lycorine
AlkaPlorer ID: AK001392
Synonym: '(-)-lycorine', 'Amarylline', 'SA149_21.1', 'Lycorine', 'Galanthidine', '(-)-Lycorine', 'Licorine', 'Narcissine'
IUPAC Name: (1S,17R,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
Structure
SMILES: O[C@H]1[C@H]2C3=CC4=C(C=C3CN3CCC(=C[C@H]1O)[C@H]23)OCO4
InChI: InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14+,15-,16-/m1/s1
InChIKey: XGVJWXAYKUHDOO-MSQAHXEGSA-N
Reference
Occurrence of two epimeric alkaloids and metabolism compared with lycorine in Crinum latifolium
PubChem CID: 12305849
CAS: 476-28-8
LOTUS: LTS0013699
SuperNatural Ⅲ: SN0429806-13
NPASS: NPC190332
Source
Properties Information
Molecule Weight: 287.31500000000005
TPSA？: 62.16000000000001
MolLogP？: 0.7485999999999997
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | IC50 | 10000.0 | nM | 10.1021/jm901031h |
| Homo sapiens | SK-MEL-28 | IC50 | 10000.0 | nM | 10.1021/jm901031h |
| Mus musculus | B16-F10 | IC50 | 10000.0 | nM | 10.1021/jm901031h |
| None | NON-PROTEIN TARGET | IC50 | 10000.0 | nM | 10.1021/jm901031h |