homo sapiens | PC-3 | IC50 | 55900.0 | nM | 10.1021/jm900852b |
| Homo sapiens | PC-3 | Inhibition | 46.2 | % | 10.1021/jm00107a018 |
| Homo sapiens | PC-6 | IC50 | 50.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | PC-6 | IC50 | 50.0 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | PC-8 | IC50 | 0.28 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | PC-8 | IC50 | 1100.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | PC-9 | IC50 | 1.6 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | PC-9 | IC50 | 6600.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Potency | 30131.3 | nM | None |
| Homo sapiens | PFSK-1 | IC50 | 8737.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Phosphodiesterase 3A | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Phosphodiesterase 4D | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Phosphodiesterase 5A | IC50 | nan | None | None |
| Homo sapiens | Phosphodiesterase 5A | Ki | nan | None | None |
| Homo sapiens | Platelet activating factor receptor | IC50 | nan | None | None |
| Homo sapiens | Platelet activating factor receptor | Ki | nan | None | None |
| Homo sapiens | Pregnane X receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Prelamin-A/C | Potency | 39.8 | nM | None |
| Homo sapiens | Progesterone receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Protein kinase C alpha | IC50 | nan | None | None |
| Homo sapiens | Protein kinase C alpha | Ki | nan | None | None |
| Homo sapiens | PSN1 | IC50 | 192.81 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | QG-56 | Inhibition | 24.4 | % | 10.1021/jm00107a018 |
| Homo sapiens | QG-95 | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | QIMR-WIL | IC50 | 52306.26 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ramos-2G6-4C10 | IC50 | 867.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCC10RGB | IC50 | 4684.28 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RCM-1 | IC50 | 4013.09 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RD | IC50 | 1273.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | IC50 | nan | None | None |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | Ki | nan | None | None |
| Homo sapiens | RERF-LC-MS | IC50 | 1764.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RH-1 | IC50 | 328.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RH-18 | IC50 | 46378.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RKO | IC50 | 598.58 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RMG-I | IC50 | 18556.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RO82-W-1 | IC50 | 8486.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-2650 | IC50 | 401.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI 6410 | IC50 | 60.0 | nM | 10.1021/jm00356a032 |
| Homo sapiens | RPMI-7951 | IC50 | 339.52 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8226 | IC50 | 62505.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RPMI-8866 | IC50 | 740.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RS4-11 | IC50 | 381.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RT-112 | IC50 | 0.0086 | ug.mL-1 | None |
| Homo sapiens | RT-112 | IC50 | 0.038 | ug.mL-1 | None |
| Homo sapiens | RT-112 | IC50 | 0.042 | ug.mL-1 | None |
| Homo sapiens | RT-112 | IC50 | 501.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Runt-related transcription factor 1/Core-binding factor subunit beta | Potency | 39810.7 | nM | None |
| Homo sapiens | RVH-421 | IC50 | 14330.25 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | RXF 393 | IC50 | 700.32 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | S-117 | IC50 | 2924.22 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAOS-2 | IC50 | 2.7 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | SAOS-2 | IC50 | 681.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SAS | IC50 | 107.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-1 | IC50 | 14202.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SBC-5 | IC50 | 19506.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-15 | IC50 | 1080.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-25 | IC50 | 5668.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-4 | IC50 | 965.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCC-9 | IC50 | 2447.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SCH | IC50 | 3268.93 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Serine/threonine-protein kinase mTOR | Potency | 73.6 | nM | None |
| Homo sapiens | Serine/threonine-protein kinase mTOR | Potency | 926.8 | nM | None |
| Homo sapiens | Serine/threonine-protein kinase mTOR | Potency | 1309.2 | nM | None |
| Homo sapiens | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | IC50 | nan | None | None |
| Homo sapiens | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Ki | nan | None | None |
| Homo sapiens | Serotonin 1a (5-HT1a) receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 1a (5-HT1a) receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | IC50 | nan | None | None |
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | Ki | nan | None | None |
| Homo sapiens | Serotonin 2b (5-HT2b) receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 2b (5-HT2b) receptor | IC50 | nan | None | None |
| Homo sapiens | Serotonin 2b (5-HT2b) receptor | Ki | nan | None | None |
| Homo sapiens | Serotonin 2c (5-HT2c) receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 2c (5-HT2c) receptor | IC50 | nan | None | None |
| Homo sapiens | Serotonin 2c (5-HT2c) receptor | Ki | nan | None | None |
| Homo sapiens | Serotonin 3a (5-HT3a) receptor | AC50 | 30000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin 6 (5-HT6) receptor | IC50 | nan | None | None |
| Homo sapiens | Serotonin 6 (5-HT6) receptor | Ki | nan | None | None |
| Homo sapiens | Serotonin transporter | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Serotonin transporter | IC50 | nan | None | None |
| Homo sapiens | Serotonin transporter | Ki | nan | None | None |
| Homo sapiens | SF-126 | IC50 | 693.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-268 | IC50 | 7.68 | nM | 10.1016/j.bmcl.2009.03.069 |
| Homo sapiens | SF-268 | IC50 | 1360.68 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-268 | IC50 | 7680.0 | nM | 10.1016/j.ejmech.2010.02.011 |
| Homo sapiens | SF-295 | IC50 | 4033.91 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SF-539 | IC50 | 716.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SH-4 | IC50 | 8142.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SHP77 | IC50 | 94885.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SIG-M5 | Ratio IC50 | 9.0 | None | None |
| Homo sapiens | Sigma opioid receptor | IC50 | nan | None | None |
| Homo sapiens | Sigma opioid receptor | Ki | nan | None | None |
| Homo sapiens | SiHa | IC50 | 856.06 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SJRH30 | IC50 | 683.38 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SJSA-1 | IC50 | 235.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-BR-3 | IC50 | 870.0 | nM | 10.1016/j.ejmech.2020.112624 |
| Homo sapiens | SK-ES1 | IC50 | 0.09 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | SKG-IIIa | IC50 | 915.03 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-HEP1 | IC50 | 556.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-HEP1 | IC50 | 1800.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | SK-LMS-1 | IC50 | 144164.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-LU-1 | IC50 | 1312.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-1 | IC50 | 2902.49 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-2 | IC50 | 4028.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-24 | IC50 | 6274.9 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-28 | IC50 | 11.1 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | SK-MEL-28 | IC50 | 798.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-28 | IC50 | 1000.0 | nM | 10.1021/jm990417j |
| Homo sapiens | SK-MEL3 | IC50 | 11162.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MEL-30 | IC50 | 27399.89 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-MES-1 | IC50 | 806.82 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-AS | IC50 | 450.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-DZ | IC50 | 1072.13 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-NEP-1 | IC50 | 3545.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-N-FI | IC50 | 5064.08 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-OV-3 | IC50 | 990.0 | nM | 10.1016/j.ejmech.2020.112624 |
| Homo sapiens | SK-OV-3 | IC50 | 171679.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-PN-DW | IC50 | 415.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SK-UT-1 | IC50 | 181.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SMMC-7721 | GI | 13.01 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | GI | 16.15 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | GI | 24.02 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | GI | 44.49 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | GI | 63.1 | % | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | IC50 | 13.0 | nM | 10.1016/j.ejmech.2018.05.056 |
| Homo sapiens | SMMC-7721 | IC50 | 27.1 | nM | 10.1016/j.ejmech.2019.02.071 |
| Homo sapiens | SN12C | IC50 | 622.92 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNB-7 | IC50 | 1000.0 | nM | 10.1021/jm990417j |
| Homo sapiens | SNB-75 | IC50 | 9360.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU1 | IC50 | 96.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-387 | IC50 | 288.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-423 | IC50 | 880.8 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-449 | IC50 | 5308.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-5 | IC50 | 133061.84 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SNU-638 | IC50 | 150.0 | nM | 10.1021/jm900852b |
| Homo sapiens | SNU-638 | IC50 | 1080.0 | nM | 10.1016/j.ejmech.2018.06.003 |
| Homo sapiens | SNU-C2B | IC50 | 15464.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Solute carrier organic anion transporter family member 1B1 | Inhibition | 78.64 | % | 10.1124/mol.112.084152 |
| Homo sapiens | Solute carrier organic anion transporter family member 1B3 | Activity | 17.7 | % | 10.1016/j.ejmech.2015.01.011 |
| Homo sapiens | Solute carrier organic anion transporter family member 1B3 | Inhibition | 95.76 | % | 10.1124/mol.112.084152 |
| Homo sapiens | ST-KM-1 | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | ST-KM-1 | Inhibition | 48.6 | % | 10.1021/jm00107a018 |
| Homo sapiens | SW1088 | IC50 | 3313.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 1116 | IC50 | 5120.0 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW13 | IC50 | 476.18 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1417 | IC50 | 22585.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1463 | IC50 | 8018.73 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1573 | IC50 | 2676.71 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1573 | IC50 | 10500000.0 | nM | 10.1021/jm0612923 |
| Homo sapiens | SW1710 | IC50 | 1729.15 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1783 | IC50 | 4613.83 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW1990 | IC50 | 3827.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW48 | IC50 | 365.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW48 | IC50 | 410000.0 | nM | 10.1021/jm00078a006 |
| Homo sapiens | SW480 | ED50 | 3.42 | ug ml-1 | 10.1021/np50077a010 |
| Homo sapiens | SW480 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | SW480 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | SW480 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | SW-620 | IC50 | 349.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW-620 | IC50 | 30000.0 | nM | 10.1016/j.bmc.2010.02.023 |
| Homo sapiens | SW626 | IC50 | 2760.3 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW684 | IC50 | 50028.96 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW756 | IC50 | 719.42 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW780 | IC50 | 1320.41 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW837 | IC50 | 30853.77 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW872 | IC50 | 8077.34 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW900 | IC50 | 1621.61 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW948 | IC50 | 8561.21 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 954 | IC50 | 51300.17 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW 962 | IC50 | 3739.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | SW982 | IC50 | 91.23 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T-24 | IC50 | 0.053 | ug.mL-1 | None |
| Homo sapiens | T-24 | IC50 | 0.5 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | T-24 | IC50 | 0.5 | ug.mL-1 | 10.1021/jm00107a018 |
| Homo sapiens | T-24 | IC50 | 1.256 | ug.mL-1 | None |
| Homo sapiens | T-24 | IC50 | 1.71 | ug.mL-1 | None |
| Homo sapiens | T-24 | IC50 | 78.56 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T-24 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | T-24 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | T47D | IC50 | 2700.0 | nM | 10.1021/jm900852b |
| Homo sapiens | T47D | IC50 | 2720.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| Homo sapiens | T47D | IC50 | 32188.36 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T84 | IC50 | 41245.95 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | T98G | IC50 | 1718.11 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TCC-SUP | IC50 | 0.011 | ug.mL-1 | None |
| Homo sapiens | TCC-SUP | IC50 | 0.245 | ug.mL-1 | None |
| Homo sapiens | TCC-SUP | IC50 | 0.354 | ug.mL-1 | None |
| Homo sapiens | TCC-SUP | IC50 | 3304.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-1 | IC50 | 118344.16 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-10 | IC50 | 3908.67 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-11 | IC50 | 2954.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-12 | IC50 | 109081.14 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-2 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | TE-2 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | TE-2 | IC50 | 100.0 | ug.mL-1 | 10.1021/jm00401a001 |
| Homo sapiens | TE-5 | IC50 | 380.6 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-6 | IC50 | 8249.62 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-8 | IC50 | 219.1 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TE-9 | IC50 | 1787.54 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC11TKB | IC50 | 1731.45 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC1TKB | IC50 | 4521.2 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TGBC24TKB | IC50 | 1851.7 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | THP-1 | IC50 | 0.0004 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.0008 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.0016 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.002 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.0054 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.0164 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.0604 | ug.mL-1 | None |
| Homo sapiens | THP-1 | IC50 | 0.605 | ug.mL-1 | None |
| Homo sapiens | THP-1 | Ratio | 20.0 | None | None |
| Homo sapiens | THP-1 | Ratio IC50 | 25.0 | None | None |
| Homo sapiens | THP-1 | Ratio IC50 | 50.0 | None | None |
| Homo sapiens | THP-1 | Ratio IC50 | 70.0 | None | None |
| Homo sapiens | Thromboxane A2 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Thromboxane-A synthase | IC50 | nan | None | None |
| Homo sapiens | Thromboxane-A synthase | Ki | nan | None | None |
| Homo sapiens | Thymidine kinase, cytosolic | IC50 | 1000000.0 | nM | 10.1016/j.bmc.2007.01.049 |
| Homo sapiens | Thymidine kinase, cytosolic | IC50 | 1000000.0 | nM | 10.1016/s0960-894x(01)00207-4 |
| Homo sapiens | Thymidine kinase, cytosolic | Relative velocity | 1.0 | % | 10.1021/jm00394a039 |
| Homo sapiens | Thymidine kinase, cytosolic | Relative velocity | 22.0 | % | 10.1021/jm00394a039 |
| Homo sapiens | Thymidine kinase, cytosolic | Relative velocity | 361.0 | % | 10.1021/jm00394a039 |
| Homo sapiens | Thymidine kinase, mitochondrial | IC50 | 1000000.0 | nM | 10.1016/j.bmc.2007.01.049 |
| Homo sapiens | Thymidine kinase, mitochondrial | IC50 | 1000000.0 | nM | 10.1016/s0960-894x(01)00207-4 |
| Homo sapiens | Thyroid hormone receptor beta-1 | Potency | 2238721.1 | nM | None |
| Homo sapiens | TI-73 | IC50 | 612.66 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TK-10 | IC50 | 1733.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | TYK-nu | IC50 | 660.85 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Type-1 angiotensin II receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Tyrosine-protein kinase FYN | IC50 | nan | None | None |
| Homo sapiens | Tyrosine-protein kinase FYN | Ki | nan | None | None |
| Homo sapiens | Tyrosine-protein kinase LCK | IC50 | nan | None | None |
| Homo sapiens | Tyrosine-protein kinase LCK | Ki | nan | None | None |
| Homo sapiens | Tyrosine-protein kinase SRC | IC50 | nan | None | 10.1016/j.ejmech.2007.10.011 |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 36.6 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 41.1 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 94.4 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 118.9 | nM | None |
| Homo sapiens | U-118-MG | IC50 | 4155.47 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-251 | IC50 | 0.002 | ug.mL-1 | None |
| Homo sapiens | U-251 | IC50 | 0.022 | ug.mL-1 | None |
| Homo sapiens | U-251 | IC50 | 1129.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-251 | Ratio IC50 | 10.0 | None | None |
| Homo sapiens | U-266 | IC50 | 15537.48 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U2OS | IC50 | 343.87 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U2OS | Inhibition | 43.9 | % | 10.1021/jm00107a018 |
| Homo sapiens | U-87 MG | IC50 | 850.0 | nM | 10.1016/j.ejmech.2020.112624 |
| Homo sapiens | U-87 MG | IC50 | 1742.57 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | U-87 MG | IC50 | 2880.0 | nM | 10.1016/j.bmcl.2019.08.003 |
| Homo sapiens | U-937 | Activity | 2.65 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 4.2 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 5.35 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 5.55 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 8.7 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 8.8 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 10.55 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 11.05 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 11.2 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 69.7 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 79.05 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | 83.2 | % | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | Activity | nan | None | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | U-937 | GI | 59.88 | % | 10.1007/s00044-012-0001-6 |
| Homo sapiens | U-937 | GI | 85.08 | % | 10.1007/s00044-012-0001-6 |
| Homo sapiens | U-937 | IC50 | 0.31 | ug.mL-1 | 10.1021/jm00105a037 |
| Homo sapiens | U-937 | IC50 | 0.46 | ug.mL-1 | 10.1021/jm00106a049 |
| Homo sapiens | U-937 | IC50 | 2.0 | nM | 10.1016/j.bmcl.2019.03.044 |
| Homo sapiens | UACC-257 | IC50 | 4464.37 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-62 | IC50 | 665.53 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UACC-893 | IC50 | 32635.51 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 | Potency | 281.8 | nM | None |
| Homo sapiens | UMC-11 | IC50 | 84137.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UMUC3 | IC50 | 342.27 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | UO-31 | IC50 | 1250.79 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VA-ES-BJ | IC50 | 71.65 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | IC50 | nan | None | None |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | Ki | nan | None | None |
| Homo sapiens | Vasoactive intestinal polypeptide receptor 1 | IC50 | nan | None | None |
| Homo sapiens | Vasoactive intestinal polypeptide receptor 1 | Ki | nan | None | None |
| Homo sapiens | Vasopressin V1a receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | Vasopressin V1a receptor | IC50 | nan | None | None |
| Homo sapiens | Vasopressin V1a receptor | Ki | nan | None | None |
| Homo sapiens | Vasopressin V2 receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Homo sapiens | VM-CUB-1 | IC50 | 533.46 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | VMRC-RCZ | IC50 | 1353.99 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | WI-38 | IC50 | 100.0 | ug.mL-1 | 10.1016/j.ejmech.2022.114651 |
| Homo sapiens | WM-115 | IC50 | 3993.33 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YAPC | IC50 | 5447.69 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YH-13 | IC50 | 327.55 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | YKG-1 | IC50 | 298.31 | nM | 10.6019/CHEMBL1201861 |
| Homo sapiens | Z-138 | Activity | 0.68 | g | 10.1016/j.ejmech.2019.03.062 |
| Homo sapiens | Z-138 | TGI | 60.95 | % | 10.1016/j.ejmech.2019.03.062 |
| Homo sapiens | ZR-75-30 | IC50 | 75525.4 | nM | 10.6019/CHEMBL1201861 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | EC50 | 0.2 | ug.mL-1 | 10.1016/j.bmcl.2008.12.103 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | EC50 | 1.6 | ug.mL-1 | 10.1021/np020234r |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | ED50 | 0.00034 | mM l-1 | 10.1021/jm00382a005 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | IC50 | 300.0 | nM | 10.1016/S0960-894X(97)00117-0 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Inhibition | 0.0 | % | 10.1021/jm00355a007 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Inhibition | 90.0 | % | 10.1021/jm00187a005 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Inhibition | 93.6 | % | 10.1021/jm00355a007 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Inhibition | 99.99 | % | 10.1021/jm00187a005 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Inhibition | nan | % | 10.1021/jm00191a011 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | MIC | 0.02 | ug.mL-1 | 10.1021/jm00192a008 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | MIC | 0.03 | ug.mL-1 | 10.1021/jm00192a008 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | MIC | 3.0 | ug.mL-1 | 10.1021/jm00216a003 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | MIC | 3.0 | ug.mL-1 | 10.1021/jm00216a004 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Survival | 0.0 | % | 10.1021/jm00191a011 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Survival | 40.0 | % | 10.1021/jm00191a011 |
| Human alphaherpesvirus 1 | Human alphaherpesvirus 1 | Virus rating | 2.7 | None | 10.1021/jm00382a005 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | EC50 | 0.52 | ug.mL-1 | 10.1016/j.bmcl.2008.12.103 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | EC50 | 3.0 | ug.mL-1 | 10.1021/np020234r |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | ED50 | 0.0011 | mM l-1 | 10.1021/jm00382a005 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | IC50 | 2000.0 | nM | 10.1016/S0960-894X(97)00117-0 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | MIC | 0.03 | ug.mL-1 | 10.1021/jm00192a008 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | MIC | 0.04 | ug.mL-1 | 10.1021/jm00192a008 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | MIC | 3.0 | ug.mL-1 | 10.1021/jm00216a003 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | MIC | 3.0 | ug.mL-1 | 10.1021/jm00216a004 |
| Human alphaherpesvirus 2 | Human alphaherpesvirus 2 | Virus rating | 2.7 | None | 10.1021/jm00382a005 |
| Human herpesvirus 1 | Thymidine kinase | IC50 | 1000000.0 | nM | 10.1016/j.bmc.2007.01.049 |
| Human herpesvirus 1 | Thymidine kinase | Relative velocity | 3.0 | % | 10.1021/jm00394a039 |
| Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) | Thymidine kinase | IC50 | 1000000.0 | nM | 10.1016/s0960-894x(01)00207-4 |
| Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) | Thymidine kinase | Relative velocity | 10.0 | % | 10.1021/jm00394a039 |
| Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | AC50 | 736.0 | nM | None |
| Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | AC50 | 1100.0 | nM | None |
| Human respirovirus 3 | Human respirovirus 3 | ED50 | 0.5 | mM l-1 | 10.1021/jm00382a005 |
| Human respirovirus 3 | Human respirovirus 3 | Virus rating | 0.0 | None | 10.1021/jm00382a005 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | Inhibition | 5.64 | % | 10.6019/CHEMBL4513141 |
| Leishmania amazonensis | Leishmania amazonensis | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Leishmania donovani | Leishmania donovani | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Leishmania infantum | Leishmania infantum | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Leishmania major | Leishmania major | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Leishmania mexicana | Leishmania mexicana | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Mus musculus | B16 | IC50 | 0.24 | ug.mL-1 | 10.1021/jm00106a049 |
| Mus musculus | B16 | IC50 | 30620.0 | nM | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | B16 | IC50 | 49220.0 | nM | 10.1039/C0MD00208A |
| Mus musculus | B16 | ID50 | 0.1 | ug ml-1 | 10.1021/jm00077a017 |
| Mus musculus | Bone marrow | AUC | 46.0 | nmol/g | 10.1021/jm0607449 |
| Mus musculus | CCRF S-180 | Activity | 0.582 | g | 10.1016/j.bmc.2009.06.011 |
| Mus musculus | CCRF S-180 | Activity | 0.74 | g | 10.1016/j.ejmech.2009.05.006 |
| Mus musculus | CCRF S-180 | Activity | 0.814 | g | 10.1016/j.ejmech.2011.02.017 |
| Mus musculus | CCRF S-180 | ED50 | 0.2 | uM | 10.1021/jm00106a034 |
| Mus musculus | CCRF S-180 | ED50 | 0.2 | uM | 10.1021/jm00112a040 |
| Mus musculus | CCRF S-180 | GI | 7.86 | % | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | CCRF S-180 | GI | 20.57 | % | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | CCRF S-180 | GI | 31.93 | % | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | CCRF S-180 | IC50 | 25430.0 | nM | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | CCRF S-180 | IC50 | 40330.0 | nM | 10.1039/C0MD00208A |
| Mus musculus | CCRF S-180 | Inhibition | 6.8 | % | 10.1016/j.bmc.2010.07.043 |
| Mus musculus | CCRF S-180 | Inhibition | 24.3 | % | 10.1016/j.bmc.2010.07.043 |
| Mus musculus | CCRF S-180 | Inhibition | 54.8 | % | 10.1016/j.bmc.2010.07.043 |
| Mus musculus | CCRF S-180 | Inhibition | 54.8 | % | 10.1016/j.ejmech.2009.05.006 |
| Mus musculus | CCRF S-180 | Inhibition | 54.8 | % | 10.1016/j.ejmech.2011.02.017 |
| Mus musculus | CCRF S-180 | Inhibition | 98.0 | % | 10.1021/jm00209a010 |
| Mus musculus | CCRF S-180 | TGI | 7.86 | % | 10.1039/C0MD00208A |
| Mus musculus | CCRF S-180 | TGI | 20.57 | % | 10.1039/C0MD00208A |
| Mus musculus | CCRF S-180 | TGI | 31.93 | % | 10.1039/C0MD00208A |
| Mus musculus | CCRF S-180 | TGI | 54.8 | % | 10.1007/s00044-010-9504-1 |
| Mus musculus | Cytidine deaminase | Relative initial rate | 15.0 | None | 10.1021/jm00356a032 |
| Mus musculus | Dihydrofolate reductase | Log 1/C | 7.18 | None | 10.1021/jm00369a019 |
| Mus musculus | Dihydrofolate reductase | Log 1/C | 7.2 | None | 10.1021/jm00369a019 |
| Mus musculus | H22 | IC50 | 25980.0 | nM | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | H22 | IC50 | 37820.0 | nM | 10.1039/C0MD00208A |
| Mus musculus | L1210 | Active dose range | 5.0 | mg kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Active dose range | 50.0 | mg kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Active dose range | 100.0 | mg kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Activity | 550.0 | Zone units | 10.1021/np50064a011 |
| Mus musculus | L1210 | Activity | nan | None | 10.1021/jm00227a018 |
| Mus musculus | L1210 | Activity | nan | None | 10.1021/jm00385a032 |
| Mus musculus | L1210 | ED50 | 0.05 | uM | 10.1021/jm00106a034 |
| Mus musculus | L1210 | ED50 | 0.05 | uM | 10.1021/jm00112a040 |
| Mus musculus | L1210 | ED50 | 0.1 | uM | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ED50 | 0.19 | uM | 10.1021/jm00380a004 |
| Mus musculus | L1210 | ED50 | 2.76 | ug ml-1 | 10.1021/np50077a010 |
| Mus musculus | L1210 | IC50 | 0.097 | ug.mL-1 | 10.1021/jm00105a037 |
| Mus musculus | L1210 | IC50 | 0.097 | ug.mL-1 | 10.1021/jm00401a001 |
| Mus musculus | L1210 | IC50 | 0.4 | nM | 10.1016/j.bmc.2009.07.038 |
| Mus musculus | L1210 | IC50 | 10.0 | nM | 10.1021/jm00096a006 |
| Mus musculus | L1210 | IC50 | 24.0 | nM | 10.1016/j.ejmech.2009.10.032 |
| Mus musculus | L1210 | IC50 | 24.0 | nM | 10.1021/jm901590f |
| Mus musculus | L1210 | IC50 | 31.0 | nM | 10.1016/S0960-894X(97)00044-9 |
| Mus musculus | L1210 | IC50 | 36.0 | nM | 10.1021/jm00111a004 |
| Mus musculus | L1210 | IC50 | 50.0 | nM | 10.1021/jm00078a006 |
| Mus musculus | L1210 | IC50 | 80.0 | nM | 10.1021/jm00105a064 |
| Mus musculus | L1210 | IC50 | 100.0 | nM | 10.1021/jm00096a006 |
| Mus musculus | L1210 | IC50 | 120.0 | nM | 10.1021/jm00078a007 |
| Mus musculus | L1210 | IC50 | 170.0 | nM | 10.1021/jm0004446 |
| Mus musculus | L1210 | IC50 | 103000.0 | nM | 10.1016/j.bmc.2009.07.038 |
| Mus musculus | L1210 | ID50 | 2.5e-06 | mM l-1 | 10.1021/jm00382a005 |
| Mus musculus | L1210 | ID50 | 0.02 | uM | 10.1021/jm00392a029 |
| Mus musculus | L1210 | ILS | 7.0 | % | 10.1021/jm00227a018 |
| Mus musculus | L1210 | ILS | 8.0 | % | 10.1021/jm00227a018 |
| Mus musculus | L1210 | ILS | 11.1 | % | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ILS | 15.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 16.0 | % | 10.1021/jm00227a018 |
| Mus musculus | L1210 | ILS | 18.8 | % | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ILS | 19.0 | % | 10.1021/jm00186a011 |
| Mus musculus | L1210 | ILS | 19.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | ILS | 28.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 34.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 34.0 | % | 10.1021/jm00227a018 |
| Mus musculus | L1210 | ILS | 38.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 40.0 | % | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ILS | 44.0 | % | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ILS | 45.0 | % | 10.1021/jm00186a011 |
| Mus musculus | L1210 | ILS | 45.0 | % | 10.1021/jm00197a030 |
| Mus musculus | L1210 | ILS | 47.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 50.0 | % | 10.1021/jm00186a011 |
| Mus musculus | L1210 | ILS | 62.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 69.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 84.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 89.0 | % | 10.1021/jm00186a011 |
| Mus musculus | L1210 | ILS | 91.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 92.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 92.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 100.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 100.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | ILS | 121.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 123.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 127.0 | % | 10.1021/jm00196a015 |
| Mus musculus | L1210 | ILS | 129.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | ILS | 131.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 138.0 | % | 10.1021/jm00230a007 |
| Mus musculus | L1210 | ILS | 143.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | ILS | 161.0 | % | 10.1021/jm00385a016 |
| Mus musculus | L1210 | Life span | 12.8 | day | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Life span | 13.0 | day | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Life span | 14.0 | day | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Life span | 16.25 | day | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Life span | 16.6 | day | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Log CR | 1.61 | None | 10.1021/jm00169a014 |
| Mus musculus | L1210 | Mean increased life span | 102.0 | % | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Mean increased life span | 105.0 | % | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Mean increased life span | 128.0 | % | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Mean increased life span | 157.0 | % | 10.1021/jm00356a032 |
| Mus musculus | L1210 | Mean increased life span | 162.0 | % | 10.1021/jm00356a032 |
| Mus musculus | L1210 | MST | 9.5 | day | 10.1021/jm00197a030 |
| Mus musculus | L1210 | MST | 10.0 | day | 10.1021/jm00197a030 |
| Mus musculus | L1210 | MST | 13.0 | day | 10.1021/jm00197a030 |
| Mus musculus | L1210 | MST | 14.0 | day | 10.1021/jm00197a030 |
| Mus musculus | L1210 | MST | 14.5 | day | 10.1021/jm00197a030 |
| Mus musculus | L1210 | Optimal dose | 100.0 | mg | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Optimal dose | 200.0 | mg | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Optimal dose | 300.0 | mg | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Optimal dose | 400.0 | mg uM kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Range | 9.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Range | 11.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Range | 15.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Ratio IC50 | 257500.0 | None | 10.1016/j.bmc.2009.07.038 |
| Mus musculus | L1210 | Survival time | 9.0 | day | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Survival time | 10.0 | day | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Survival time | 14.0 | day | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Survivors | 0.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Survivors | 0.0 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Survivors | 1.0 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | T/C | 9.5 | % | 10.1021/jm00160a041 |
| Mus musculus | L1210 | T/C | 9.5 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | T/C | 13.5 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | T/C | 14.0 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | T/C | 14.5 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | T/C | 16.0 | % | 10.1021/jm00160a041 |
| Mus musculus | L1210 | T/C | 17.0 | % | 10.1021/jm00160a041 |
| Mus musculus | L1210 | T/C | 17.0 | None | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Weight change | -6.1 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Weight change | -5.8 | None | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Weight change | -3.8 | g mouse-1 | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Weight change | -3.64 | g mouse-1 | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Weight change | -2.9 | g mouse-1 | 10.1021/jm00160a041 |
| Mus musculus | L1210 | Weight change | -0.63 | g mouse-1 | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Weight change | 2.0 | g mouse-1 | 10.1021/jm00186a011 |
| Mus musculus | L1210 | Weight change | 2.37 | g mouse-1 | 10.1021/jm00160a041 |
| Mus musculus | L5178Y | ID50 | 0.02 | ug ml-1 | 10.1021/jm00187a005 |
| Mus musculus | L5178Y | ID50 | 20.0 | ug ml-1 | 10.1021/jm00184a006 |
| Mus musculus | L5178Y | ID50 | 79.0 | ug ml-1 | 10.1021/jm00184a006 |
| Mus musculus | Lewis lung carcinoma cell line | IC50 | 5600.0 | nM | 10.1021/jm00078a007 |
| Mus musculus | Liver | AUC | 19.2 | nmol/g.hr | 10.1021/jm0607449 |
| Mus musculus | Liver | Ratio AUC | 0.16 | None | 10.1021/jm0607449 |
| Mus musculus | Liver | Ratio AUC | 0.42 | None | 10.1021/jm0607449 |
| Mus musculus | Monoamine oxidase A | Activity | nan | None | 10.1021/jm800656v |
| Mus musculus | Monoamine oxidase B | Activity | nan | None | 10.1021/jm800656v |
| Mus musculus | MPC-11 | ED50 | 0.99 | uM | 10.1021/jm00353a010 |
| Mus musculus | MPC-11 | LD50 | 1.91 | uM | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | 30 day survivors | 1.0 | None | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Active dose range | 5.0 | mg uM kg-1 day-1 | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Activity | -4.2 | g | 10.1021/jm00197a030 |
| Mus musculus | Mus musculus | Activity | -3.8 | g | 10.1021/jm00197a030 |
| Mus musculus | Mus musculus | Activity | -3.64 | g | 10.1021/jm00197a030 |
| Mus musculus | Mus musculus | Activity | -2.46 | g | 10.1021/jm00197a030 |
| Mus musculus | Mus musculus | Activity | -1.8 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | -1.25 | g | 10.1021/jm00197a030 |
| Mus musculus | Mus musculus | Activity | -1.0 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | -0.4 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | -0.3 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | -0.2 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | 0.0 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | 0.16 | g | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | Mus musculus | Activity | 0.29 | g | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | Mus musculus | Activity | 0.3 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | 0.4 | g | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Activity | 1.62 | g | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | Mus musculus | Activity | 7.12 | g | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | Mus musculus | Activity | 7.5 | None | 10.1016/j.ejmech.2011.05.004 |
| Mus musculus | Mus musculus | Activity | 11.0 | None | 10.1021/jm051029m |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1021/jm00196a015 |
| Mus musculus | Mus musculus | Average survival (days) | 8.4 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | Average survival (days) | 9.6 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | Average survival (days) | 19.7 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | Average weight | 19.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 20.2 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 21.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 22.0 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 22.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 22.6 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Average weight | 24.0 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ID50 | 0.01 | uM | 10.1021/jm00392a029 |
| Mus musculus | Mus musculus | ILS | -22.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | -13.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | -11.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | 0.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 12.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 14.0 | % | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | ILS | 17.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | 23.0 | % | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | ILS | 27.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 43.0 | % | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | ILS | 44.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 50.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | 53.0 | % | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | ILS | 62.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 63.0 | % | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | ILS | 64.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 65.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | 65.0 | % | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | ILS | 68.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 74.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 75.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 80.0 | % | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | ILS | 82.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | ILS | 87.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 100.0 | % | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | ILS | 100.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 104.0 | % | 10.1021/jm00124a013 |
| Mus musculus | Mus musculus | ILS | 112.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | ILS | 126.0 | % | 10.1021/jm00124a013 |
| Mus musculus | Mus musculus | ILS | 129.0 | % | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | ILS | 129.0 | % | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | ILS | 138.0 | % | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | ILS | 147.0 | % | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Inhibition ratio | 83.0 | % | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Inhibition ratio | 87.7 | % | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Log kill | 0.7 | None | 10.1021/jm0005149 |
| Mus musculus | Mus musculus | Log kill | 1.9 | None | 10.1021/jm0005149 |
| Mus musculus | Mus musculus | Log kill | 2.8 | None | 10.1021/jm0005149 |
| Mus musculus | Mus musculus | Log kill | 5.0 | None | 10.1021/jm0005149 |
| Mus musculus | Mus musculus | Long-term survivors | nan | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | Mean hemagglutination titers | 3.4 | None | 10.1021/jm00136a008 |
| Mus musculus | Mus musculus | Median T/C | 8.0 | None | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Median T/C | 14.0 | None | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Median T/C | 16.0 | None | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | NA | nan | None | 10.1021/jm0005149 |
| Mus musculus | Mus musculus | No. of survivors | 0.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Optimal dose | 9.2 | mg uM kg day-1 | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Optimal dose | 60.0 | uM kg-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Optimal dose | 100.0 | uM kg-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Optimal dose | 200.0 | uM kg-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Optimal dose | 300.0 | uM kg-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Range of survival days | 8.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | Range of survival days | 10.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | Range of survival days | 15.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | Survivors | 0.0 | None | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Survivors | 0.0 | None | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | T/C | 7.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 8.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 8.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | T/C | 10.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | T/C | 10.5 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 12.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 13.0 | day | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | T/C | 14.0 | day | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | T/C | 14.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 15.5 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 16.0 | None | 10.1021/jm00167a016 |
| Mus musculus | Mus musculus | T/C | 21.0 | None | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | T/C | 111.0 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | T/C | 126.0 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | T/C | 258.0 | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | T/C | nan | None | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | T/C | nan | None | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Toxic deaths | nan | None | 10.1021/jm00112a040 |
| Mus musculus | Mus musculus | Tumor weight | 0.34 | g | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Tumor weight | 0.47 | g | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Weight change | -14.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -7.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -6.1 | g mouse-1 | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Weight change | -5.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -4.56 | g mouse-1 on day 8 | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Weight change | -4.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -3.8 | g mouse-1 | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Weight change | -3.1 | g mouse-1 | 10.1021/jm00064a012 |
| Mus musculus | Mus musculus | Weight change | -3.1 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -2.66 | g mouse-1 on day 8 | 10.1021/jm00380a004 |
| Mus musculus | Mus musculus | Weight change | -1.8 | g mouse-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Weight change | -1.6 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -1.1 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -1.0 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | -0.93 | g mouse-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Weight change | -0.87 | g mouse-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Weight change | -0.4 | None | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Weight change | -0.1 | None | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Weight change | 0.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 0.2 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 0.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 0.5 | g mouse-1 | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | Weight change | 0.6 | g mouse-1 | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | Weight change | 0.7 | None | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Weight change | 0.8 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 0.8 | g mouse-1 | 10.1021/jm00353a010 |
| Mus musculus | Mus musculus | Weight change | 0.8 | None | 10.1021/jm00078a007 |
| Mus musculus | Mus musculus | Weight change | 1.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 2.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 2.4 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 2.6 | g mouse-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Weight change | 3.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 3.6 | g mouse-1 | 10.1021/jm00117a020 |
| Mus musculus | Mus musculus | Weight change | 3.8 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 4.0 | g mouse-1 | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 7.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 11.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 19.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change | 20.0 | % | 10.1021/jm00344a016 |
| Mus musculus | Mus musculus | Weight change difference | -2.5 | g | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | Weight change difference | -2.2 | g | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | Weight change difference | -1.0 | g | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | Weight change difference | -0.9 | g | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | Weight change difference | -0.7 | g | 10.1021/jm00115a017 |
| Mus musculus | Mus musculus | Weight change difference | -0.5 | g | 10.1021/jm00115a017 |
| Mus musculus | Nitric oxide synthase, inducible | IC50 | nan | None | None |
| Mus musculus | Nitric oxide synthase, inducible | Ki | nan | None | None |
| Mus musculus | P388 | Active dose range | 20.0 | mg kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | P388 | Active dose range | 100.0 | mg kg-1 day-1 | 10.1021/jm00160a041 |
| Mus musculus | P388 | ED50 | 0.02 | uM | 10.1021/jm00106a034 |
| Mus musculus | P388 | ED50 | 0.02 | uM | 10.1021/jm00112a040 |
| Mus musculus | P388 | IC50 | 140.0 | nM | 10.1021/jm0004446 |
| Mus musculus | P388 | IC50 | 1233.0 | nM | 10.1021/np50063a010 |
| Mus musculus | P388 | ID50 | 1.2e-06 | mM l-1 | 10.1021/jm00382a005 |
| Mus musculus | P388 | ID50 | 0.02 | uM | 10.1021/jm00392a029 |
| Mus musculus | P388 | ILS | 36.0 | None | 10.1021/jm00160a041 |
| Mus musculus | P388 | ILS | 109.0 | None | 10.1021/jm00160a041 |
| Mus musculus | P388 | Inhibition | 99.0 | % | 10.1021/jm00365a003 |
| Mus musculus | P388 | IZ | 10.0 | mm | 10.1021/np50063a010 |
| Mus musculus | P388 | IZ | 20.0 | mm | 10.1021/np50063a010 |
| Mus musculus | P388 | IZ | 40.0 | mm | 10.1021/np50063a010 |
| Mus musculus | P388 | Optimal dose | 200.0 | mg | 10.1021/jm00160a041 |
| Mus musculus | P388 | Optimal dose | 500.0 | mg | 10.1021/jm00160a041 |
| Mus musculus | P388 | Range | 14.0 | None | 10.1021/jm00160a041 |
| Mus musculus | P388 | Range | 22.0 | None | 10.1021/jm00160a041 |
| Mus musculus | P388 | Survivors | 0.0 | None | 10.1021/jm00160a041 |
| Mus musculus | P388 | T/C | 15.0 | % | 10.1021/jm00160a041 |
| Mus musculus | P388 | T/C | 23.0 | % | 10.1021/jm00160a041 |
| Mus musculus | P388 | Weight change | -3.62 | g mouse-1 | 10.1021/jm00160a041 |
| Mus musculus | P388 | Weight change | 0.72 | g mouse-1 | 10.1021/jm00160a041 |
| Mus musculus | P815 | ID50 | 0.02 | ug ml-1 | 10.1021/jm00187a005 |
| Mus musculus | P815 | ID50 | 10.0 | ug ml-1 | 10.1021/jm00184a006 |
| Mus musculus | P815 | ID50 | 40.0 | ug ml-1 | 10.1021/jm00184a006 |
| Mus musculus | Plasma | AUC | 29429.62 | ng.hr.mL-1 | 10.1021/jm0607449 |
| Mus musculus | Thymidylate synthase | ED50 | 0.03 | uM | 10.1021/jm00157a031 |
| Oryctolagus cuniculus | Angiotensin-converting enzyme | IC50 | nan | None | None |
| Oryctolagus cuniculus | Angiotensin-converting enzyme | Ki | nan | None | None |
| Oryctolagus cuniculus | Arachidonate 15-lipoxygenase | IC50 | nan | None | None |
| Oryctolagus cuniculus | Arachidonate 15-lipoxygenase | Ki | nan | None | None |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Pneumocystis carinii | Pneumocystis carinii | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | Inhibition | 9.51 | % | 10.6019/CHEMBL4513141 |
| Rattus norvegicus | Aldose reductase | IC50 | nan | None | None |
| Rattus norvegicus | Aldose reductase | Ki | nan | None | None |
| Rattus norvegicus | Alpha-1a adrenergic receptor | IC50 | nan | None | None |
| Rattus norvegicus | Alpha-1a adrenergic receptor | Ki | nan | None | None |
| Rattus norvegicus | Alpha-1b adrenergic receptor | IC50 | nan | None | None |
| Rattus norvegicus | Alpha-1b adrenergic receptor | Ki | nan | None | None |
| Rattus norvegicus | Androgen Receptor | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Rattus norvegicus | Androgen Receptor | IC50 | nan | None | None |
| Rattus norvegicus | Androgen Receptor | Ki | nan | None | None |
| Rattus norvegicus | Cyclooxygenase-1 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Rattus norvegicus | GABA receptor alpha-1 subunit | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Rattus norvegicus | Glycine receptor | IC50 | nan | None | None |
| Rattus norvegicus | Glycine receptor | Ki | nan | None | None |
| Rattus norvegicus | Hepatocyte | AUC | 5.0 | nmol.hr/g | 10.1021/jm0607449 |
| Rattus norvegicus | Insulin receptor | IC50 | nan | None | None |
| Rattus norvegicus | Insulin receptor | Ki | nan | None | None |
| Rattus norvegicus | Nitric-oxide synthase, brain | IC50 | nan | None | None |
| Rattus norvegicus | Nitric-oxide synthase, brain | Ki | nan | None | None |
| Rattus norvegicus | Peripheral myelin protein 22 | Potency | 9992.4 | nM | None |
| Rattus norvegicus | Peripheral myelin protein 22 | Potency | 12817.8 | nM | None |
| Rattus norvegicus | Protein kinase C (PKC) | IC50 | nan | None | 10.1016/j.ejmech.2007.10.011 |
| Rattus norvegicus | Rattus norvegicus | ALB | 40200.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALB | 40300.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALB | 40700.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALB | 41000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALB | 42300.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 271.17 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 275.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 292.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 302.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 306.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALP | 313.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALT | 41.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALT | 45.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALT | 50.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALT | 52.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | ALT | 61.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 78.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 81.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 82.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 84.17 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 91.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | AST | 100.83 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BASO | 0.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BASOLE | 0.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BILI | 1.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BILI | 1.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BILI | 2.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BUN | 110.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BUN | 116.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BUN | 120.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BUN | 126.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | BUN | 133.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 99.0 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 99.33 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 99.5 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 100.25 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 100.67 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHLORIDE | 101.67 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 676.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 680.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 711.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 713.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 730.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CHOL | 776.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 242.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 261.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 313.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 326.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 427.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CK | 554.5 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 26000000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 26330000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 27000000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 31000000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 32330000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CO2 | 34670000.0 | nM | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CREAT | 1.9 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CREAT | 2.1 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CREAT | 2.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | CREAT | 3.1 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOS | 0.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOS | 10.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOS | 53.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOS | 62.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOSLE | 0.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOSLE | 0.33 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | EOSLE | 0.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | GLUC | 1510.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | GLUC | 1590.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | GLUC | 1630.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | GLUC | 1683.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | GLUC | 1720.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 26.53 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 28.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 33.22 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 33.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 33.83 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HCT | 34.77 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 107000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 113000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 129700.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 132300.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 135300.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | HGB | 136200.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | Inhibition | -4.0 | % | 10.1021/jm00230a007 |
| Rattus norvegicus | Rattus norvegicus | Inhibition | 7.0 | % | 10.1021/jm00230a007 |
| Rattus norvegicus | Rattus norvegicus | Inhibition | 20.0 | % | 10.1021/jm00230a007 |
| Rattus norvegicus | Rattus norvegicus | LDH | 55.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LDH | 65.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LDH | 75.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LDH | 75.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LDH | 88.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LDH | 93.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 10.67 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 11.0 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 11.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 11.5 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 13.33 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LIPASE | 18.83 | U.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 3604.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 5539.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 6967.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 7623.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 7739.83 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYM | 7855.5 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 89.17 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 91.33 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 92.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 93.17 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 95.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | LYMLE | 95.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 24.6 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 25.28 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 25.43 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 25.7 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 25.8 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCH | 26.47 | pg | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 390500.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 392000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 393000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 394000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 400000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCHC | 403700.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 62.78 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 63.07 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 64.75 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 65.13 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 65.53 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MCV | 66.2 | fL | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 0.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 16.67 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 31.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 36.17 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 62.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONO | 74.83 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONOLE | 0.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONOLE | 0.33 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | MONOLE | 0.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 4.0 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 4.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 6.5 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 7.33 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 7.67 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTLE | 9.5 | % | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 152.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 244.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 568.33 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 575.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 686.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | NEUTSG | 832.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 92.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 96.2 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 101.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 104.2 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 108.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PHOS | 112.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1092000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1093330.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1095670.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1096000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1145330.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PLAT | 1216670.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.08 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.4 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.41 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.45 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.61 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | POTASSIUM | 5.7 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 57000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 57700.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 58000.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 59300.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 60800.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | PROT | 61700.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 4200000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 4400000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 5120000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 5130000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 5140000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBC | 5550000.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | RBCNUC | 0.0 | /100WBC | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 143.1 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 143.75 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 144.13 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 144.57 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 145.23 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | SODIUM | 145.37 | mEq.L-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | Tissue Severity Score | nan | None | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 5.2 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 5.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 6.8 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 8.0 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 8.3 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | URATE | 8.7 | ug.mL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 3770.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 5800.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 7570.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 8430.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 8470.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Rattus norvegicus | WBC | 8700.0 | cells.uL-1 | 10.6019/CHEMBL3885881 |
| Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | IC50 | nan | None | None |
| Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Ki | nan | None | None |
| Rattus norvegicus | Serotonin 1b (5-HT1b) receptor | IC50 | nan | None | None |
| Rattus norvegicus | Serotonin 1b (5-HT1b) receptor | Ki | nan | None | None |
| Rattus norvegicus | Solute carrier family 22 member 1 | Activity | nan | None | 10.1016/s0006-2952(00)00334-8 |
| Rattus norvegicus | Solute carrier family 22 member 2 | Activity | nan | None | 10.1016/s0006-2952(00)00334-8 |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 891.3 | nM | None |
| Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1C subunit | AC50 | 10000.0 | nM | 10.1038/s41467-023-40064-9 |
| Severe acute respiratory syndrome coronavirus 2 | Replicase polyprotein 1ab | Inhibition | 20.65 | % | 10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Hit score | -0.0665 | None | 10.1101/2020.04.21.054387 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | -4.27 | % | 10.21203/rs.3.rs-23951/v1 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | -0.18 | % | 10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition index | -0.1033 | None | 10.1101/2020.04.03.023846 |
| Staphylococcus aureus | Staphylococcus aureus | Inhibition | 17.83 | % | 10.6019/CHEMBL4513141 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 1000000.0 | nM | 10.1128/aac.00081-07 |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC | nan | None | 10.1128/aac.00081-07 |
| Streptococcus sp. | Streptococcus sp. | MIC | 1000000.0 | nM | 10.1128/aac.00081-07 |
| Suid alphaherpesvirus 1 | Suid alphaherpesvirus 1 | Inhibition | nan | % | 10.1021/jm00191a011 |
| Toxoplasma gondii | Toxoplasma gondii | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Trichomonas vaginalis | Trichomonas vaginalis | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Trypanosoma brucei | 6-phospho-1-fructokinase | Potency | 7.6 | nM | None |
| Trypanosoma brucei | Trypanosoma brucei | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Trypanosoma brucei brucei | Trypanosoma brucei brucei | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Trypanosoma cruzi | Trypanosoma cruzi | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| Vaccinia virus | Vaccinia virus | ED50 | 0.00034 | mM l-1 | 10.1021/jm00382a005 |
| Vaccinia virus | Vaccinia virus | ED50 | 0.07 | uM | 10.1021/jm00227a018 |
| Vaccinia virus | Vaccinia virus | Inhibition | nan | % | 10.1021/jm00191a011 |
| Vaccinia virus | Vaccinia virus | MIC | 0.02 | ug.mL-1 | 10.1021/jm00192a008 |
| Vaccinia virus | Vaccinia virus | MID | 0.02 | ug ml-1 | 10.1021/jm00191a010 |
| Vaccinia virus | Vaccinia virus | Virus rating | 2.8 | None | 10.1021/jm00382a005 |
| Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) | Thymidine kinase | IC50 | 1000000.0 | nM | 10.1016/j.bmc.2007.01.049 |
| Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) | Thymidine kinase | IC50 | 1000000.0 | nM | 10.1016/s0960-894x(01)00207-4 |
| Vesicular stomatitis virus | Vesicular stomatitis virus | MIC | 4.0 | ug.mL-1 | 10.1021/jm00192a008 |
| Vesicular stomatitis virus | Vesicular stomatitis virus | MID | 10.0 | ug ml-1 | 10.1021/jm00191a010 |
| None | ADMET | Activity | nan | None | 10.1021/acs.jmedchem.1c01196 |
| None | ADMET | CC50 | 100000.0 | nM | 10.1021/jm800981y |
| None | ADMET | CL | 169300.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| None | ADMET | CL | 228300.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| None | ADMET | CL | 245100.0 | mL.min-1.g-1 | 10.1124/dmd.112.048769 |
| None | ADMET | F | 20.0 | % | 10.1021/acs.jmedchem.1c00790 |
| None | ADMET | GI50 | 250.0 | nM | 10.1021/np200523b |
| None | ADMET | IC50 | 590.0 | nM | 10.1016/j.bmcl.2013.03.048 |
| None | ADMET | IC50 | 700.0 | nM | 10.1021/jm061445m |
| None | ADMET | IC50 | 800.0 | nM | 10.1016/j.ejmech.2010.03.021 |
| None | ADMET | IC50 | 2300.0 | nM | 10.1021/jm00078a006 |
| None | ADMET | IC50 | 4990.0 | nM | 10.1016/j.bmc.2016.04.003 |
| None | ADMET | ID50 | 0.03 | ug ml-1 | 10.1021/jm00152a007 |
| None | ADMET | ID50 | 0.04 | ug ml-1 | 10.1021/jm00152a007 |
| None | ADMET | ID50 | 0.05 | ug ml-1 | 10.1021/jm00152a007 |
| None | ADMET | ID50 | 200.0 | ug ml-1 | 10.1021/jm00152a007 |
| None | ADMET | Km | 1560.0 | nM | 10.1124/dmd.112.048769 |
| None | ADMET | Km | 2450.0 | nM | 10.1124/dmd.112.048769 |
| None | ADMET | Km | 2540.0 | nM | 10.1124/dmd.112.048769 |
| None | ADMET | MIC | 0.05 | ug.mL-1 | 10.1021/jm00192a008 |
| None | ADMET | MIC | 0.1 | ug.mL-1 | 10.1021/jm00192a008 |
| None | ADMET | Ratio | 2.0 | None | 10.1124/dmd.112.048769 |
| None | ADMET | Ratio | 2.5 | None | 10.1124/dmd.112.048769 |
| None | ADMET | Ratio | 2.7 | None | 10.1124/dmd.112.048769 |
| None | ADMET | Ratio | 6.0 | None | 10.1124/dmd.112.048769 |
| None | ADMET | Ratio IC50 | 0.6 | None | 10.1016/j.bmcl.2013.03.048 |
| None | ADMET | Ratio IC50 | 2.0 | None | 10.1016/j.ejmech.2022.114651 |
| None | ADMET | Vmax | 264.0 | nmol/min/mg | 10.1124/dmd.112.048769 |
| None | ADMET | Vmax | 580.3 | nmol/min/mg | 10.1124/dmd.112.048769 |
| None | ADMET | Vmax | 599.4 | nmol/min/mg | 10.1124/dmd.112.048769 |
| None | AMML | IC50 | 2300.0 | nM | 10.1021/jm00160a041 |
| None | Bone marrow cell | GI50 | 64100.0 | nM | 10.1021/acs.jmedchem.8b00813 |
| None | CML/BC | IC50 | 210.0 | nM | 10.1021/jm00160a041 |
| None | Glioblastoma cell line | IC50 | 100000.0 | nM | 10.1021/jm00160a041 |
| None | Hepatotoxicity | Alkaline Phosphatase Increase - Activity Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Alkaline Phosphatase Increase - Index Value | 4.1 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Alkaline Phosphatase Increase - Number of Reports | 4.0 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Composite Activity - Active | 3.0 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Composite Activity - Marginal | 0.0 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Composite Activity - Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | GGT Increase - Activity Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | GGT Increase - Index Value | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | GGT Increase - Number of Reports | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | Hepatotoxicity | nan | None | 10.1021/tx900326k |
| None | Hepatotoxicity | HepSE_bilirubinemia | 1.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_cholecystitis | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_cholelithiasis | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_cirrhosis | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_Combined Scores | 2.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_elevated liver function tests | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_hepatic failure | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_hepatic necrosis | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_hepatitis | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_hepatomegaly | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_jaundice | 1.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_liver disease | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_liver fatty | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | HepSE_liver function tests abnormal | 0.0 | None | 10.1371/journal.pcbi.1002310 |
| None | Hepatotoxicity | LDH Increase - Activity Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | LDH Increase - Index Value | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | LDH Increase - Number of Reports | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | LTKB_BD DILI severity score | 3.0 | None | 10.1016/j.drudis.2011.05.007 |
| None | Hepatotoxicity | SGOT Increase - Activity Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | SGOT Increase - Index Value | 6.1 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | SGOT Increase - Number of Reports | 4.0 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | SGPT Increase - Activity Score | nan | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | SGPT Increase - Index Value | 4.1 | None | 10.2174/1570163043334794 |
| None | Hepatotoxicity | SGPT Increase - Number of Reports | 4.0 | None | 10.2174/1570163043334794 |
| None | L1210 (1565) | ID50 | 0.1 | ug ml-1 | 10.1021/jm00077a017 |
| None | NON-PROTEIN TARGET | AbsAC35_uM | 0.477 | uM | None |
| None | NON-PROTEIN TARGET | Activity | 0.0 | Zone units | 10.1021/np50064a011 |
| None | NON-PROTEIN TARGET | Activity | 18.0 | % | 10.1021/jm00205a025 |
| None | NON-PROTEIN TARGET | Activity | 55.0 | % | 10.1016/j.bmcl.2009.06.056 |
| None | NON-PROTEIN TARGET | Activity | 76.0 | % | 10.1021/jm00205a025 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1016/j.bmcl.2009.06.056 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/acs.jmedchem.5b01275 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/jm00205a025 |
| None | NON-PROTEIN TARGET | EC50 | 22.8 | nM | 10.1021/jm9005059 |
| None | NON-PROTEIN TARGET | EC50 | 261.2 | nM | 10.1021/jm9005059 |
| None | NON-PROTEIN TARGET | ED50 | 0.1 | uM | 10.1021/jm00353a010 |
| None | NON-PROTEIN TARGET | ED50 | 1.88 | ug ml-1 | 10.1021/np50077a010 |
| None | NON-PROTEIN TARGET | ED50 | 2.13 | ug ml-1 | 10.1021/np50077a010 |
| None | NON-PROTEIN TARGET | ED50 | 2.67 | ug ml-1 | 10.1021/np50077a010 |
| None | NON-PROTEIN TARGET | ED50 | 4.6 | ug ml-1 | 10.1021/np50077a010 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (acute) | 28.6 | % | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (animal toxicity known) | nan | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (benign tumour) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (granulomatous hepatitis) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (mechanism) | nan | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (moderate) | 33.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (moderate) | 75.0 | % | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | Hepatotoxicity (time to onset) | nan | None | 10.1016/s0399-8320(04)95062-2 |
| None | NON-PROTEIN TARGET | IC50 | 29.0 | nM | 10.1021/jm800981y |
| None | NON-PROTEIN TARGET | IC50 | 150.0 | nM | 10.1016/j.ejmech.2014.06.031 |
| None | NON-PROTEIN TARGET | IC50 | 260.0 | nM | 10.1016/j.bmcl.2010.01.039 |
| None | NON-PROTEIN TARGET | IC50 | 650.0 | nM | 10.1021/jm0004446 |
| None | NON-PROTEIN TARGET | IC50 | 780.0 | nM | 10.1021/jm0004446 |
| None | NON-PROTEIN TARGET | IC50 | 920.0 | nM | 10.1016/j.bmcl.2013.03.048 |
| None | NON-PROTEIN TARGET | IC50 | 1700.0 | nM | 10.1016/j.bmc.2009.07.038 |
| None | NON-PROTEIN TARGET | IC50 | 2120.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| None | NON-PROTEIN TARGET | IC50 | 3980.0 | nM | 10.1021/acs.jmedchem.5b00553 |
| None | NON-PROTEIN TARGET | IC50 | 33300.0 | nM | 10.1016/j.ejmech.2010.03.021 |
| None | NON-PROTEIN TARGET | IC50 | 100000.0 | nM | 10.1016/j.bmc.2009.07.038 |
| None | NON-PROTEIN TARGET | IC50 | 6333000.0 | nM | 10.1016/j.bmc.2009.07.038 |
| None | NON-PROTEIN TARGET | IC50 | nan | None | 10.1016/j.bmc.2010.01.068 |
| None | NON-PROTEIN TARGET | Inhibition | 91.0 | % | 10.1021/jm00209a010 |
| None | Non-small cell lung cancer cell line | IC50 | 34000.0 | nM | 10.1021/jm00160a041 |
| None | No relevant target | AbsAC35 | 7.36 | uM | None |
| None | No relevant target | LogD | -2.13 | None | 10.1021/jm00169a014 |
| None | No relevant target | LogP | -2.8 | None | 10.1016/j.ejmech.2009.12.043 |
| None | No relevant target | LogP | -2.13 | None | 10.1021/jm00369a019 |
| None | No relevant target | LogP | -0.94 | None | 10.1016/j.ejmech.2009.02.028 |
| None | No relevant target | Retention_time | 2.07 | min | 10.1021/jm00209a010 |
| None | No relevant target | T1/2 | 34.0 | hr | 10.1021/jm00196a015 |
| None | Nucleic Acid | Inhibition | 83.0 | % | 10.1016/S0960-894X(01)81161-6 |
| None | Osteoclast-like | Inhibition | 99.0 | % | 10.1021/jm00365a003 |
| None | Phospholipidosis | Phospholipidosis | nan | None | 10.1080/15376510701857262 |
| None | Small cell lung cancer cell line | IC50 | 100000.0 | nM | 10.1021/jm00160a041 |
| None | Unchecked | AbsAC35 | 15.82 | uM | None |
| None | Unchecked | AbsAC35 | 26.13 | uM | None |
| None | Unchecked | AbsAC35 | 27.48 | uM | None |
| None | Unchecked | AbsAC35_uM | 0.448 | uM | None |
| None | Unchecked | Ac50 | 10.0 | uM | None |
| None | Unchecked | Ac50 | 28.18 | uM | None |
| None | Unchecked | Ac50 | 35.48 | uM | None |
| None | Unchecked | AC50 | 10000.0 | nM | None |
| None | Unchecked | AC50 | 28183.8 | nM | None |
| None | Unchecked | AC50 | 35481.3 | nM | None |
| None | Unchecked | CC50 | 190.0 | nM | 10.1016/j.bmcl.2022.128605 |
| None | Unchecked | CC50 | 1799.0 | nM | None |
| None | Unchecked | GI50 | 100000.0 | nM | 10.1021/acs.jmedchem.8b00813 |
| None | Unchecked | Hepatotoxicity (acute) | 14.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (association with vascular disease) | 7.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (choleostasis) | 3.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (chronic liver disease) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (cirrhosis) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (comment) | nan | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (cytolytic) | 6.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (malignant tumour) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (severe hepatitis) | 6.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (steatosis) | 0.0 | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | Hepatotoxicity (successful reintroduction) | nan | None | 10.1016/s0399-8320(04)95062-2 |
| None | Unchecked | IC50 | 3.7 | nM | 10.1016/S0960-894X(97)00044-9 |
| None | Unchecked | IC50 | 30.0 | nM | 10.1016/S0960-894X(97)00044-9 |
| None | Unchecked | IC50 | 160.0 | nM | None |
| None | Unchecked | IC50 | 5940.0 | nM | 10.1016/j.ejmech.2020.112624 |
| None | Unchecked | IC50 | 80000.0 | nM | None |
| None | Unchecked | IC50 | nan | None | None |
| None | Unchecked | Ki | nan | None | None |
| None | Unchecked | Max_Activity | 26.0 | uM | None |
| None | Unchecked | Potency | 446.7 | nM | None |
| None | Unchecked | Potency | 5011.9 | nM | None |
| None | Unchecked | Potency | 5802.4 | nM | None |
| None | Unchecked | Potency | 5804.8 | nM | None |
| None | Unchecked | Potency | 7079.5 | nM | None |
| None | Unchecked | Potency | 35481.3 | nM | None |
| None | Unchecked | Ratio | 0.902 | None | 10.1016/s0960-894x(01)00513-3 |
| None | Unchecked | Ratio | 1.0 | None | 10.1021/jm00111a004 |
| None | Unchecked | Ratio IC50 | 1.23 | None | 10.1016/j.bmc.2016.04.003 |
| None | Unchecked | Ratio IC50 | 1.23 | None | 10.1016/j.bmcl.2019.08.003 |
| None | Unchecked | Ratio IC50 | 1.23 | None | 10.1021/acs.jmedchem.6b00764 |
| None | Unchecked | Ratio IC50 | 1.31 | None | 10.1021/acs.jmedchem.6b00764 |
| None | Unchecked | Ratio IC50 | 1.41 | None | 10.1016/j.bmcl.2019.08.003 |
| None | Unchecked | Ratio IC50 | 1.41 | None | 10.1021/acs.jmedchem.6b00764 |
| None | Unchecked | Ratio IC50 | 1.44 | None | 10.1016/j.bmcl.2019.08.003 |
| None | Unchecked | Ratio IC50 | 1.73 | None | 10.1016/j.bmcl.2019.08.003 |
| None | Unchecked | Ratio IC50 | 1.75 | None | 10.1016/j.bmcl.2019.08.003 |
| None | Unchecked | Ratio IC50 | 1.75 | None | 10.1021/acs.jmedchem.6b00764 |
| None | Unchecked | Ratio IC50 | 6.0 | None | 10.1016/j.ejmech.2020.112624 |
| None | Unchecked | Ratio IC50 | 6.83 | None | 10.1016/j.ejmech.2020.112624 |
| None | Unchecked | Ratio IC50 | 6.99 | None | 10.1016/j.ejmech.2020.112624 |
| None | Unchecked | Ratio IC50 | 7.16 | None | 10.1016/j.ejmech.2020.112624 |
| None | Unchecked | Ratio IC50 | 7.33 | None | 10.1016/j.ejmech.2020.112624 |