Molecule

Elliptecine

AlkaPlorer ID: AK001360

Synonym: None

IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole

Structure

SMILES: CC1=C2NC3=CC=CC=C3C2=C(C)C2=CN=CC=C12

InChI: InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3

InChIKey: CTSPAMFJBXKSOY-UHFFFAOYSA-N

Reference

Alkaloids from the Australian Rainforest Tree <i>Ochrosia moorei</i>

PubChem CID: 3213

CAS: 519-23-3

LOTUS: LTS0046132

COCONUT: CNP0419453

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Ochrosia elliptica	Ochrosia	Apocynaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 246.313

TPSA？: 28.68

MolLogP？: 4.486140000000003

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 4

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Acinetobacter baumannii	Acinetobacter baumannii	MIC	10000.0	nM	10.6019/CHEMBL4296183
Bacillus anthracis	Anthrax lethal factor	Potency	5011.9	nM	None
Bacillus anthracis	Anthrax lethal factor	Potency	10000.0	nM	None
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	14125.4	nM	None
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	22387.2	nM	None
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Potency	17782.8	nM	None
Bacillus subtilis (strain 168)	DNA polymerase III	Potency	23778.1	nM	None
Bos taurus	Calf thymus DNA	Activity	70.0	%	10.1021/np50078a006
Bos taurus	Calf thymus DNA	EC50	22200.0	nM	10.1021/jm011117g
Bos taurus	Calf thymus DNA	IC50	200000.0	nM	10.1016/j.bmcl.2016.02.034
Bos taurus	Calf thymus DNA	K app	1.5e-06	M-1	10.1021/jm00383a011
Bos taurus	Calf thymus DNA	rf50	2.5	None	10.1021/jm00383a011
Candida albicans	Candida albicans	MIC	10000.0	nM	10.6019/CHEMBL4296183
Chlorocebus sabaeus	Vero	IC50	0.2	ug.mL-1	10.1021/np030067a
Chlorocebus sabaeus	Vero	IC50	0.2	ug.mL-1	10.1021/np030429e
Chlorocebus sabaeus	Vero	IC50	0.4	ug.mL-1	10.1021/np0004404
Chlorocebus sabaeus	Vero	IC50	0.4	ug.mL-1	10.1021/np9000703
Chlorocebus sabaeus	Vero	IC50	0.48	ug.mL-1	10.1021/np900352n
Chlorocebus sabaeus	Vero	IC50	0.6	ug.mL-1	10.1021/np0502286
Chlorocebus sabaeus	Vero	IC50	0.7	ug.mL-1	10.1021/np900342b
Chlorocebus sabaeus	Vero	IC50	0.87	ug.mL-1	10.1021/acs.jnatprod.9b00947
Chlorocebus sabaeus	Vero	IC50	1.16	ug.mL-1	10.1021/np900082h
Chlorocebus sabaeus	Vero	IC50	1.18	ug.mL-1	10.1021/np900777r
Chlorocebus sabaeus	Vero	IC50	4.0	ug.mL-1	10.1021/acs.jnatprod.0c01308
Chlorocebus sabaeus	Vero	IC50	400.0	nM	10.1021/acs.jnatprod.5b01054
Chlorocebus sabaeus	Vero	IC50	800.0	nM	10.1021/np050036a
Chlorocebus sabaeus	Vero	IC50	1190.0	nM	10.1021/np400268d
Chlorocebus sabaeus	Vero	IC50	1690.0	nM	10.1021/np800702c
Chlorocebus sabaeus	Vero	IC50	1750.0	nM	10.1021/np900650c
Chlorocebus sabaeus	Vero	IC50	1940.0	nM	10.1016/j.bmc.2015.04.036
Chlorocebus sabaeus	Vero	IC50	1940.0	nM	10.1016/j.ejmech.2014.05.019
Chlorocebus sabaeus	Vero	IC50	1940.0	nM	10.1016/j.ejmech.2014.07.087
Chlorocebus sabaeus	Vero	IC50	1940.0	nM	10.1016/j.ejmech.2017.10.057
Chlorocebus sabaeus	Vero	IC50	1940.0	nM	10.1021/np070689m
Chlorocebus sabaeus	Vero	IC50	2030.0	nM	10.1021/np0701069
Chlorocebus sabaeus	Vero	IC50	2100.0	nM	10.1021/np700740a
Chlorocebus sabaeus	Vero	IC50	2290.0	nM	10.1016/j.bmcl.2010.03.054
Chlorocebus sabaeus	Vero	IC50	2400.0	nM	10.1016/j.ejmech.2021.113861
Chlorocebus sabaeus	Vero	IC50	2440.0	nM	10.1021/np050433l
Chlorocebus sabaeus	Vero	IC50	3100.0	nM	10.1021/acs.jnatprod.8b00869
Chlorocebus sabaeus	Vero	IC50	3300.0	nM	10.1021/acs.jnatprod.5b00826
Chlorocebus sabaeus	Vero	IC50	3300.0	nM	10.1021/acs.jnatprod.6b00973
Chlorocebus sabaeus	Vero	IC50	3800.0	nM	10.1021/np1000363
Chlorocebus sabaeus	Vero	IC50	3800.0	nM	10.1021/np5005328
Chlorocebus sabaeus	Vero	IC50	3820.0	nM	10.1016/j.ejmech.2011.05.041
Chlorocebus sabaeus	Vero	IC50	3820.0	nM	10.1021/np100654m
Chlorocebus sabaeus	Vero	IC50	4050.0	nM	10.1016/j.ejmech.2015.09.001
Chlorocebus sabaeus	Vero	IC50	4060.0	nM	10.1016/j.bmc.2018.07.036
Chlorocebus sabaeus	Vero	IC50	4060.0	nM	10.1021/acsmedchemlett.9b00161
Chlorocebus sabaeus	Vero	IC50	4100.0	nM	10.1021/acs.jnatprod.8b00205
Chlorocebus sabaeus	Vero	IC50	4260.0	nM	10.1016/j.bmcl.2016.06.007
Chlorocebus sabaeus	Vero	IC50	4470.0	nM	10.1021/np100282k
Chlorocebus sabaeus	Vero	IC50	4500.0	nM	10.1021/acs.jnatprod.1c00232
Chlorocebus sabaeus	Vero	IC50	5500.0	nM	10.1021/np900316x
Chlorocebus sabaeus	Vero	IC50	6480.0	nM	10.1016/j.bmcl.2014.04.105
Chlorocebus sabaeus	Vero	IC50	7470.0	nM	10.1021/acs.jnatprod.9b00647
Chlorocebus sabaeus	Vero	IC50	7900.0	nM	10.1021/acs.jnatprod.0c01212
Chlorocebus sabaeus	Vero	IC50	9800.0	nM	10.1021/np200429b
Chlorocebus sabaeus	Vero	IC50	12000.0	nM	10.1021/np100849x
Chlorocebus sabaeus	Vero	IC50	15510.0	nM	10.1021/np500476h
Chlorocebus sabaeus	Vero	Ratio IC50	2.88	None	10.1016/j.bmcl.2014.04.105
Cricetulus griseus	CHO	IC50	20.0	nM	10.1016/j.ejmech.2019.111807
Cryptococcus neoformans	Cryptococcus neoformans	MIC	10000.0	nM	10.6019/CHEMBL4296183
Ebolavirus	Ebolavirus	Inhibition	99.0	%	10.1128/aac.00138-10
Electrophorus electricus	Acetylcholinesterase	Inhibition	-1.87	%	10.1016/j.bmc.2012.09.040
Equus caballus	Cholinesterase	Inhibition	44.09	%	10.1016/j.bmc.2012.09.040
Equus caballus	Ferritin light chain	Potency	35481.3	nM	None
Escherichia coli	Escherichia coli	MIC	10000.0	nM	10.6019/CHEMBL4296183
Escherichia coli K-12	Endonuclease 4	Potency	2818.4	nM	None
Homo sapiens	15-hydroxyprostaglandin dehydrogenase [NAD+]	Potency	5011.9	nM	None
Homo sapiens	15-hydroxyprostaglandin dehydrogenase [NAD+]	Potency	8912.5	nM	None
Homo sapiens	3-phosphoinositide dependent protein kinase-1	Thermal melting change	8.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	5637	IC50	890.0	nM	10.1016/j.bmc.2009.05.016
Homo sapiens	78 kDa glucose-regulated protein	Potency	26121.6	nM	None
Homo sapiens	78 kDa glucose-regulated protein	Potency	44668.4	nM	None
Homo sapiens	A-427	IC50	890.0	nM	10.1016/j.bmc.2009.05.016
Homo sapiens	A-431	GI50	650.0	nM	10.1016/j.ejmech.2019.01.015
Homo sapiens	A-431	GI50	3200.0	nM	10.1016/j.ejmech.2014.02.064
Homo sapiens	A-431	IC50	470.0	nM	10.1016/j.bmc.2010.12.037
Homo sapiens	A498	GI50	794.33	nM	None
Homo sapiens	A498	IC50	1740.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	A549	ED50	2.37	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	A549	GI50	410.0	nM	10.1021/jm00040a011
Homo sapiens	A549	GI50	503.5	nM	None
Homo sapiens	A549	IC50	400.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	A549	IC50	470.0	nM	10.1016/j.ejmech.2011.01.034
Homo sapiens	A549	IC50	850.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	A549	IC50	1100.0	nM	10.1021/np2003512
Homo sapiens	A549	IC50	1160.0	nM	10.1016/j.bmcl.2021.128135
Homo sapiens	A549	IC50	1200.0	nM	10.1016/j.ejmech.2017.07.035
Homo sapiens	A549	IC50	1220.0	nM	10.1016/j.bmcl.2004.04.094
Homo sapiens	A549	IC50	1900.0	nM	10.1016/j.bmc.2010.10.057
Homo sapiens	A549	IC50	1900.0	nM	10.1016/j.bmc.2011.01.064
Homo sapiens	A549	IC50	1900.0	nM	10.1016/j.bmcl.2007.04.064
Homo sapiens	A549	IC50	1960.0	nM	10.1016/j.bmcl.2018.03.068
Homo sapiens	A549	IC50	2070.0	nM	10.1016/j.bmc.2006.09.040
Homo sapiens	A549	IC50	2130.0	nM	10.1016/j.bmcl.2020.127741
Homo sapiens	A549	IC50	2250.0	nM	10.1016/j.bmcl.2020.127263
Homo sapiens	A549	IC50	3400.0	nM	10.1016/j.bmc.2010.06.098
Homo sapiens	A549	IC50	3400.0	nM	10.1016/j.bmc.2011.03.018
Homo sapiens	A549	IC50	3450.0	nM	10.1016/j.ejmech.2022.114200
Homo sapiens	A549	IC50	10000.0	nM	10.1021/jm011117g
Homo sapiens	A549	IC50	nan	None	10.1016/j.ejmech.2014.05.019
Homo sapiens	A549	IC50	nan	None	10.1016/j.ejmech.2014.07.087
Homo sapiens	A549	IC50	nan	None	10.1016/j.ejmech.2015.09.001
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	7079.5	nM	None
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	15848.9	nM	None
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	35481.3	nM	None
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	Thermal melting change	1.8	degrees C	10.1073/pnas.0708800104
Homo sapiens	Arachidonate 12-lipoxygenase	Potency	39810.7	nM	None
Homo sapiens	Arachidonate 15-lipoxygenase, type II	Potency	3981.1	nM	None
Homo sapiens	Arachidonate 15-lipoxygenase, type II	Potency	5011.9	nM	None
Homo sapiens	Ataxin-2	Potency	3548.1	nM	None
Homo sapiens	Ataxin-2	Potency	10000.0	nM	None
Homo sapiens	ATPase family AAA domain-containing protein 5	Potency	12995.3	nM	None
Homo sapiens	ATPase family AAA domain-containing protein 5	Potency	16353.5	nM	None
Homo sapiens	ATPase family AAA domain-containing protein 5	Potency	32629.4	nM	None
Homo sapiens	ATP-dependent DNA helicase Q1	Potency	4466.8	nM	None
Homo sapiens	ATP-dependent DNA helicase Q1	Potency	10000.0	nM	None
Homo sapiens	ATP-dependent DNA helicase Q1	Potency	31622.8	nM	None
Homo sapiens	Bloom syndrome protein	Potency	7943.3	nM	None
Homo sapiens	Breast carcinoma cell	IC50	0.1	ug.mL-1	10.1016/s0960-894x(03)00241-5
Homo sapiens	Bromodomain adjacent to zinc finger domain protein 2B	Potency	56234.1	nM	None
Homo sapiens	CAKI-1	GI50	1010.0	nM	10.1021/jm00040a011
Homo sapiens	CAKI-1	GI50	1213.39	nM	None
Homo sapiens	CaM kinase I delta	Thermal melting change	1.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase I gamma	Thermal melting change	0.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase II alpha	Thermal melting change	2.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase II beta	Thermal melting change	1.0	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase II delta	Thermal melting change	-0.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase II gamma	Thermal melting change	1.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM kinase IV	Thermal melting change	0.4	degrees C	10.1073/pnas.0708800104
Homo sapiens	CaM-kinase kinase beta	Thermal melting change	1.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	Thermal melting change	5.9	degrees C	10.1073/pnas.0708800104
Homo sapiens	Casein kinase I gamma 1	Thermal melting change	0.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	Casein kinase I gamma 2	Thermal melting change	0.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	Casein kinase I isoform gamma-3	Thermal melting change	0.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	Caspase-1	Potency	12589.3	nM	None
Homo sapiens	Caspase-7	Potency	12589.3	nM	None
Homo sapiens	CCRF-CEM	GI50	411.15	nM	None
Homo sapiens	CCRF-CEM	GI50	415.0	nM	10.1021/jm00040a011
Homo sapiens	Cellular tumor antigen p53	Potency	10000.0	nM	None
Homo sapiens	Cellular tumor antigen p53	Potency	12589.3	nM	None
Homo sapiens	Cerebroside-sulfatase	Potency	22387.2	nM	None
Homo sapiens	Chromobox protein homolog 1	Potency	50118.7	nM	None
Homo sapiens	Col2	ED50	0.3	ug ml-1	10.1021/np020597r
Homo sapiens	Col2	ED50	0.5	ug ml-1	10.1021/np7007347
Homo sapiens	Col2	ED50	0.53	ug ml-1	10.1021/np060323u
Homo sapiens	Col2	ED50	2.2	uM	10.1021/np3006887
Homo sapiens	Col2	ED50	2.72	uM	10.1016/j.bmcl.2011.11.085
Homo sapiens	Col2	IC50	1220.0	nM	10.1016/j.bmcl.2004.04.094
Homo sapiens	Col2	IC50	1220.0	nM	10.1021/np030370b
Homo sapiens	Col2	IC50	1820.0	nM	10.1016/j.bmc.2006.09.040
Homo sapiens	Col2	IC50	2300.0	nM	10.1016/j.bmc.2010.10.057
Homo sapiens	Col2	IC50	2300.0	nM	10.1016/j.bmc.2011.01.064
Homo sapiens	Col2	IC50	2300.0	nM	10.1016/j.bmcl.2007.04.064
Homo sapiens	COLO 205	GI50	502.34	nM	None
Homo sapiens	COLO 205	GI50	588.0	nM	10.1021/jm00040a011
Homo sapiens	Cyclin-dependent kinase 2	Thermal melting change	1.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	Cyclin-dependent kinase 6	Thermal melting change	0.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	Cyclin-dependent kinase-like 1	Thermal melting change	0.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	Cytochrome P450 1A1	IC50	19.3	nM	10.1016/j.ejmech.2019.111807
Homo sapiens	Cytochrome P450 1A2	AC50	19.95	nM	None
Homo sapiens	Cytochrome P450 2C19	AC50	3162.28	nM	None
Homo sapiens	Cytochrome P450 2C19	Potency	3162.3	nM	None
Homo sapiens	Cytochrome P450 2C19	Potency	6309.6	nM	None
Homo sapiens	Cytochrome P450 2C9	AC50	1000000000.0	nM	None
Homo sapiens	Cytochrome P450 2C9	Potency	39810.7	nM	None
Homo sapiens	Cytochrome P450 2D6	AC50	6309.57	nM	None
Homo sapiens	Cytochrome P450 2D6	Potency	6309.6	nM	None
Homo sapiens	Cytochrome P450 2D6	Potency	31622.8	nM	None
Homo sapiens	Cytochrome P450 3A4	AC50	158.49	nM	None
Homo sapiens	Cytochrome P450 3A4	Potency	158.5	nM	None
Homo sapiens	Cytochrome P450 3A4	Potency	398.1	nM	None
Homo sapiens	DAN-G	IC50	nan	None	10.1016/j.bmc.2009.05.016
Homo sapiens	Death-associated protein kinase 3	Thermal melting change	4.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	DLD-1	GI50	509.33	nM	None
Homo sapiens	DMS-114	GI50	552.0	nM	10.1021/jm00040a011
Homo sapiens	DMS-114	GI50	939.72	nM	None
Homo sapiens	DMS-273	GI50	377.57	nM	None
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	3162.3	nM	None
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	4466.8	nM	None
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	5011.9	nM	None
Homo sapiens	DNA-(apurinic or apyrimidinic site) lyase	Potency	7943.3	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3F	Potency	10000.0	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3F	Potency	18356.4	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3F	Potency	29092.9	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3G	Potency	14581.0	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3G	Potency	15848.9	nM	None
Homo sapiens	DNA dC->dU-editing enzyme APOBEC-3G	Potency	29092.9	nM	None
Homo sapiens	DNA polymerase beta	Potency	3981.1	nM	None
Homo sapiens	DNA polymerase beta	Potency	15848.9	nM	None
Homo sapiens	DNA polymerase eta	Potency	25118.9	nM	None
Homo sapiens	DNA polymerase eta	Potency	89125.1	nM	None
Homo sapiens	DNA polymerase iota	Potency	14125.4	nM	None
Homo sapiens	DNA polymerase kappa	Potency	2667.9	nM	None
Homo sapiens	DNA polymerase kappa	Potency	37685.8	nM	None
Homo sapiens	DNA polymerase kappa	Potency	79432.8	nM	None
Homo sapiens	DNA topoisomerase I	Activity	nan	None	10.1016/j.bmcl.2007.04.064
Homo sapiens	DNA topoisomerase I	IC50	nan	None	10.1016/j.bmc.2010.10.057
Homo sapiens	DNA topoisomerase I	Inhibition	nan	%	10.1016/j.ejmech.2015.11.004
Homo sapiens	DNA topoisomerase I	Inhibition	nan	%	10.1016/j.ejmech.2019.111583
Homo sapiens	DNA topoisomerase II alpha	Activity	nan	None	10.1021/jm800499x
Homo sapiens	DNA topoisomerase II alpha	IC50	3300.0	nM	10.1073/pnas.0708800104
Homo sapiens	DNA topoisomerase II alpha	Inhibition	86.0	%	10.1016/j.ejmech.2021.113860
Homo sapiens	DNA topoisomerase II alpha	Inhibition	88.3	%	10.1016/j.ejmech.2015.08.040
Homo sapiens	DNA topoisomerase II alpha	Inhibition	nan	%	10.1016/j.bmc.2009.08.064
Homo sapiens	DNA topoisomerase II alpha	Inhibition	nan	%	10.1016/j.bmcl.2016.02.034
Homo sapiens	DNA topoisomerase II alpha	Inhibition	nan	%	10.1016/j.ejmech.2015.11.004
Homo sapiens	DNA topoisomerase II alpha	Inhibition	nan	%	10.1016/j.ejmech.2017.01.003
Homo sapiens	DNA topoisomerase II beta	Inhibition	29.2	%	10.1016/j.ejmech.2021.113860
Homo sapiens	Dopamine D1 receptor	Potency	4.1	nM	None
Homo sapiens	Dopamine D1 receptor	Potency	10000.0	nM	None
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	Thermal melting change	1.0	degrees C	10.1073/pnas.0708800104
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	Thermal melting change	6.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Dual specificity protein kinase CLK2	Thermal melting change	3.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Dual specificity protein kinase CLK3	Thermal melting change	4.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	Dual specificty protein kinase CLK1	Thermal melting change	6.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	EKVX	GI50	933.25	nM	None
Homo sapiens	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Potency	12589.3	nM	None
Homo sapiens	FaDu	IC50	1850.0	nM	10.1016/j.bmcl.2021.128135
Homo sapiens	Flap endonuclease 1	Potency	3981.1	nM	None
Homo sapiens	Flap endonuclease 1	Potency	10621.3	nM	None
Homo sapiens	Flap endonuclease 1	Potency	11917.3	nM	None
Homo sapiens	Galanin receptor 2	EC50	55700.0	nM	None
Homo sapiens	Geminin	Potency	5804.8	nM	None
Homo sapiens	Geminin	Potency	7079.5	nM	None
Homo sapiens	Geminin	Potency	7307.8	nM	None
Homo sapiens	Geminin	Potency	9200.0	nM	None
Homo sapiens	Geminin	Potency	14125.4	nM	None
Homo sapiens	Glucocorticoid receptor	IC50	90000.0	nM	10.1021/np070655e
Homo sapiens	Glucose transporter	Inhibition	17.48	%	10.6019/CHEMBL3433997
Homo sapiens	Glycogen synthase kinase-3 beta	Thermal melting change	5.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1	Potency	11220.2	nM	None
Homo sapiens	HCC 2998	GI50	2679.17	nM	None
Homo sapiens	HCT-116	GI50	272.27	nM	None
Homo sapiens	HCT-116	GI50	290.0	nM	10.1021/jm9602930
Homo sapiens	HCT-116	IC50	300.0	nM	10.1016/j.bmcl.2006.09.093
Homo sapiens	HCT-116	IC50	410.0	nM	10.1016/j.ejmech.2011.01.034
Homo sapiens	HCT-116	IC50	1000.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	HCT-116	IC50	nan	None	10.1021/acs.jnatprod.6b00782
Homo sapiens	HCT-15	ED50	0.17	ug ml-1	10.1021/np980222z
Homo sapiens	HCT-15	ED50	0.24	ug ml-1	10.1021/np9900627
Homo sapiens	HCT-15	GI50	401.79	nM	None
Homo sapiens	HCT-15	GI50	1910.0	nM	10.1016/j.ejmech.2013.09.023
Homo sapiens	HCT-15	IC50	nan	None	10.1021/acs.jnatprod.6b00782
Homo sapiens	HCT-8	ID50	2.6e-07	M	10.1021/jm00157a040
Homo sapiens	HEK293	CC50	1130.0	nM	10.6019/CHEMBL4296183
Homo sapiens	HEK293	ED50	1.9	uM	10.1021/np3006887
Homo sapiens	HEK293	ED50	2.27	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	HEK293	IC50	1690.0	nM	10.1016/j.bmcl.2021.127841
Homo sapiens	HEK293	IC50	1900.0	nM	10.1016/j.bmcl.2018.03.068
Homo sapiens	HEK293	IC50	6580.0	nM	10.1016/j.bmcl.2021.128054
Homo sapiens	HEK293	Potency	6510.4	nM	None
Homo sapiens	HEK293	Potency	20596.2	nM	None
Homo sapiens	HEK293	Potency	25118.9	nM	None
Homo sapiens	HeLa	GI50	300.0	nM	10.1016/j.ejmech.2014.02.064
Homo sapiens	HeLa	GI50	470.0	nM	10.1016/j.ejmech.2019.01.015
Homo sapiens	HeLa	GI50	3280.0	nM	10.1016/j.ejmech.2013.09.023
Homo sapiens	HeLa	IC50	0.4	ug.mL-1	10.1021/np800447k
Homo sapiens	HeLa	IC50	290.0	nM	10.1016/j.ejmech.2008.12.011
Homo sapiens	HeLa	IC50	290.0	nM	10.1021/jm900627v
Homo sapiens	HeLa	IC50	310.0	nM	10.1016/j.bmc.2010.12.037
Homo sapiens	HeLa	IC50	1000.0	nM	10.1016/j.ejmech.2015.11.004
Homo sapiens	HeLa	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	HeLa	IC50	1600.0	nM	10.1039/C6MD00587J
Homo sapiens	HeLa	IC50	2000.0	nM	10.1021/acs.jnatprod.8b01078
Homo sapiens	HeLa	IC50	9810.0	nM	10.1039/C2MD20335A
Homo sapiens	HeLa	IC50	9850.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	HeLa	IC50	nan	None	10.1021/acs.jnatprod.6b00782
Homo sapiens	HeLa	Incorporation	8.0	%	10.1021/jm00390a014
Homo sapiens	HeLa	Incorporation	25.0	%	10.1021/jm00390a014
Homo sapiens	HeLa	Incorporation	47.0	%	10.1021/jm00390a014
Homo sapiens	HeLa	Incorporation	56.0	%	10.1021/jm00390a014
Homo sapiens	HeLa	Incorporation	65.0	%	10.1021/jm00390a014
Homo sapiens	HeLa	Incorporation	78.0	%	10.1021/jm00390a014
Homo sapiens	Hemoglobin beta chain	Potency	12589.3	nM	None
Homo sapiens	Hemoglobin beta chain	Potency	31622.8	nM	None
Homo sapiens	HEp-2	IC50	0.4	ug.mL-1	10.1021/np800447k
Homo sapiens	HEp-2	IC50	9850.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	HepG2	GI50	2900.0	nM	10.1016/j.ejmech.2011.09.029
Homo sapiens	HepG2	GI50	5380.0	nM	10.1016/j.ejmech.2013.09.023
Homo sapiens	HepG2	IC50	0.36	ug.mL-1	10.1016/j.bmcl.2015.09.069
Homo sapiens	HepG2	IC50	1.26	nM	10.1016/j.bmcl.2014.03.091
Homo sapiens	HepG2	IC50	1.26	nM	10.1016/j.bmcl.2014.09.065
Homo sapiens	HepG2	IC50	850.0	nM	10.1016/j.bmcl.2020.127404
Homo sapiens	HepG2	IC50	930.0	nM	10.1016/j.ejmech.2019.111700
Homo sapiens	HepG2	IC50	930.0	nM	10.1016/j.ejmech.2020.112044
Homo sapiens	HepG2	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	HepG2	IC50	1200.0	nM	10.1016/j.bmcl.2014.09.079
Homo sapiens	HepG2	IC50	1200.0	nM	10.1039/C6MD00587J
Homo sapiens	HepG2	IC50	1300.0	nM	10.1016/j.bmcl.2015.05.051
Homo sapiens	HepG2	IC50	1340.0	nM	10.1016/j.bmcl.2021.128054
Homo sapiens	HepG2	IC50	1380.0	nM	10.1016/j.bmcl.2017.05.003
Homo sapiens	HepG2	IC50	1460.0	nM	10.1016/j.bmcl.2016.05.092
Homo sapiens	HepG2	IC50	1500.0	nM	10.1021/acs.jnatprod.5b00677
Homo sapiens	HepG2	IC50	1660.0	nM	10.1016/j.bmcl.2021.127841
Homo sapiens	HepG2	IC50	1710.0	nM	10.1016/j.bmcl.2015.06.005
Homo sapiens	HepG2	IC50	2070.0	nM	10.1016/j.bmcl.2015.10.040
Homo sapiens	HepG2	IC50	2720.0	nM	10.1016/j.bmcl.2018.10.016
Homo sapiens	HepG2	IC50	2900.0	nM	10.1016/j.ejmech.2015.11.004
Homo sapiens	HepG2	IC50	3500.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	HepG2	IC50	nan	None	10.1016/j.ejmech.2014.05.019
Homo sapiens	HepG2	IC50	nan	None	10.1016/j.ejmech.2014.07.087
Homo sapiens	HepG2	IC50	nan	None	10.1016/j.ejmech.2015.09.001
Homo sapiens	HepG2	Inhibition	38.0	%	10.1038/nature09107
Homo sapiens	HepG2	Potency	12589.3	nM	None
Homo sapiens	HERG	Potency	19952.6	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	11220.2	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	21192.3	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	39810.7	nM	None
Homo sapiens	Histone-lysine N-methyltransferase MLL	Potency	1584.9	nM	None
Homo sapiens	Histone-lysine N-methyltransferase MLL	Potency	10000.0	nM	None
Homo sapiens	HL-60	GI50	883.08	nM	None
Homo sapiens	HL-60	GI50	2000.0	nM	10.1016/j.ejmech.2014.02.064
Homo sapiens	HL-60	IC50	640.0	nM	10.1016/j.bmc.2010.12.037
Homo sapiens	HL-60	IC50	660.0	nM	10.1016/j.ejmech.2008.12.011
Homo sapiens	HL-60	IC50	660.0	nM	10.1021/jm900627v
Homo sapiens	HL-60	IC50	1700.0	nM	10.1016/j.ejmech.2019.111700
Homo sapiens	HL-60	IC50	1700.0	nM	10.1016/j.ejmech.2020.112044
Homo sapiens	HL-60	IC50	2000.0	nM	10.1039/C6MD00587J
Homo sapiens	HL-60	IC50	2600.0	nM	10.1016/j.bmc.2006.09.040
Homo sapiens	HL-60	IC50	2930.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	HL-60	IC50	5800.0	nM	10.1016/j.bmc.2010.10.057
Homo sapiens	HL-60	IC50	5800.0	nM	10.1016/j.bmc.2011.01.064
Homo sapiens	HL-60	IC50	5800.0	nM	10.1016/j.bmcl.2007.04.064
Homo sapiens	Homo sapiens	TGI	2900.0	nM	10.1021/jm00040a010
Homo sapiens	Homo sapiens	TGI	3000.0	nM	10.1021/jm00040a010
Homo sapiens	Homo sapiens	TGI correlation coefficient	0.5	None	10.1021/jm00040a010
Homo sapiens	HOP-18	GI50	1492.79	nM	None
Homo sapiens	HOP-62	GI50	818.46	nM	None
Homo sapiens	HOP-92	GI50	538.27	nM	None
Homo sapiens	HT-1080	IC50	210.0	nM	10.1016/j.ejmech.2011.01.034
Homo sapiens	HT-1080	IC50	4300.0	nM	10.1016/j.bmc.2010.10.057
Homo sapiens	HT-1080	IC50	4300.0	nM	10.1016/j.bmc.2011.01.064
Homo sapiens	HT-1080	IC50	4300.0	nM	10.1016/j.bmcl.2007.04.064
Homo sapiens	HT-1080	IC50	5010.0	nM	10.1016/j.bmc.2006.09.040
Homo sapiens	HT-29	ED50	2.68	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	HT-29	GI50	862.98	nM	None
Homo sapiens	HT-29	IC50	1950.0	nM	10.1016/j.bmcl.2021.128135
Homo sapiens	HT-29	IC50	2000.0	nM	10.1016/j.bmcl.2018.03.068
Homo sapiens	HT-29	IC50	2060.0	nM	10.1016/j.ejmech.2017.07.035
Homo sapiens	HT-29	IC50	2160.0	nM	10.1016/j.bmcl.2020.127263
Homo sapiens	HT-29	IC50	2590.0	nM	10.1016/j.bmcl.2020.127741
Homo sapiens	HT-29	IC50	14900.0	nM	10.1021/jm061184g
Homo sapiens	HT-29	IC50	15000.0	nM	10.1021/jm011117g
Homo sapiens	HuCC-A1	ED50	3.46	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	HuCC-A1	IC50	2430.0	nM	10.1016/j.bmcl.2020.127263
Homo sapiens	HUVEC	IC50	370.0	nM	10.1021/np030370b
Homo sapiens	Hypoxia-inducible factor 1 alpha	Potency	5011.9	nM	None
Homo sapiens	Hypoxia-inducible factor 1 alpha	Potency	12589.3	nM	None
Homo sapiens	Hypoxia-inducible factor 1 alpha	Potency	31622.8	nM	None
Homo sapiens	IGROV-1	GI50	729.46	nM	None
Homo sapiens	IGROV-1	GI50	860.0	nM	10.1021/jm9602930
Homo sapiens	IGROV-1	GI50	862.0	nM	10.1021/jm00040a011
Homo sapiens	Importin subunit beta-1/Snurportin-1	Potency	70794.6	nM	None
Homo sapiens	Inactive serine/threonine-protein kinase VRK3	Thermal melting change	1.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Ishikawa	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	Ishikawa	IC50	1500.0	nM	10.1016/j.ejmech.2015.11.004
Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic	Potency	10322.5	nM	None
Homo sapiens	K562	GI50	469.89	nM	None
Homo sapiens	K562	IC50	380.0	nM	10.1016/j.ejmech.2011.01.034
Homo sapiens	KB	Activity	96.3	%	10.1016/j.bmcl.2017.08.063
Homo sapiens	KB	ED50	0.04	ug ml-1	10.1021/np020597r
Homo sapiens	KB	ED50	0.04	ug ml-1	10.1021/np50112a012
Homo sapiens	KB	ED50	0.1	ug ml-1	10.1021/np980222z
Homo sapiens	KB	ED50	0.33	ug ml-1	10.1021/np9900627
Homo sapiens	KB	ED50	0.36	ug ml-1	10.1021/np50022a010
Homo sapiens	KB	ED50	0.65	ug ml-1	10.1021/np060323u
Homo sapiens	KB	ED50	0.7	ug ml-1	10.1021/np7007347
Homo sapiens	KB	ED50	1.31	ug ml-1	10.1021/np060233p
Homo sapiens	KB	ED50	2.2	uM	10.1021/np3006887
Homo sapiens	KB	ED50	2.34	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	KB	ED50	2.46	uM	10.1016/j.bmcl.2011.11.085
Homo sapiens	KB	IC50	0.1	ug.mL-1	10.1021/np0004404
Homo sapiens	KB	IC50	0.19	ug.mL-1	10.1021/np100632g
Homo sapiens	KB	IC50	0.2	ug.mL-1	10.1021/np030067a
Homo sapiens	KB	IC50	0.2	ug.mL-1	10.1021/np030429e
Homo sapiens	KB	IC50	0.2	ug.mL-1	10.1021/np9000703
Homo sapiens	KB	IC50	0.21	ug.mL-1	10.1021/np0502286
Homo sapiens	KB	IC50	0.21	ug.mL-1	10.1021/np060190c
Homo sapiens	KB	IC50	0.24	ug.mL-1	10.1021/np060164e
Homo sapiens	KB	IC50	0.26	ug.mL-1	10.1021/np050001a
Homo sapiens	KB	IC50	0.3	ug.mL-1	10.1016/s0960-894x(03)00111-2
Homo sapiens	KB	IC50	0.3	ug.mL-1	10.1021/np020055+
Homo sapiens	KB	IC50	0.3	ug.mL-1	10.1021/np0502793
Homo sapiens	KB	IC50	0.36	ug.mL-1	10.1021/np049757k
Homo sapiens	KB	IC50	0.36	ug.mL-1	10.1021/np0503202
Homo sapiens	KB	IC50	0.36	ug.mL-1	10.1021/np070293a
Homo sapiens	KB	IC50	0.36	ug.mL-1	10.1021/np800805f
Homo sapiens	KB	IC50	0.36	ug.mL-1	10.1021/np9003189
Homo sapiens	KB	IC50	0.37	ug.mL-1	10.1021/np900021h
Homo sapiens	KB	IC50	0.4	ug.mL-1	10.1021/np030519j
Homo sapiens	KB	IC50	0.4	ug.mL-1	10.1021/np800447k
Homo sapiens	KB	IC50	0.41	ug.mL-1	10.1021/np070629g
Homo sapiens	KB	IC50	0.45	ug.mL-1	10.1021/np900777r
Homo sapiens	KB	IC50	0.46	ug.mL-1	10.1021/np010006h
Homo sapiens	KB	IC50	0.48	ug.mL-1	10.1021/np900352n
Homo sapiens	KB	IC50	0.67	ug.mL-1	10.1021/np070083y
Homo sapiens	KB	IC50	1.26	nM	10.1016/j.bmcl.2014.03.091
Homo sapiens	KB	IC50	1.26	nM	10.1016/j.bmcl.2014.09.065
Homo sapiens	KB	IC50	160.0	nM	10.1021/np030370b
Homo sapiens	KB	IC50	800.0	nM	10.1021/np050036a
Homo sapiens	KB	IC50	810.0	nM	10.1016/j.ejmech.2019.111700
Homo sapiens	KB	IC50	810.0	nM	10.1016/j.ejmech.2020.112044
Homo sapiens	KB	IC50	812.0	nM	10.1021/np060249f
Homo sapiens	KB	IC50	1100.0	nM	10.1021/np100282k
Homo sapiens	KB	IC50	1190.0	nM	10.1021/np400268d
Homo sapiens	KB	IC50	1200.0	nM	10.1016/j.bmcl.2014.09.079
Homo sapiens	KB	IC50	1200.0	nM	10.1039/C6MD00587J
Homo sapiens	KB	IC50	1250.0	nM	10.1021/np2004903
Homo sapiens	KB	IC50	1260.0	nM	10.1016/j.bmcl.2016.05.092
Homo sapiens	KB	IC50	1260.0	nM	10.1016/j.bmcl.2021.128054
Homo sapiens	KB	IC50	1300.0	nM	10.1016/j.bmcl.2015.05.051
Homo sapiens	KB	IC50	1380.0	nM	10.1021/np800702c
Homo sapiens	KB	IC50	1400.0	nM	10.1021/acs.jnatprod.5b00677
Homo sapiens	KB	IC50	1660.0	nM	10.1016/j.bmcl.2015.10.040
Homo sapiens	KB	IC50	1750.0	nM	10.1016/j.bmcl.2021.127841
Homo sapiens	KB	IC50	1780.0	nM	10.1016/j.ejmech.2011.05.041
Homo sapiens	KB	IC50	1790.0	nM	10.1016/j.bmcl.2010.03.054
Homo sapiens	KB	IC50	1790.0	nM	10.1016/j.bmcl.2017.05.003
Homo sapiens	KB	IC50	1790.0	nM	10.1021/np100654m
Homo sapiens	KB	IC50	1870.0	nM	10.1016/j.ejmech.2017.07.035
Homo sapiens	KB	IC50	1920.0	nM	10.1016/j.bmcl.2020.127263
Homo sapiens	KB	IC50	1950.0	nM	10.1016/j.bmcl.2018.10.016
Homo sapiens	KB	IC50	1980.0	nM	10.1021/np5005328
Homo sapiens	KB	IC50	1990.0	nM	10.1021/np070689m
Homo sapiens	KB	IC50	2070.0	nM	10.1016/j.bmcl.2015.06.005
Homo sapiens	KB	IC50	2150.0	nM	10.1016/j.bmcl.2018.03.068
Homo sapiens	KB	IC50	2200.0	nM	10.1016/j.bmcl.2020.127741
Homo sapiens	KB	IC50	2200.0	nM	10.1021/np700740a
Homo sapiens	KB	IC50	2250.0	nM	10.1016/j.bmcl.2014.04.105
Homo sapiens	KB	IC50	2400.0	nM	10.1016/j.bmcl.2006.08.018
Homo sapiens	KB	IC50	2500.0	nM	10.1021/np1000363
Homo sapiens	KB	IC50	2500.0	nM	10.1021/np900316x
Homo sapiens	KB	IC50	2810.0	nM	10.1016/j.bmcl.2017.08.063
Homo sapiens	KB	IC50	3980.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	KB	IC50	4870.0	nM	10.1021/np3006937
Homo sapiens	KB	IC50	5200.0	nM	10.1021/np3000365
Homo sapiens	KB	IC50	5300.0	nM	10.1021/np070010e
Homo sapiens	KB	IC50	5410.0	nM	10.1021/np0601197
Homo sapiens	KB	IC50	6100.0	nM	10.1021/acs.jnatprod.0c01212
Homo sapiens	KB	IC50	8200.0	nM	10.1021/acs.jnatprod.8b00205
Homo sapiens	KB	IC50	8280.0	nM	10.1016/j.bmcl.2016.06.007
Homo sapiens	KB	ID50	0.07	uM ml-1	10.1021/jm00047a008
Homo sapiens	KM12	GI50	473.15	nM	None
Homo sapiens	KM-20L2	GI50	548.28	nM	None
Homo sapiens	LNCaP	ED50	0.8	ug ml-1	10.1021/np020597r
Homo sapiens	LNCaP	ED50	0.8	ug ml-1	10.1021/np50112a012
Homo sapiens	LNCaP	IC50	1950.0	nM	10.1016/j.bmcl.2017.05.003
Homo sapiens	LNCaP	IC50	1990.0	nM	10.1016/j.bmcl.2015.06.005
Homo sapiens	LNCaP	IC50	3210.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	LNCaP	IC50	3250.0	nM	10.1021/np030370b
Homo sapiens	LOX IMVI	GI50	535.8	nM	None
Homo sapiens	LOX IMVI	GI50	560.0	nM	10.1021/jm9602930
Homo sapiens	Lu1	ED50	0.02	ug ml-1	10.1021/np020597r
Homo sapiens	Lu1	ED50	0.2	ug ml-1	10.1021/np50112a012
Homo sapiens	Lu1	ED50	0.2	ug ml-1	10.1021/np7007347
Homo sapiens	Lu1	ED50	0.56	ug ml-1	10.1021/np060323u
Homo sapiens	Lu1	ED50	1.1	uM	10.1021/np3006887
Homo sapiens	Lu1	ED50	1.62	uM	10.1016/j.bmcl.2011.11.085
Homo sapiens	Lu1	IC50	80.0	nM	10.1021/np030370b
Homo sapiens	Lu1	IC50	1200.0	nM	10.1021/acs.jnatprod.5b00677
Homo sapiens	Lu1	IC50	1600.0	nM	10.1039/C6MD00587J
Homo sapiens	Lu1	IC50	1700.0	nM	10.1016/j.ejmech.2019.111700
Homo sapiens	Lu1	IC50	2310.0	nM	10.1016/j.bmcl.2015.10.040
Homo sapiens	Lu1	IC50	2720.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	11220.2	nM	None
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	12589.3	nM	None
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	17782.8	nM	None
Homo sapiens	Lysosomal alpha-glucosidase	Potency	35481.3	nM	None
Homo sapiens	M19-MEL	GI50	857.04	nM	None
Homo sapiens	Malme-3M	GI50	2009.09	nM	None
Homo sapiens	Malme-3M	GI50	2520.0	nM	10.1021/jm00040a011
Homo sapiens	MAP kinase ERK1	Thermal melting change	0.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	MAP kinase ERK2	Potency	10000.0	nM	None
Homo sapiens	MAP kinase p38 beta	Thermal melting change	0.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	MCF-10A	IC50	1200.0	nM	10.1016/j.ejmech.2019.111583
Homo sapiens	MCF7	ED50	0.4	ug ml-1	10.1021/np7007347
Homo sapiens	MCF7	ED50	1.66	uM	10.1016/j.bmcl.2017.10.063
Homo sapiens	MCF7	ED50	2.3	uM	10.1021/np3006887
Homo sapiens	MCF7	ED50	2.71	uM	10.1016/j.bmcl.2011.11.085
Homo sapiens	MCF7	GI50	571.48	nM	None
Homo sapiens	MCF7	GI50	710.0	nM	10.1021/jm9602930
Homo sapiens	MCF7	GI50	740.0	nM	10.1021/jm9602930
Homo sapiens	MCF7	GI50	4320.0	nM	10.1016/j.ejmech.2013.09.023
Homo sapiens	MCF7	IC50	0.44	ug.mL-1	10.1016/j.bmcl.2015.09.069
Homo sapiens	MCF7	IC50	2.1	nM	10.1016/j.bmcl.2014.09.065
Homo sapiens	MCF7	IC50	2.15	nM	10.1016/j.bmcl.2014.03.091
Homo sapiens	MCF7	IC50	430.0	nM	10.1016/j.bmc.2009.05.016
Homo sapiens	MCF7	IC50	800.0	nM	10.1021/acs.jnatprod.9b00140
Homo sapiens	MCF7	IC50	900.0	nM	10.1021/acs.jnatprod.5b00677
Homo sapiens	MCF7	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	MCF7	IC50	1250.0	nM	10.1016/j.ejmech.2015.11.004
Homo sapiens	MCF7	IC50	1250.0	nM	10.1016/j.ejmech.2019.111583
Homo sapiens	MCF7	IC50	1340.0	nM	10.1016/j.bmcl.2017.05.003
Homo sapiens	MCF7	IC50	1530.0	nM	10.1016/j.ejmech.2017.07.035
Homo sapiens	MCF7	IC50	1540.0	nM	10.1016/j.bmcl.2015.10.040
Homo sapiens	MCF7	IC50	1580.0	nM	10.1016/j.bmcl.2021.127841
Homo sapiens	MCF7	IC50	1600.0	nM	10.1016/j.bmc.2010.06.098
Homo sapiens	MCF7	IC50	1600.0	nM	10.1016/j.bmc.2011.03.018
Homo sapiens	MCF7	IC50	1600.0	nM	10.1021/acs.jnatprod.6b00782
Homo sapiens	MCF7	IC50	1700.0	nM	10.1016/j.ejmech.2019.111700
Homo sapiens	MCF7	IC50	1700.0	nM	10.1016/j.ejmech.2020.112044
Homo sapiens	MCF7	IC50	1790.0	nM	10.1016/j.bmcl.2020.127263
Homo sapiens	MCF7	IC50	1800.0	nM	10.1016/j.bmcl.2015.05.051
Homo sapiens	MCF7	IC50	1950.0	nM	10.1016/j.bmcl.2015.06.005
Homo sapiens	MCF7	IC50	1990.0	nM	10.1016/j.bmcl.2018.03.068
Homo sapiens	MCF7	IC50	2000.0	nM	10.1021/acs.jnatprod.6b00782
Homo sapiens	MCF7	IC50	2180.0	nM	10.1016/j.bmcl.2020.127741
Homo sapiens	MCF7	IC50	2400.0	nM	10.1039/C6MD00587J
Homo sapiens	MCF7	IC50	2480.0	nM	10.1016/j.bmcl.2021.128054
Homo sapiens	MCF7	IC50	9850.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	MCF7	IC50	16720.0	nM	10.1039/C2MD20335A
Homo sapiens	MCF7	IC50	nan	None	10.1021/np900316x
Homo sapiens	MDA-MB-231	IC50	100.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	MDA-MB-231	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
Homo sapiens	MDA-MB-231	IC50	1820.0	nM	10.1016/j.ejmech.2015.11.004
Homo sapiens	MDA-MB-231	IC50	1850.0	nM	10.1016/j.ejmech.2019.111583
Homo sapiens	MDA-MB-231	IC50	2030.0	nM	10.1016/j.bmcl.2021.128135
Homo sapiens	MDA-MB-231	IC50	2300.0	nM	10.1021/jm011117g
Homo sapiens	MDA-MB-231	IC50	3210.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	MDA-MB-231	IC50	nan	None	10.1021/acs.jnatprod.6b00782
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	14125.4	nM	None
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	15848.9	nM	None
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	19952.6	nM	None
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	28183.8	nM	None
Homo sapiens	microRNA 21	Potency	6561.4	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	10000.0	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	11220.2	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	12589.3	nM	None
Homo sapiens	Mitogen-activated protein kinase 6	Thermal melting change	1.5	degrees C	10.1073/pnas.0708800104
Homo sapiens	Mitogen-activated protein kinase kinase kinase 5	Thermal melting change	0.4	degrees C	10.1073/pnas.0708800104
Homo sapiens	MOLT-4	GI50	256.45	nM	None
Homo sapiens	MOLT-4	GI50	380.0	nM	10.1021/jm9602930
Homo sapiens	Mothers against decapentaplegic homolog 3	Potency	35481.3	nM	None
Homo sapiens	M-phase phosphoprotein 8	Potency	631.0	nM	None
Homo sapiens	MRC5	IC50	1300.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	MSTO-211H	GI50	770.0	nM	10.1016/j.ejmech.2019.01.015
Homo sapiens	Muscleblind-like protein 1	Potency	17782.8	nM	None
Homo sapiens	Myotonin-protein kinase	Thermal melting change	3.5	degrees C	10.1073/pnas.0708800104
Homo sapiens	NCI/ADR-RES	GI50	659.17	nM	None
Homo sapiens	NCI-H187	Activity	99.24	%	10.1016/j.bmcl.2017.08.063
Homo sapiens	NCI-H187	IC50	0.26	ug.mL-1	10.1021/np0503202
Homo sapiens	NCI-H187	IC50	0.26	ug.mL-1	10.1021/np800805f
Homo sapiens	NCI-H187	IC50	0.3	ug.mL-1	10.1021/np0502793
Homo sapiens	NCI-H187	IC50	0.3	ug.mL-1	10.1021/np9000703
Homo sapiens	NCI-H187	IC50	0.32	ug.mL-1	10.1021/np049757k
Homo sapiens	NCI-H187	IC50	0.32	ug.mL-1	10.1021/np050001a
Homo sapiens	NCI-H187	IC50	0.32	ug.mL-1	10.1021/np0502286
Homo sapiens	NCI-H187	IC50	0.32	ug.mL-1	10.1021/np070293a
Homo sapiens	NCI-H187	IC50	0.32	ug.mL-1	10.1021/np9003189
Homo sapiens	NCI-H187	IC50	0.4	ug.mL-1	10.1021/np030519j
Homo sapiens	NCI-H187	IC50	0.44	ug.mL-1	10.1021/np900021h
Homo sapiens	NCI-H187	IC50	0.44	ug.mL-1	10.1021/np900352n
Homo sapiens	NCI-H187	IC50	0.52	ug.mL-1	10.1021/np070629g
Homo sapiens	NCI-H187	IC50	0.68	ug.mL-1	10.1021/np900777r
Homo sapiens	NCI-H187	IC50	800.0	nM	10.1021/np050036a
Homo sapiens	NCI-H187	IC50	950.0	nM	10.1016/j.bmcl.2017.08.063
Homo sapiens	NCI-H187	IC50	1160.0	nM	10.1021/np400268d
Homo sapiens	NCI-H187	IC50	1500.0	nM	10.1021/np1000363
Homo sapiens	NCI-H187	IC50	1590.0	nM	10.1021/np0601197
Homo sapiens	NCI-H187	IC50	1710.0	nM	10.1021/np070689m
Homo sapiens	NCI-H187	IC50	1820.0	nM	10.1021/np2004903
Homo sapiens	NCI-H187	IC50	2000.0	nM	10.1021/np700740a
Homo sapiens	NCI-H187	IC50	2230.0	nM	10.1021/np060249f
Homo sapiens	NCI-H187	IC50	2760.0	nM	10.1021/np100654m
Homo sapiens	NCI-H187	IC50	2770.0	nM	10.1016/j.bmcl.2010.03.054
Homo sapiens	NCI-H187	IC50	2770.0	nM	10.1016/j.ejmech.2011.05.041
Homo sapiens	NCI-H187	IC50	3100.0	nM	10.1021/np3000365
Homo sapiens	NCI-H187	IC50	3600.0	nM	10.1021/np900316x
Homo sapiens	NCI-H187	IC50	4400.0	nM	10.1021/np800702c
Homo sapiens	NCI-H187	IC50	9100.0	nM	10.1021/acs.jnatprod.0c01212
Homo sapiens	NCI-H187	IC50	9300.0	nM	10.1021/acs.jnatprod.9b00647
Homo sapiens	NCI-H187	IC50	13700.0	nM	10.1021/acs.jnatprod.1c00232
Homo sapiens	NCI-H1993	IC50	200.0	nM	10.1021/np2003512
Homo sapiens	NCI-H1993	IC50	nan	None	10.1021/np2003512
Homo sapiens	NCI-H226	GI50	1419.06	nM	None
Homo sapiens	NCI-H23	GI50	656.15	nM	None
Homo sapiens	NCI-H292	IC50	1000.0	nM	10.1021/np2003512
Homo sapiens	NCI-H292	IC50	nan	None	10.1021/np2003512
Homo sapiens	NCI-H322M	GI50	294.44	nM	None
Homo sapiens	NCI-H322M	GI50	310.0	nM	10.1021/jm9602930
Homo sapiens	NCI-H358	IC50	200.0	nM	10.1021/jm00104a011
Homo sapiens	NCI-H358	IC50	800.0	nM	10.1021/np2003512
Homo sapiens	NCI-H417	IC50	870.0	nM	10.1021/jm00104a011
Homo sapiens	NCI-H460	GI50	149.97	nM	None
Homo sapiens	NCI-H460	GI50	5770.0	nM	10.1016/j.ejmech.2013.09.023
Homo sapiens	NCI-H460	IC50	510.0	nM	10.1021/jm00104a011
Homo sapiens	NCI-H522	GI50	1156.11	nM	None
Homo sapiens	NCI-H69	IC50	1800.0	nM	10.1021/jm00104a011
Homo sapiens	Neuropeptide S receptor	Potency	10000.0	nM	None
Homo sapiens	NHDF	IC50	10000.0	nM	10.1016/j.bmc.2011.03.018
Homo sapiens	Niemann-Pick C1 protein	Potency	3162.3	nM	None
Homo sapiens	Niemann-Pick C1 protein	Potency	58047.9	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	7307.8	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	10322.5	nM	None
Homo sapiens	Nuclear factor NF-kappa-B p105 subunit	Potency	1412.5	nM	None
Homo sapiens	OVCAR	ED50	0.58	ug ml-1	10.1021/np9900627
Homo sapiens	OVCAR-3	GI50	322.11	nM	None
Homo sapiens	OVCAR-4	GI50	801.68	nM	None
Homo sapiens	OVCAR-5	GI50	1458.81	nM	None
Homo sapiens	OVCAR-8	GI50	406.44	nM	None
Homo sapiens	PDZ-binding kinase	Thermal melting change	0.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Peripheral myelin protein 22	Potency	7568.6	nM	None
Homo sapiens	Polypyrimidine tract-binding protein 1	Potency	12589.3	nM	None
Homo sapiens	Polypyrimidine tract-binding protein 1	Potency	31622.8	nM	None
Homo sapiens	Prelamin-A/C	Potency	7943.3	nM	None
Homo sapiens	Prelamin-A/C	Potency	10000.0	nM	None
Homo sapiens	Prelamin-A/C	Potency	11220.2	nM	None
Homo sapiens	Prelamin-A/C	Potency	12589.3	nM	None
Homo sapiens	Ras-related protein Rab-9A	Potency	46109.1	nM	None
Homo sapiens	Regulator of G-protein signaling 4	Potency	1683.4	nM	None
Homo sapiens	Ribosomal protein S6 kinase alpha 3	Thermal melting change	1.8	degrees C	10.1073/pnas.0708800104
Homo sapiens	Ribosomal protein S6 kinase alpha 3	Thermal melting change	3.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	RPMI-8226	GI50	616.6	nM	None
Homo sapiens	RT-4	IC50	1210.0	nM	10.1016/j.bmc.2009.05.016
Homo sapiens	RXF 393	GI50	287.74	nM	None
Homo sapiens	Serine/threonine-protein kinase 10	Thermal melting change	1.9	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase 16	Thermal melting change	10.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase 17A	Thermal melting change	0.8	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase 2	Thermal melting change	4.1	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase 25	Thermal melting change	nan	None	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase 38	Thermal melting change	1.1	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase Chk2	Thermal melting change	2.0	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase MST1	Thermal melting change	4.0	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase MST4	Thermal melting change	0.4	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase MST4	Thermal melting change	4.6	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase mTOR	Potency	13091.8	nM	None
Homo sapiens	Serine/threonine-protein kinase mTOR	Potency	26121.6	nM	None
Homo sapiens	Serine/threonine-protein kinase NEK2	Thermal melting change	0.5	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase NEK6	Thermal melting change	2.5	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase OSR1	Thermal melting change	0.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PAK 4	Thermal melting change	0.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PAK6	Thermal melting change	-0.5	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PAK7	Thermal melting change	0.9	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	Thermal melting change	-0.4	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PIM1	Thermal melting change	4.8	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PIM2	Thermal melting change	7.1	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PIM3	Thermal melting change	1.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PLK1	Thermal melting change	3.9	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase PLK4	Thermal melting change	3.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase RIO2	Thermal melting change	3.8	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase VRK1	Thermal melting change	0.4	degrees C	10.1073/pnas.0708800104
Homo sapiens	Serine/threonine-protein kinase VRK2	Thermal melting change	-0.7	degrees C	10.1073/pnas.0708800104
Homo sapiens	SF-268	GI50	698.23	nM	None
Homo sapiens	SF-268	GI50	816.0	nM	10.1021/jm00040a011
Homo sapiens	SF-295	GI50	805.38	nM	None
Homo sapiens	SF-539	GI50	866.96	nM	None
Homo sapiens	SH-SY5Y	IC50	2130.0	nM	10.1016/j.bmcl.2021.128135
Homo sapiens	Signal transducer and activator of transcription 6	Potency	7943.3	nM	None
Homo sapiens	Signal transducer and activator of transcription 6	Potency	12589.3	nM	None
Homo sapiens	Signal transducer and activator of transcription 6	Potency	15848.9	nM	None
Homo sapiens	Signal transducer and activator of transcription 6	Potency	25118.9	nM	None
Homo sapiens	Signal transducer and activator of transcription 6	Potency	100000.0	nM	None
Homo sapiens	SK-HEP1	IC50	400.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	SK-LU-1	IC50	1380.0	nM	10.1016/j.bmcl.2018.10.016
Homo sapiens	SK-LU-1	IC50	1540.0	nM	10.1016/j.bmcl.2021.127841
Homo sapiens	SK-MEL-2	GI50	2766.94	nM	None
Homo sapiens	SK-MEL-2	IC50	1140.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	SK-MEL-2	IC50	1910.0	nM	10.1016/j.bmcl.2017.05.003
Homo sapiens	SK-MEL-2	IC50	2150.0	nM	10.1016/j.bmcl.2015.06.005
Homo sapiens	SK-MEL-28	GI50	1503.14	nM	None
Homo sapiens	SK-MEL-5	GI50	944.06	nM	None
Homo sapiens	SK-MES-1	IC50	200.0	nM	10.1021/np2003512
Homo sapiens	SK-OV-3	GI50	1614.36	nM	None
Homo sapiens	SN12C	GI50	730.0	nM	10.1021/jm9602930
Homo sapiens	SN12C	GI50	1059.25	nM	None
Homo sapiens	SN12K1	GI50	559.76	nM	None
Homo sapiens	SNB-19	GI50	826.04	nM	None
Homo sapiens	SNB-75	GI50	1465.55	nM	None
Homo sapiens	SNB-78	GI50	1475.71	nM	None
Homo sapiens	SNU-638	IC50	1640.0	nM	10.1016/j.ejmech.2011.01.034
Homo sapiens	SNU-638	IC50	2000.0	nM	10.1016/j.bmcl.2004.04.094
Homo sapiens	SNU-638	IC50	2200.0	nM	10.1016/j.bmc.2010.10.057
Homo sapiens	SNU-638	IC50	2200.0	nM	10.1016/j.bmc.2011.01.064
Homo sapiens	SNU-638	IC50	2200.0	nM	10.1016/j.bmcl.2007.04.064
Homo sapiens	SNU-638	IC50	2700.0	nM	10.1021/acs.jnatprod.6b00006
Homo sapiens	Sphingomyelin phosphodiesterase	Potency	25118.9	nM	None
Homo sapiens	Stem cell growth factor receptor	IC50	200.0	nM	10.1021/jm050231m
Homo sapiens	Stem cell growth factor receptor	IC50	10000.0	nM	10.1021/jm050231m
Homo sapiens	Survival motor neuron protein	Potency	5623.4	nM	None
Homo sapiens	Survival motor neuron protein	Potency	11220.2	nM	None
Homo sapiens	Survival motor neuron protein	Potency	14125.4	nM	None
Homo sapiens	SW480	IC50	0.38	ug.mL-1	10.1016/j.bmcl.2015.09.069
Homo sapiens	SW480	IC50	3170.0	nM	10.1016/j.bmcl.2015.05.066
Homo sapiens	SW-620	GI50	359.75	nM	None
Homo sapiens	Thrombopoietin	Potency	10000.0	nM	None
Homo sapiens	Thyroid stimulating hormone receptor	Potency	25118.9	nM	None
Homo sapiens	TRAF2- and NCK-interacting kinase	Thermal melting change	-0.2	degrees C	10.1073/pnas.0708800104
Homo sapiens	Tyrosine-protein kinase JAK1	Thermal melting change	2.3	degrees C	10.1073/pnas.0708800104
Homo sapiens	Tyrosine-protein kinase LCK	IC50	18500.0	nM	10.1073/pnas.0708800104
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	1458.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	2310.9	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	6309.6	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	14125.4	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	31622.8	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	50118.7	nM	None
Homo sapiens	U-251	GI50	770.9	nM	None
Homo sapiens	U-251	GI50	930.0	nM	10.1021/jm9602930
Homo sapiens	UACC-257	GI50	1422.33	nM	None
Homo sapiens	UACC-62	GI50	1479.11	nM	None
Homo sapiens	Ubiquitin carboxyl-terminal hydrolase 1	Potency	7079.5	nM	None
Homo sapiens	Ubiquitin carboxyl-terminal hydrolase 1	Potency	79432.8	nM	None
Homo sapiens	UO-31	GI50	1954.34	nM	None
Homo sapiens	Voltage-gated T-type calcium channel alpha-1H subunit	EC50	3990.0	nM	None
Homo sapiens	XF498	GI50	1811.34	nM	None
Homo sapiens	ZR-75-1	ED50	0.9	ug ml-1	10.1021/np50112a012
Human immunodeficiency virus 1	Human immunodeficiency virus type 1 reverse transcriptase	IC50	150.0	ug.mL-1	10.1021/np50073a012
Human immunodeficiency virus 1	Human immunodeficiency virus type 1 reverse transcriptase	IC50	182000.0	nM	10.1016/j.bmcl.2012.05.041
Influenza A virus	Nonstructural protein 1	Potency	2511.9	nM	None
Influenza A virus	Nonstructural protein 1	Potency	7943.3	nM	None
Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	10000.0	nM	10.6019/CHEMBL4296183
Leishmania mexicana	Glucose transporter	Inhibition	14.72	%	10.6019/CHEMBL3433997
Mus musculus	L1210	Activity	50.0	%	10.1021/jm061184g
Mus musculus	L1210	Co	1.4	uM	10.1021/jm00383a011
Mus musculus	L1210	ED50	0.85	uM	10.1021/jm00383a011
Mus musculus	L1210	IC50	190.0	nM	10.1021/jm061184g
Mus musculus	L1210	IC50	500.0	nM	10.1016/S0960-894X(97)10138-X
Mus musculus	L1210	ID50	1e-07	M	10.1021/jm00157a040
Mus musculus	L1210	ID50	0.99	uM	10.1021/jm00135a010
Mus musculus	L1210	ID50	0.99	uM	10.1021/jm00364a015
Mus musculus	L1210	ID50	0.99	uM	10.1021/jm00383a004
Mus musculus	L1210	LD0	50.0	mg kg-1	10.1021/jm00135a010
Mus musculus	Mus musculus	IC50	300.0	nM	10.1016/j.bmc.2016.12.031
Mus musculus	Mus musculus	IC50	320.0	nM	10.1016/j.ejmech.2016.07.074
Mus musculus	Mus musculus	ILS	68.0	%	10.1021/jm00135a010
Mus musculus	Mus musculus	ILS	128.0	%	10.1021/jm00402a007
Mus musculus	Mus musculus	ILS	139.0	%	10.1021/jm00402a007
Mus musculus	Mus musculus	ILS	nan	None	10.1021/jm00402a007
Mus musculus	Mus musculus	LD0	50.0	mg kg-1	10.1021/jm00383a004
Mus musculus	Mus musculus	NADH oxidized	0.0	nM min-1	10.1021/jm00135a010
Mus musculus	Mus musculus	Oxygen consumed	0.0	nM min-1	10.1021/jm00135a010
Mus musculus	NIH3T3	IC50	3.0	nM	10.1016/j.bmcl.2006.09.093
Mus musculus	Nuclear receptor ROR-gamma	Potency	5623.4	nM	None
Mus musculus	Nuclear receptor ROR-gamma	Potency	7079.5	nM	None
Mus musculus	Nuclear receptor ROR-gamma	Potency	10000.0	nM	None
Mus musculus	P338	IC50	0.44	ug.mL-1	10.1016/j.bmcl.2015.09.069
Mus musculus	P388	ED50	0.2	ug ml-1	10.1021/np7007347
Mus musculus	P388	ED50	0.52	ug ml-1	10.1021/np060323u
Mus musculus	P388	ED50	1.0	ug ml-1	10.1021/np060233p
Mus musculus	P388	ED50	1.9	uM	10.1021/np3006887
Mus musculus	P388	ED50	2.12	uM	10.1016/j.bmcl.2017.10.063
Mus musculus	P388	ED50	2.44	uM	10.1016/j.bmcl.2011.11.085
Mus musculus	P388	GI50	382.82	nM	None
Mus musculus	P388	IC50	1340.0	nM	10.1016/j.ejmech.2017.07.035
Mus musculus	P388	IC50	1700.0	nM	10.1016/j.ejmech.2019.111700
Mus musculus	P388	IC50	1700.0	nM	10.1016/j.ejmech.2020.112044
Mus musculus	P388	IC50	1790.0	nM	10.1016/j.bmcl.2020.127263
Mus musculus	P388	IC50	1840.0	nM	10.1016/j.bmcl.2018.03.068
Mus musculus	P388	ILS	20.0	%	10.1021/jm00390a014
Mus musculus	P388	ILS	30.0	%	10.1021/jm00390a014
Mus musculus	P388	ILS	60.0	%	10.1021/jm00390a014
Mus musculus	P388	MST	12.0	None	10.1021/jm00390a014
Mus musculus	P388	MST	13.0	None	10.1021/jm00390a014
Mus musculus	P388	MST	16.0	None	10.1021/jm00390a014
Mus musculus	P388/ADR	GI50	824.14	nM	None
Mus musculus	R1	Activity	nan	None	10.1021/np070655e
Oncorhynchus gorbuscha	Salmon testes DNA	Activity	nan	None	10.1016/j.ejmech.2019.01.015
Oncorhynchus gorbuscha	Salmon testes DNA	Activity	nan	None	10.1021/acs.jnatprod.0c00946
Plasmodium berghei	Plasmodium berghei	Inhibition	70.0	%	10.1016/j.bmcl.2014.04.070
Plasmodium berghei	Plasmodium berghei	Inhibition	nan	%	10.1016/j.bmcl.2014.04.070
Plasmodium berghei	Plasmodium berghei	MST	40.0	day	10.1016/j.bmcl.2014.04.070
Plasmodium falciparum	Hexose transporter 1	Inhibition	20.91	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Plasmodium falciparum	IC50	0.4	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.52	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.56	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	0.93	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	1.41	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	1.66	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	1.78	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	73.0	nM	10.1016/j.bmc.2009.02.050
Plasmodium falciparum	Plasmodium falciparum	IC50	350.0	nM	10.1016/j.bmcl.2014.04.070
Plasmodium falciparum	Plasmodium falciparum	IC50	398.11	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	501.19	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	810.0	nM	10.1016/j.bmcl.2014.04.070
Plasmodium falciparum	Plasmodium falciparum	IC50	1000.0	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	1130.0	nM	10.1016/j.bmcl.2014.04.070
Plasmodium falciparum	Plasmodium falciparum	IC50	1258.93	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	1584.89	nM	10.1038/nchembio.215
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1016/j.ejmech.2014.07.087
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1016/j.ejmech.2015.09.001
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/np0502286
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/np700740a
Plasmodium falciparum	Plasmodium falciparum	Inhibition	2.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	95.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	97.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Potency	1041.8	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	1168.9	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	1852.6	nM	None
Plasmodium falciparum	Plasmodium falciparum	XC50	795.61	nM	10.1038/nature09107
Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	10000.0	nM	10.6019/CHEMBL4296183
Rattus norvegicus	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	AC50	231.0	nM	None
Rattus norvegicus	INS1	AC50	2124.0	nM	None
Rattus norvegicus	Muscarinic acetylcholine receptor M1	Potency	25118.9	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	3548.1	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	23778.1	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	25118.9	nM	None
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Potency	29934.9	nM	None
Saccharomyces cerevisiae	Saccharomyces cerevisiae	Potency	14581.0	nM	None
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	-44.57	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	19952.62	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	20000.0	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.3	%	10.6019/CHEMBL4495565
Staphylococcus aureus	Staphylococcus aureus	MIC	10000.0	nM	10.6019/CHEMBL4296183
Streptococcus	Streptococcus	EC50	7702.0	nM	None
Streptococcus pyogenes serotype M1	Streptokinase A	EC50	3024.0	nM	None
Streptococcus pyogenes serotype M1	Streptokinase A	EC50	150000.0	nM	None
Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	EC50	2251.0	nM	None
Trypanosoma brucei	6-phospho-1-fructokinase	Potency	8492.1	nM	None
Trypanosoma cruzi	Cruzipain	Potency	19952.6	nM	None
Trypanosoma cruzi	Cruzipain	Potency	25118.9	nM	None
Xanthomonas vasicola	Type-2 restriction enzyme XhoI	Inhibition	nan	%	10.1016/j.bmc.2009.08.064
None	ADMET	CC50	80.0	nM	10.1021/np030370b
None	ADMET	ED50	1.77	ug ml-1	10.1021/np060233p
None	ADMET	GI50	2060.0	nM	10.1016/j.ejmech.2013.09.023
None	ADMET	GI50	3300.0	nM	10.1016/j.ejmech.2011.09.029
None	ADMET	IC50	0.1	ug.mL-1	10.1016/s0960-894x(03)00241-5
None	ADMET	IC50	1200.0	nM	10.1016/j.ejmech.2015.11.004
None	ADMET	IC50	1300.0	nM	10.1021/acs.jnatprod.5b00677
None	ADMET	IC50	1900.0	nM	10.1016/j.bmcl.2006.08.018
None	ADMET	IC50	2700.0	nM	10.1016/j.bmcl.2006.08.018
None	ADMET	IC50	5970.0	nM	10.1016/j.bmc.2006.09.040
None	ADMET	IC50	6100.0	nM	10.1021/np070010e
None	ADMET	IC50	10000.0	nM	10.1016/j.bmc.2010.06.098
None	ADMET	IC50	140000.0	nM	10.1016/j.bmcl.2014.04.070
None	ADMET	Inhibition	8.0	%	10.1128/aac.00138-10
None	BC1 cell line	IC50	0.3	ug.mL-1	10.1016/s0960-894x(03)00111-2
None	NON-PROTEIN TARGET	ED50	0.2	ug ml-1	10.1021/np50112a012
None	NON-PROTEIN TARGET	ED50	0.2	ug ml-1	10.1021/np7007347
None	NON-PROTEIN TARGET	ED50	0.3	ug ml-1	10.1021/np50112a012
None	NON-PROTEIN TARGET	ED50	0.41	ug ml-1	10.1021/np9900627
None	NON-PROTEIN TARGET	ED50	0.6	ug ml-1	10.1021/np060323u
None	NON-PROTEIN TARGET	ED50	0.65	ug ml-1	10.1021/np060323u
None	NON-PROTEIN TARGET	ED50	1.26	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.03	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.11	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.15	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.19	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.2	uM	10.1021/np3006887
None	NON-PROTEIN TARGET	ED50	2.31	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	2.43	uM	10.1016/j.bmcl.2016.10.045
None	NON-PROTEIN TARGET	ED50	3.56	uM	10.1016/j.bmcl.2011.11.085
None	NON-PROTEIN TARGET	ED50	nan	None	10.1021/np50112a012
None	NON-PROTEIN TARGET	IC50	0.1	ug.mL-1	10.1016/s0960-894x(03)00241-5
None	NON-PROTEIN TARGET	IC50	0.1	ug.mL-1	10.1021/np0004404
None	NON-PROTEIN TARGET	IC50	0.13	ug.mL-1	10.1021/np070083y
None	NON-PROTEIN TARGET	IC50	0.13	ug.mL-1	10.1021/np070629g
None	NON-PROTEIN TARGET	IC50	0.14	ug.mL-1	10.1021/np060190c
None	NON-PROTEIN TARGET	IC50	0.2	ug.mL-1	10.1021/np030067a
None	NON-PROTEIN TARGET	IC50	0.2	ug.mL-1	10.1021/np030429e
None	NON-PROTEIN TARGET	IC50	0.2	ug.mL-1	10.1021/np9000703
None	NON-PROTEIN TARGET	IC50	0.21	ug.mL-1	10.1021/np100632g
None	NON-PROTEIN TARGET	IC50	0.21	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	0.22	ug.mL-1	10.1021/np060164e
None	NON-PROTEIN TARGET	IC50	0.26	ug.mL-1	10.1021/np049757k
None	NON-PROTEIN TARGET	IC50	0.26	ug.mL-1	10.1021/np070293a
None	NON-PROTEIN TARGET	IC50	0.26	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	0.27	ug.mL-1	10.1021/np0502286
None	NON-PROTEIN TARGET	IC50	0.3	ug.mL-1	10.1021/np020055+
None	NON-PROTEIN TARGET	IC50	0.3	ug.mL-1	10.1021/np0502793
None	NON-PROTEIN TARGET	IC50	0.3	ug.mL-1	10.1021/np100632g
None	NON-PROTEIN TARGET	IC50	0.3	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	0.32	ug.mL-1	10.1021/np0503202
None	NON-PROTEIN TARGET	IC50	0.32	ug.mL-1	10.1021/np800805f
None	NON-PROTEIN TARGET	IC50	0.36	ug.mL-1	10.1021/np050001a
None	NON-PROTEIN TARGET	IC50	0.4	ug.mL-1	10.1021/np030519j
None	NON-PROTEIN TARGET	IC50	0.6	ug.mL-1	10.1021/np010006h
None	NON-PROTEIN TARGET	IC50	0.63	ug.mL-1	10.1016/j.bmcl.2015.09.069
None	NON-PROTEIN TARGET	IC50	1.0	ug.mL-1	10.1021/jm020452h
None	NON-PROTEIN TARGET	IC50	1.21	ug.mL-1	10.1021/np100632g
None	NON-PROTEIN TARGET	IC50	1.21	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	1.8	nM	10.1016/j.bmcl.2014.09.065
None	NON-PROTEIN TARGET	IC50	1.82	nM	10.1016/j.bmcl.2014.03.091
None	NON-PROTEIN TARGET	IC50	2.02	ug.mL-1	10.1021/np100632g
None	NON-PROTEIN TARGET	IC50	2.02	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	7.11	ug.mL-1	10.1021/np100632g
None	NON-PROTEIN TARGET	IC50	7.11	ug.mL-1	10.1021/np9003189
None	NON-PROTEIN TARGET	IC50	490.0	nM	10.1021/np070689m
None	NON-PROTEIN TARGET	IC50	520.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	530.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	600.0	nM	10.1021/np2003512
None	NON-PROTEIN TARGET	IC50	682.0	nM	10.1021/np060249f
None	NON-PROTEIN TARGET	IC50	750.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	800.0	nM	10.1016/j.bmc.2009.05.016
None	NON-PROTEIN TARGET	IC50	800.0	nM	10.1021/np050036a
None	NON-PROTEIN TARGET	IC50	1000.0	nM	10.1021/acs.jnatprod.5b00961
None	NON-PROTEIN TARGET	IC50	1010.0	nM	10.1016/j.ejmech.2010.05.029
None	NON-PROTEIN TARGET	IC50	1100.0	nM	10.1016/j.ejmech.2008.12.011
None	NON-PROTEIN TARGET	IC50	1200.0	nM	10.1021/np700740a
None	NON-PROTEIN TARGET	IC50	1200.0	nM	10.1021/np800702c
None	NON-PROTEIN TARGET	IC50	1270.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	1390.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	1620.0	nM	10.1016/j.ejmech.2010.05.029
None	NON-PROTEIN TARGET	IC50	1750.0	nM	10.1016/j.ejmech.2015.11.004
None	NON-PROTEIN TARGET	IC50	1950.0	nM	10.1016/j.ejmech.2016.07.074
None	NON-PROTEIN TARGET	IC50	2000.0	nM	10.1016/j.bmc.2016.12.031
None	NON-PROTEIN TARGET	IC50	2000.0	nM	10.1016/j.ejmech.2015.11.004
None	NON-PROTEIN TARGET	IC50	2030.0	nM	10.1021/acs.jnatprod.5b00961
None	NON-PROTEIN TARGET	IC50	2100.0	nM	10.1016/j.bmc.2016.12.031
None	NON-PROTEIN TARGET	IC50	2100.0	nM	10.1016/j.ejmech.2014.05.032
None	NON-PROTEIN TARGET	IC50	2200.0	nM	10.1016/j.bmcl.2015.05.051
None	NON-PROTEIN TARGET	IC50	3820.0	nM	10.1016/j.bmcl.2015.05.066
None	NON-PROTEIN TARGET	IC50	4500.0	nM	10.1016/j.ejmech.2010.05.029
None	NON-PROTEIN TARGET	IC50	5930.0	nM	10.1021/np0601197
None	NON-PROTEIN TARGET	IC50	6580.0	nM	10.1021/np500476h
None	NON-PROTEIN TARGET	IC50	9340.0	nM	10.1016/j.ejmech.2010.05.029
None	NON-PROTEIN TARGET	IC50	15000.0	nM	10.1073/pnas.0708800104
None	NON-PROTEIN TARGET	IC50	18270.0	nM	10.1021/np500476h
None	NON-PROTEIN TARGET	IC50	25210.0	nM	10.1016/j.ejmech.2010.05.029
None	NON-PROTEIN TARGET	IC50	37920.0	nM	10.1021/np500476h
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.ejmech.2014.05.019
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.ejmech.2014.07.087
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.ejmech.2015.09.001
None	NON-PROTEIN TARGET	Potency	398.1	nM	None
None	NON-PROTEIN TARGET	Potency	446.7	nM	None
None	NON-PROTEIN TARGET	Potency	707.9	nM	None
None	NON-PROTEIN TARGET	Potency	794.3	nM	None
None	NON-PROTEIN TARGET	Potency	1122.0	nM	None
None	NON-PROTEIN TARGET	Potency	1412.5	nM	None
None	NON-PROTEIN TARGET	Potency	1995.3	nM	None
None	No relevant target	pKa	7.4	None	10.1021/acs.jmedchem.7b01182
None	No relevant target	pKa	7.4	None	10.1021/jm00047a008
None	No relevant target	solubility	nan	None	10.1021/acs.jnatprod.0c00946
None	Nucleic Acid	Activity	30.0	%	10.1021/np50078a006
None	Nucleic Acid	Activity	nan	None	10.1016/j.bmc.2009.08.064
None	Nucleic Acid	Activity	nan	None	10.1016/j.ejmech.2008.12.011
None	Nucleic Acid	Activity	nan	None	10.1021/jm800499x
None	Nucleic Acid	C50	1039.0	nM	10.1021/jm00157a040
None	Nucleic Acid	Delta Tm	9.8	degrees C	10.1021/jm00047a008
None	Nucleic Acid	Log Kd	5.18	None	10.1021/jm00370a007
None	Unchecked	Activity	nan	None	10.1016/j.bmc.2016.12.031
None	Unchecked	Activity	nan	None	10.1016/j.bmcl.2006.09.093
None	Unchecked	EC50	117.0	nM	None
None	Unchecked	EC50	177.0	nM	None
None	Unchecked	EC50	2400.0	nM	None
None	Unchecked	EC50	2530.0	nM	None
None	Unchecked	EC50	2720.0	nM	None
None	Unchecked	EC50	6170.0	nM	None
None	Unchecked	EC50	120000.0	nM	None
None	Unchecked	ED50	2.17	uM	10.1016/j.bmcl.2017.10.063
None	Unchecked	ED50	4.16	uM	10.1016/j.bmcl.2017.10.063
None	Unchecked	ED50	4.75	uM	10.1016/j.bmcl.2017.10.063
None	Unchecked	IC50	465.0	nM	None
None	Unchecked	IC50	1050.0	nM	10.1016/j.ejmech.2021.113999
None	Unchecked	IC50	1100.0	nM	10.1016/j.bmcl.2020.127404
None	Unchecked	IC50	1300.0	nM	10.1016/j.bmcl.2020.127404
None	Unchecked	IC50	1700.0	nM	10.1016/j.ejmech.2020.112044
None	Unchecked	IC50	1810.0	nM	10.1016/j.bmcl.2020.127263
None	Unchecked	IC50	1830.0	nM	10.1016/j.bmcl.2021.128054
None	Unchecked	IC50	1870.0	nM	10.1016/j.bmcl.2020.127741
None	Unchecked	IC50	1890.0	nM	10.1016/j.bmcl.2021.128135
None	Unchecked	IC50	1970.0	nM	10.1016/j.bmcl.2021.128135
None	Unchecked	IC50	2020.0	nM	10.1016/j.bmcl.2018.03.068
None	Unchecked	IC50	2040.0	nM	10.1016/j.bmcl.2020.127741
None	Unchecked	IC50	2110.0	nM	10.1016/j.bmcl.2020.127741
None	Unchecked	IC50	2170.0	nM	10.1016/j.ejmech.2017.07.035
None	Unchecked	IC50	2190.0	nM	10.1016/j.bmcl.2020.127263
None	Unchecked	IC50	2420.0	nM	10.1016/j.bmcl.2020.127741
None	Unchecked	IC50	2430.0	nM	10.1016/j.bmcl.2020.127263
None	Unchecked	IC50	6580.0	nM	10.1021/acs.jnatprod.6b00908
None	Unchecked	IC50	9340.0	nM	10.1021/acs.jnatprod.6b00908
None	Unchecked	IC50	18790.0	nM	None
None	Unchecked	IC50	19560.0	nM	None
None	Unchecked	IC50	21190.0	nM	None
None	Unchecked	IC50	26270.0	nM	None
None	Unchecked	IC50	30000.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	32891.0	nM	None
None	Unchecked	IC50	69740.0	nM	None
None	Unchecked	IFI	7.3	%	10.1038/nature09107
None	Unchecked	Imax	nan	None	10.1016/j.bmc.2013.03.031
None	Unchecked	Inhibition	nan	%	10.1038/nchembio873
None	Unchecked	Ka	4.2	10'5/M	10.1016/j.bmc.2016.12.031
None	Unchecked	Ka	12.3	10'5/M	10.1016/j.bmc.2016.12.031
None	Unchecked	Potency	891.3	nM	None
None	Unchecked	Potency	1778.3	nM	None
None	Unchecked	Potency	2059.6	nM	None
None	Unchecked	Potency	2238.7	nM	None
None	Unchecked	Potency	3662.6	nM	None
None	Unchecked	Potency	3981.1	nM	None
None	Unchecked	Potency	4109.5	nM	None
None	Unchecked	Potency	4466.8	nM	None
None	Unchecked	Potency	5804.8	nM	None
None	Unchecked	Potency	7943.3	nM	None
None	Unchecked	Potency	8912.5	nM	None
None	Unchecked	Potency	9196.2	nM	None
None	Unchecked	Potency	10000.0	nM	None
None	Unchecked	Potency	11220.2	nM	None
None	Unchecked	Potency	11582.1	nM	None
None	Unchecked	Potency	17782.8	nM	None
None	Unchecked	Potency	23109.3	nM	None
None	Unchecked	Potency	25118.9	nM	None
None	Unchecked	Potency	28183.8	nM	None
None	Unchecked	Potency	29092.9	nM	None
None	Unchecked	Ratio	1.0	None	10.1021/jm00040a010
None	Unchecked	Ratio IC50	15.6	None	10.1016/j.ejmech.2019.111807
None	Unchecked	Ratio IC50	290.0	None	10.1016/j.bmcl.2014.04.070