4(3H)-Quinazolinone, 2-(2-hydroxyphenyl)-
AlkaPlorer ID: AK001298
Synonym: None
IUPAC Name: 2-(2-hydroxyphenyl)-3H-quinazolin-4-one
Structure
SMILES: C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=CC=C3O
InChI: InChI=1S/C14H10N2O2/c17-12-8-4-2-6-10(12)13-15-11-7-3-1-5-9(11)14(18)16-13/h1-8,17H,(H,15,16,18)
InChIKey: OVVWPYNVWLHEGE-UHFFFAOYSA-N
Reference
Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria
PubChem CID: 135458774
CAS: 1026-04-6
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Isatis tinctoria | Isatis | Brassicaceae | Brassicales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 238.246
TPSA？: 65.98
MolLogP？: 2.2957000000000005
Number of H-Donors: 2
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 15-hydroxyprostaglandin dehydrogenase [NAD+] | Potency | 2818.4 | nM | None |
| Homo sapiens | Beta-glucuronidase | IC50 | 10000.0 | nM | 10.1016/j.bmc.2014.04.039 |
| Homo sapiens | Beta-glucuronidase | IC50 | 10000.0 | nM | 10.1016/j.ejmech.2019.111921 |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 3162.3 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 35481.3 | nM | None |
| Homo sapiens | PC-3 | IC50 | 30000.0 | nM | 10.1016/j.bmc.2014.04.039 |
| Trypanosoma cruzi | Cruzipain | Potency | 31622.8 | nM | None |
| None | Unchecked | IC50 | 10360.0 | nM | 10.1016/j.bmc.2015.10.038 |
| None | Unchecked | Potency | 11220.2 | nM | None |
| None | Unchecked | Potency | 12589.3 | nM | None |
| None | Unchecked | Potency | 14125.4 | nM | None |