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Isogranulatimide

AlkaPlorer ID: AK001306

Synonym: None

IUPAC Name: 8-hydroxy-2,4,9,19-tetrazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(19),3,5,7,11,13,15,17-octaen-10-one

Structure

SMILES: O=C1N=C(O)C2=C1C1=C(NC3=CC=CC=C31)N1C=NC=C21

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InChI: InChI=1S/C15H8N4O2/c20-14-11-9-5-16-6-19(9)13-10(12(11)15(21)18-14)7-3-1-2-4-8(7)17-13/h1-6,17H,(H,18,20,21)

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InChIKey: WXUJAQBSBZLVEV-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Didemnum granulatum Didemnum Didemnidae Aplousobranchia Ascidiacea Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 276.255

TPSA？: 82.74999999999999

MolLogP？: 2.4272

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change 1.9 degrees C 10.1073/pnas.0708800104
Homo sapiens A549 IC50 18100.0 nM 10.1016/j.bmc.2007.05.073
Homo sapiens A549 IC50 79000.0 nM 10.1016/j.ejmech.2012.06.012
Homo sapiens Activin receptor type-1B Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change 3.6 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change 3.4 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change 3.6 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change 6.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase beta Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 5.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I delta Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 4.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 3.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 3.6 degrees C 10.1073/pnas.0708800104
Homo sapiens CDK3/cyclin E Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1 IC50 10000.0 nM 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 5.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 2.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 3.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Death-associated protein kinase 1 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change 5.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens DNA-dependent protein kinase IC50 10000.0 nM 10.1073/pnas.0708800104
Homo sapiens DNA topoisomerase I Activity nan None 10.1016/j.bmc.2007.05.073
Homo sapiens DU-145 IC50 13100.0 nM 10.1016/j.bmc.2007.05.073
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change 5.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 14.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change 2.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 4.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Ephrin type-A receptor 1 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta IC50 500.0 nM 10.1073/pnas.0708800104
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 8.8 degrees C 10.1073/pnas.0708800104
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens HCT-116 Activity 17.2 % 10.1016/j.ejmech.2012.06.012
Homo sapiens HCT-116 Activity_index 17.2 None 10.1016/j.bmcl.2021.128009
Homo sapiens HCT-116 IC50 13000.0 nM 10.1016/j.bmc.2008.02.061
Homo sapiens HCT-116 IC50 13000.0 nM 10.1021/jm070664k
Homo sapiens Hepatocyte growth factor receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 146.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens HT-29 IC50 13700.0 nM 10.1016/j.bmc.2007.05.073
Homo sapiens HT-29 IC50 13700.0 nM 10.1016/j.bmc.2008.02.061
Homo sapiens HT-29 IC50 13700.0 nM 10.1016/j.ejmech.2007.03.026
Homo sapiens HT-29 IC50 13700.0 nM 10.1021/jm070664k
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 3.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase IC50 100.0 nM 10.1016/j.bmcl.2011.04.149
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens LoVo IC50 62000.0 nM 10.1016/j.ejmech.2012.06.012
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens MCF7 Activity 35.0 % 10.1021/np060285e
Homo sapiens MCF7 IC50 1000.0 nM 10.1021/np0304316
Homo sapiens MCF7 IC50 40000.0 nM 10.1021/np0304316
Homo sapiens MCF7 IC50 99000.0 nM 10.1016/j.ejmech.2012.06.012
Homo sapiens Misshapen-like kinase 1 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 2.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change 2.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens PC-3 IC50 91000.0 nM 10.1016/j.ejmech.2012.06.012
Homo sapiens PDZ-binding kinase Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 5.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 5.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 7.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 2.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change nan None 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 2.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 100.0 nM 10.1016/j.bmc.2008.02.061
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 100.0 nM 10.1016/j.bmc.2014.06.028
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 100.0 nM 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 440.0 nM 10.1016/j.bmc.2007.05.073
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 440.0 nM 10.1016/j.ejmech.2007.03.026
Homo sapiens Serine/threonine-protein kinase Chk1 IC50 440.0 nM 10.1021/jm070664k
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 89.7 % 10.1016/j.bmc.2007.05.073
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 89.7 % 10.1016/j.bmc.2008.02.061
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 89.7 % 10.1016/j.ejmech.2007.03.026
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 89.7 % 10.1021/jm070664k
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 IC50 3000.0 nM 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change 6.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 5.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 2.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change 1.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 1.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 3.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change 1.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change 3.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change 9.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 8.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 8.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 9.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 3.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 7.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 1.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 7.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 2.0 % 10.1042/bj20121418
Mus musculus B16-F10 IC50 35000.0 nM 10.1016/j.ejmech.2012.06.012
Mus musculus L1210 IC50 10000.0 nM 10.1016/j.bmc.2007.05.073
Mus musculus L1210 IC50 10000.0 nM 10.1016/j.bmc.2008.02.061
Mus musculus L1210 IC50 10000.0 nM 10.1016/j.ejmech.2007.03.026
Mus musculus L1210 IC50 10000.0 nM 10.1021/jm070664k
None NON-PROTEIN TARGET IC50 13000.0 nM 10.1016/j.ejmech.2007.03.026
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1016/j.ejmech.2012.06.012
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2012.06.012
None Unchecked Activity nan None 10.1016/j.bmc.2007.05.073

Metabolism Information