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6-Aminonicotinamide

AlkaPlorer ID: AK001454

Synonym: None

IUPAC Name: 6-aminopyridine-3-carboxamide

Structure

SMILES: C1=CC(=NC=C1C(=O)N)N

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InChI: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

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InChIKey: ZLWYEPMDOUQDBW-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 137.14199999999997

TPSA？: 82.0

MolLogP？: -0.23729999999999996

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Escherichia coli (strain K12) tRNA (guanine-N(1)-)-methyltransferase IC50 26000.0 nM 10.1016/j.bmcl.2023.129331
Escherichia coli (strain K12) tRNA (guanine-N(1)-)-methyltransferase Kd 1300.0 nM 10.1016/j.bmcl.2023.129331
Homo sapiens 6-phosphogluconate dehydrogenase FC 2.5 None 10.1021/acsmedchemlett.2c00404
Homo sapiens 6-phosphogluconate dehydrogenase FC 150.0 None 10.1021/acsmedchemlett.2c00404
Homo sapiens 6-phosphogluconate dehydrogenase Inhibition nan % 10.1021/acsmedchemlett.2c00404
Homo sapiens 786-0 GI50 3539.97 nM None
Homo sapiens A498 GI50 14893.61 nM None
Homo sapiens A549 GI50 54450.27 nM None
Homo sapiens ACHN GI50 54325.03 nM None
Homo sapiens BT-549 GI50 14092.89 nM None
Homo sapiens CAKI-1 GI50 17619.76 nM None
Homo sapiens CCRF-CEM GI50 12331.05 nM None
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens COLO 205 GI50 14223.29 nM None
Homo sapiens DU-145 GI50 2296.15 nM None
Homo sapiens EKVX GI50 21727.01 nM None
Homo sapiens Geminin Potency 5804.8 nM None
Homo sapiens Geminin Potency 16360.1 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 31622.8 nM None
Homo sapiens Glucose-6-phosphate 1-dehydrogenase FC 2.0 None 10.1021/acsmedchemlett.2c00404
Homo sapiens HCC 2998 GI50 31477.48 nM None
Homo sapiens HCT-116 GI50 186637.97 nM None
Homo sapiens HCT-15 GI50 17538.81 nM None
Homo sapiens HepG2 Potency 25118.9 nM None
Homo sapiens HL-60 GI50 53333.49 nM None
Homo sapiens HOP-62 GI50 11967.41 nM None
Homo sapiens HOP-92 GI50 213304.49 nM None
Homo sapiens Hs-578T GI50 6165.95 nM None
Homo sapiens HT-29 GI50 3926.45 nM None
Homo sapiens IGROV-1 GI50 107894.67 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 2592.9 nM None
Homo sapiens K562 GI50 16672.47 nM None
Homo sapiens KM12 GI50 48083.93 nM None
Homo sapiens LOX IMVI GI50 3349.65 nM None
Homo sapiens M14 GI50 6237.35 nM None
Homo sapiens Malme-3M GI50 33189.45 nM None
Homo sapiens MCF7 GI50 389.05 nM None
Homo sapiens MDA-MB-231 GI50 39355.01 nM None
Homo sapiens MDA-MB-435 GI50 4655.86 nM None
Homo sapiens MDA-N GI50 14321.88 nM None
Homo sapiens MOLT-4 GI50 38636.7 nM None
Homo sapiens NAD(+) hydrolase SARM1 Activity nan None None
Homo sapiens NAD(+) hydrolase SARM1 Inhibition nan % None
Homo sapiens NCI/ADR-RES GI50 244906.32 nM None
Homo sapiens NCI-H226 GI50 35727.28 nM None
Homo sapiens NCI-H23 GI50 9977.0 nM None
Homo sapiens NCI-H322M GI50 28313.92 nM None
Homo sapiens NCI-H460 GI50 5164.16 nM None
Homo sapiens NCI-H522 GI50 99770.01 nM None
Homo sapiens Nicotinamide N-methyltransferase IC50 3620.0 nM 10.1021/acs.jmedchem.2c01166
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 20596.2 nM None
Homo sapiens OVCAR-3 GI50 67764.15 nM None
Homo sapiens OVCAR-4 GI50 7014.55 nM None
Homo sapiens OVCAR-5 GI50 322106.88 nM None
Homo sapiens OVCAR-8 GI50 17619.76 nM None
Homo sapiens PC-3 GI50 29716.66 nM None
Homo sapiens RPMI-8226 GI50 9749.9 nM None
Homo sapiens RXF 393 GI50 138.04 nM None
Homo sapiens SF-268 GI50 19054.61 nM None
Homo sapiens SF-295 GI50 5069.91 nM None
Homo sapiens SF-539 GI50 8433.35 nM None
Homo sapiens SK-MEL-2 GI50 124451.46 nM None
Homo sapiens SK-MEL-28 GI50 3365.12 nM None
Homo sapiens SK-MEL-5 GI50 758.58 nM None
Homo sapiens SK-OV-3 GI50 399944.75 nM None
Homo sapiens SN12C GI50 15922.09 nM None
Homo sapiens SNB-19 GI50 14723.13 nM None
Homo sapiens SNB-75 GI50 15595.53 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 103.17 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 108.63 % 10.1124/mol.112.084152
Homo sapiens SR GI50 14321.88 nM None
Homo sapiens Survival motor neuron protein Potency 35481.3 nM None
Homo sapiens SW-620 GI50 82035.15 nM None
Homo sapiens T47D GI50 255270.13 nM None
Homo sapiens TK-10 GI50 399944.75 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1636.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2909.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4109.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5804.8 nM None
Homo sapiens U-251 GI50 1849.27 nM None
Homo sapiens UACC-257 GI50 986.28 nM None
Homo sapiens UACC-62 GI50 16106.46 nM None
Homo sapiens UO-31 GI50 29376.5 nM None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
None ADMET Activity nan None 10.1021/acsmedchemlett.2c00404
None Unchecked Potency 4610.9 nM None

Metabolism Information