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name Structure Reference Source Properties Activities Metabolism

Lycorine

AlkaPlorer ID: AK001382

Synonym: None

IUPAC Name: (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol

Structure

SMILES: O[C@H]1[C@H]2C3=CC4=C(C=C3CN3CCC(=C[C@@H]1O)[C@H]23)OCO4

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InChI: InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1

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InChIKey: XGVJWXAYKUHDOO-DANNLKNASA-N

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Reference

Seed oils of Ungernia victoris

PubChem CID: 72378

CAS: 2188-68-3

LOTUS: LTS0186544

NPASS: NPC181653

data_source: manually

Source

Species Genus Family Order Class Phylum Kingdom Domain
Zephyranthes candida Zephyranthes Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Reticularia lycoperdon Reticularia Reticulariaceae Liceales Eumycetozoa Evosea None Eukaryota
Crinum asiaticum Crinum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ramalina siliquosa Ramalina Ramalinaceae Lecanorales Lecanoromycetes Ascomycota Fungi Eukaryota
Corynandra viscosa Corynandra Cleomaceae Brassicales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hippeastrum argentinum Hippeastrum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stachys aegyptiaca Stachys Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ferula persica Ferula Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Elaeocarpus sphaericus Elaeocarpus Elaeocarpaceae Oxalidales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Angelica hirsutiflora Angelica Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Datura wrightii Datura Solanaceae Solanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Salvia keerlii Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cinchona officinalis Cinchona Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Anthoceros punctatus Anthoceros Anthocerotaceae Anthocerotales Anthocerotopsida Streptophyta Viridiplantae Eukaryota
Actaea heracleifolia Actaea Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Zephyranthes carinata Zephyranthes Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ligularia przewalskii Ligularia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dryopteris dilatata Dryopteris Dryopteridaceae Polypodiales Polypodiopsida Streptophyta Viridiplantae Eukaryota
Lupinus holosericeus Lupinus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None None Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Crinum yemense Crinum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dalbergia candenatensis Dalbergia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Searsia leptodictya Searsia Anacardiaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Helichrysum asperum Helichrysum Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hosta plantaginea Hosta Asparagaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Murraya paniculata Murraya Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Clivia miniata Clivia Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Crinum amabile Crinum Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Narcissus Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ligularia altaica Ligularia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Narcissus Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 287.31500000000005

TPSA？: 62.16000000000001

MolLogP？: 0.7485999999999997

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Chlorocebus sabaeus Vero Activity nan None 10.1021/np50023a009
Chlorocebus sabaeus Vero CC50 21000.0 nM 10.1016/j.ejmech.2021.113698
Chlorocebus sabaeus Vero C1008 CC50 14900.0 nM 10.1021/acs.jmedchem.0c00626
Dengue virus Dengue virus EC50 400.0 nM 10.1016/j.ejmech.2019.05.010
dengue virus type 4 dengue virus type 4 IC50 0.24 ug.mL-1 10.1021/np50089a003
Edwardsiella ictaluri Edwardsiella ictaluri MIC 287.0 ug.mL-1 10.1016/j.bmcl.2017.09.052
Electrophorus electricus Acetylcholinesterase IC50 200000.0 nM 10.1021/acs.jnatprod.5b00785
Electrophorus electricus Acetylcholinesterase IC50 213000.0 nM 10.1016/j.ejmech.2020.112792
Entamoeba histolytica Entamoeba histolytica IC50 0.23 ug.mL-1 10.1016/j.bmcl.2019.126642
Enterovirus A71 Enterovirus A71 Activity 18.0 % 10.1016/j.bmcl.2012.01.102
Enterovirus A71 Enterovirus A71 Activity nan None 10.1021/acsmedchemlett.7b00188
Enterovirus A71 Enterovirus A71 Survival 30.0 % 10.1021/acsmedchemlett.7b00188
Enterovirus C Enterovirus C Activity nan None 10.1021/np50023a009
Enterovirus C Enterovirus C pTCD50 100.0 None 10.1021/np50023a009
Enterovirus C Enterovirus C pTCD50 1000.0 None 10.1021/np50023a009
Enterovirus C Enterovirus C pTCD50 10000.0 None 10.1021/np50023a009
Equus caballus Cholinesterase IC50 200000.0 nM 10.1021/acs.jnatprod.5b00785
Escherichia coli Escherichia coli IZ 13.0 mm 10.1016/j.bmcl.2017.09.052
Flavobacterium columnare Flavobacterium columnare MIC 100000.0 nM 10.1016/j.bmcl.2017.09.052
Homo sapiens 786-0 GI50 3104.56 nM None
Homo sapiens A2780 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens A-431 ED50 1.3 ug ml-1 10.1021/np50098a017
Homo sapiens A498 GI50 2964.83 nM None
Homo sapiens A549 Activity 90.0 % 10.1021/jm901031h
Homo sapiens A549 Activity nan None 10.1021/jm901031h
Homo sapiens A549 GI50 900.0 nM 10.1016/j.bmc.2011.09.051
Homo sapiens A549 GI50 1389.95 nM None
Homo sapiens A549 GI50 3000.0 nM 10.1016/j.bmcl.2013.12.073
Homo sapiens A549 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens A549 IC50 1900.0 nM 10.1021/np3005425
Homo sapiens A549 IC50 2000.0 nM 10.1021/np900731p
Homo sapiens A549 IC50 4200.0 nM 10.1021/np9008255
Homo sapiens A549 IC50 4300.0 nM 10.1021/jm901031h
Homo sapiens A549 Ratio IC50 10.0 None 10.1021/np3005425
Homo sapiens Acetylcholinesterase IC50 155000.0 nM 10.1021/np0702077
Homo sapiens Acetylcholinesterase IC50 200000.0 nM 10.1021/acs.jnatprod.7b00301
Homo sapiens Acetylcholinesterase Ki nan None 10.1016/j.bmcl.2010.06.130
Homo sapiens ACHN GI50 849.18 nM None
Homo sapiens AGS IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens BJ Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens BJ IC50 1900.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens BT-549 GI50 1663.41 nM None
Homo sapiens BT-549 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens CAKI-1 GI50 1244.51 nM None
Homo sapiens CCRF-CEM Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens CCRF-CEM GI50 1823.9 nM None
Homo sapiens CCRF-CEM IC50 1600.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens COLO 201 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens COLO 205 GI50 1253.14 nM None
Homo sapiens Cytochrome P450 3A4 Ki nan None 10.1016/j.bmcl.2009.04.086
Homo sapiens DNA topoisomerase I Inhibition nan % 10.1016/j.bmcl.2011.09.097
Homo sapiens DNA topoisomerase II alpha Inhibition nan % 10.1016/j.bmcl.2011.09.097
Homo sapiens DU-145 GI50 1324.34 nM None
Homo sapiens EKVX GI50 2393.32 nM None
Homo sapiens G-361 Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens G-361 IC50 5000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens HCC 2998 GI50 2328.09 nM None
Homo sapiens HCT-116 GI50 1261.83 nM None
Homo sapiens HCT-15 GI50 1327.39 nM None
Homo sapiens HeLa Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens HeLa IC50 10600.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens HeLa S3 Inhibition nan % 10.1016/j.ejmech.2016.05.004
Homo sapiens HepG2 IC50 3700.0 nM 10.1021/np3005425
Homo sapiens HepG2 Ratio IC50 10.0 None 10.1021/np3005425
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens HL-60 GI50 2142.89 nM None
Homo sapiens HL-60 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens HL-60 IC50 1600.0 nM 10.1021/np3005425
Homo sapiens HOP-62 GI50 1778.28 nM None
Homo sapiens Hs-578T GI50 2910.72 nM None
Homo sapiens Hs 683 IC50 2000.0 nM 10.1021/np900731p
Homo sapiens HT-1080 ED50 0.5 ug ml-1 10.1021/np50098a017
Homo sapiens HT-29 GI50 1458.81 nM None
Homo sapiens HT-29 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens HT-29 IC50 3200.0 nM 10.1021/np3005425
Homo sapiens HT-29 Ratio IC50 10.0 None 10.1021/np3005425
Homo sapiens Huh-7 CC50 66120.0 nM 10.1073/pnas.0802982105
Homo sapiens IGROV-1 GI50 331.89 nM None
Homo sapiens Jurkat IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens K562 Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens K562 GI50 1196.74 nM None
Homo sapiens K562 IC50 2300.0 nM 10.1021/np3005425
Homo sapiens K562 IC50 3600.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens K562 Ratio IC50 10.0 None 10.1021/np3005425
Homo sapiens KB ED50 0.3 ug ml-1 10.1021/np50098a017
Homo sapiens KM12 GI50 2703.96 nM None
Homo sapiens LNCaP ED50 0.5 ug ml-1 10.1021/np50098a017
Homo sapiens LOX IMVI GI50 970.51 nM None
Homo sapiens M14 GI50 1862.09 nM None
Homo sapiens Malme-3M GI50 1923.09 nM None
Homo sapiens MCF7 Activity nan None 10.1016/j.bmcl.2012.08.005
Homo sapiens MCF7 Activity nan None 10.1021/jm901031h
Homo sapiens MCF7 GI50 201.37 nM None
Homo sapiens MCF7 GI50 4000.0 nM 10.1016/j.bmc.2011.09.051
Homo sapiens MCF7 GI50 10900.0 nM 10.1016/j.bmcl.2013.12.073
Homo sapiens MCF7 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens MCF7 IC50 13000.0 nM 10.1016/j.bmcl.2012.08.005
Homo sapiens MDA-MB-231 GI50 1648.16 nM None
Homo sapiens MDA-MB-231 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens MDA-MB-435 GI50 2070.14 nM None
Homo sapiens MDA-N GI50 2594.18 nM None
Homo sapiens MOLT-4 GI50 1294.2 nM None
Homo sapiens MOLT-4 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens NCI/ADR-RES GI50 2312.06 nM None
Homo sapiens NCI-H1299 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens NCI-H226 GI50 2760.58 nM None
Homo sapiens NCI-H23 GI50 2421.03 nM None
Homo sapiens NCI-H322M GI50 1432.19 nM None
Homo sapiens NCI-H460 GI50 1264.74 nM None
Homo sapiens NCI-H522 GI50 1051.96 nM None
Homo sapiens NHDF IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens NHDF IC50 100000.0 nM 10.1021/jm901031h
Homo sapiens OVCAR-3 GI50 2471.72 nM None
Homo sapiens OVCAR-4 GI50 1336.6 nM None
Homo sapiens OVCAR-5 GI50 2500.35 nM None
Homo sapiens OVCAR-8 GI50 1531.09 nM None
Homo sapiens PANC-1 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens PC-3 GI50 1445.44 nM None
Homo sapiens PC-3 GI50 4000.0 nM 10.1016/j.bmc.2011.09.051
Homo sapiens Regulator of G-protein signaling 4 Potency 4744.4 nM None
Homo sapiens RPMI-8226 GI50 2009.09 nM None
Homo sapiens RXF 393 GI50 299.92 nM None
Homo sapiens SAOS-2 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens SF-268 GI50 801.68 nM None
Homo sapiens SF-295 GI50 2685.34 nM None
Homo sapiens SF-539 GI50 1803.02 nM None
Homo sapiens SK-BR-3 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens SK-MEL IC50 8400.0 nM 10.1021/np9008255
Homo sapiens SK-MEL-2 ED50 1.6 ug ml-1 10.1021/np50098a017
Homo sapiens SK-MEL-2 GI50 375.84 nM None
Homo sapiens SK-MEL-28 GI50 2697.74 nM None
Homo sapiens SK-MEL-28 GI50 3700.0 nM 10.1016/j.bmcl.2013.12.073
Homo sapiens SK-MEL-28 GI50 4000.0 nM 10.1016/j.bmc.2011.09.051
Homo sapiens SK-MEL-28 IC50 2000.0 nM 10.1021/np900731p
Homo sapiens SK-MEL-28 IC50 8500.0 nM 10.1021/jm901031h
Homo sapiens SK-MEL-5 GI50 1415.79 nM None
Homo sapiens SK-OV-3 GI50 1840.77 nM None
Homo sapiens SN12C GI50 1702.16 nM None
Homo sapiens SNB-19 GI50 2108.63 nM None
Homo sapiens SNB-75 GI50 3133.29 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 60.96 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 97.14 % 10.1124/mol.112.084152
Homo sapiens SR GI50 1468.93 nM None
Homo sapiens Survival motor neuron protein Potency 1122.0 nM None
Homo sapiens SW480 IC50 300.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens SW-620 GI50 2612.16 nM None
Homo sapiens T47D GI50 2488.86 nM None
Homo sapiens T98G GI50 3000.0 nM 10.1016/j.bmc.2011.09.051
Homo sapiens T98G GI50 5200.0 nM 10.1016/j.bmcl.2013.12.073
Homo sapiens TK-10 GI50 2673.01 nM None
Homo sapiens U-251 GI50 1990.67 nM None
Homo sapiens UACC-257 GI50 650.13 nM None
Homo sapiens UACC-62 GI50 2079.7 nM None
Homo sapiens UO-31 GI50 1472.31 nM None
Homo sapiens Zinc finger protein GLI1 IC50 19000.0 nM 10.1016/j.ejmech.2022.114867
Homo sapiens ZR-75-1 ED50 0.9 ug ml-1 10.1021/np50098a017
Human coronavirus OC43 Human coronavirus OC43 Activity 83.3 % 10.1021/acs.jmedchem.0c00626
Human coronavirus OC43 Human coronavirus OC43 EC50 150.0 nM 10.1021/acs.jmedchem.0c00626
Japanese encephalitis virus Japanese encephalitis virus IC50 0.33 ug.mL-1 10.1021/np50089a003
Macaca mulatta LLC-MK2 CC50 3810.0 nM 10.1021/acs.jmedchem.0c00626
Measles morbillivirus Measles morbillivirus pTCD50 100.0 None 10.1021/np50023a009
Measles morbillivirus Measles morbillivirus pTCD50 1000.0 None 10.1021/np50023a009
Mesocricetus auratus BHK-21 CC50 4370.0 nM 10.1021/acs.jmedchem.0c00626
Mus musculus B16-F10 Activity nan None 10.1021/jm901031h
Mus musculus B16-F10 GI50 2000.0 nM 10.1016/j.bmc.2011.09.051
Mus musculus B16-F10 GI50 2600.0 nM 10.1016/j.bmcl.2013.12.073
Mus musculus B16-F10 IC50 2000.0 nM 10.1021/np900731p
Mus musculus B16-F10 IC50 6300.0 nM 10.1021/jm901031h
Mus musculus B16-F10 IC50 6300.0 nM 10.1021/np9008255
Mus musculus B16-F10 Inhibition nan % 10.1021/np900731p
Mus musculus B16-F10 MTD 40.0 mg kg-1 10.1021/jm901031h
Mus musculus Mus musculus Activity nan None 10.1021/jm901031h
Mus musculus Mus musculus MTD 80.0 mg kg-1 10.1021/jm901031h
Mus musculus P388 ED50 0.9 ug ml-1 10.1021/np50098a017
Mus musculus P388 T/C 135.0 % 10.1021/np50035a007
Plasmodium falciparum Plasmodium falciparum EC50 156.2 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum EC50 607.0 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum ED50 300.0 ug ml-1 10.1021/np50098a017
Plasmodium falciparum Plasmodium falciparum ED50 320.0 ug ml-1 10.1021/np50098a017
Plasmodium falciparum Plasmodium falciparum IC50 0.62 ug.mL-1 10.1016/j.bmc.2009.02.050
Plasmodium falciparum Plasmodium falciparum IC50 130.0 nM 10.1016/j.bmc.2010.05.023
Punta Toro virus Punta Toro virus IC50 0.5 ug.mL-1 10.1021/np50089a003
Rhodococcus fascians Rhodococcus fascians IZ 0.0 mm 10.1016/j.bmcl.2017.09.052
Rhodococcus fascians Rhodococcus fascians IZ 0.0 mm 10.1021/np50040a008
Rift Valley fever virus Rift Valley fever virus IC50 0.93 ug.mL-1 10.1021/np50089a003
Sandfly fever Sicilian virus Sandfly fever Sicilian virus IC50 nan None 10.1021/np50089a003
Semliki Forest virus Semliki Forest virus pTCD50 100.0 None 10.1021/np50023a009
Semliki Forest virus Semliki Forest virus pTCD50 1000.0 None 10.1021/np50023a009
Semliki Forest virus Semliki Forest virus pTCD50 10000.0 None 10.1021/np50023a009
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome-related coronavirus SARS-CoV EC50 15.7 nM 10.1021/acs.jnatprod.0c00968
Severe acute respiratory syndrome-related coronavirus SARS-CoV IC50 15.7 nM 10.1021/acs.jmedchem.0c00626
Simplexvirus Simplexvirus pTCD50 100.0 None 10.1021/np50023a009
Simplexvirus Simplexvirus pTCD50 1000.0 None 10.1021/np50023a009
Solanum tuberosum Solanum tuberosum Inhibition 80.0 % 10.1021/np50036a041
Staphylococcus aureus Staphylococcus aureus IZ 15.0 mm 10.1016/j.bmcl.2017.09.052
Staphylococcus aureus Staphylococcus aureus MIC 287.0 ug.mL-1 10.1016/j.bmcl.2017.09.052
Tobacco mosaic virus Tobacco mosaic virus Activity nan None 10.1021/np0702077
Trichomonas vaginalis Trichomonas vaginalis Activity 20.0 % 10.1016/j.bmcl.2019.126642
Trichomonas vaginalis Trichomonas vaginalis Activity 40.0 % 10.1016/j.bmcl.2019.126642
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.1 ug.mL-1 10.1016/j.bmcl.2019.126642
Yellow fever virus Yellow fever virus IC50 0.28 ug.mL-1 10.1021/np50089a003
Zika virus Zika virus EC50 390.0 nM 10.1016/j.ejmech.2021.113698
None ADMET Activity 76.1 % 10.1021/np030529k
None ADMET Activity 98.2 % 10.1021/np030529k
None ADMET Activity 98.3 % 10.1021/np030529k
None ADMET Activity 101.4 % 10.1021/np030529k
None ADMET Activity 105.4 % 10.1021/np030529k
None ADMET IC50 4900.0 nM 10.1021/np3005425
None ADMET IC50 100000.0 nM 10.1021/jm901031h
None ADMET TI 4.6 None 10.1021/np50089a003
None ADMET TI 5.4 None 10.1021/np50089a003
None ADMET TI 7.3 None 10.1021/np50089a003
None ADMET TI 8.2 None 10.1021/np50089a003
None ADMET TI 10.0 None 10.1021/np50023a009
None ADMET TI 10.4 None 10.1021/np50089a003
None Macrophage IC50 2500.0 nM 10.1021/np030529k
None Macrophage Inhibition 0.0 % 10.1021/np030529k
None Macrophage Inhibition 2.8 % 10.1021/np030529k
None Macrophage Inhibition 20.6 % 10.1021/np030529k
None Macrophage Inhibition 54.4 % 10.1021/np030529k
None Macrophage Inhibition 91.4 % 10.1021/np030529k
None NON-PROTEIN TARGET Activity nan None 10.1021/jm901031h
None NON-PROTEIN TARGET ED50 0.3 ug ml-1 10.1021/np50098a017
None NON-PROTEIN TARGET ED50 0.4 ug ml-1 10.1021/np50098a017
None NON-PROTEIN TARGET ED50 0.8 ug ml-1 10.1021/np50098a017
None NON-PROTEIN TARGET ED50 0.9 ug ml-1 10.1021/np50098a017
None NON-PROTEIN TARGET ED50 1.6 ug ml-1 10.1021/np50098a017
None NON-PROTEIN TARGET GI50 900.0 nM 10.1016/j.bmc.2011.09.051
None NON-PROTEIN TARGET GI50 2100.0 nM 10.1016/j.bmcl.2013.12.073
None NON-PROTEIN TARGET GI50 3000.0 nM 10.1016/j.bmc.2011.09.051
None NON-PROTEIN TARGET IC50 2000.0 nM 10.1021/np900731p
None NON-PROTEIN TARGET IC50 4500.0 nM 10.1021/np9008255
None NON-PROTEIN TARGET IC50 5100.0 nM 10.1021/jm901031h
None NON-PROTEIN TARGET IC50 6700.0 nM 10.1021/jm901031h
None NON-PROTEIN TARGET IC50 6900.0 nM 10.1021/np9008255
None NON-PROTEIN TARGET IC50 7600.0 nM 10.1021/jm901031h
None NON-PROTEIN TARGET IC50 7600.0 nM 10.1021/np9008255
None No relevant target LogP -0.78 None 10.1016/j.bmcl.2013.12.073
None Nucleic Acid Activity nan None 10.1016/j.bmcl.2011.09.097
None Unchecked Activity 90.0 % 10.1021/jm901031h
None Unchecked Activity nan None 10.1021/jm901031h
None Unchecked EC50 470.0 nM 10.1021/acs.jmedchem.0c00626
None Unchecked IFI nan % 10.1073/pnas.0802982105
None Unchecked Potency 3162.3 nM None
None Unchecked Ratio CC50/EC50 8.11 None 10.1021/acs.jmedchem.0c00626
None Unchecked Ratio CC50/EC50 29.1 None 10.1021/acs.jmedchem.0c00626
None Unchecked Ratio CC50/EC50 954.0 None 10.1021/acs.jmedchem.0c00626
None Unchecked Ratio ED50 1.0 None 10.1021/np50098a017
None Unchecked Ratio IC50 10.0 None 10.1021/np3005425

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT024859 O[C@@H]1CC=C2CCN3Cc4cc5c(cc4[C@H]1[C@@H]23)OCO5>>O[C@H]1C=C2CCN3Cc4cc5c(cc4[C@H]([C@@H]1O)[C@@H]23)OCO5 RXN-18152
AKRT024860 O[C@H]1C=C2CCN3Cc4cc5c(cc4[C@H]([C@@H]1O)[C@@H]23)OCO5>>COc1ccc(CNCCc2ccc(O)cc2)cc1O MNXR173561