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name Structure Reference Source Properties Activities Metabolism

Papaverine

AlkaPlorer ID: AK001361

Synonym: None

IUPAC Name: 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline

Structure

SMILES: COC1=CC=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1OC

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InChI: InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3

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InChIKey: XQYZDYMELSJDRZ-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Papaver commutatum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 339.3910000000001

TPSA？: 49.81

MolLogP？: 3.860000000000003

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 2818.4 nM None
Bos taurus Phosphodiesterase 1 IC50 8800.0 nM 10.1021/jm00356a011
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Canis lupus familiaris Canis familiaris ED100 1825.0 ug 10.1021/jm00198a024
Cavia porcellus Ileum Emax 72.3 % 10.1021/np060073h
Cavia porcellus Ileum Emax 91.76 % 10.1021/np030303h
Cavia porcellus Ileum IC50 4230.0 nM 10.1021/np030303h
Cavia porcellus Ileum pD2 5.08 None 10.1021/np50041a008
Cavia porcellus Ileum pD2 5.08 None 10.1021/np50059a043
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cryptosporidium parvum Cryptosporidium parvum IC50 nan None 10.1016/j.bmc.2010.01.068
Electrophorus electricus Acetylcholinesterase IC50 24300.0 nM 10.1007/s00044-008-9122-3
Entamoeba histolytica Entamoeba histolytica IC50 nan None 10.1016/j.bmc.2010.01.068
Homo sapiens Acetylcholinesterase IC50 24330.0 nM 10.1016/j.bmcl.2006.01.067
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Inhibition 46.4 % 10.1016/j.bmcl.2006.01.067
Homo sapiens Acetylcholinesterase Inhibition 88.2 % 10.1016/j.bmcl.2006.01.067
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 3548.1 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Arachidonate 12-lipoxygenase Potency 7079.5 nM None
Homo sapiens Arachidonate 15-lipoxygenase Potency 39810.7 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile acid receptor FXR Activity 13.3 % 10.1016/j.bmc.2014.02.049
Homo sapiens Bile salt export pump AC50 46000.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 10000.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 6.0 nM None
Homo sapiens CREB-binding protein Potency 562.3 nM None
Homo sapiens CREB-binding protein Potency 707.9 nM None
Homo sapiens CREB-binding protein Potency 1258.9 nM None
Homo sapiens CREB-binding protein Potency 7943.3 nM None
Homo sapiens CREB-binding protein Potency 10000.0 nM None
Homo sapiens CREB-binding protein Potency 15848.9 nM None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 1A2 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 3981.07 nM None
Homo sapiens Cytochrome P450 2C19 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 IC50 762.0 nM None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C19 Potency 3981.1 nM None
Homo sapiens Cytochrome P450 2C19 Potency 5011.9 nM None
Homo sapiens Cytochrome P450 2C19 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 2C9 AC50 39810.72 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 2C9 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2D6 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2D6 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2D6 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 2D6 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 2D6 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 1995.26 nM None
Homo sapiens Cytochrome P450 3A4 AC50 2511.89 nM None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 1995.3 nM None
Homo sapiens Cytochrome P450 3A4 Potency 2511.9 nM None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA polymerase kappa Potency 3196.1 nM None
Homo sapiens DNA polymerase kappa Potency 5011.9 nM None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 Potency 5802.4 nM None
Homo sapiens HepG2 IC50 relative 12800.0 nM 10.6019/EOS300108
Homo sapiens HepG2-CD81 HEPG2TOX ASSAY - CC50 8.78 uM 10.1126/science.aat9446
Homo sapiens HepG2-CD81 HEPG2TOX ASSAY - CC90 8.78 uM 10.1126/science.aat9446
Homo sapiens HERG AC50 5600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 7244.36 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -15.32 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -1.39 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 707.9 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 5623.4 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 11.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 11.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 5.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.28 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.54 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.52 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 0.95 L.kg-1 10.1021/jm901371v
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 2511.9 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 10000.0 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 7943.3 nM None
Homo sapiens MAP kinase ERK2 Potency 31622.8 nM None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 23130.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 7307.8 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 10000.0 nM None
Homo sapiens Phosphodiesterase 1 IC50 9000.0 nM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 1 IC50 21600.0 nM 10.1021/jm00076a003
Homo sapiens Phosphodiesterase 10A IC20 0.65 uM 10.1021/acs.jmedchem.0c01013
Homo sapiens Phosphodiesterase 10A IC50 17.0 nM 10.1016/j.bmc.2010.10.038
Homo sapiens Phosphodiesterase 10A IC50 21.0 nM 10.1016/j.ejmech.2011.05.072
Homo sapiens Phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmc.2014.03.028
Homo sapiens Phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmc.2019.06.021
Homo sapiens Phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmcl.2012.01.046
Homo sapiens Phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmcl.2014.12.054
Homo sapiens Phosphodiesterase 10A IC50 36.0 nM 10.1021/acs.jmedchem.1c00115
Homo sapiens Phosphodiesterase 10A IC50 38.0 nM 10.1016/j.ejmech.2020.112854
Homo sapiens Phosphodiesterase 10A IC50 40.0 nM 10.1021/jm3004976
Homo sapiens Phosphodiesterase 10A IC50 56.9 nM 10.1021/jm1002793
Homo sapiens Phosphodiesterase 10A IC50 76.0 nM 10.1021/jm1002793
Homo sapiens Phosphodiesterase 10A IC50 92.3 nM 10.1039/C5MD00419E
Homo sapiens Phosphodiesterase 10A IC50 97.0 nM 10.1016/j.bmcl.2019.03.021
Homo sapiens Phosphodiesterase 10A IC50 210.0 nM 10.1016/j.bmc.2013.07.030
Homo sapiens Phosphodiesterase 10A IC50 210.0 nM 10.1016/j.bmcl.2011.04.067
Homo sapiens Phosphodiesterase 10A Inhibition 16.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 10A Inhibition 17.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 10A Inhibition 53.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 10A Inhibition 57.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 10A Inhibition 89.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 10A Inhibition 94.0 % 10.1016/j.ejmech.2019.04.020
Homo sapiens Phosphodiesterase 2A IC50 2300.0 nM 10.1021/jm00076a003
Homo sapiens Phosphodiesterase 2A IC50 17000.0 nM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 3A AC50 370.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A IC50 284.0 nM 10.1021/jm3004976
Homo sapiens Phosphodiesterase 3A IC50 287.0 nM 10.1021/acs.jmedchem.9b00224
Homo sapiens Phosphodiesterase 3A IC50 917.0 nM 10.1016/j.ejmech.2011.05.072
Homo sapiens Phosphodiesterase 3A IC50 1300.0 nM 10.1016/j.bmc.2019.06.021
Homo sapiens Phosphodiesterase 3A Ki 279.0 nM 10.1021/jm060653b
Homo sapiens Phosphodiesterase 3B IC50 1030.0 nM 10.1016/j.ejmech.2011.05.072
Homo sapiens Phosphodiesterase 3B Ki 417.0 nM 10.1021/jm060653b
Homo sapiens Phosphodiesterase 4A IC50 1600.0 nM 10.1021/acs.jmedchem.9b00224
Homo sapiens Phosphodiesterase 4D AC50 1000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D IC50 1400.0 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 5A IC50 8800.0 nM 10.1021/jm00076a003
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphodiesterase; PDE3 & PDE4 IC50 6600.0 nM 10.1021/jm50001a001
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 1995.3 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Ras-related protein Rab-9A Potency 91999.7 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine hydroxymethyltransferase, mitochondrial IC50 2691.53 nM None
Homo sapiens Serine hydroxymethyltransferase, mitochondrial Inhibition 59.2 % None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 11.0 % 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 56.0 % 10.1021/jm00381a019
Homo sapiens Solute carrier family 22 member 1 Inhibition 66.3 % 10.1021/jm8003152
Homo sapiens Sphingomyelin phosphodiesterase Activity 118.2 % 10.1021/jm070524a
Homo sapiens Survival motor neuron protein Potency 7943.3 nM None
Homo sapiens Thrombopoietin Potency 12589.3 nM None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 3162.3 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 5011.9 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 12589.3 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 13335.9 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 12589.3 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 200.0 ug.mL-1 10.1021/np50073a012
Influenza A virus Influenza A virus IC50 2000.0 nM 10.1021/acs.jmedchem.1c00302
Influenza B virus Influenza B virus IC50 2000.0 nM 10.1021/acs.jmedchem.1c00302
Leishmania amazonensis Leishmania amazonensis IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania donovani Leishmania donovani IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania infantum Leishmania infantum IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania major Leishmania major IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania mexicana Leishmania mexicana IC50 nan None 10.1016/j.bmc.2010.01.068
Mus musculus Mus musculus Activity nan None 10.1021/jm00217a005
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 2.8 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 12589.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 28183.8 nM None
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Parainfluenza virus 5 Parainfluenza virus 5 IC50 2000.0 nM 10.1021/acs.jmedchem.1c00302
Plasmodium berghei Plasmodium berghei LUCIFERASE EXPRESSION CONTROL - IC50 8.78 uM 10.1126/science.aat9446
Plasmodium berghei Plasmodium berghei LUCIFERASE EXPRESSION CONTROL - IC90 8.78 uM 10.1126/science.aat9446
Plasmodium berghei Plasmodium berghei LUCIFERASE INFECTION ASSAY - IC50 8.78 uM 10.1126/science.aat9446
Plasmodium berghei Plasmodium berghei LUCIFERASE INFECTION ASSAY - IC90 8.78 uM 10.1126/science.aat9446
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum Potency 3219.7 nM None
Pneumocystis carinii Pneumocystis carinii IC50 nan None 10.1016/j.bmc.2010.01.068
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmcl.2015.10.100
Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A IC50 36.0 nM 10.1016/j.bmcl.2019.03.021
Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A IC50 36.0 nM 10.1016/j.ejmech.2011.05.072
Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A IC50 36.0 nM 10.1016/j.ejmech.2018.03.046
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Ileum IC50 0.059 nM 10.1007/s00044-011-9601-9
Rattus norvegicus Ileum IC50 6.2 nM 10.1007/s00044-011-9601-9
Rattus norvegicus Ileum IC50 7.07 nM 10.1007/s00044-011-9601-9
Rattus norvegicus Ileum IC50 9.44 nM 10.1007/s00044-011-9601-9
Rattus norvegicus Ileum IC50 1550.0 nM 10.1021/np990061e
Rattus norvegicus Ileum Ratio IC50 1.0 None 10.1007/s00044-011-9601-9
Rattus norvegicus Inositol monophosphatase 1 Potency 17782.8 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Intestine Kd 15848.93 nM 10.1021/np50041a008
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 56.2 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 7943.3 nM None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peripheral myelin protein 22 Potency 1547.2 nM None
Rattus norvegicus Phosphodiesterase 1 IC50 12000.0 nM 10.1021/jm00356a011
Rattus norvegicus Phosphodiesterase 1 IC50 21000.0 nM 10.1021/jm00356a011
Rattus norvegicus Phosphodiesterase 4 Ki 8e-06 None 10.1021/jm00185a008
Rattus norvegicus Plasma Fu 0.073 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus ALB 29000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 30000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 31000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 32000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 36700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 37000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 37300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALBGLOB 1.1 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.2 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.3 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 289.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 334.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 347.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 374.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 1003.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1042.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1162.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1181.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1231.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1235.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1249.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1310.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1322.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1354.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1358.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1378.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1381.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1398.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1418.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1422.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1463.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1489.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1494.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1530.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1542.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1546.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1563.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1569.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1572.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1633.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1651.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1691.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1731.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1776.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1841.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 26.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 34.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 35.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 36.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 36.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 36.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 37.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 38.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 45.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 47.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 48.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 48.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 19.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 20.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 25.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 25.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 56.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 57.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 60.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 62.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 66.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 66.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 72.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 72.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 72.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 74.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 78.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 79.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 82.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILDIR 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.02 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.08 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.02 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.04 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.075 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.08 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.1 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.12 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.14 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.16 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.2 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.22 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.36 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 4.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Blood pressure -23.0 mmHg 10.1021/jm00072a016
Rattus norvegicus Rattus norvegicus Blood pressure -21.0 mmHg 10.1021/jm001017v
Rattus norvegicus Rattus norvegicus Blood pressure -18.0 mmHg 10.1021/jm00072a016
Rattus norvegicus Rattus norvegicus Blood pressure -16.0 mmHg 10.1021/jm001017v
Rattus norvegicus Rattus norvegicus BP -20.0 mmHg 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus BP -15.0 mmHg 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus BUN 76.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 78.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 100.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 110.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 112.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 114.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 116.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 134.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 154.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 158.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 162.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 166.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 172.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 176.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 180.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 182.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 186.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 194.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 198.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 200.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 202.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 101.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 102.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 103.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 105.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 109.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 110.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 111.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 112.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 114.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Change -19.0 % 10.1016/s0960-894x(99)00569-7
Rattus norvegicus Rattus norvegicus Change -18.0 % 10.1016/s0960-894x(99)00569-7
Rattus norvegicus Rattus norvegicus Change -16.0 % 10.1016/s0960-894x(99)00569-7
Rattus norvegicus Rattus norvegicus Change -5.0 % 10.1016/s0960-894x(99)00569-7
Rattus norvegicus Rattus norvegicus CHLORIDE 105.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 107.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 107.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 108.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 576.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 613.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 642.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 643.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 652.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 663.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 676.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 682.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 686.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 714.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 720.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 732.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 734.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 736.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 740.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 746.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 752.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 764.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 770.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 772.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 778.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 782.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 784.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 792.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 794.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 818.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 820.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 822.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 826.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 830.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CK 129.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 131.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 142.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 170.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cl 105.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 5.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 5.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 6.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus dp/dt -604.0 mmHg s-1 10.1021/jm00072a016
Rattus norvegicus Rattus norvegicus dP/dt -1204.0 mmHg s-1 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus Emax 96.7 % 10.1016/j.bmcl.2006.05.082
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2990.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3068.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3086.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3092.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3128.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3132.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3144.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3148.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3158.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3162.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3168.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3178.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3190.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3194.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3216.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3224.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3250.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3258.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3268.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3278.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3280.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3326.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3374.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3392.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3396.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3416.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3426.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 3.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1686.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1720.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1743.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1784.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1790.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1798.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1802.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1806.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1810.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1814.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1820.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1830.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1836.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1838.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1854.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1868.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1890.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1896.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1908.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1910.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1914.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1918.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1934.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1936.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1954.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1956.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1958.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1960.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1974.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1982.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1994.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1996.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2022.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2032.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2114.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 35.07 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.97 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 38.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Heart rate -21.0 beats min-1 10.1021/jm00072a016
Rattus norvegicus Rattus norvegicus Heart rate -18.0 beats min-1 10.1021/jm991004l
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 131000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 141000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 141300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 143000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 144000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 144300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 145000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 146000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 154000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus IC50 1550.0 nM 10.1016/j.bmcl.2006.05.082
Rattus norvegicus Rattus norvegicus LDH 120.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 141.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 141.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 142.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 147.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 150.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 151.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 151.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 153.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 157.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 159.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 160.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 160.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 160.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 161.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 162.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 164.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 164.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 166.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 166.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 169.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 171.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 171.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 173.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 179.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 179.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 182.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 183.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 184.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 190.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 207.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 248.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 71.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 74.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 81.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 81.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 84.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 18.5 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 18.6 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 18.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.0 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.4 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.6 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.0 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 23.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.87 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.97 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 32.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 390700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 402000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 411700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 412700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 56.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 56.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 57.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 57.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 58.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 59.13 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.33 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.5 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.1 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 20.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 21.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 23.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 60.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 62.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 66.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 67.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 68.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 69.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 72.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 73.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 75.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 77.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 78.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 79.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 87.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 88.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 89.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 91.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 92.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 94.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 95.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 97.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 100.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 102.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 111.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOSLPD 1232.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1240.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1246.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1252.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1266.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1284.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1298.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1316.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1328.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1336.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1346.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1350.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1364.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1374.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1392.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1402.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1424.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1426.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1438.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1440.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1462.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1474.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1484.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1488.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1490.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1494.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1498.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1524.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1534.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1556.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1560.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 973000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1004000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1006000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1013000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1053000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1062000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1070000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1077000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1083000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1085000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1087000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1099000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1112000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1113000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1116000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1117000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1132000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1141000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1142000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1144000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1164000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1166000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1169000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1171000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1178000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1190000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1192000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1205000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1229000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1230000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1247000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1264000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1285000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1296000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1313000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.9 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.1 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.3 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.5 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 6.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.23 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 53000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 54000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 61300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PT 15.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Ratio IC50 3.76 None 10.1016/j.bmcl.2006.05.082
Rattus norvegicus Rattus norvegicus RBC 5800000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5940000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6130000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6200000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6224000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6246000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6278000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6280000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6338000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6364000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6374000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6386000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6388000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6390000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6394000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6418000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6432000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6448000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6456000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6476000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6478000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6482000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6498000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6520000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6540000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6542000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6618000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6640000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7064000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7070000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7226000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7286000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7604000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7725000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7730000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7750000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 3.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 8.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 8.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 139.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.5 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 149.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 152.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 153.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TERMBW 213.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 214.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 217.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 219.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 223.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 223.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 228.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 231.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 231.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 234.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 237.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 239.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 240.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 240.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 245.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 246.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 267.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 281.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 287.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 315.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 316.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 326.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 331.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 373.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 380.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 413.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 422.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TRIG 334.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 340.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 384.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 438.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 476.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 546.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 550.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 638.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 640.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 656.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 698.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 784.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 818.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 860.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 878.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 910.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 986.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1016.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1098.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1160.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1192.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1198.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1230.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1232.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1258.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1260.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1326.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1452.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1524.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1680.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 6410.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7310.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7880.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8240.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8400.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8460.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8570.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8670.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8760.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8850.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9030.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9430.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10240.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10410.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10540.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10550.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10660.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10720.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10850.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11040.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11090.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11600.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11890.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12130.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12250.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12320.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12410.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12560.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12830.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15190.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 15230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WEIGHT 0.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 3.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 16.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 16.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 17.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 335.9 nM None
Rattus norvegicus Uterus Emax 98.52 % 10.1016/j.bmcl.2017.12.017
Rattus norvegicus Uterus IC50 420.0 nM 10.1016/j.bmcl.2017.12.017
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 17.4 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.03666 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.24 % 10.6019/CHEMBL4495565
Sus scrofa Phosphodiesterase 3A IC50 620.0 nM 10.1021/jm00076a003
Sus scrofa Phosphodiesterase 4A IC50 1700.0 nM 10.1021/jm00076a003
Toxoplasma gondii Toxoplasma gondii IC50 nan None 10.1016/j.bmc.2010.01.068
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei Trypanosoma brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1016/j.bmc.2010.01.068
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CL 11.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET MRT 1.4 hr 10.1124/dmd.108.020479
None ADMET T1/2 1.8 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.95 L.kg-1 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Activity 10.0 ug ml-1 10.1021/np50039a003
None NON-PROTEIN TARGET Activity 25.0 ug ml-1 10.1021/np50039a003
None NON-PROTEIN TARGET Activity 100.0 ug ml-1 10.1021/np50039a003
None NON-PROTEIN TARGET Fu 0.073 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 3.3 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 11.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 53.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.068
None No relevant target LogD 3.71 None 10.1016/j.ejmech.2011.05.072
None No relevant target LogD7.4 2.81 None 10.6019/CHEMBL3301361
None No relevant target LogP 2.73 None 10.1021/jm801441s
None No relevant target LogP 2.93 None 10.1021/jm070524a
None No relevant target LogP 2.95 None 10.1021/jm801441s
None No relevant target LogP 3.0 None 10.1016/j.bmcl.2021.128318
None No relevant target Log PNalk 0.75 None 10.1021/jm048980b
None No relevant target pKa 6.25 None 10.1021/jm070524a
None No relevant target Rm 2.79 None 10.1016/j.bmcl.2021.128318
None No relevant target Solubility 46.0 ug.mL-1 10.1016/j.bmc.2010.08.003
None No relevant target Solubility 38000.0 nM 10.6019/CHEMBL3301361
None Unchecked Hepatotoxicity (acute) 9.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 6.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 7.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 550.0 nM 10.1021/jm00376a013
None Unchecked IC50 665.0 nM None
None Unchecked IC50 817.0 nM None
None Unchecked IC50 1100.0 nM 10.1016/j.bmcl.2011.08.036
None Unchecked IC50 15400.0 nM 10.1021/acs.jmedchem.0c01013
None Unchecked IC50 nan None None
None Unchecked Inhibition 90.0 % 10.1021/np970569m
None Unchecked Ki 17.0 nM 10.1021/jm060653b
None Unchecked Ki nan None None
None Unchecked Potency 707.9 nM None
None Unchecked Potency 2909.3 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Ratio IC50 9.0 None 10.1016/j.ejmech.2011.05.072

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011790 COc1ccc(C[C@@H]2NC=Cc3cc(OC)c(OC)cc32)cc1OC>>COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC RXN-14873
AKRT011799 COc1ccc(C[C@@H]2NCCc3cc(OC)c(OC)cc32)cc1OC>>COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC R11748