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name Structure Reference Source Properties Activities Metabolism

Harmine

AlkaPlorer ID: AK001335

Synonym: None

IUPAC Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

Structure

SMILES: COC1=CC=C2C(=C1)NC1=C(C)N=CC=C12

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InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

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InChIKey: BXNJHAXVSOCGBA-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Kopsia griffithii Kopsia Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 212.252

TPSA？: 37.91

MolLogP？: 3.033120000000001

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Alternaria solani Alternaria solani Activity 15.7 % 10.1016/j.ejmech.2021.114057
Bipolaris maydis Bipolaris maydis Activity 22.7 % 10.1016/j.ejmech.2021.114057
Bos taurus Calf thymus DNA Activity 320.0 nm 10.1039/C6MD00681G
Bos taurus Dopamine transporter Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Brassica rapa subsp. oleifera Brassica rapa subsp. oleifera GI 20.16 % 10.3390/molecules17043969
Brassica rapa subsp. oleifera Brassica rapa subsp. oleifera GI 53.71 % 10.3390/molecules17043969
Brugia malayi Endochitinase Inhibition nan % 10.1021/ml500516r
Caenorhabditis elegans Caenorhabditis elegans Drug uptake 0.052 nmol/mg 10.1021/ml500516r
Candida albicans Candida albicans MIC 500.0 ug.mL-1 10.1016/j.ejmech.2021.114057
Canis lupus familiaris MDCK-II GI50 2300.0 nM 10.1021/acs.jmedchem.6b00035
Canis lupus familiaris MDCK-II GI50 2420.0 nM 10.1021/acs.jmedchem.6b00035
Culex quinquefasciatus Culex quinquefasciatus Activity nan None 10.3390/molecules15117775
Echinochloa crus-galli Echinochloa crus-galli GI 10.82 % 10.3390/molecules17043969
Echinochloa crus-galli Echinochloa crus-galli GI 32.49 % 10.3390/molecules17043969
Electrophorus electricus Acetylcholinesterase IC50 10100.0 nM 10.1016/j.ejmech.2021.114095
Electrophorus electricus Acetylcholinesterase IC50 22890.0 nM 10.1016/j.bmcl.2012.02.057
Electrophorus electricus Acetylcholinesterase Inhibition 74.1 % 10.1016/j.bmcl.2012.02.057
Equus caballus Cholinesterase IC50 13600.0 nM 10.1016/j.ejmech.2021.114095
Equus caballus Cholinesterase Inhibition 74.1 % 10.1016/j.ejmech.2021.114095
Gallus gallus Tyrosine-protein kinase SRC Activity 88.0 % 10.1042/bj20070797
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 5011.9 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 7943.3 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 31622.8 nM None
Homo sapiens 1A9 ED50 1.6 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 87.0 % 10.1042/bj20070797
Homo sapiens 769-P IC50 48900.0 nM 10.1016/j.ejmech.2012.11.033
Homo sapiens 769-P IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens 786-0 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens A-375 IC50 72500.0 nM 10.1016/j.ejmech.2012.11.033
Homo sapiens A-375 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens A549 Activity nan None 10.1016/j.bmc.2021.116367
Homo sapiens A549 ED50 2.4 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens A549 IC50 5230.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens A549 IC50 5890.0 nM 10.1016/j.bmc.2019.06.007
Homo sapiens A549 IC50 7760.0 nM 10.1016/j.ejmech.2017.10.054
Homo sapiens A549 IC50 17120.0 nM 10.1016/j.bmc.2021.116367
Homo sapiens A549 IC50 42250.0 nM 10.1016/j.bmcl.2016.06.087
Homo sapiens A549 IC50 52560.0 nM 10.1039/C5MD00581G
Homo sapiens A549 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens Acetylcholinesterase IC50 11300.0 nM 10.1016/j.ejmech.2018.08.093
Homo sapiens Acetylcholinesterase IC50 nan None 10.1016/j.bmcl.2012.02.057
Homo sapiens Acetylcholinesterase Inhibition 23.75 % 10.1016/j.bmcl.2012.02.057
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 5623.4 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 8912.5 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 11220.2 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 31622.8 nM None
Homo sapiens Alpha-1a adrenergic receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Alpha-1b adrenergic receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Alpha-2a adrenergic receptor Inhibition 59.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Alpha-2a adrenergic receptor Ki 2540.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Alpha-2b adrenergic receptor Inhibition 32.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Alpha-2b adrenergic receptor Ki 1130.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Alpha-2c adrenergic receptor Inhibition 45.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Alpha-2c adrenergic receptor Ki 810.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 15848.9 nM None
Homo sapiens Ataxin-2 Potency 10000.0 nM None
Homo sapiens ATP-binding cassette sub-family G member 2 GI50 1220.0 nM 10.1021/acs.jmedchem.6b00035
Homo sapiens ATP-binding cassette sub-family G member 2 GI50 1840.0 nM 10.1021/acs.jmedchem.6b00035
Homo sapiens ATP-binding cassette sub-family G member 2 GI50 1950.0 nM 10.1021/acs.jmedchem.6b00035
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 5080.0 nM 10.1021/acs.jmedchem.6b00035
Homo sapiens ATP-binding cassette sub-family G member 2 Inhibition nan % 10.1021/acs.jmedchem.6b00035
Homo sapiens Bel-7402 Activity 36.1 % 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel-7402 Activity nan None 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel-7402 IC50 54000.0 nM 10.1016/j.ejmech.2008.03.030
Homo sapiens Bel-7402 IC50 54000.0 nM 10.1016/j.ejmech.2012.11.045
Homo sapiens Bel-7402 IC50 nan None 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel7402/5-FU Activity 2.68 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 6.24 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 17.12 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 73.96 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity nan None 10.1016/j.ejmech.2019.02.054
Homo sapiens Beta-1 adrenergic receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Beta-2 adrenergic receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens BGC-823 IC50 15630.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens BGC-823 IC50 63200.0 nM 10.1016/j.ejmech.2012.11.033
Homo sapiens BGC-823 IC50 68000.0 nM 10.1016/j.ejmech.2008.03.030
Homo sapiens BGC-823 IC50 68000.0 nM 10.1016/j.ejmech.2012.11.045
Homo sapiens BR serine/threonine-protein kinase 2 Activity 83.0 % 10.1042/bj20070797
Homo sapiens CAKI-1 ED50 1.9 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens CAL-27 Activity 64.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 82.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 90.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 92.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 93.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 107.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 110.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 113.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 133.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 139.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 141.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 143.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Activity 210.0 % 10.1021/acsmedchemlett.1c00630
Homo sapiens CAL-27 Inhibition nan % 10.1021/acsmedchemlett.1c00630
Homo sapiens CaM kinase I alpha Activity 94.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Activity 95.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 81.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 80.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 250000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Casein kinase I alpha Activity 15.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Casein kinase I alpha Activity 15.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Casein kinase I delta Activity 13.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Casein kinase I delta Activity 13.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Casein kinase I delta Activity 60.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta IC50 1500.0 nM 10.1042/bj20070797
Homo sapiens Casein kinase I delta/epsilon IC50 1500.0 nM 10.1016/j.ejmech.2016.07.040
Homo sapiens Casein kinase I epsilon Activity 1.7 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Casein kinase I epsilon Activity 1.7 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Casein kinase I epsilon IC50 10000.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Casein kinase I gamma 2 Activity 19.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Casein kinase I gamma 2 Activity 19.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Casein kinase II Activity 68.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II IC50 nan None 10.1016/j.ejmech.2016.02.017
Homo sapiens Casein kinase II Inhibition nan % 10.1021/jm301034u
Homo sapiens Casein kinase II alpha Activity 11.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Casein kinase II alpha Activity 11.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Casein kinase II alpha (prime) Activity 23.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens CDK2/Cyclin A2 IC50 10000.0 nM 10.1016/j.bmcl.2017.04.080
Homo sapiens CDK9/cyclin T1 IC50 720.0 nM 10.1021/jm301034u
Homo sapiens Cell division cycle 2-like protein kinase 6 Activity 83.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Cell division cycle 2-like protein kinase 6 Inhibition nan % 10.1021/acsmedchemlett.1c00630
Homo sapiens Cell division protein kinase 8 Activity 55.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Cell division protein kinase 8 Inhibition nan % 10.1021/acsmedchemlett.1c00630
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens Citron Rho-interacting kinase Activity 29.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens c-Jun N-terminal kinase 1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Activity 91.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Activity 91.0 % 10.1042/bj20070797
Homo sapiens COLO 205 IC50 8000.0 nM 10.1016/j.bmcl.2012.06.003
Homo sapiens COLO 205 IC50 8000.0 nM 10.1016/j.bmcl.2017.01.088
Homo sapiens COLO 205 IC50 26000.0 nM 10.1016/j.bmcl.2012.01.126
Homo sapiens COLO 205 IC50 46000.0 nM 10.1016/j.bmc.2011.12.001
Homo sapiens CWR22R IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens Cyclin-dependent kinase 1 IC50 17000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 17000.0 nM 10.1016/j.ejmech.2021.113688
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 18000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 2 IC50 33000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cyclin-dependent kinase 2 Inhibition 62.0 % 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 86.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 30000.0 nM 10.1021/jm301034u
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 33000.0 nM 10.1016/j.ejmech.2021.113688
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 35000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 5 IC50 8000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cyclin-dependent kinase 5 Inhibition 68.0 % 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 8000.0 nM 10.1016/j.bmcl.2014.09.017
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 8000.0 nM 10.1021/jm301034u
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 10000.0 nM 10.1016/j.ejmech.2012.11.030
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 10000.0 nM 10.1016/j.ejmech.2016.08.069
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 10000.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 20000.0 nM 10.1016/j.ejmech.2021.113688
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 21000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 7 Activity 21.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Cyclin-dependent kinase 7 Activity 21.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Cyclin-dependent kinase 7 IC50 10000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 10000.0 nM 10.1021/jm301034u
Homo sapiens Cyclin-dependent kinase 9 IC50 720.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Cyclin-dependent kinase-like 5 Activity 100.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Cytochrome P450 1A2 AC50 398.11 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2D6 Ki 50000.0 nM 10.1021/jm00061a004
Homo sapiens Cytochrome P450 2D6 Potency 7943.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 3A4 Potency 39810.7 nM None
Homo sapiens Death-associated protein kinase 1 Activity 78.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Death-associated protein kinase 2 Activity 72.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Death-associated protein kinase 3 Activity 69.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 7943.3 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 11220.2 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 19952.6 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 31622.8 nM None
Homo sapiens Dopamine receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens DU-145 IC50 9630.0 nM 10.1016/j.bmc.2019.06.007
Homo sapiens DU-145 IC50 12020.0 nM 10.1016/j.ejmech.2017.10.054
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 73.0 % 10.1042/bj20070797
Homo sapiens Dual specificity protein kinase CLK2 Activity 2.4 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual specificity protein kinase CLK2 Activity 2.4 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual specificity protein kinase CLK2 Activity nan None 10.1021/jm301034u
Homo sapiens Dual specificity protein kinase CLK2 IC50 120.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual specificity protein kinase CLK2 IC50 1152.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity protein kinase CLK3 Activity nan None 10.1021/jm301034u
Homo sapiens Dual specificity protein kinase CLK3 IC50 3000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual specificity protein kinase CLK3 IC50 8811.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity protein kinase CLK4 Activity 13.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual specificity protein kinase CLK4 Activity 13.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual specificity protein kinase CLK4 Activity nan None 10.1021/jm301034u
Homo sapiens Dual specificity protein kinase CLK4 IC50 24.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual specificity protein kinase CLK4 IC50 102.2 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity protein kinase CLK4 Potency 67.1 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 0.0 % 10.1016/j.ejmech.2018.08.007
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 0.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 0.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 4.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity nan None 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A FC 2.0 None 10.1021/acs.jmedchem.7b01847
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 8.81 nM 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 12.0 nM 10.1016/j.ejmech.2021.114062
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 21.83 nM 10.1021/acs.jmedchem.6b01083
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 22.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 27.0 nM 10.1021/acs.jmedchem.0c02050
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 27.0 nM 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 29.0 nM 10.1016/j.ejmech.2016.07.040
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 29.0 nM 10.1016/j.ejmech.2016.08.069
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 30.0 nM 10.1016/j.bmcl.2012.01.028
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 30.0 nM 10.1016/j.ejmech.2016.08.069
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 32.0 nM 10.1021/acs.jmedchem.1c00023
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 33.0 nM 10.1016/j.ejmech.2018.08.093
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 33.0 nM 10.1021/acs.jmedchem.5b00098
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 33.0 nM 10.1021/acs.jmedchem.6b01840
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 33.0 nM 10.1021/jm401049v
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 41.0 nM 10.1016/j.bmcl.2017.03.037
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 48.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 56.0 nM 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 60.0 nM 10.1016/j.bmcl.2014.09.017
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 60.0 nM 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 61.7 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1016/j.bmc.2022.116921
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1016/j.bmcl.2015.05.034
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1016/j.ejmech.2012.11.030
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1021/acsmedchemlett.1c00630
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1021/jm300542e
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 80.0 nM 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 85.0 nM 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 100.0 nM 10.1021/acs.jmedchem.0c02050
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 130.0 nM 10.1016/j.ejmech.2016.02.017
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 150.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 192.2 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 200.0 nM 10.1021/acs.jmedchem.1c01115
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 270.0 nM 10.1021/acs.jmedchem.2c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 400.0 nM 10.1016/j.ejmech.2016.02.017
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 700.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition 60.0 % 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/acs.jmedchem.2c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 5.474 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 13.4 nM 10.1021/acs.jmedchem.2c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 33.0 nM 10.1016/j.bmcl.2013.02.096
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A TIME 0.01967 hr 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Tm 10.5 degrees C 10.1021/acs.jmedchem.2c01887
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Activity 6.1 % 10.1016/j.ejmech.2018.08.007
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Activity 6.1 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Activity 6.1 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Activity nan None 10.1021/jm301034u
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 28.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 28.0 nM 10.1021/jm301034u
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 57.4 nM 10.1021/acs.jmedchem.6b01083
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 94.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 160.0 nM 10.1021/acs.jmedchem.6b01840
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 166.0 nM 10.1016/j.ejmech.2018.08.093
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 166.0 nM 10.1021/acs.jmedchem.5b00098
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 180.0 nM 10.1016/j.ejmech.2016.02.017
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 292.9 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibition nan % 10.1021/acs.jmedchem.5b00098
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibition nan % None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 166.0 nM 10.1016/j.bmcl.2013.02.096
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 3.2 % 10.1016/j.ejmech.2018.08.007
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 3.2 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 3.2 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 15.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity nan None 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 120.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 120.0 nM 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 690.0 nM 10.1016/j.bmcl.2012.01.028
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 900.0 nM 10.1016/j.ejmech.2012.11.030
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 900.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 900.0 nM 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 1900.0 nM 10.1016/j.ejmech.2018.08.093
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 1900.0 nM 10.1021/acs.jmedchem.3c00106
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 2000.0 nM 10.1021/acs.jmedchem.5b00098
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 2000.0 nM 10.1021/acs.jmedchem.6b01840
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 3000.0 nM 10.1016/j.ejmech.2016.02.017
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 3166.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 6.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 210.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 210.0 nM 10.1021/jm301034u
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 410.0 nM 10.1021/acs.jmedchem.6b01840
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 800.0 nM 10.1016/j.ejmech.2012.11.030
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 800.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 800.0 nM 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 2857.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 8356.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 9500.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 9500.0 nM 10.1021/jm301034u
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 74000.0 nM 10.1021/acs.jmedchem.5b00098
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 80000.0 nM 10.1016/j.ejmech.2018.08.093
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 IC50 80000.0 nM 10.1021/acs.jmedchem.6b01840
Homo sapiens Dual specificty protein kinase CLK1 AC50 11.6 nM None
Homo sapiens Dual specificty protein kinase CLK1 AC50 23.0 nM None
Homo sapiens Dual specificty protein kinase CLK1 Activity 0.35 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Dual specificty protein kinase CLK1 Activity 0.35 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Dual specificty protein kinase CLK1 Activity nan None 10.1021/jm301034u
Homo sapiens Dual specificty protein kinase CLK1 IC50 26.0 nM 10.1016/j.ejmech.2012.11.030
Homo sapiens Dual specificty protein kinase CLK1 IC50 26.0 nM 10.1016/j.ejmech.2016.08.069
Homo sapiens Dual specificty protein kinase CLK1 IC50 72.0 nM 10.1016/j.ejmech.2016.07.040
Homo sapiens Dual specificty protein kinase CLK1 IC50 220.0 nM 10.1016/j.ejmech.2016.02.017
Homo sapiens Dual specificty protein kinase CLK1 IC50 242.3 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificty protein kinase CLK1 IC50 298.9 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificty protein kinase CLK1 Inhibition nan % 10.1021/jm200274d
Homo sapiens Dual specificty protein kinase CLK1 Kd 12.11 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Dual specificty protein kinase CLK1 TIME 0.0165 hr 10.1021/acs.jmedchem.2c02068
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 12589.3 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 15848.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.ejmech.2016.02.017
Homo sapiens FaDu Activity nan None 10.1021/acsmedchemlett.1c00630
Homo sapiens Flap endonuclease 1 Potency 50118.7 nM None
Homo sapiens GABA-A receptor; anion channel IC50 100000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.bmcl.2014.09.017
Homo sapiens Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.ejmech.2016.07.040
Homo sapiens Glycogen synthase kinase-3 alpha IC50 10000.0 nM 10.1021/jm301034u
Homo sapiens Glycogen synthase kinase-3 beta Activity 87.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Activity nan None 10.1021/acs.jmedchem.2c02068
Homo sapiens Glycogen synthase kinase-3 beta IC50 350.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Glycogen synthase kinase-3 beta IC50 10000.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Glycogen synthase kinase-3 beta IC50 10000.0 nM 10.1021/jm301034u
Homo sapiens Glycogen synthase kinase-3 beta IC50 32100.0 nM 10.1016/j.ejmech.2021.113554
Homo sapiens Glycogen synthase kinase-3 beta IC50 32100.0 nM 10.1016/j.ejmech.2021.114095
Homo sapiens Glycogen synthase kinase-3 beta IC50 50000.0 nM 10.1021/acs.jmedchem.9b01624
Homo sapiens Glycogen synthase kinase-3 beta IC50 nan None 10.1016/j.bmcl.2017.03.037
Homo sapiens Glycogen synthase kinase-3 beta IC50 nan None 10.1021/acs.jmedchem.2c01887
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 29.0 % 10.1016/j.ejmech.2021.113554
Homo sapiens Glycogen synthase kinase-3 beta Inhibition nan % 10.1021/acs.jmedchem.2c01887
Homo sapiens Glycogen synthase kinase-3 beta Kd 3560.0 nM 10.1021/acs.jmedchem.2c01887
Homo sapiens Glycogen synthase kinase-3 beta Kd 10000.0 nM 10.1021/acs.jmedchem.2c02068
Homo sapiens Glycogen synthase kinase-3 beta Tm nan None 10.1021/acs.jmedchem.2c01887
Homo sapiens H9 IC50 26400.0 nM 10.1021/np0101189
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.5b01052
Homo sapiens HCT-116 IC50 6940.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens HCT-116 IC50 43800.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens HCT-116 IC50 43800.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens HCT-116 IC50 46700.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens HCT-116 IC50 46700.0 nM 10.1039/C6MD00681G
Homo sapiens Heat shock protein HSP90 Activity nan None 10.1021/jm901796s
Homo sapiens HEK-293T Activity nan None 10.1021/acsmedchemlett.1c00630
Homo sapiens HEK-293T Activity nan None 10.1021/ml500516r
Homo sapiens HEL ED50 1.9 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens HeLa IC50 8000.0 nM 10.1016/j.ejmech.2018.07.050
Homo sapiens HeLa IC50 9660.0 nM 10.1016/j.bmc.2019.06.007
Homo sapiens HeLa IC50 16210.0 nM 10.1016/j.ejmech.2017.10.054
Homo sapiens HeLa IC50 60000.0 nM 10.1016/j.ejmech.2008.03.030
Homo sapiens HeLa IC50 60000.0 nM 10.1016/j.ejmech.2012.11.045
Homo sapiens HeLa IC50 85280.0 nM 10.1039/C5MD00581G
Homo sapiens HepG2 IC50 16800.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens HepG2 IC50 46000.0 nM 10.1016/j.ejmech.2008.03.030
Homo sapiens HepG2 IC50 46000.0 nM 10.1016/j.ejmech.2012.11.045
Homo sapiens HepG2 IC50 49960.0 nM 10.1021/acs.jmedchem.0c00354
Homo sapiens HepG2 IC50 51200.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens HepG2 IC50 51200.0 nM 10.1039/C6MD00681G
Homo sapiens HepG2 IC50 53600.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens HepG2 IC50 53600.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens HepG2 IC50 250000.0 nM 10.1016/j.ejmech.2019.111927
Homo sapiens HepG2 IC50 250000.0 nM 10.1016/j.ejmech.2021.113687
Homo sapiens HepG2 IC50 250000.0 nM 10.1016/j.ejmech.2022.114408
Homo sapiens HGC-27 IC50 3520.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens Histone acetyltransferase GCN5 Potency 15848.9 nM None
Homo sapiens Histone deacetylase IC50 10000.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase IC50 10000.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase IC50 10000.0 nM 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 1 IC50 1000.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 1 IC50 1000.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Histone deacetylase 1 IC50 1000.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens HL-60 IC50 7550.0 nM 10.1021/acs.jnatprod.6b01146
Homo sapiens Homeodomain-interacting protein kinase 1 Activity 21.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 8.6 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 8.6 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 108.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 9.4 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 9.4 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Hs 683 IC50 37000.0 nM 10.1016/j.ejmech.2015.02.044
Homo sapiens Hs 683 IC50 37000.0 nM 10.1021/jm300542e
Homo sapiens HT-29 Activity 20.9 % 10.1021/acs.jmedchem.0c00354
Homo sapiens HT-29 Activity nan None 10.1021/acs.jmedchem.0c00354
Homo sapiens HT-29 IC50 3520.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HT-29 IC50 41800.0 nM 10.1021/acs.jmedchem.0c00354
Homo sapiens HT-29 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens Huh-7 IC50 nan None 10.1016/j.ejmech.2017.12.061
Homo sapiens Huh-7 IC50 nan None 10.1021/acs.jnatprod.8b00843
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 6309.6 nM None
Homo sapiens IMR-32 IC50 38000.0 nM 10.1016/j.bmcl.2012.01.126
Homo sapiens IMR-32 IC50 68000.0 nM 10.1016/j.bmc.2011.12.001
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 73.0 % 10.1042/bj20070797
Homo sapiens Interleukin-1 receptor-associated kinase 1 Activity 17.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Interleukin-1 receptor-associated kinase 1 Activity 17.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Interleukin-1 receptor-associated kinase 3 Activity 15.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Interleukin-1 receptor-associated kinase 3 Activity 15.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens K562 IC50 14000.0 nM 10.1016/j.bmcl.2012.06.003
Homo sapiens K562 IC50 14000.0 nM 10.1016/j.bmcl.2017.01.088
Homo sapiens K562 IC50 32000.0 nM 10.1016/j.bmcl.2012.01.126
Homo sapiens K562 IC50 45000.0 nM 10.1016/j.bmc.2011.12.001
Homo sapiens K562 IC50 45000.0 nM 10.1016/j.bmcl.2012.03.091
Homo sapiens KB ED50 2.2 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 2.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 3.7 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB ED50 4.3 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens KB IC50 57800.0 nM 10.1016/j.ejmech.2012.11.033
Homo sapiens KB IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens L02 IC50 25090.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens LoVo IC50 53200.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens LoVo IC50 53200.0 nM 10.1039/C6MD00681G
Homo sapiens Lysine-specific demethylase 4D-like Potency 12589.3 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 14125.4 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Activity 110.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Activity 98.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Activity 90.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Activity 95.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 IC50 30000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 82.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 100.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Activity 103.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Activity 88.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Activity 80.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Activity 8.0 % 10.1042/bj20070797
Homo sapiens MCF7 ED50 10.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens MCF7 IC50 3520.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens MCF7 IC50 10780.0 nM 10.1016/j.ejmech.2017.10.054
Homo sapiens MCF7 IC50 15270.0 nM 10.1016/j.bmcl.2022.128698
Homo sapiens MCF7 IC50 16940.0 nM 10.1016/j.bmcl.2021.127952
Homo sapiens MCF7 IC50 68330.0 nM 10.1016/j.bmcl.2016.06.087
Homo sapiens MCF7 IC50 70700.0 nM 10.1039/C5MD00581G
Homo sapiens MCF7 IC50 72000.0 nM 10.1016/j.ejmech.2008.03.030
Homo sapiens MCF7 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens MCF7 IC50 nan None 10.1016/j.ejmech.2017.12.061
Homo sapiens MDA-MB-231 IC50 21910.0 nM 10.1016/j.bmcl.2021.127952
Homo sapiens MDA-MB-231 IC50 32000.0 nM 10.1016/j.bmcl.2012.06.003
Homo sapiens MDA-MB-231 IC50 32000.0 nM 10.1016/j.bmcl.2017.01.088
Homo sapiens MDA-MB-231 IC50 54000.0 nM 10.1016/j.bmc.2011.12.001
Homo sapiens MDA-MB-231 IC50 54000.0 nM 10.1016/j.bmcl.2012.03.091
Homo sapiens MDA-MB-231 IC50 nan None 10.1016/j.ejmech.2021.113258
Homo sapiens MDA-MB-435 IC50 17100.0 nM 10.1016/j.ejmech.2021.113258
Homo sapiens MDA-MB-435 IC50 100000.0 nM 10.1016/j.ejmech.2021.113258
Homo sapiens MDA-MB-468 IC50 nan None 10.1016/j.ejmech.2021.113258
Homo sapiens Mitogen-activated protein kinase 15 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Monoamine oxidase A IC50 1.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.bmc.2022.117030
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.bmcl.2022.129038
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.ejmech.2022.114828
Homo sapiens Monoamine oxidase A IC50 5.0 nM 10.1016/j.bmc.2022.116921
Homo sapiens Monoamine oxidase A IC50 1000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Monoamine oxidase A Inhibition 95.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Monoamine oxidase A Ki 1.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Monoamine oxidase A Ki 5.0 nM 10.1016/j.bmcl.2009.11.106
Homo sapiens Monoamine oxidase A Ki 16.9 nM 10.1016/j.bmc.2010.11.041
Homo sapiens Monoamine oxidase A Ki 17.0 nM 10.1021/jm2006782
Homo sapiens Monoamine oxidase B Ki 120800.0 nM 10.1016/j.bmc.2010.11.041
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 35481.3 nM None
Homo sapiens Muscarinic acetylcholine receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Myosin light chain kinase, smooth muscle Activity 87.0 % 10.1042/bj20070797
Homo sapiens NCI-H1299 IC50 nan None 10.1016/j.ejmech.2019.02.054
Homo sapiens NCI-H2228 IC50 31060.0 nM 10.1016/j.bmc.2021.116367
Homo sapiens Nischarin Ki 22.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Nischarin Ki 13800.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Norepinephrine transporter Inhibition 86.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Norepinephrine transporter Ki 3260.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 23109.3 nM None
Homo sapiens Nuclear factor of activated T-cells cytoplasmic 1 EC50 nan None 10.1016/j.bmcl.2017.03.037
Homo sapiens OE33 IC50 18000.0 nM 10.1021/jm300542e
Homo sapiens OS-RC-2 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens PANC-1 Activity nan None None
Homo sapiens PANC-1 Inhibition nan % None
Homo sapiens PC-3 IC50 3520.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3 Activity 13.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3 Activity 13.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Activity 36.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens PI3-kinase p110-gamma subunit Activity 49.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens PI4-kinase beta subunit Activity 12.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens PI4-kinase beta subunit Activity 12.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Protein kinase C alpha Activity 82.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C beta IC50 nan None 10.1016/j.ejmech.2016.02.017
Homo sapiens Protein kinase C mu Activity 80.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C (PKC) IC50 250000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Protein kinase C (PKC) IC50 250000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Protein kinase C zeta Activity 83.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 1 IC50 1500.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Rho-associated protein kinase 2 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 IC50 40000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Ribosomal protein S6 kinase 1 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 105.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 4 Activity 40.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 83.0 % 10.1042/bj20070797
Homo sapiens SCaBER IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens Serine/threonine-protein kinase 17B Activity 73.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Serine/threonine-protein kinase AKT Activity 101.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 99.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 104.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase haspin Activity 2.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Serine/threonine-protein kinase haspin Activity 2.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Serine/threonine-protein kinase haspin IC50 590.0 nM 10.1016/j.bmcl.2012.01.028
Homo sapiens Serine/threonine-protein kinase haspin IC50 590.0 nM 10.1016/j.ejmech.2021.113688
Homo sapiens Serine/threonine-protein kinase MST2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 108.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 45.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 10000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Serine/threonine-protein kinase PIM1 IC50 10000.0 nM 10.1021/jm301034u
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 39.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 88.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 64.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 IC50 4300.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Serine/threonine-protein kinase PIM3 IC50 4300.0 nM 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 2a (5-HT2a) receptor Inhibition 23.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Serotonin 2c (5-HT2c) receptor Inhibition 75.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 9340.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 3 (5-HT3) receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 10000.0 nM 10.1021/jm030080s
Homo sapiens Serotonin 6 (5-HT6) receptor Inhibition 37.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 1480.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin 7 (5-HT7) receptor Inhibition 30.0 % 10.1021/acs.jmedchem.9b01379
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 5500.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens Serotonin transporter Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Homo sapiens SGC-7901 IC50 40820.0 nM 10.1016/j.bmcl.2016.06.087
Homo sapiens SH-SY5Y Activity nan None 10.1016/j.ejmech.2021.113911
Homo sapiens SK-MEL-2 ED50 18.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Homo sapiens SK-OV-3 IC50 74600.0 nM 10.1016/j.ejmech.2012.11.033
Homo sapiens SMMC-7721 IC50 47600.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens SMMC-7721 IC50 47600.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens SMMC-7721 IC50 55300.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens SMMC-7721 IC50 55300.0 nM 10.1039/C6MD00681G
Homo sapiens SMMC-7721 IC50 59440.0 nM 10.1016/j.bmcl.2016.06.087
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 105.32 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 101.75 % 10.1124/mol.112.084152
Homo sapiens Sphingomyelin phosphodiesterase Activity 92.1 % 10.1021/jm070524a
Homo sapiens Survival motor neuron protein Potency 3162.3 nM None
Homo sapiens Survival motor neuron protein Potency 3548.1 nM None
Homo sapiens SW480 IC50 nan None 10.1021/acs.jmedchem.5b01052
Homo sapiens T98G IC50 24000.0 nM 10.1021/jm300542e
Homo sapiens TGF-beta receptor type II Activity 78.0 % 10.1021/acs.jmedchem.8b00658
Homo sapiens Tyrosine-protein kinase CSK Activity 86.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase FYN IC50 250000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Tyrosine-protein kinase FYN IC50 250000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Tyrosine-protein kinase LCK IC50 250000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Tyrosine-protein kinase LCK IC50 250000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Tyrosine-protein kinase Lyn IC50 250000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Tyrosine-protein kinase Lyn IC50 250000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1636.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2059.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2310.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4109.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9441.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11582.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11885.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12589.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 12995.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 19952.6 nM None
Homo sapiens U-251 IC50 nan None 10.1016/j.ejmech.2012.11.045
Homo sapiens U-87 MG ED50 14.5 ug ml-1 10.1016/s0960-894x(99)00598-3
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 520.0 nM 10.1021/np0101189
Leishmania donovani Leishmania donovani IC50 230.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 3700.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania infantum Leishmania infantum IC50 230.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania infantum Leishmania infantum IC50 3700.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania infantum Leishmania infantum IC50 3700.0 nM 10.1016/j.ejmech.2016.08.014
Lipaphis erysimi Lipaphis erysimi Activity nan None 10.3390/molecules15117775
Lipaphis erysimi Lipaphis erysimi mortality 49.62 % 10.3390/molecules15117775
Mus musculus 4T1 IC50 nan None 10.1016/j.ejmech.2021.113258
Mus musculus B16 Activity nan None 10.1016/j.ejmech.2012.11.033
Mus musculus CT26 Activity nan None 10.1016/j.ejmech.2012.11.033
Mus musculus Dual specificity protein kinase CLK1 IC50 72.0 nM 10.1021/jm301034u
Mus musculus Dual specificity protein kinase CLK2 IC50 280.0 nM 10.1021/jm301034u
Mus musculus Dual specificity protein kinase CLK3 IC50 10000.0 nM 10.1021/jm301034u
Mus musculus Dual specificity protein kinase CLK4 IC50 50.0 nM 10.1021/jm301034u
Mus musculus Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/acs.jmedchem.9b01379
Mus musculus FM3A EC50 18000.0 nM 10.1016/j.bmcl.2004.01.055
Mus musculus FM3A Selective toxicity 0.82 None 10.1016/j.bmcl.2004.01.055
Mus musculus H22 Activity nan None 10.1016/j.ejmech.2012.11.033
Mus musculus HT-22 IC50 56500.0 nM 10.1021/acs.jmedchem.2c02068
Mus musculus Lewis lung carcinoma cell line Inhibition 33.7 % 10.1016/j.ejmech.2012.11.045
Mus musculus Mus musculus Activity 8.5 % 10.1016/j.ejmech.2012.11.033
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2012.11.033
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2012.11.045
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2021.113554
Mus musculus Mus musculus FC 2.0 None 10.1021/acs.jmedchem.9b01379
Mus musculus Mus musculus LD50 59.0 mg.kg-1 10.1016/j.ejmech.2012.11.033
Mus musculus Mus musculus LD50 59.0 mg.kg-1 10.1016/j.ejmech.2012.11.045
Mus musculus Mus musculus MED 6.0 mg kg-1 10.1021/acs.jmedchem.9b01379
Mus musculus NIH3T3 IC50 nan None 10.1016/j.ejmech.2017.10.054
Mus musculus Nuclear receptor ROR-gamma Potency 8912.5 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 15848.9 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus Smoothened homolog Inhibition nan % None
Mus musculus Tyrosine-protein kinase LCK Activity 81.0 % 10.1042/bj20070797
Onchocerca volvulus Chitinase IC50 7060.0 nM 10.1021/ml500516r
Onchocerca volvulus Chitinase Ki 3780.0 nM 10.1021/ml500516r
Onchocerca volvulus Onchocerca volvulus Inhibition 57.0 % 10.1021/ml500516r
Plasmodium berghei Plasmodium berghei IC50 nan None 10.1016/j.ejmech.2019.111927
Plasmodium falciparum Plasmodium falciparum Activity 70.0 % 10.1021/jm901796s
Plasmodium falciparum Plasmodium falciparum EC50 22000.0 nM 10.1016/j.bmcl.2004.01.055
Plasmodium falciparum Plasmodium falciparum IC50 28.0 nM 10.1021/jm901796s
Plasmodium falciparum Plasmodium falciparum IC50 50.1 nM 10.1021/jm901796s
Plasmodium falciparum Plasmodium falciparum IC50 182.4 nM 10.1021/jm901796s
Plasmodium falciparum Plasmodium falciparum IC50 8250.0 nM 10.1016/j.ejmech.2019.111927
Plasmodium falciparum Plasmodium falciparum IC50 8250.0 nM 10.1016/j.ejmech.2021.113687
Plasmodium falciparum Plasmodium falciparum IC50 8250.0 nM 10.1016/j.ejmech.2022.114408
Plasmodium falciparum Plasmodium falciparum IC50 27700.0 nM 10.1016/j.ejmech.2019.111927
Plasmodium falciparum Plasmodium falciparum IC50 27700.0 nM 10.1016/j.ejmech.2021.113687
Plasmodium falciparum Plasmodium falciparum IC50 27777.8 nM 10.1016/j.ejmech.2022.114408
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.ejmech.2022.114408
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 29.0 nM 10.1016/j.ejmech.2012.11.030
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 34.0 nM 10.1021/jm301034u
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 56.0 nM 10.1021/jm301034u
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Inhibition 99.1 % 10.1016/j.ejmech.2021.113554
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Inhibition 99.9 % 10.1016/j.ejmech.2021.113554
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Inhibition nan % 10.1021/jm301034u
Rattus norvegicus GABA-A receptor; anion channel Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Rattus norvegicus Metabotropic glutamate receptor Ki 10000.0 nM 10.1016/j.bmcl.2003.09.027
Rattus norvegicus Mitogen-activated protein kinase 1 IC50 30000.0 nM 10.1021/jm301034u
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 7790.0 nM 10.1016/j.bmcl.2003.09.027
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 56234.1 nM None
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Sus scrofa Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.bmcl.2017.04.080
Sus scrofa Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.ejmech.2012.11.030
Sus scrofa Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.ejmech.2016.08.069
Sus scrofa Glycogen synthase kinase-3 IC50 19000.0 nM 10.1021/jm301034u
Trypanosoma brucei Trypanosoma brucei IC50 74000.0 nM 10.1016/j.bmcl.2014.06.030
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 74000.0 nM 10.1016/j.bmcl.2014.06.030
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
Trypanosoma cruzi Trypanothione reductase Inhibition 11.0 % 10.1016/j.bmc.2008.05.074
None ADMET Activity nan None 10.1016/j.bmcl.2022.128698
None ADMET Activity nan None 10.1021/acs.jmedchem.9b01379
None ADMET BPR 9.0 None 10.1021/acs.jmedchem.9b01379
None ADMET permeability 44.6 10^-6 cm/s 10.1016/j.ejmech.2021.113554
None ADMET Ratio IC50 30.0 None 10.1016/j.ejmech.2022.114408
None ADMET Ratio IC50/EC50 50.8 uM 10.1021/np0101189
None ADMET Selectivity Index 30.0 None 10.1016/j.ejmech.2021.113687
None Molecular identity unknown Inhibition nan % 10.1021/acs.jnatprod.8b00843
None NON-PROTEIN TARGET Activity 15.3 % 10.1016/j.ejmech.2012.11.033
None NON-PROTEIN TARGET Activity 34.1 % 10.1016/j.ejmech.2012.11.033
None NON-PROTEIN TARGET IC50 7200.0 nM 10.1016/j.ejmech.2016.02.017
None NON-PROTEIN TARGET IC50 32000.0 nM 10.1021/jm300542e
None NON-PROTEIN TARGET IC50 42800.0 nM 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET IC50 46700.0 nM 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET IC50 62450.0 nM 10.1039/C5MD00581G
None NON-PROTEIN TARGET IC50 70360.0 nM 10.1039/C5MD00581G
None NON-PROTEIN TARGET IC50 130000.0 nM 10.1016/j.ejmech.2011.09.027
None NON-PROTEIN TARGET IC50 130000.0 nM 10.1021/jm901816j
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2012.11.045
None NON-PROTEIN TARGET Imax 40.31 % 10.3390/molecules15117775
None NON-PROTEIN TARGET Inhibition 30.8 % 10.1016/j.ejmech.2012.11.045
None No relevant target LogD7.4 2.9 None 10.6019/CHEMBL3301361
None No relevant target LogP 3.56 None 10.1021/jm070524a
None No relevant target pKa 7.5 None 10.1021/jm070524a
None No relevant target solubility nan None 10.1021/jm300542e
None No relevant target Solubility 55000.0 nM 10.6019/CHEMBL3301361
None Pancreatic beta cell EC50 7480.0 nM 10.1021/acs.jmedchem.9b01624
None Pancreatic beta cell Efficacy 60.0 % 10.1021/acs.jmedchem.9b01624
None Unchecked Activity 0.8 % 10.1021/acs.jmedchem.0c02050
None Unchecked Activity 5.0 % 10.1021/acs.jmedchem.0c02050
None Unchecked Activity 72.0 % 10.1042/bj20070797
None Unchecked Activity 85.0 % 10.1042/bj20070797
None Unchecked Activity nan None 10.1021/acs.jmedchem.8b00658
None Unchecked Activity nan None 10.1021/acs.jmedchem.9b01379
None Unchecked Activity nan None 10.1021/jm301034u
None Unchecked Emax 10.0 uM 10.1021/acs.jmedchem.9b01379
None Unchecked IC50 1500.0 nM 10.1016/j.ejmech.2012.11.030
None Unchecked IC50 1500.0 nM 10.1016/j.ejmech.2016.08.069
None Unchecked IC50 1800.0 nM 10.1021/jm301034u
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2017.04.080
None Unchecked IC50 10000.0 nM 10.1021/jm301034u
None Unchecked IC50 18000.0 nM 10.1021/jm301034u
None Unchecked IC50 47800.0 nM 10.1021/acs.jmedchem.0c00354
None Unchecked IC50 50000.0 nM 10.1021/acs.jmedchem.0c00354
None Unchecked IC50 250000.0 nM 10.1016/s0960-894x(02)00094-x
None Unchecked Inhibition 93.0 % 10.1016/j.ejmech.2021.113258
None Unchecked Inhibition nan % 10.1021/jm100476d
None Unchecked Inhibition nan % 10.1021/ml500516r
None Unchecked Ki 49.0 nM 10.1016/j.bmcl.2003.11.078
None Unchecked Potency 281.8 nM None
None Unchecked Potency 5011.9 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio 0.3 None 10.1021/jm300542e
None Unchecked Ratio 2.0 None 10.1021/acs.jmedchem.6b00035
None Unchecked Ratio IC50 1.26 None 10.1021/acs.jmedchem.2c02068
None Unchecked Ratio IC50 1.33 None 10.1016/j.ejmech.2021.114095
None Unchecked Ratio IC50 1.52 None 10.1021/acs.jmedchem.2c02068
None Unchecked Ratio IC50 4.84 None 10.1021/acs.jmedchem.2c02068
None Unchecked Ratio IC50 30.0 None 10.1016/j.ejmech.2019.111927
None Unchecked Ratio IC50 50.0 None 10.1016/j.bmcl.2012.01.028
None Unchecked Ratio IC50 50.0 None 10.1021/acs.jmedchem.2c02068
None Unchecked Selectivity ratio 1.35 None 10.1021/jm401049v
None Unchecked Selectivity ratio 1.42 None 10.1021/jm401049v

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT000488 *C.Cc1nccc2c1[nH]c1cc(O)ccc12>>COc1ccc2c(c1)[nH]c1c(C)nccc12 RXN-9320
AKRT011902 COc1ccc2c3c([nH]c2c1)C(C)=NCC3>>COc1ccc2c(c1)[nH]c1c(C)nccc12 RXN-9318