Navigation

name Structure Reference Source Properties Activities Metabolism

Arborinine

AlkaPlorer ID: AK001199

Synonym: None

IUPAC Name: 1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one

Structure

SMILES: COC1=CC2=C(C(O)=C1OC)C(=O)C1=CC=CC=C1N2C

copy

InChI: InChI=1S/C16H15NO4/c1-17-10-7-5-4-6-9(10)14(18)13-11(17)8-12(20-2)16(21-3)15(13)19/h4-8,19H,1-3H3

copy

InChIKey: ATBZZQPALSPNMF-UHFFFAOYSA-N

copy

Reference

Furoquinoline Alkaloids from Teclea nobilis.

PubChem CID: 5281832

CAS: 5489-57-6

LOTUS: LTS0214986

SuperNatural Ⅲ: SN0014682

COCONUT: CNP0178533

data_source: manually

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 285.29900000000004

TPSA？: 60.69

MolLogP？: 2.4145000000000003

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens A549 IC50 35000.0 nM 10.1016/j.bmc.2010.03.040
Homo sapiens Adenosine A3 receptor Displacement 63.0 % 10.1021/jm950661k
Homo sapiens DLD-1 IC50 74000.0 nM 10.1016/j.bmc.2010.03.040
Homo sapiens Lysine-specific histone demethylase 1 Inhibition 99.33 % 10.1016/j.ejmech.2021.114042
Homo sapiens Monoamine oxidase A Inhibition 23.67 % 10.1016/j.ejmech.2021.114042
Homo sapiens Monoamine oxidase B Inhibition 31.0 % 10.1016/j.ejmech.2021.114042
Homo sapiens Raji Activity 60.0 % 10.1021/np0400611
Homo sapiens Raji Activity 80.0 % 10.1021/np0400611
Homo sapiens SGC-7901 IC50 1960.0 nM 10.1016/j.ejmech.2021.114042
Plasmodium falciparum Plasmodium falciparum IC50 3850.0 nM 10.1021/np0106182
Plasmodium falciparum Plasmodium falciparum IC50 9340.0 nM 10.1021/np0106182
Rattus norvegicus Adenosine A1 receptor Ki 12700.0 nM 10.1021/jm950661k
Rattus norvegicus Adenosine A2a receptor Ki 6470.0 nM 10.1021/jm950661k
None Heme IC50 42000.0 nM 10.1016/j.bmcl.2011.04.127
None Heme Inhibition nan % 10.1016/j.bmcl.2011.04.127
None Heme Ka 3.9 10'4/M 10.1016/j.bmcl.2011.04.127
None NON-PROTEIN TARGET IC50 56000.0 nM 10.1016/j.bmc.2010.03.040
None Unchecked Activity 2.7 % 10.1021/np0400611
None Unchecked Activity 39.6 % 10.1021/np0400611
None Unchecked Activity 74.3 % 10.1021/np0400611
None Unchecked Activity 95.6 % 10.1021/np0400611
None Unchecked IC50 240.0 nM 10.1016/j.ejmech.2021.114042

Metabolism Information