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name Structure Reference Source Properties Activities Metabolism

Vinblastine

AlkaPlorer ID: AK001516

Synonym: None

IUPAC Name: methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

Structure

SMILES: CC[C@]1(O)C[C@@H]2CN(CCC3=C(NC4=CC=CC=C34)[C@@](C(=O)OC)(C3=CC4=C(C=C3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1

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InChI: InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

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InChIKey: JXLYSJRDGCGARV-CFWMRBGOSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Scoparia dulcis Scoparia Plantaginaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 810.9889999999998

TPSA？: 154.10000000000002

MolLogP？: 3.990900000000003

Number of H-Donors: 3

Number of H-Acceptors: 12

RingCount: 9

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacopa monnieri Bacopa monnieri Activity 0.6 cm 10.1007/s00044-011-9832-9
Bacopa monnieri Bacopa monnieri Activity 2.0 None 10.1007/s00044-011-9832-9
Bacopa monnieri Bacopa monnieri Activity 6.0 None 10.1007/s00044-011-9832-9
Bacopa monnieri Bacopa monnieri Activity nan None 10.1007/s00044-011-9832-9
Bos taurus Calf thymus DNA Activity 70.0 % 10.1021/np50078a006
Bos taurus Monoamine oxidase B Ki 77000.0 nM 10.1021/jm00169a002
Bos taurus Monoamine oxidase B Ki 77000.0 nM 10.1021/np50081a001
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Bos taurus Tubulin IC50 600.0 nM 10.1016/j.ejmech.2015.02.051
Bos taurus Tubulin IC50 700.0 nM 10.1021/jm970177c
Bos taurus Tubulin beta chain Ki 100000.0 nM 10.1016/s0960-894x(01)00759-4
Canis lupus familiaris MDCK Ratio 1.8 None 10.1124/dmd.110.034629
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus sabaeus Vero EC50 3700.0 nM 10.1021/jm990568m
Chlorocebus sabaeus Vero ED50 1.0 10'-1 ug/ml 10.1021/np020543h
Chlorocebus sabaeus Vero ED50 1.0 ug ml-1 10.1021/np980482g
Chlorocebus sabaeus Vero IC50 27060.0 nM 10.1007/s00044-010-9361-y
Cricetulus griseus CHO Activity nan None 10.1021/np50028a027
Cricetulus griseus CHO IC50 17.0 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO IC50 17.0 nM 10.1021/jm200488a
Cricetulus griseus CHO Log CR 1.46 None 10.1021/jm00169a014
Cricetulus griseus CHO-TAX 5-6 IC50 6.9 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-TAX 5-6 IC50 6.9 nM 10.1021/jm200488a
Cricetulus griseus CHO-TAX 5-6 Ratio IC50 0.41 None 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-TAX 5-6 Ratio IC50 0.41 None 10.1021/jm200488a
Cricetulus griseus CHO-VV 3-2 IC50 66.0 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-VV 3-2 IC50 66.0 nM 10.1021/jm200488a
Cricetulus griseus CHO-VV 3-2 Ratio IC50 3.9 None 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-VV 3-2 Ratio IC50 3.9 None 10.1021/jm200488a
Homo sapiens 23132-87 IC50 20.64 nM 10.6019/CHEMBL1201861
Homo sapiens 5637 IC50 0.951 nM 10.6019/CHEMBL1201861
Homo sapiens 639-V IC50 5.605 nM 10.6019/CHEMBL1201861
Homo sapiens 647-V IC50 23.03 nM 10.6019/CHEMBL1201861
Homo sapiens 697 IC50 6.225 nM 10.6019/CHEMBL1201861
Homo sapiens 769-P IC50 25.55 nM 10.6019/CHEMBL1201861
Homo sapiens 786-0 IC50 0.31 nM 10.1021/jm200454y
Homo sapiens 786-0 IC50 4.5 nM 10.1021/jm200454y
Homo sapiens 786-0 IC50 15.58 nM 10.6019/CHEMBL1201861
Homo sapiens 8305C IC50 3.67 nM 10.6019/CHEMBL1201861
Homo sapiens 8505C IC50 3.109 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 6.335 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 31.39 nM 10.6019/CHEMBL1201861
Homo sapiens A 172 IC50 9.616 nM 10.6019/CHEMBL1201861
Homo sapiens A204 IC50 8.765 nM 10.6019/CHEMBL1201861
Homo sapiens A2058 IC50 1.218 nM 10.6019/CHEMBL1201861
Homo sapiens A2058 IC50 3.7 nM 10.1021/np300900a
Homo sapiens A2058 IC50 4.0 nM 10.1021/np300792t
Homo sapiens A2058 IC50 4.0 nM 10.1021/np3008446
Homo sapiens A2058 Ratio IC50 250.0 None 10.1021/np3008446
Homo sapiens A2780 IC50 4.608 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 IC50 5.0 nM 10.1021/np034035z
Homo sapiens A2780 IC50 61.66 nM 10.1016/j.bmc.2007.07.024
Homo sapiens A-375 IC50 23.53 nM 10.6019/CHEMBL1201861
Homo sapiens A388 IC50 6.915 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 4.32 nM 10.6019/CHEMBL1201861
Homo sapiens A-427 IC50 12.55 nM 10.6019/CHEMBL1201861
Homo sapiens A-431 ED50 0.05 ug ml-1 10.1021/np50113a007
Homo sapiens A-431 IC50 4975.15 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 5.938 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 1.867 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity 30.0 % 10.1021/acs.jnatprod.5b00258
Homo sapiens A549 Activity nan None 10.1021/acs.jnatprod.5b00258
Homo sapiens A549 Activity nan None 10.1021/jm070834t
Homo sapiens A549 EC50 0.5 nM 10.1021/jm050674q
Homo sapiens A549 EC50 0.9 nM 10.1021/jm050674q
Homo sapiens A549 IC50 1.1 nM 10.1021/jm060197r
Homo sapiens A549 IC50 4.954 nM 10.6019/CHEMBL1201861
Homo sapiens A549 IC50 9.9 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens A549 IC50 17.0 nM 10.1016/j.bmcl.2010.10.118
Homo sapiens A549 IC50 20.0 nM 10.1021/jm3013097
Homo sapiens A549 IC50 nan None 10.1016/j.ejmech.2011.10.013
Homo sapiens A549 IC50 nan None 10.1021/jm200392p
Homo sapiens A673 IC50 6.875 nM 10.6019/CHEMBL1201861
Homo sapiens A704 IC50 119.71 nM 10.6019/CHEMBL1201861
Homo sapiens ABC-1 IC50 15.49 nM 10.6019/CHEMBL1201861
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN IC50 25.0 nM 10.1021/jm061348t
Homo sapiens ACHN IC50 59.04 nM 10.6019/CHEMBL1201861
Homo sapiens ACN IC50 40.29 nM 10.6019/CHEMBL1201861
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens AGS IC50 12.3 nM 10.6019/CHEMBL1201861
Homo sapiens ALL-PO IC50 5.215 nM 10.6019/CHEMBL1201861
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens AM-38 IC50 36.92 nM 10.6019/CHEMBL1201861
Homo sapiens AN3-CA IC50 9.765 nM 10.6019/CHEMBL1201861
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens ASPC1 IC50 13.21 nM 10.6019/CHEMBL1201861
Homo sapiens ATN-1 IC50 1.034 nM 10.6019/CHEMBL1201861
Homo sapiens AU565 IC50 3.448 nM 10.6019/CHEMBL1201861
Homo sapiens AU565 IC50 4.0 nM 10.1021/ml400281w
Homo sapiens BALL-1 IC50 313.17 nM 10.6019/CHEMBL1201861
Homo sapiens BB30-HNC IC50 8.315 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 12.56 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 20.7 nM 10.6019/CHEMBL1201861
Homo sapiens BCPAP IC50 2.33 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 1.416 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 1.126 nM 10.6019/CHEMBL1201861
Homo sapiens BEN IC50 81.23 nM 10.6019/CHEMBL1201861
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens BFTC-905 IC50 3.773 nM 10.6019/CHEMBL1201861
Homo sapiens BFTC-909 IC50 7.532 nM 10.6019/CHEMBL1201861
Homo sapiens BHT-101 IC50 31.36 nM 10.6019/CHEMBL1201861
Homo sapiens BHY IC50 15.33 nM 10.6019/CHEMBL1201861
Homo sapiens Bile salt export pump IC50 62000.0 nM 10.1023/a:1023278211849
Homo sapiens Bile salt export pump IC50 114700.0 nM 10.1023/a:1023278211849
Homo sapiens BPH-1 IC50 3.263 nM 10.6019/CHEMBL1201861
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens BT-20 IC50 37.68 nM 10.6019/CHEMBL1201861
Homo sapiens BT-474 IC50 94.15 nM 10.6019/CHEMBL1201861
Homo sapiens BT-549 IC50 7.977 nM 10.6019/CHEMBL1201861
Homo sapiens BV-173 IC50 42.27 nM 10.6019/CHEMBL1201861
Homo sapiens BXPC-3 IC50 8.01 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 16.88 nM 10.6019/CHEMBL1201861
Homo sapiens C32 IC50 866.85 nM 10.6019/CHEMBL1201861
Homo sapiens C-33-A IC50 12.66 nM 10.6019/CHEMBL1201861
Homo sapiens C3A IC50 332.14 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 27.01 nM 10.6019/CHEMBL1201861
Homo sapiens Ca9-22 IC50 6.391 nM 10.6019/CHEMBL1201861
Homo sapiens Caco-2 Activity 42.0 % 10.1021/jm060639z
Homo sapiens Caco-2 Activity 72.0 % 10.1021/jm060639z
Homo sapiens Caco-2 Activity 81.0 % 10.1021/jm060639z
Homo sapiens Caco-2 IC50 0.46 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens Caco-2 IC50 2.8 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens Caco-2 Papp 5.1 nm/s 10.1021/jm900047j
Homo sapiens Caco-2 permeability 0.1 10'-6 cm/s 10.1128/aac.00246-07
Homo sapiens Caco-2 permeability 41.9 10'-6 cm/s 10.1128/aac.00246-07
Homo sapiens Caco-2 Permeability 1.54 *10e6 10.1021/jm990482t
Homo sapiens Caco-2 Permeability 12.5 *10e6 10.1021/jm990482t
Homo sapiens Caco-2 Permeability nan None 10.1021/jm990482t
Homo sapiens CAKI-1 IC50 24.61 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-120 IC50 87.26 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-12T IC50 55.97 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-27 IC50 2.086 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-33 IC50 6.184 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-39 IC50 5.114 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-51 IC50 16.39 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-54 IC50 60.59 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-62 IC50 10.1 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-72 IC50 647.18 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-85-1 IC50 6079.95 nM 10.6019/CHEMBL1201861
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calu-3 IC50 551.0 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-6 IC50 149.1 nM 10.6019/CHEMBL1201861
Homo sapiens CAMA-1 IC50 32.01 nM 10.6019/CHEMBL1201861
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 78.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity nan None 10.1016/j.neuropharm.2006.07.038
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 21000.0 nM 10.1124/dmd.104.002477
Homo sapiens Canalicular multispecific organic anion transporter 1 Km 137300.0 nM 10.1023/a:1016192413308
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens CAPAN-1 IC50 52.3 nM 10.6019/CHEMBL1201861
Homo sapiens Capan-2 IC50 114.18 nM 10.6019/CHEMBL1201861
Homo sapiens CaR-1 IC50 45.73 nM 10.6019/CHEMBL1201861
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens CAS-1 IC50 93.12 nM 10.6019/CHEMBL1201861
Homo sapiens Ca-Ski IC50 4.694 nM 10.6019/CHEMBL1201861
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM GI50 0.02 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens CCRF-CEM GI50 4.0 nM 10.1021/jm501244f
Homo sapiens CCRF-CEM GI50 210.0 nM 10.1021/jm501244f
Homo sapiens CCRF-CEM IC50 0.03 ug.mL-1 10.1021/np970226o
Homo sapiens CCRF-CEM IC50 0.1 ug.mL-1 10.1021/jm00129a023
Homo sapiens CCRF-CEM IC50 0.38 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens CCRF-CEM IC50 0.38 nM 10.1021/jm200488a
Homo sapiens CCRF-CEM IC50 0.4 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 0.7 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 0.7 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 0.7 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 0.7 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 0.73 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 0.73 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 0.73 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 0.73 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 0.8 nM 10.1016/j.bmc.2012.10.001
Homo sapiens CCRF-CEM IC50 0.8 nM 10.1021/jm300388h
Homo sapiens CCRF-CEM IC50 1.0 nM 10.1021/jm5008193
Homo sapiens CCRF-CEM IC50 1.2 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens CCRF-CEM IC50 1.3 nM 10.1016/j.ejmech.2014.02.018
Homo sapiens CCRF-CEM IC50 2.0 nM 10.1016/j.ejmech.2014.05.028
Homo sapiens CCRF-CEM IC50 2.0 nM 10.1021/jm400043d
Homo sapiens CCRF-CEM IC50 2.9 nM 10.1016/j.ejmech.2014.06.066
Homo sapiens CCRF-CEM IC50 4.0 nM 10.1016/j.ejmech.2011.10.013
Homo sapiens CCRF-CEM IC50 4.0 nM 10.1021/jm061307x
Homo sapiens CCRF-CEM IC50 4.1 nM 10.1021/jm200392p
Homo sapiens CCRF-CEM IC50 9.4 nM 10.1021/np2006499
Homo sapiens CCRF-CEM IC50 10.05 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM IC50 28.7 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 78.0 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 78.0 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 78.0 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 78.0 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 80.0 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 80.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 80.0 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 80.0 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 206.6 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 496.0 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 496.0 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 496.0 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 500.0 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 500.0 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 500.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 500.0 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 500.0 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 670.0 nM 10.1016/j.ejmech.2014.02.018
Homo sapiens CCRF-CEM IC50 870.0 nM 10.1016/j.ejmech.2014.06.066
Homo sapiens CCRF-CEM LC50 5.73 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens CCRF-CEM Log CR 1.28 None 10.1021/jm00169a014
Homo sapiens CCRF-CEM Ratio 525.0 None 10.1021/jm501244f
Homo sapiens CCRF-CEM Ratio IC50 2.0 None 10.1021/jm061307x
Homo sapiens CCRF-CEM Ratio IC50 56.1 None 10.1016/j.ejmech.2011.10.013
Homo sapiens CCRF-CEM Ratio IC50 56.1 None 10.1021/jm200392p
Homo sapiens CCRF-CEM Ratio IC50 89.0 None 10.1021/jm061307x
Homo sapiens CCRF-CEM Ratio IC50 105.0 None 10.1016/j.ejmech.2014.05.028
Homo sapiens CCRF-CEM Ratio IC50 105.0 None 10.1021/jm400043d
Homo sapiens CCRF-CEM Ratio IC50 106.0 None 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM Ratio IC50 106.2 None 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM Ratio IC50 107.0 None 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM Ratio IC50 193.0 None 10.1021/jm5008193
Homo sapiens CCRF-CEM Ratio IC50 248.86 None 10.1016/j.ejmech.2014.02.018
Homo sapiens CCRF-CEM Ratio IC50 256.2 None 10.1016/j.bmc.2012.10.001
Homo sapiens CCRF-CEM Ratio IC50 300.0 None 10.1016/j.ejmech.2014.06.066
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM Ratio IC50 679.5 None 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM Ratio IC50 680.0 None 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM Ratio IC50 685.0 None 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM Ratio IC50 1579.0 None 10.1016/j.ejmech.2011.08.034
Homo sapiens CCRF-CEM TGI 1.91 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens CEM-VLB Ratio IC50 1579.0 None 10.1021/jm200488a
Homo sapiens CFPAC-1 IC50 93.2 nM 10.6019/CHEMBL1201861
Homo sapiens CGTH-W-1 IC50 5.556 nM 10.6019/CHEMBL1201861
Homo sapiens ChaGo-K-1 IC50 1.013 nM 10.6019/CHEMBL1201861
Homo sapiens CHL-1 IC50 12.0 nM 10.6019/CHEMBL1201861
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens CHP-212 IC50 3.547 nM 10.6019/CHEMBL1201861
Homo sapiens Col2 ED50 0.01 ug ml-1 10.1021/np50113a007
Homo sapiens COLO 320 IC50 0.52 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens COLO 320 IC50 1.6 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens COLO 320DM IC50 0.52 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens COLO 320DM IC50 1.6 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens COLO-320-HSR IC50 203.92 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 562.6 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-678 IC50 2480.78 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-679 IC50 5415.81 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-680N IC50 74.71 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 7.666 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-741 IC50 2.139 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-792 IC50 25.63 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 3.342 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 136.2 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 19.17 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L105 IC50 65.75 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L23 IC50 3.623 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 24.32 nM 10.6019/CHEMBL1201861
Homo sapiens CP50-MEL-B IC50 13.12 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 48.58 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 1.636 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 1.405 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 101.38 nM 10.6019/CHEMBL1201861
Homo sapiens CWR22R IC50 9.815 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclooxygenase-1 AC50 623.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 9251.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 26870.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 26000.0 nM 10.1021/jm021012t
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Log 1/Km -0.834 None 10.1016/j.bmcl.2005.06.015
Homo sapiens D-247MG IC50 6.979 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 9.278 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 39.1 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 7.255 nM 10.6019/CHEMBL1201861
Homo sapiens D-392MG IC50 18.86 nM 10.6019/CHEMBL1201861
Homo sapiens D-423MG IC50 8.639 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 23.49 nM 10.6019/CHEMBL1201861
Homo sapiens D-542MG IC50 3876.68 nM 10.6019/CHEMBL1201861
Homo sapiens D-566MG IC50 2.043 nM 10.6019/CHEMBL1201861
Homo sapiens Daoy IC50 3.102 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 1.687 nM 10.6019/CHEMBL1201861
Homo sapiens DBTRG-05MG IC50 225.99 nM 10.6019/CHEMBL1201861
Homo sapiens DEL IC50 2.16 nM 10.6019/CHEMBL1201861
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Detroit 562 IC50 5.531 nM 10.6019/CHEMBL1201861
Homo sapiens DJM-1 IC50 2816.86 nM 10.6019/CHEMBL1201861
Homo sapiens DK-MG IC50 6.646 nM 10.6019/CHEMBL1201861
Homo sapiens DLD-1 EC50 129.0 nM 10.1021/jm049640t
Homo sapiens DLD-1 EC50 160.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens DLD-1 GI50 10.0 nM 10.1021/np058042u
Homo sapiens DLD-1 IC50 nan None 10.1016/j.bmcl.2011.01.097
Homo sapiens DLD-1 IC50 nan None 10.1016/j.bmcl.2011.01.111
Homo sapiens DLD-1 LC50 2480.0 nM 10.1021/np058042u
Homo sapiens DLD-1 TGI 2440.0 nM 10.1021/np058042u
Homo sapiens DMS-114 IC50 20.94 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-273 IC50 3.396 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 534.65 nM 10.6019/CHEMBL1201861
Homo sapiens DNA polymerase iota Potency 44668.4 nM None
Homo sapiens DOHH-2 IC50 1.809 nM 10.6019/CHEMBL1201861
Homo sapiens DOK IC50 4.196 nM 10.6019/CHEMBL1201861
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DoTc2-4510 IC50 16.52 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 23.21 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 Activity nan None 10.1016/j.bmcl.2009.07.089
Homo sapiens DU-145 IC50 0.063 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens DU-145 IC50 0.063 nM 10.1021/jm200488a
Homo sapiens DU-145 IC50 98.66 nM 10.6019/CHEMBL1201861
Homo sapiens DU-4475 IC50 383.01 nM 10.6019/CHEMBL1201861
Homo sapiens ECC10 IC50 21.16 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 3.531 nM 10.6019/CHEMBL1201861
Homo sapiens EFM-19 IC50 5.242 nM 10.6019/CHEMBL1201861
Homo sapiens EFO-21 IC50 44.03 nM 10.6019/CHEMBL1201861
Homo sapiens EFO-27 IC50 7.449 nM 10.6019/CHEMBL1201861
Homo sapiens EGI-1 IC50 10.81 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 278.22 nM 10.6019/CHEMBL1201861
Homo sapiens EM-2 IC50 5.316 nM 10.6019/CHEMBL1201861
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens EOL1 IC50 1.261 nM 10.6019/CHEMBL1201861
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens EPLC-272H IC50 10.78 nM 10.6019/CHEMBL1201861
Homo sapiens ES1 IC50 4.714 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 2.766 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 13.83 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 3.882 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 115.12 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 5.753 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 3.24 nM 10.6019/CHEMBL1201861
Homo sapiens ESS-1 IC50 4.876 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens ETK-1 IC50 5.788 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 3.148 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 7.151 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 36.52 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 7.832 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 510.36 nM 10.6019/CHEMBL1201861
Homo sapiens EW-22 IC50 29.35 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 18.01 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 37.21 nM 10.6019/CHEMBL1201861
Homo sapiens FaDu IC50 20.02 nM 10.6019/CHEMBL1201861
Homo sapiens FTC-133 IC50 8.444 nM 10.6019/CHEMBL1201861
Homo sapiens G-361 IC50 4123.67 nM 10.6019/CHEMBL1201861
Homo sapiens G-401 IC50 8.671 nM 10.6019/CHEMBL1201861
Homo sapiens G-402 IC50 17.58 nM 10.6019/CHEMBL1201861
Homo sapiens GAK IC50 219.86 nM 10.6019/CHEMBL1201861
Homo sapiens GAMG IC50 19.38 nM 10.6019/CHEMBL1201861
Homo sapiens GB-1 IC50 39.85 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 49.73 nM 10.6019/CHEMBL1201861
Homo sapiens GCT IC50 4.728 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 5.3 nM None
Homo sapiens Geminin Potency 749.9 nM None
Homo sapiens GI-1 IC50 4.362 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 6.076 nM 10.6019/CHEMBL1201861
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens GMS-10 IC50 11.28 nM 10.6019/CHEMBL1201861
Homo sapiens GOTO IC50 8.207 nM 10.6019/CHEMBL1201861
Homo sapiens GP5d IC50 4.674 nM 10.6019/CHEMBL1201861
Homo sapiens GR-ST IC50 7.631 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 1.92 nM 10.6019/CHEMBL1201861
Homo sapiens H4 IC50 5.837 nM 10.6019/CHEMBL1201861
Homo sapiens H69AR IC50 1.6 nM 10.1021/jm061348t
Homo sapiens H9 IC50 2.248 nM 10.6019/CHEMBL1201861
Homo sapiens HAL-01 IC50 233.41 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 4.211 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1143 IC50 3.8 nM 10.1021/ml400281w
Homo sapiens HCC1187 IC50 2.754 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1395 IC50 29.25 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1419 IC50 57.16 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1569 IC50 92.26 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1806 IC50 0.6303 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1937 IC50 2049.18 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1954 IC50 121.72 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 79.26 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 IC50 19.83 nM 10.6019/CHEMBL1201861
Homo sapiens HCC38 IC50 58.38 nM 10.6019/CHEMBL1201861
Homo sapiens HCC70 IC50 3.5 nM 10.1021/ml400281w
Homo sapiens HCC70 IC50 20.8 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-4 IC50 18.09 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 20.01 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity nan None 10.1021/ml200236a
Homo sapiens HCT-116 EC50 36.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens HCT-116 EC50 36.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens HCT-116 EC50 44.0 nM 10.1021/jm7010657
Homo sapiens HCT-116 GI50 0.001 ug.mL-1 10.1016/s0960-894x(02)00568-1
Homo sapiens HCT-116 GI50 10.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens HCT-116 GI50 10.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens HCT-116 GI50 nan None 10.1016/j.bmc.2009.02.029
Homo sapiens HCT-116 GI50 nan None 10.1021/jm7010657
Homo sapiens HCT-116 IC50 0.7 nM 10.1021/jm060197r
Homo sapiens HCT-116 IC50 1.1 nM 10.1016/j.bmc.2008.12.022
Homo sapiens HCT-116 IC50 1.1 nM 10.1016/j.bmc.2009.06.018
Homo sapiens HCT-116 IC50 1.3 nM 10.1021/jm900365v
Homo sapiens HCT-116 IC50 1.42 nM 10.1021/jm101318b
Homo sapiens HCT-116 IC50 1.42 nM 10.1021/jm301201z
Homo sapiens HCT-116 IC50 1.8 nM 10.1016/j.bmc.2008.04.024
Homo sapiens HCT-116 IC50 1.8 nM 10.1016/j.bmc.2010.01.061
Homo sapiens HCT-116 IC50 1.8 nM 10.1016/j.bmc.2010.11.030
Homo sapiens HCT-116 IC50 3.0 nM 10.1021/jm3013097
Homo sapiens HCT-116 IC50 3.0 nM 10.1021/np034035z
Homo sapiens HCT-116 IC50 3.5 nM 10.1021/jm4004347
Homo sapiens HCT-116 IC50 3.5 nM 10.1021/jm500530v
Homo sapiens HCT-116 IC50 3.626 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/j.bmcl.2004.10.002
Homo sapiens HCT-116 IC50 6.8 nM 10.1016/j.bmcl.2010.09.091
Homo sapiens HCT-116 IC50 6.8 nM 10.1021/jm3014376
Homo sapiens HCT-116 IC50 6.8 nM 10.1021/jm3015684
Homo sapiens HCT-116 IC50 6.8 nM 10.1021/ml200236a
Homo sapiens HCT-116 IC50 6.8 nM 10.1021/ml400281w
Homo sapiens HCT-116 IC50 8.7 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens HCT-116 IC50 8.7 nM 10.1021/np2006499
Homo sapiens HCT-116 IC50 27.0 nM 10.1016/j.bmcl.2010.10.118
Homo sapiens HCT-116 IC50 135.0 nM 10.1021/np034035z
Homo sapiens HCT-116 IC50 600.0 nM 10.1016/j.bmcl.2010.09.091
Homo sapiens HCT-116 Ratio IC50 45.0 None 10.1021/np034035z
Homo sapiens HCT-116 Ratio IC50 90.0 None 10.1021/ml400281w
Homo sapiens HCT-116/VM46 IC50 110.0 nM 10.1021/ml400281w
Homo sapiens HCT-116/VM46 IC50 600.0 nM 10.1021/jm3014376
Homo sapiens HCT-116/VM46 IC50 600.0 nM 10.1021/jm3015684
Homo sapiens HCT-116/VM46 IC50 600.0 nM 10.1021/ml200236a
Homo sapiens HCT-15 IC50 10.0 nM 10.1021/jm900365v
Homo sapiens HCT-15 IC50 24.0 nM 10.1021/jm3013097
Homo sapiens HCT-15 IC50 28.5 nM 10.1016/j.bmcl.2011.01.097
Homo sapiens HCT-15 IC50 28.5 nM 10.1016/j.bmcl.2011.01.111
Homo sapiens HCT-15 IC50 43.0 nM 10.1016/s0960-894x(01)00759-4
Homo sapiens HCT-15 IC50 78.58 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-15 IC50 79.4 nM 10.1021/jm061348t
Homo sapiens HDLM-2 IC50 642.79 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 3.33 nM 10.6019/CHEMBL1201861
Homo sapiens HEC-1 IC50 11.35 nM 10.6019/CHEMBL1201861
Homo sapiens HEL IC50 32.84 nM 10.6019/CHEMBL1201861
Homo sapiens HeLa Activity 2.3 nM 10.1021/jm3009629
Homo sapiens HeLa Activity 80.0 % 10.1021/acs.jmedchem.5b00310
Homo sapiens HeLa Activity 80.0 % 10.1021/jm2012886
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.5b00310
Homo sapiens HeLa Activity nan None 10.1021/jm060232u
Homo sapiens HeLa Activity nan None 10.1021/jm2012886
Homo sapiens HeLa Activity nan None 10.1021/jm500561a
Homo sapiens HeLa ED 0.0015 ug ml-1 10.1021/jm00169a021
Homo sapiens HeLa ED50 20.0 ug ml-1 10.1021/np800148w
Homo sapiens HeLa GI50 0.9 nM 10.1016/j.bmcl.2008.12.077
Homo sapiens HeLa GI50 60.0 nM 10.1021/jm900850t
Homo sapiens HeLa IC50 10.0 nM 10.1021/jm3013097
Homo sapiens H-EMC-SS IC50 255.94 nM 10.6019/CHEMBL1201861
Homo sapiens HEp-2 ED50 0.001 ug ml-1 10.1021/np0504457
Homo sapiens HEp-2 ED50 20.0 ug ml-1 10.1021/np800148w
Homo sapiens HepG2 Activity 14.38 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 14.38 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity 16.13 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 16.13 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity 24.25 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 24.25 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity 45.13 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 45.13 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity 55.0 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 55.0 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity 72.13 % 10.1007/s00044-011-9965-x
Homo sapiens HepG2 Activity 72.13 % 10.1007/s00044-012-0142-7
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2013.04.057
Homo sapiens HepG2 Activity nan None 10.1021/jm500561a
Homo sapiens HepG2 IC50 0.07 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 0.26 nM 10.1021/np070458f
Homo sapiens HepG2 IC50 4.6 ug.mL-1 10.1007/s00044-011-9965-x
Homo sapiens HepG2 IC50 4.6 ug.mL-1 10.1007/s00044-012-0142-7
Homo sapiens HepG2 IC50 80.7 nM 10.1021/jm500561a
Homo sapiens HepG2 IC50 81.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens HepG2 IC50 440.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 5946000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 nan None 10.1021/jm900365v
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HGC-27 IC50 1.012 nM 10.6019/CHEMBL1201861
Homo sapiens HH IC50 6.367 nM 10.6019/CHEMBL1201861
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 3162.3 nM None
Homo sapiens HL-60 Activity 6.6 % 10.1021/jm070194u
Homo sapiens HL-60 Activity 10.1 % 10.1021/jm070194u
Homo sapiens HL-60 Activity 83.3 % 10.1021/jm070194u
Homo sapiens HL-60 GI50 0.036 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HL-60 IC50 1.0 nM 10.1016/j.bmcl.2010.10.118
Homo sapiens HL-60 IC50 1.0 nM 10.1021/jm900365v
Homo sapiens HL-60 IC50 1.11 nM 10.1021/jm101318b
Homo sapiens HL-60 IC50 1.11 nM 10.1021/jm301201z
Homo sapiens HL-60 IC50 1.6 nM 10.1021/np900365r
Homo sapiens HL-60 IC50 4.371 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 LC50 1.51 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HL-60 TGI 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HLE IC50 4.235 nM 10.6019/CHEMBL1201861
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens HMV-2 cell line IC50 3.905 nM 10.6019/CHEMBL1201861
Homo sapiens HN IC50 4.15 nM 10.6019/CHEMBL1201861
Homo sapiens HO-1-N-1 IC50 1.756 nM 10.6019/CHEMBL1201861
Homo sapiens Homo sapiens CL 0.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 3.1 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 3.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 2.6 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 2.64 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Fa 0.05 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fabs 5.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens F_fraction 0.05 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 1.02 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.98 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 28.0 L.kg-1 10.1021/jm901371v
Homo sapiens HOP-62 IC50 1406.87 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-92 IC50 25.92 nM 10.6019/CHEMBL1201861
Homo sapiens HOS IC50 6.25 nM 10.6019/CHEMBL1201861
Homo sapiens HPAF-II IC50 40.05 nM 10.6019/CHEMBL1201861
Homo sapiens Hs-578T IC50 17.31 nM 10.6019/CHEMBL1201861
Homo sapiens HSC-2 IC50 20.2 nM 10.6019/CHEMBL1201861
Homo sapiens HSC-3 IC50 4.389 nM 10.6019/CHEMBL1201861
Homo sapiens HSC-4 IC50 2.355 nM 10.6019/CHEMBL1201861
Homo sapiens HT ED50 0.02 ug ml-1 10.1021/np50113a007
Homo sapiens HT IC50 15.64 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 IC50 0.099 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens HT-1080 IC50 0.099 nM 10.1021/jm200488a
Homo sapiens HT-1080 IC50 4.228 nM 10.6019/CHEMBL1201861
Homo sapiens HT1197 IC50 99.76 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1376 IC50 60.4 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 3.319 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity 44.0 % 10.1021/np500497r
Homo sapiens HT-29 EC50 2.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens HT-29 GI50 2.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens HT-29 GI50 2.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens HT-29 IC50 0.53 nM 10.1021/np070487q
Homo sapiens HT-29 IC50 4.0 nM 10.1021/np50063a010
Homo sapiens HT-29 IC50 4.5 nM 10.1021/acs.jnatprod.5b00357
Homo sapiens HT-29 IC50 30.0 nM 10.1021/jm3013097
Homo sapiens HT-29 IC50 45.85 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 IZ 10.0 mm 10.1021/np50063a010
Homo sapiens HT-29 IZ 25.0 mm 10.1021/np50063a010
Homo sapiens HT-29 IZ 40.0 mm 10.1021/np50063a010
Homo sapiens HT-3 IC50 37.07 nM 10.6019/CHEMBL1201861
Homo sapiens HT55 IC50 391.6 nM 10.6019/CHEMBL1201861
Homo sapiens HTC-C3 IC50 10.38 nM 10.6019/CHEMBL1201861
Homo sapiens HuCCT-1 IC50 17.29 nM 10.6019/CHEMBL1201861
Homo sapiens Huh-7 IC50 87.74 nM 10.6019/CHEMBL1201861
Homo sapiens HuO-3N1 IC50 4.827 nM 10.6019/CHEMBL1201861
Homo sapiens HuO9 IC50 12.64 nM 10.6019/CHEMBL1201861
Homo sapiens HuP-T3 IC50 17.96 nM 10.6019/CHEMBL1201861
Homo sapiens HuP-T4 IC50 43.18 nM 10.6019/CHEMBL1201861
Homo sapiens HuT78 GI50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HuT78 LC50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HuT78 TGI 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens HuTu80 IC50 12.28 nM 10.6019/CHEMBL1201861
Homo sapiens HUVEC Activity nan None 10.1016/j.bmc.2010.11.010
Homo sapiens HUVEC IC50 0.8 nM 10.1021/jm4004347
Homo sapiens HUVEC IC50 49.0 nM 10.1016/j.bmc.2010.11.010
Homo sapiens HUVEC Inhibition nan % 10.1016/j.bmc.2010.11.010
Homo sapiens IA-LM IC50 68.58 nM 10.6019/CHEMBL1201861
Homo sapiens IGR-1 IC50 2.076 nM 10.6019/CHEMBL1201861
Homo sapiens IGROV-1 IC50 215.27 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-90 IC50 1000.0 nM 10.1021/np3008446
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens IST-MEL1 IC50 4.526 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 67.68 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 1.187 nM 10.6019/CHEMBL1201861
Homo sapiens J82 IC50 68.47 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 0.608 nM 10.6019/CHEMBL1201861
Homo sapiens JEG-3 IC50 12.48 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 0.7882 nM 10.6019/CHEMBL1201861
Homo sapiens Jurkat Activity nan None 10.1016/j.bmc.2007.12.026
Homo sapiens Jurkat Activity nan None 10.1021/jm070528f
Homo sapiens Jurkat GI50 10.0 nM 10.1021/jm900850t
Homo sapiens Jurkat IC50 nan None 10.1021/jm0704189
Homo sapiens JVM-2 IC50 5585.18 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 1.705 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 4.682 nM 10.6019/CHEMBL1201861
Homo sapiens K562 Activity 30.0 % 10.1021/jm049876x
Homo sapiens K562 Activity 33.0 % 10.1021/jm049876x
Homo sapiens K562 Activity 37.0 % 10.1021/jm049876x
Homo sapiens K562 EC50 1.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens K562 GI50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens K562 GI50 300.0 nM 10.1021/jm900850t
Homo sapiens K562 GI50 nan nM 10.1021/jm049876x
Homo sapiens K562 IC50 0.36 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens K562 IC50 0.36 nM 10.1021/jm200488a
Homo sapiens K562 IC50 0.88 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 IC50 2.7 nM 10.1021/jm500530v
Homo sapiens K562 IC50 7.0 nM 10.1021/jm4004347
Homo sapiens K562 IC50 10.0 nM 10.1016/j.bmcl.2015.02.045
Homo sapiens K562 IC50 170.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 IC50 1082.28 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 3000.0 nM 10.1021/jm049876x
Homo sapiens K562 IC50 193000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 LC50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens K562 TGI 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens KALS-1 IC50 7.787 nM 10.6019/CHEMBL1201861
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KARPAS-299 IC50 1657.4 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 1.793 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 8.059 nM 10.6019/CHEMBL1201861
Homo sapiens KB ED50 0.002 ug ml-1 10.1021/np50094a004
Homo sapiens KB ED50 0.002 ug ml-1 10.1021/np50113a007
Homo sapiens KB ED50 0.05 ug ml-1 10.1021/np0504457
Homo sapiens KB ED50 0.1 10'-4 ug/ml 10.1021/np020543h
Homo sapiens KB ED50 0.1 10'-4 ug/ml 10.1021/np980482g
Homo sapiens KB ED50 20.0 ug ml-1 10.1021/np800148w
Homo sapiens KB IC50 0.046 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens KB IC50 0.46 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens KB IC50 0.8 nM 10.1021/jm101318b
Homo sapiens KB IC50 0.8 nM 10.1021/jm301201z
Homo sapiens KB IC50 0.8 nM 10.1021/jm900365v
Homo sapiens KB IC50 1.0 nM 10.1021/jm801064y
Homo sapiens KB Relative IC50 1.3 nM 10.1021/jm9505122
Homo sapiens KB Relative IC50 2000.0 nM 10.1021/jm9505122
Homo sapiens KB 3-1 IC50 9271000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens KB 3-1 Relative IC50 1.0 nM 10.1021/jm9505122
Homo sapiens KE-37 IC50 3.993 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 18.38 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 33.33 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 9.324 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 309.24 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 IC50 14.42 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 IC50 5.339 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 20.76 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 18.69 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-62 IC50 5.802 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 20.16 nM 10.6019/CHEMBL1201861
Homo sapiens KOSC-2 IC50 0.6975 nM 10.6019/CHEMBL1201861
Homo sapiens KP-4 IC50 2.369 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YN IC50 46.36 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 22.91 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 7.987 nM 10.6019/CHEMBL1201861
Homo sapiens KU-19-19 IC50 43.72 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 16.79 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 233.07 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 3.69 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-140 IC50 44.94 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-150 cell line IC50 46.53 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-180 IC50 6.385 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-270 IC50 9.632 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-410 IC50 9.297 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-450 IC50 9.649 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-510 IC50 5.875 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-520 cell line IC50 47.62 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-70 cell line IC50 48.35 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 5.997 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 309.15 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 7.015 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 47.7 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 40.27 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 10.12 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 145.03 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 64.11 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 8.574 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 21.23 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 7.896 nM 10.6019/CHEMBL1201861
Homo sapiens LCLC-103H cell line IC50 1.502 nM 10.6019/CHEMBL1201861
Homo sapiens LCLC-97TM1 IC50 5.491 nM 10.6019/CHEMBL1201861
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LK-2 IC50 7.503 nM 10.6019/CHEMBL1201861
Homo sapiens LN-405 IC50 12.4 nM 10.6019/CHEMBL1201861
Homo sapiens LNCaP ED50 0.1 ug ml-1 10.1021/np50113a007
Homo sapiens LNCaP-Clone-FGC IC50 8.279 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo IC50 6.025 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo IC50 nan None 10.1016/j.ejmech.2011.10.013
Homo sapiens LoVo IC50 nan None 10.1021/jm200392p
Homo sapiens LOX IMVI IC50 6.977 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 2844.0 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 53.33 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 66.35 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 56.27 nM 10.6019/CHEMBL1201861
Homo sapiens Lu1 ED50 0.02 ug ml-1 10.1021/np50113a007
Homo sapiens LU-134-A IC50 8.582 nM 10.6019/CHEMBL1201861
Homo sapiens LU-135 IC50 35.58 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 14.08 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 115.72 nM 10.6019/CHEMBL1201861
Homo sapiens LU-99A IC50 20.83 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 10.29 nM 10.6019/CHEMBL1201861
Homo sapiens M059J IC50 15.06 nM 10.6019/CHEMBL1201861
Homo sapiens M14 IC50 3.191 nM 10.6019/CHEMBL1201861
Homo sapiens M21 Activity nan None 10.1016/j.bmc.2008.06.006
Homo sapiens M21 GI50 10.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens M21 GI50 10.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MC116 IC50 7.953 nM 10.6019/CHEMBL1201861
Homo sapiens MCF7 Activity 7.82 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 7.82 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 Activity 15.18 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 15.18 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 Activity 29.6 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 29.6 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 Activity 48.75 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 48.75 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 Activity 60.35 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 60.35 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 Activity 76.24 % 10.1007/s00044-011-9965-x
Homo sapiens MCF7 Activity 76.24 % 10.1007/s00044-012-0142-7
Homo sapiens MCF7 EC50 3.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens MCF7 GI50 0.4 nM 10.1016/j.bmcl.2008.12.077
Homo sapiens MCF7 GI50 2.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens MCF7 GI50 2.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens MCF7 GI50 2.3 nM 10.1016/s0960-894x(98)00477-6
Homo sapiens MCF7 GI50 10.0 nM 10.1021/np058042u
Homo sapiens MCF7 GI50 10.0 nM 10.1021/np9004129
Homo sapiens MCF7 GI50 10000.0 nM 10.1021/jm900850t
Homo sapiens MCF7 IC50 0.02 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens MCF7 IC50 0.02 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens MCF7 IC50 0.047 ug.mL-1 10.1021/np300414d
Homo sapiens MCF7 IC50 0.047 ug.mL-1 10.1021/np500762w
Homo sapiens MCF7 IC50 0.22 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens MCF7 IC50 0.22 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens MCF7 IC50 0.7 nM 10.1021/jm500530v
Homo sapiens MCF7 IC50 0.79 nM 10.1016/j.bmcl.2010.10.118
Homo sapiens MCF7 IC50 1.02 ug.mL-1 10.1021/np500762w
Homo sapiens MCF7 IC50 1.08 ug.mL-1 10.1021/np300414d
Homo sapiens MCF7 IC50 1.22 ug.mL-1 10.1021/np500762w
Homo sapiens MCF7 IC50 1.37 ug.mL-1 10.1021/np300414d
Homo sapiens MCF7 IC50 2.8 nM 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 IC50 2.8 nM 10.1021/jm070194u
Homo sapiens MCF7 IC50 4.6 nM 10.1021/jm900365v
Homo sapiens MCF7 IC50 6.1 ug.mL-1 10.1007/s00044-011-9965-x
Homo sapiens MCF7 IC50 6.1 ug.mL-1 10.1007/s00044-012-0142-7
Homo sapiens MCF7 IC50 10.9 nM 10.1021/np400585t
Homo sapiens MCF7 IC50 31.6 nM 10.6019/CHEMBL1201861
Homo sapiens MCF7 IC50 110.0 nM 10.1021/ml400281w
Homo sapiens MCF7 IC50 1900.0 nM 10.1007/s00044-010-9361-y
Homo sapiens MCF7 IC50 nan None 10.1016/j.bmc.2010.01.061
Homo sapiens MCF7 IC50 nan None 10.1021/jm0704189
Homo sapiens MCF7 IC50 nan None 10.1021/jm900365v
Homo sapiens MCF7 LC50 2500.0 nM 10.1021/np058042u
Homo sapiens MCF7 LC50 2500.0 nM 10.1021/np9004129
Homo sapiens MCF7 Ratio IC50 1.1 None 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 Ratio IC50 134.0 None 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 Relative IC50 0.5 nM 10.1021/jm9505122
Homo sapiens MCF7 Relative IC50 1.0 nM 10.1021/jm9505122
Homo sapiens MCF7 Relative IC50 17500.0 nM 10.1021/jm9505122
Homo sapiens MCF7 TGI 1600.0 nM 10.1021/np058042u
Homo sapiens MCF7 TGI 1600.0 nM 10.1021/np9004129
Homo sapiens MC-IXC IC50 2.985 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-157 IC50 9.064 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-175-VII IC50 267.63 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.bmc.2007.12.026
Homo sapiens MDA-MB-231 IC50 0.12 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens MDA-MB-231 IC50 0.12 nM 10.1021/jm200488a
Homo sapiens MDA-MB-231 IC50 8.78 nM 10.1021/np5010328
Homo sapiens MDA-MB-231 IC50 11.0 nM 10.1021/jm970177c
Homo sapiens MDA-MB-231 IC50 31.0 nM 10.1021/np2006499
Homo sapiens MDA-MB-231 IC50 44.59 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-361 IC50 1.662 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-415 IC50 18.55 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-435 Activity 21.0 % 10.1021/np500497r
Homo sapiens MDA-MB-435 Activity 49.0 % 10.1016/j.bmc.2012.08.017
Homo sapiens MDA-MB-435 GI50 0.25 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens MDA-MB-435 IC50 0.27 nM 10.1021/np070487q
Homo sapiens MDA-MB-435 IC50 0.29 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 0.34 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 0.4 nM 10.1021/jm4001117
Homo sapiens MDA-MB-435 IC50 0.42 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 0.49 nM 10.1021/np5010328
Homo sapiens MDA-MB-435 IC50 0.5 nM 10.1021/acs.jnatprod.5b00357
Homo sapiens MDA-MB-435 IC50 4.4 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 11.0 nM 10.1021/jm100884b
Homo sapiens MDA-MB-435 IC50 27.5 nM 10.1021/jm100884b
Homo sapiens MDA-MB-435 LC50 1.0 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens MDA-MB-435 Ratio IC50 10.0 None 10.1021/jm060593+
Homo sapiens MDA-MB-435 Ratio IC50 15.0 None 10.1021/jm060593+
Homo sapiens MDA-MB-435 TGI 0.25 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens MDA-MB-453 IC50 3.285 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-468 IC50 4.6 nM 10.1021/ml400281w
Homo sapiens ME-180 IC50 4.473 nM 10.6019/CHEMBL1201861
Homo sapiens MEG-01 IC50 14.74 nM 10.6019/CHEMBL1201861
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MEL-HO IC50 53.86 nM 10.6019/CHEMBL1201861
Homo sapiens MEL-JUSO IC50 17.51 nM 10.6019/CHEMBL1201861
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 35481.3 nM None
Homo sapiens MES-SA Ratio IC50 224.18 None 10.1016/j.bmcl.2011.01.097
Homo sapiens MeWo IC50 9.134 nM 10.6019/CHEMBL1201861
Homo sapiens MFE-280 IC50 36.08 nM 10.6019/CHEMBL1201861
Homo sapiens MFH-ino IC50 588.37 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 135.5 nM 10.6019/CHEMBL1201861
Homo sapiens MG-63 IC50 14.16 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-ES-1 IC50 5.129 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 38.85 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 1.493 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 IC50 3.388 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-1 IC50 10.1 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-28 IC50 2.698 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-45 IC50 48.42 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-7 IC50 76.69 nM 10.6019/CHEMBL1201861
Homo sapiens ML-2 IC50 8.652 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 4.652 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 15.09 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 29.44 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 880.24 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-13 IC50 5.603 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 2.429 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 GI50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens MOLT-4 IC50 3.847 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 LC50 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens MOLT-4 TGI 0.25 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 11220.2 nM None
Homo sapiens MPP-89 IC50 30.28 nM 10.6019/CHEMBL1201861
Homo sapiens MRC5 Activity 51.5 % 10.1016/j.bmc.2010.10.060
Homo sapiens MRC5 Activity 60.06 % 10.1016/j.ejmech.2011.02.062
Homo sapiens MRC5 IC50 24.0 nM 10.1021/np2006499
Homo sapiens MS-1 IC50 30.83 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 12.22 nM 10.6019/CHEMBL1201861
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1016/j.cellbi.2005.11.008
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1016/s0378-4274(01)00306-x
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1159/000056161
Homo sapiens Multidrug resistance-associated protein 1 IC50 30000.0 nM 10.1074/jbc.271.16.9683
Homo sapiens Multidrug resistance protein 3 Activity nan None 10.1038/nrd3028
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens MV4-11 IC50 2.805 nM 10.6019/CHEMBL1201861
Homo sapiens MX1 IC50 2.0 nM 10.1021/jm060197r
Homo sapiens MX1 IC50 2.2 nM 10.1016/j.bmc.2008.12.022
Homo sapiens MX1 IC50 2.2 nM 10.1016/j.bmc.2009.06.018
Homo sapiens MX1 IC50 2.9 nM 10.1016/j.bmc.2008.04.024
Homo sapiens MX1 IC50 2.9 nM 10.1016/j.bmc.2010.01.061
Homo sapiens MX1 IC50 2.9 nM 10.1016/j.bmc.2010.11.030
Homo sapiens MZ1-PC IC50 24.19 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 60.31 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 11.08 nM 10.6019/CHEMBL1201861
Homo sapiens N592 IC50 4.0 nM 10.1021/jm00077a016
Homo sapiens NB10 IC50 7.317 nM 10.6019/CHEMBL1201861
Homo sapiens NB12 IC50 61.41 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 3.274 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 4.953 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 21.77 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 15.7 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 80.02 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 5.73 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 195.12 nM 10.6019/CHEMBL1201861
Homo sapiens NBsusSR IC50 3.232 nM 10.6019/CHEMBL1201861
Homo sapiens NCI/ADR-RES GI50 350.0 nM 10.1016/s0960-894x(98)00477-6
Homo sapiens NCI/ADR-RES IC50 200.0 nM 10.1021/jm3013097
Homo sapiens NCI/ADR-RES IC50 200.0 nM 10.1021/jm500561a
Homo sapiens NCI/ADR-RES IC50 582.0 nM 10.1021/jm2003427
Homo sapiens NCI/ADR-RES IC50 3900.0 ug.mL-1 10.1021/jm9700169
Homo sapiens NCI-H1048 IC50 10.06 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 223.56 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 43.74 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 EC50 73.0 nM 10.1021/jm049640t
Homo sapiens NCI-H1299 EC50 82.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens NCI-H1299 IC50 16.42 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 133.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 19.54 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 4.277 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1437 IC50 7.76 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1563 IC50 21.46 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1573 IC50 30.74 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 4.236 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1623 IC50 503.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 5.519 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 126.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1651 IC50 23.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1666 IC50 20.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1693 IC50 78.21 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1703 IC50 1.431 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1755 IC50 19.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 28.46 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1792 IC50 4.391 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1793 IC50 29.6 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 191.13 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1975 IC50 24.23 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1993 IC50 3395.38 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2009 IC50 53.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2029 IC50 203.7 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2030 IC50 27.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2052 IC50 24.65 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2087 IC50 30.53 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 13.15 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2122 IC50 3.436 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 25.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2170 IC50 33.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2228 IC50 41.09 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 IC50 13.81 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2291 IC50 232.1 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 5.706 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2342 IC50 950.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2347 IC50 135.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2405 IC50 826.38 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2452 IC50 9.587 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H28 IC50 34.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H292 IC50 3.03 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H358 IC50 37.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H441 IC50 473.3 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 2.122 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 GI50 10.0 nM 10.1021/np058042u
Homo sapiens NCI-H460 GI50 10.0 nM 10.1021/np9004129
Homo sapiens NCI-H460 IC50 3.4 nM 10.1016/s0960-894x(01)00759-4
Homo sapiens NCI-H460 IC50 46.39 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 LC50 2100.0 nM 10.1021/np058042u
Homo sapiens NCI-H460 LC50 2100.0 nM 10.1021/np9004129
Homo sapiens NCI-H460 TGI 350.0 nM 10.1021/np058042u
Homo sapiens NCI-H460 TGI 350.0 nM 10.1021/np9004129
Homo sapiens NCI-H510A IC50 2.753 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H520 IC50 4.5 nM 10.1021/ml400281w
Homo sapiens NCI-H520 IC50 30.13 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 5.136 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H596 IC50 156.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H630 IC50 241.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H650 IC50 27.08 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H661 IC50 8.047 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 1.6 nM 10.1021/jm061348t
Homo sapiens NCI-H69 IC50 525.78 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 Reduction 0.0 % 10.1016/j.bmcl.2003.12.015
Homo sapiens NCI-H69 Reduction 88.0 % 10.1016/j.bmcl.2003.12.015
Homo sapiens NCI-H69 Reduction 94.0 % 10.1016/j.bmcl.2003.12.015
Homo sapiens NCI-H69 Reduction 95.0 % 10.1016/j.bmcl.2003.12.015
Homo sapiens NCI-H720 IC50 6.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 IC50 175.7 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H747 IC50 81.18 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H810 IC50 68.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 1642.17 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-N87 IC50 5.671 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 5.122 nM 10.6019/CHEMBL1201861
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens NH-12 IC50 26.35 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 1.273 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 8.484 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 270.54 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 38.83 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 7.859 nM 10.6019/CHEMBL1201861
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NOS-1 IC50 40.88 nM 10.6019/CHEMBL1201861
Homo sapiens NTERA-2-cl-D1 IC50 5.893 nM 10.6019/CHEMBL1201861
Homo sapiens NUGC-3 IC50 3.455 nM 10.6019/CHEMBL1201861
Homo sapiens NY IC50 5315.23 nM 10.6019/CHEMBL1201861
Homo sapiens OAW-28 IC50 40.72 nM 10.6019/CHEMBL1201861
Homo sapiens OAW-42 IC50 233.12 nM 10.6019/CHEMBL1201861
Homo sapiens OC-314 IC50 2.225 nM 10.6019/CHEMBL1201861
Homo sapiens OCI-AML2 IC50 138.49 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 7.561 nM 10.6019/CHEMBL1201861
Homo sapiens OE19 IC50 412.2 nM 10.6019/CHEMBL1201861
Homo sapiens OE33 IC50 28.59 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 144.1 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 3.742 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 69.84 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-3 GI50 10.0 nM 10.1021/np058042u
Homo sapiens OVCAR-3 IC50 1.82 nM 10.1021/np5010328
Homo sapiens OVCAR-3 IC50 46.86 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-3 LC50 920.0 nM 10.1021/np058042u
Homo sapiens OVCAR-3 TGI 10.0 nM 10.1021/np058042u
Homo sapiens OVCAR-4 IC50 27.94 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-5 IC50 13.6 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-8 IC50 3.9 nM 10.1021/jm2003427
Homo sapiens OVCAR-8 IC50 6.554 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-8 IC50 15.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens OVCAR-8 IC50 15.0 nM 10.1021/jm2012886
Homo sapiens OVCAR-8 IC50 15.0 nM 10.1021/jm3013097
Homo sapiens OVCAR-8 RatioGI50 500.0 None 10.1039/c3md00130j
Homo sapiens OVCAR-8 Ratio IC50 149.0 None 10.1021/jm2003427
Homo sapiens P12-Ichikawa IC50 1.704 nM 10.6019/CHEMBL1201861
Homo sapiens P30-OHK IC50 11.07 nM 10.6019/CHEMBL1201861
Homo sapiens PA-1 IC50 0.025 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens PA-1 IC50 0.03 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens PA-1 IC50 0.15 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens PA-1 IC50 1.15 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens PA-1 IC50 4.6 nM 10.1021/ml400281w
Homo sapiens PA-1 IC50 8.092 nM 10.6019/CHEMBL1201861
Homo sapiens PANC-03-27 IC50 5.472 nM 10.6019/CHEMBL1201861
Homo sapiens PANC-08-13 IC50 61.47 nM 10.6019/CHEMBL1201861
Homo sapiens Panc1005 IC50 42.8 nM 10.6019/CHEMBL1201861
Homo sapiens PBMC Activity nan None 10.1016/j.ejmech.2013.10.076
Homo sapiens PC-14 IC50 3.534 nM 10.6019/CHEMBL1201861
Homo sapiens PC-3 GI50 5.2 nM 10.1039/c3md00130j
Homo sapiens PC-3 GI50 nan None 10.1039/c3md00130j
Homo sapiens PC-3 IC50 5.0 nM 10.1021/np300792t
Homo sapiens PC-3 IC50 5.5 nM 10.1021/jm101318b
Homo sapiens PC-3 IC50 33.37 nM 10.6019/CHEMBL1201861
Homo sapiens PC-3 IC50 766.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens PC-3 IC50 nan None 10.1016/j.bmc.2010.01.061
Homo sapiens PC-3 IC50 nan None 10.1016/j.bmc.2010.11.030
Homo sapiens PFSK-1 IC50 4.972 nM 10.6019/CHEMBL1201861
Homo sapiens P-glycoprotein 1 Activity 1.2 uM 10.1074/jbc.m706175200
Homo sapiens P-glycoprotein 1 Activity 4.5 uM 10.1074/jbc.m706175200
Homo sapiens P-glycoprotein 1 Activity 31.0 % 10.1016/j.bmc.2009.02.002
Homo sapiens P-glycoprotein 1 Activity 33.0 nM/mg*min 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity 35.0 % 10.1016/j.bmc.2009.02.002
Homo sapiens P-glycoprotein 1 Activity 42.0 uM 10.1074/jbc.m706175200
Homo sapiens P-glycoprotein 1 Activity 44.0 % 10.1016/s0006-2952(96)00656-9
Homo sapiens P-glycoprotein 1 Activity 75.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Activity nan None 10.1002/pros.10354
Homo sapiens P-glycoprotein 1 Activity nan None 10.1007/s004240050829
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bcp.2003.08.027
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0928-0987(03)00204-5
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/np100429s
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1025001131513
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/nrd3028
Homo sapiens P-glycoprotein 1 Activity nan None 10.1124/jpet.102.045096
Homo sapiens P-glycoprotein 1 Activity nan None 10.1152/ajpcell.00418.2002
Homo sapiens P-glycoprotein 1 Activity nan None 10.1248/bpb.22.1355
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 Binding site fraction 0.4 None 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 EC50 14600.0 nM 10.1097/00001813-199607000-00012
Homo sapiens P-glycoprotein 1 EC50 34000.0 nM 10.1097/00001813-199607000-00012
Homo sapiens P-glycoprotein 1 Hill coefficient 2.06 None 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 2000.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 IC50 10000.0 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 10471.29 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 17700.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 19900.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 29000.0 nM 10.1124/dmd.104.002477
Homo sapiens P-glycoprotein 1 IC50 29500.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 34000.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 IC50 50000.0 nM 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Inhibition 75.0 % 10.1021/jm021012t
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2010.02.062
Homo sapiens P-glycoprotein 1 Kd 3000.0 nM None
Homo sapiens P-glycoprotein 1 Ki 100.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 1300.0 nM 10.1021/jm020941h
Homo sapiens P-glycoprotein 1 Ki 2100.0 nM 10.1016/s0006-2952(98)00212-3
Homo sapiens P-glycoprotein 1 Ki 15000.0 nM 10.1023/a:1022359300826
Homo sapiens P-glycoprotein 1 Ki 36500.0 nM 10.1023/a:1011076217118
Homo sapiens P-glycoprotein 1 Ki 140000.0 nM 10.1023/a:1016140429238
Homo sapiens P-glycoprotein 1 Km 800.0 nM 10.1074/jbc.271.6.3163
Homo sapiens P-glycoprotein 1 Km 5710.0 nM 10.1023/a:1013358126640
Homo sapiens P-glycoprotein 1 Km 18990.0 nM 10.1023/a:1018972102702
Homo sapiens P-glycoprotein 1 Km 99400.0 nM None
Homo sapiens P-glycoprotein 1 Km 252800.0 nM 10.1023/a:1016140429238
Homo sapiens P-glycoprotein 1 % maximum response 24.4 % None
Homo sapiens P-glycoprotein 1 Papp 10.0 nm/s None
Homo sapiens P-glycoprotein 1 Papp 232.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 4.31 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 23.0 None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens PSN1 IC50 1.248 nM 10.6019/CHEMBL1201861
Homo sapiens QIMR-WIL IC50 8.95 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 1.546 nM 10.6019/CHEMBL1201861
Homo sapiens RCC10RGB IC50 510.4 nM 10.6019/CHEMBL1201861
Homo sapiens RCM-1 IC50 1369.69 nM 10.6019/CHEMBL1201861
Homo sapiens RD Activity nan None 10.1021/jm500561a
Homo sapiens RD IC50 4.172 nM 10.6019/CHEMBL1201861
Homo sapiens RD IC50 52.5 nM 10.1021/jm500561a
Homo sapiens RD IC50 53.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens RERF-LC-MS IC50 15.15 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 3.4 nM 10.6019/CHEMBL1201861
Homo sapiens RH-18 IC50 1128.93 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 8.239 nM 10.6019/CHEMBL1201861
Homo sapiens RMG-I IC50 116.58 nM 10.6019/CHEMBL1201861
Homo sapiens RO82-W-1 IC50 5.57 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-2650 IC50 26.61 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-7951 IC50 1.658 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 GI50 0.003 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens RPMI-8226 IC50 2.852 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 28.0 nM 10.1016/j.bmcl.2007.12.016
Homo sapiens RPMI-8226 LC50 3.28 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens RPMI-8226 TGI 0.8 nM 10.1016/s0960-894x(01)00838-1
Homo sapiens RPMI-8866 IC50 1.966 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 4.508 nM 10.6019/CHEMBL1201861
Homo sapiens RT-112 IC50 2.708 nM 10.6019/CHEMBL1201861
Homo sapiens RVH-421 IC50 7.249 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 GI50 1.0 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens RXF 393 IC50 1.439 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 LC50 2510.0 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens RXF 393 TGI 50.0 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens S-117 IC50 5.576 nM 10.6019/CHEMBL1201861
Homo sapiens SAOS-2 IC50 32.31 nM 10.6019/CHEMBL1201861
Homo sapiens SAS IC50 28.13 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-1 IC50 8.104 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-5 IC50 7.471 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 23.15 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-25 IC50 15.68 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-4 IC50 2.395 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-9 IC50 10.66 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 29.72 nM 10.6019/CHEMBL1201861
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-126 IC50 21.9 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 GI50 10.0 nM 10.1021/np058042u
Homo sapiens SF-268 GI50 10.0 nM 10.1021/np9004129
Homo sapiens SF-268 IC50 16.19 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 LC50 2480.0 nM 10.1021/np058042u
Homo sapiens SF-268 LC50 2480.0 nM 10.1021/np9004129
Homo sapiens SF-268 TGI 1640.0 nM 10.1021/np058042u
Homo sapiens SF-268 TGI 1640.0 nM 10.1021/np9004129
Homo sapiens SF-295 IC50 36.31 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 GI50 0.6 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens SF-539 IC50 1.211 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 LC50 790.0 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens SF-539 TGI 2.5 nM 10.1016/j.ejmech.2015.02.051
Homo sapiens SH-4 IC50 43.54 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 148.18 nM 10.6019/CHEMBL1201861
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SiHa IC50 109.77 nM 10.6019/CHEMBL1201861
Homo sapiens SJRH30 IC50 59.36 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 12.06 nM 10.6019/CHEMBL1201861
Homo sapiens SK-BR-3 IC50 0.91 nM 10.1016/j.bmcl.2012.07.023
Homo sapiens SK-BR-3 IC50 72.0 nM 10.1021/np034035z
Homo sapiens SKG-IIIa IC50 17.24 nM 10.6019/CHEMBL1201861
Homo sapiens SK-HEP1 IC50 12.05 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 58.6 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LU-1 IC50 18.71 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 67.32 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 ED50 0.01 ug ml-1 10.1021/np50113a007
Homo sapiens SK-MEL-2 IC50 53.3 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-24 IC50 31.55 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-28 IC50 17.04 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL3 IC50 717.01 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-30 IC50 415.46 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MES-1 IC50 8.645 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-AS IC50 8.669 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 37.37 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 1.505 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 642.78 nM 10.6019/CHEMBL1201861
Homo sapiens SK-OV-3 IC50 0.039 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens SK-OV-3 IC50 0.039 nM 10.1021/jm200488a
Homo sapiens SK-OV-3 IC50 2.7 nM 10.1021/jm101318b
Homo sapiens SK-OV-3 IC50 8155.03 nM 10.6019/CHEMBL1201861
Homo sapiens SK-PN-DW IC50 6.138 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 11.75 nM 10.6019/CHEMBL1201861
Homo sapiens SN12C IC50 16.06 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 IC50 11.25 nM 10.6019/CHEMBL1201861
Homo sapiens SNU1 IC50 1.622 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-387 IC50 11.42 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-398 EC50 26.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens SNU-398 EC50 26.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens SNU-398 EC50 38.0 nM 10.1021/jm7010657
Homo sapiens SNU-398 GI50 5.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens SNU-398 GI50 5.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens SNU-398 GI50 nan None 10.1016/j.bmc.2009.02.029
Homo sapiens SNU-398 GI50 nan None 10.1021/jm7010657
Homo sapiens SNU-423 IC50 19.47 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-449 IC50 127.72 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 132.84 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 24.67 nM 10.6019/CHEMBL1201861
Homo sapiens Solute carrier family 22 member 1 Inhibition 1.9 % 10.1021/jm8003152
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 46800.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 57.6 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 64.1 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B1 Ki 10200.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 IC50 43500.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 54.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 81.5 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 Ki 18600.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -9.3 % 10.1021/jm300212s
Homo sapiens SW1088 IC50 16.97 nM 10.6019/CHEMBL1201861
Homo sapiens SW 1116 IC50 1163.6 nM 10.6019/CHEMBL1201861
Homo sapiens SW13 IC50 5.49 nM 10.6019/CHEMBL1201861
Homo sapiens SW1417 IC50 423.54 nM 10.6019/CHEMBL1201861
Homo sapiens SW1463 IC50 69.69 nM 10.6019/CHEMBL1201861
Homo sapiens SW1573 IC50 33.25 nM 10.6019/CHEMBL1201861
Homo sapiens SW1710 IC50 5.607 nM 10.6019/CHEMBL1201861
Homo sapiens SW1783 IC50 85.55 nM 10.6019/CHEMBL1201861
Homo sapiens SW1990 IC50 61.39 nM 10.6019/CHEMBL1201861
Homo sapiens SW48 IC50 6.943 nM 10.6019/CHEMBL1201861
Homo sapiens SW-620 IC50 8.836 nM 10.6019/CHEMBL1201861
Homo sapiens SW626 IC50 23.21 nM 10.6019/CHEMBL1201861
Homo sapiens SW684 IC50 101.3 nM 10.6019/CHEMBL1201861
Homo sapiens SW756 IC50 14.7 nM 10.6019/CHEMBL1201861
Homo sapiens SW780 IC50 2.329 nM 10.6019/CHEMBL1201861
Homo sapiens SW837 IC50 120.44 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 255.22 nM 10.6019/CHEMBL1201861
Homo sapiens SW900 IC50 25.41 nM 10.6019/CHEMBL1201861
Homo sapiens SW948 IC50 75.99 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 9.662 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 19.39 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 8.919 nM 10.6019/CHEMBL1201861
Homo sapiens T-24 IC50 5.104 nM 10.6019/CHEMBL1201861
Homo sapiens T47D EC50 25.0 nM 10.1021/jm049640t
Homo sapiens T47D EC50 32.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens T47D EC50 32.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens T47D EC50 32.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens T47D EC50 43.0 nM 10.1021/jm7010657
Homo sapiens T47D GI50 7.0 nM 10.1016/j.bmc.2009.02.029
Homo sapiens T47D GI50 7.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens T47D GI50 7.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens T47D GI50 7.0 nM 10.1021/jm7010657
Homo sapiens T47D IC50 5.0 nM 10.1021/ml400281w
Homo sapiens T47D IC50 7.711 nM 10.6019/CHEMBL1201861
Homo sapiens T84 IC50 8147.21 nM 10.6019/CHEMBL1201861
Homo sapiens T98G IC50 11.4 nM 10.6019/CHEMBL1201861
Homo sapiens TCC-SUP IC50 23.63 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 10.85 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 21.47 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 5.128 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 700.72 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 6.135 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 56.47 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 6.156 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 4.27 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC11TKB IC50 15.83 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC1TKB IC50 31.21 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 32.52 nM 10.6019/CHEMBL1201861
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 1870.0 nM None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thymidine kinase, cytosolic Activity nan None 10.1016/j.bmcl.2006.07.003
Homo sapiens TI-73 IC50 3.212 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 IC50 42.4 nM 10.6019/CHEMBL1201861
Homo sapiens Tubulin EC50 200.0 nM 10.1021/jm050674q
Homo sapiens Tubulin IC50 70.0 nM 10.1021/jm00111a012
Homo sapiens Tubulin IC50 300.0 nM 10.1021/jm049640t
Homo sapiens Tubulin IC50 2100.0 nM 10.1016/j.bmcl.2015.02.045
Homo sapiens Tubulin Inhibition nan % 10.1016/j.bmcl.2013.06.083
Homo sapiens Tubulin Inhibition nan % 10.1016/j.ejmech.2013.04.057
Homo sapiens Tubulin Inhibition nan % 10.1021/ml5004684
Homo sapiens Tubulin Inhibition nan % 10.1039/c3md00130j
Homo sapiens Tubulin beta-5 chain Activity 25.0 % 10.1021/jm801064y
Homo sapiens TYK-nu IC50 11.9 nM 10.6019/CHEMBL1201861
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 70.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 141.3 nM None
Homo sapiens U-118-MG IC50 45.16 nM 10.6019/CHEMBL1201861
Homo sapiens U-251 IC50 5.018 nM 10.6019/CHEMBL1201861
Homo sapiens U-251 IC50 8.1 nM 10.1021/np2006499
Homo sapiens U-266 IC50 10.8 nM 10.6019/CHEMBL1201861
Homo sapiens U2OS IC50 25.72 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 29.98 nM 10.6019/CHEMBL1201861
Homo sapiens U-937 IC50 0.49 nM 10.1021/np070487q
Homo sapiens U-937 IC50 6880.0 nM 10.1021/jm0704189
Homo sapiens UACC-257 IC50 90.53 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-62 IC50 8.062 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-893 IC50 98.3 nM 10.6019/CHEMBL1201861
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 56234.1 nM None
Homo sapiens UMC-11 IC50 76.22 nM 10.6019/CHEMBL1201861
Homo sapiens UMUC3 IC50 5.107 nM 10.6019/CHEMBL1201861
Homo sapiens UO-31 IC50 13.94 nM 10.6019/CHEMBL1201861
Homo sapiens VA-ES-BJ IC50 3.273 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vitamin D receptor Potency 44668.4 nM None
Homo sapiens VM-CUB-1 IC50 4.281 nM 10.6019/CHEMBL1201861
Homo sapiens VMRC-RCZ IC50 19.27 nM 10.6019/CHEMBL1201861
Homo sapiens WM-115 IC50 10.16 nM 10.6019/CHEMBL1201861
Homo sapiens WRL68 IC50 1.45 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens WRL68 IC50 1.45 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens WRL68 IC50 2.6 ug.mL-1 10.1007/s00044-011-9832-9
Homo sapiens WRL68 IC50 2.6 ug.mL-1 10.1016/j.bmcl.2006.01.077
Homo sapiens YAPC IC50 86.99 nM 10.6019/CHEMBL1201861
Homo sapiens YH-13 IC50 3.702 nM 10.6019/CHEMBL1201861
Homo sapiens YKG-1 IC50 5.534 nM 10.6019/CHEMBL1201861
Homo sapiens ZR-75-1 ED50 0.3 ug ml-1 10.1021/np50113a007
Homo sapiens ZR-75-1 IC50 8.0 nM 10.1021/ml400281w
Homo sapiens ZR-75-30 IC50 402.55 nM 10.6019/CHEMBL1201861
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 200.0 ug.mL-1 10.1021/np50073a012
Leishmania donovani Beta tubulin IC50 1000.0 nM 10.1016/j.bmcl.2004.12.026
Mus musculus B16 IC50 3.6 ug.mL-1 10.1021/np010015q
Mus musculus B16 T/C 180.0 % 10.1021/jm00169a021
Mus musculus B16 T/C 309.0 % 10.1021/np50028a016
Mus musculus Bile salt export pump Km 38300.0 nM None
Mus musculus Intestine Ratio AUC 0.7 None 10.1124/dmd.110.034629
Mus musculus J774 IC50 2.1 nM 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 Activity 90.9 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 Activity 163.3 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 IC50 0.8 nM 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 IC50 15.9 nM 10.1016/0960-894X(95)00300-I
Mus musculus L1210 IC50 0.16 nM 10.1016/j.ejmech.2011.08.034
Mus musculus L1210 IC50 0.16 nM 10.1021/jm200488a
Mus musculus L1210 IC50 3.15 nM 10.1021/jm00111a012
Mus musculus L1210 IC50 6.0 nM 10.1016/j.bmcl.2010.09.091
Mus musculus L1210 IC50 6.0 nM 10.1021/jm3014376
Mus musculus L1210 IC50 6.0 nM 10.1021/ml200236a
Mus musculus L1210 IC50 6.0 nM 10.1021/ml400281w
Mus musculus L1210 T/C 140.0 % 10.1021/jm00169a021
Mus musculus L929 IC50 0.018 ug.mL-1 10.1021/np100625a
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus ILS 0.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 14.6 % 10.1021/jm00026a014
Mus musculus Mus musculus ILS 21.6 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 24.7 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 30.3 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 30.8 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 31.9 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 35.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 37.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 40.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 42.3 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 47.1 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 48.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 49.5 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 52.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 54.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 57.6 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 58.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 59.3 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 61.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 63.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 72.9 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 74.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 81.0 % 10.1021/jm00146a017
Mus musculus Mus musculus ILS 89.0 % 10.1021/jm00026a014
Mus musculus Mus musculus ILS 112.0 % 10.1021/jm00146a017
Mus musculus Mus musculus LD50 10.0 mg.kg-1 10.1021/jm00146a017
Mus musculus Mus musculus LD50 26.0 mg.kg-1 10.1021/jm00146a017
Mus musculus Mus musculus LD50 27.4 mg.kg-1 10.1021/jm00146a017
Mus musculus Mus musculus LD50 28.0 mg.kg-1 10.1021/jm00146a017
Mus musculus Mus musculus Log kill 0.7 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 1.9 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 2.8 None 10.1021/jm0005149
Mus musculus Mus musculus Survival days 11.0 None 10.1021/jm00026a014
Mus musculus Mus musculus Survival days 15.5 None 10.1021/jm00026a014
Mus musculus Mus musculus Survivors 0.0 None 10.1021/jm00146a017
Mus musculus Mus musculus Survivors 1.0 None 10.1021/jm00146a017
Mus musculus Mus musculus Survivors 2.0 None 10.1021/jm00146a017
Mus musculus Mus musculus Survivors 4.0 None 10.1021/jm00146a017
Mus musculus Mus musculus Survivors 5.0 None 10.1021/jm00146a017
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 11220.2 nM None
Mus musculus P388 ED50 0.02 ug ml-1 10.1021/np50113a007
Mus musculus P388 ED50 1.7 ug ml-1 10.1021/np50015a017
Mus musculus P388 GI 84.0 % 10.1248/bpb.27.899
Mus musculus P388 GI50 4.1 nM 10.1016/s0960-894x(98)00477-6
Mus musculus P388 IC50 0.6 nM 10.1021/jm8003653
Mus musculus P388 IC50 0.7 nM 10.1021/np50063a010
Mus musculus P388 IC50 1.7 nM 10.1016/S0960-894X(00)80225-5
Mus musculus P388 IC50 4.1 nM 10.1021/jm060593+
Mus musculus P388 IC50 8.2 nM 10.1016/S0960-894X(00)80225-5
Mus musculus P388 IC50 27.0 nM 10.1021/jm8003653
Mus musculus P388 ILS 50.0 % 10.1016/S0960-894X(00)80225-5
Mus musculus P388 ILS 100.0 % 10.1016/S0960-894X(00)80225-5
Mus musculus P388 IZ 12.5 mm 10.1021/np50063a010
Mus musculus P388 IZ 32.5 mm 10.1021/np50063a010
Mus musculus P388 IZ 40.0 mm 10.1021/np50063a010
Mus musculus P388 LTS 2.0 None 10.1021/jm00111a012
Mus musculus P388 Ratio IC50 22.0 None 10.1021/jm060593+
Mus musculus P388 Relative IC50 0.2 nM 10.1021/jm9505122
Mus musculus P388 Relative IC50 1.0 nM 10.1021/jm9505122
Mus musculus P388 Relative IC50 19.0 nM 10.1021/jm9505122
Mus musculus P388 T/C 157.0 % 10.1021/jm00111a012
Mus musculus P388/ADR GI50 470.0 nM 10.1016/s0960-894x(98)00477-6
Mus musculus P388/ADR IC50 4.3 nM 10.1021/jm060593+
Mus musculus P388/ADR IC50 95.0 nM 10.1021/jm060593+
Mus musculus P388/ADR IC50 nan None 10.1021/jm060593+
Mus musculus P-glycoprotein 1 Activity nan None None
Mus musculus P-glycoprotein 1 IC50 8000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Activity nan None 10.1046/j.1440-1681.2000.03308.x
Mus musculus P-glycoprotein 3 Activity nan None None
Mus musculus P-glycoprotein 3 IC50 50000.0 nM 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 3.0 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 4.3 None 10.1021/jm021012t
Mus musculus P-glycoprotein 3 Ratio 5.2 None 10.1021/jm021012t
Mus musculus Plasma Ratio AUC 1.5 None 10.1124/dmd.110.034629
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 5037.0 nM None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Paracentrotus lividus Paracentrotus lividus Activity nan None 10.1016/j.ejmech.2015.02.051
Paracentrotus lividus Paracentrotus lividus EC 0.1 uM 10.1016/j.ejmech.2015.02.051
Paracentrotus lividus Paracentrotus lividus EC 0.2 uM 10.1016/j.ejmech.2015.02.051
Paracentrotus lividus Paracentrotus lividus EC 2.0 uM 10.1016/j.ejmech.2015.02.051
Plasmodium falciparum Plasmodium falciparum IC50 2.0 nM 10.1128/aac.00431-10
Plasmodium falciparum Plasmodium falciparum Potency 477.5 nM None
Plasmodium falciparum Plasmodium falciparum Potency 849.2 nM None
Plasmodium yoelii yoelii Plasmodium yoelii yoelii IC50 7950.0 nM 10.1021/jm201095h
Plasmodium yoelii yoelii Plasmodium yoelii yoelii IC50 7950.0 nM 10.1128/aac.01043-07
Rattus norvegicus A10 Activity nan None 10.1021/jm070194u
Rattus norvegicus A10 Activity nan None 10.1021/np010049y
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus C6 Activity nan None 10.1021/np960144k
Rattus norvegicus C6 LC50 66.0 nM 10.1021/np960144k
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Activity 29.0 % 10.1016/s0021-9258(17)30655-5
Rattus norvegicus Canalicular multispecific organic anion transporter 1 Activity nan None 10.1016/s0378-4274(01)00306-x
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Multidrug resistance-associated protein 6 Activity nan None 10.1021/bi012082p
Rattus norvegicus Multidrug resistance protein 1a Activity nan None 10.1007/s004240050829
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus PC-12 GI50 0.0102 ug.mL-1 10.1016/s0960-894x(02)00568-1
Rattus norvegicus Peripheral myelin protein 22 Potency 223.7 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 720.8 nM None
Rattus norvegicus Plasma Fu 0.14 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus ALB 36000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 340.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 392.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 395.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 406.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 429.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 438.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 55.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 129.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 423.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 88.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 101.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 337.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 923.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 4.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 56.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 135.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 161.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 96.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 636.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 648.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 673.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 696.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 1040.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 1923.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 242.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 526.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 599.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 622.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 645.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 732.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 11.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 17.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 21.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 42.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1210.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1350.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1570.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1673.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1868.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 2120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 28.87 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 31.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.62 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.42 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 116300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 126700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 144000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LD50 2.9 mg.kg-1 10.1021/jm00146a017
Rattus norvegicus Rattus norvegicus LDH 170.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 188.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 246.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 334.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 415.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 442.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 4520.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 5650.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6254.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7180.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10193.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11849.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 95.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 98.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.32 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.27 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.5 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.68 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 26.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 388700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 399000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 402300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 403300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.08 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.1 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 22.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 26.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 34.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 40.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 69.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 165.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 46.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 293.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 297.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 381.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 702.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 730.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 106.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 126.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 133.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 95670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 588330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 825330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1170500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1202830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1437000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.16 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.31 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.51 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.71 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.35 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4480000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4960000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5150000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5390000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5700000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5930000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.27 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.2 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 10.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 4600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 6070.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 6630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 7500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11080.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 2 Activity nan None 10.1093/toxsci/47.2.181
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 11220.2 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 6.0 mm 10.1016/j.ejmech.2010.07.050
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 11.78 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2235 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 2.15 % 10.6019/CHEMBL4495565
Sus scrofa LLC-PK1 GI50 1.5 nM 10.1039/c3md00130j
Sus scrofa LLC-PK1 GI50 86.8 nM 10.1039/c3md00130j
Sus scrofa LLC-PK1 RatioGI50 58.0 None 10.1039/c3md00130j
Sus scrofa Tubulin Activity 50.0 % 10.1021/ml400281w
Sus scrofa Tubulin IC50 600.0 nM 10.1016/s0960-894x(02)00568-1
Sus scrofa Tubulin IC50 1100.0 nM 10.1016/j.ejmech.2015.06.029
Sus scrofa Tubulin IC50 1600.0 nM 10.1016/j.bmcl.2010.10.118
Sus scrofa Tubulin Inhibition 50.0 % 10.1021/jm3014376
Sus scrofa Tubulin Inhibition 50.0 % 10.1021/jm3015684
Sus scrofa Tubulin Inhibition 73.93 % 10.1016/j.bmc.2015.10.003
Sus scrofa Tubulin Inhibition nan % 10.1016/j.bmcl.2013.06.083
Sus scrofa Tubulin Inhibition nan % 10.1021/jm4001117
Sus scrofa Tubulin Inhibition nan % 10.1021/ml200195s
Sus scrofa Tubulin alpha chain Inhibition 64.0 % 10.1021/jm970177c
Trypanosoma brucei Trypanosoma brucei IC50 410.0 nM 10.1016/j.bmcl.2012.07.023
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 94.0 nM 10.1021/jm4004279
Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Putative uncharacterized protein Potency 31622.8 nM None
None ADMET Activity 1.0 None 10.1021/jm9700169
None ADMET Activity nan None 10.1016/j.bmcl.2011.01.111
None ADMET Bullatacin index 18.8 None 10.1021/jm9700169
None ADMET CL 3.1 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 7.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 12.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 22.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 25.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET Drug uptake 18.7 % 10.1021/np50081a001
None ADMET EC50 1.2 nM 10.1021/jm990568m
None ADMET IC50 1.6 nM 10.1016/j.ejmech.2013.04.057
None ADMET IC50 8.0 nM 10.1021/jm061307x
None ADMET IC50 356.0 nM 10.1021/jm061307x
None ADMET MRT 150.0 hr 10.1124/dmd.108.020479
None ADMET Papp 0.9 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 1.0 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 2.2 10'-7 cm/s 10.1016/j.bmc.2012.03.024
None ADMET Papp 3.2 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 6.5 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 11.9 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 12.3 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 32.4 10'-7 cm/s 10.1016/j.bmc.2012.03.024
None ADMET Ratio -11.0 None 10.1124/dmd.110.034629
None ADMET Ratio -4.0 None 10.1124/dmd.110.034629
None ADMET Ratio 2.0 None 10.1124/dmd.110.034629
None ADMET Ratio 7.0 None 10.1124/dmd.110.034629
None ADMET Ratio 13.5 None 10.1124/dmd.110.034629
None ADMET Ratio 14.0 None 10.1124/dmd.110.034629
None ADMET Ratio 15.0 None 10.1016/j.bmc.2012.03.024
None ADMET Ratio 46.0 None 10.1124/dmd.110.034629
None ADMET Ratio 88.0 None 10.1124/dmd.110.034629
None ADMET Ratio 340.0 None 10.1124/dmd.110.034629
None ADMET T1/2 67.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.5 L.kg-1 10.1002/jps.20373
None ADMET Vdss 2.3 L.kg-1 10.1002/jps.20373
None ADMET Vdss 12.0 mL/min/kg 10.1002/jps.20373
None ADMET Vdss 24.0 L.kg-1 10.1002/jps.20373
None ADMET Vdss 28.0 L.kg-1 10.1124/dmd.108.020479
None EBV-positive nasopharyngeal cell line Reduction 99.0 % 10.1021/jm00366a004
None EBV-positive nasopharyngeal cell line Survival 0.01 None 10.1021/jm00366a004
None Hepatocyte TC50 5.45 10'4nM 10.1128/aac.01043-07
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Lymphocyte Activity 6.06 % 10.1016/j.ejmech.2011.01.071
None Molecular identity unknown Activity nan None 10.1021/jm500561a
None NON-PROTEIN TARGET Activity 0.0 % 10.1021/np50100a011
None NON-PROTEIN TARGET Activity 16.27 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 16.27 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 21.68 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 21.68 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 28.2 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 28.2 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 38.06 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 38.06 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 47.54 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 47.54 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 53.42 % 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET Activity 53.42 % 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET Activity 100.0 % 10.1021/np50100a011
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2013.10.076
None NON-PROTEIN TARGET EC50 8.5 nM 10.1021/jm100421n
None NON-PROTEIN TARGET EC50 12.6 nM 10.1021/jm100421n
None NON-PROTEIN TARGET EC50 13.0 nM 10.1021/jm100421n
None NON-PROTEIN TARGET EC50 28.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 162.0 nM 10.1021/jm100421n
None NON-PROTEIN TARGET EC50 2037.0 nM 10.1021/jm100421n
None NON-PROTEIN TARGET EC50 nan None 10.1038/nchembio873
None NON-PROTEIN TARGET ED50 0.06 ug ml-1 10.1021/np50113a007
None NON-PROTEIN TARGET ED50 0.5 ug ml-1 10.1021/np50113a007
None NON-PROTEIN TARGET ED50 1.1 ug ml-1 10.1021/np50113a007
None NON-PROTEIN TARGET ED50 2.4 ug ml-1 10.1021/np50015a017
None NON-PROTEIN TARGET ED50 2.6 ug ml-1 10.1021/np50094a004
None NON-PROTEIN TARGET ED50 2.6 ug ml-1 10.1021/np50113a007
None NON-PROTEIN TARGET Fu 0.14 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI50 0.3 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET GI50 1.37 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET GI50 1.6 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET GI50 2.8 nM 10.1039/c3md00130j
None NON-PROTEIN TARGET GI50 6.0 nM 10.1016/j.ejmech.2015.08.047
None NON-PROTEIN TARGET GI50 6.0 nM 10.1021/jm400711t
None NON-PROTEIN TARGET GI50 6.0 nM 10.1021/jm501518y
None NON-PROTEIN TARGET GI50 100.0 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET GI50 100.0 nM 10.1021/jm900850t
None NON-PROTEIN TARGET GI50 1402.0 nM 10.1039/c3md00130j
None NON-PROTEIN TARGET GI50 5000.0 nM 10.1016/j.ejmech.2015.08.047
None NON-PROTEIN TARGET GI50 5000.0 nM 10.1021/jm400711t
None NON-PROTEIN TARGET GI50 5000.0 nM 10.1021/jm501518y
None NON-PROTEIN TARGET GI50 nan None 10.1021/jm501518y
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 22.6 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 0.0086 ug.mL-1 10.1021/np100625a
None NON-PROTEIN TARGET IC50 0.099 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 0.099 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 0.1 ug.mL-1 10.1021/jm00123a030
None NON-PROTEIN TARGET IC50 0.11 nM 10.1016/j.bmc.2008.02.029
None NON-PROTEIN TARGET IC50 0.4 nM 10.1021/jm100884b
None NON-PROTEIN TARGET IC50 0.63 nM 10.1021/jm101318b
None NON-PROTEIN TARGET IC50 1.0 nM 10.1016/j.bmcl.2015.02.045
None NON-PROTEIN TARGET IC50 1.0 nM 10.1021/jm4004347
None NON-PROTEIN TARGET IC50 1.0 nM 10.1021/jm500530v
None NON-PROTEIN TARGET IC50 1.24 nM 10.1021/jm101318b
None NON-PROTEIN TARGET IC50 1.38 nM 10.1021/np070487q
None NON-PROTEIN TARGET IC50 1.6 nM 10.1021/jm061348t
None NON-PROTEIN TARGET IC50 1.8 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 1.8 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 2.0 nM 10.1016/j.bmcl.2015.02.045
None NON-PROTEIN TARGET IC50 2.0 nM 10.1021/np300792t
None NON-PROTEIN TARGET IC50 2.0 nM 10.1021/np3008446
None NON-PROTEIN TARGET IC50 2.28 nM 10.1016/j.bmcl.2011.01.097
None NON-PROTEIN TARGET IC50 2.28 nM 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET IC50 2.6 ug.mL-1 10.1007/s00044-011-9965-x
None NON-PROTEIN TARGET IC50 2.6 ug.mL-1 10.1007/s00044-012-0142-7
None NON-PROTEIN TARGET IC50 2.9 nM 10.1021/ml400281w
None NON-PROTEIN TARGET IC50 3.0 nM 10.1016/j.bmc.2011.05.030
None NON-PROTEIN TARGET IC50 3.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 3.0 nM 10.1021/jm070194u
None NON-PROTEIN TARGET IC50 3.0 nM 10.1021/jm3013097
None NON-PROTEIN TARGET IC50 3.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 3.5 nM 10.1021/np2006499
None NON-PROTEIN TARGET IC50 4.2 nM 10.1021/np2006499
None NON-PROTEIN TARGET IC50 5.0 nM 10.1021/jm00077a016
None NON-PROTEIN TARGET IC50 5.1 nM 10.1021/ml400281w
None NON-PROTEIN TARGET IC50 5.2 nM 10.1021/np300900a
None NON-PROTEIN TARGET IC50 7.9 nM 10.1021/ml400281w
None NON-PROTEIN TARGET IC50 8.9 nM 10.1021/jm061348t
None NON-PROTEIN TARGET IC50 9.0 nM 10.1021/np300792t
None NON-PROTEIN TARGET IC50 9.0 nM 10.1021/np3008446
None NON-PROTEIN TARGET IC50 11.0 nM 10.1021/jm4001117
None NON-PROTEIN TARGET IC50 11.0 nM 10.1021/np2006499
None NON-PROTEIN TARGET IC50 15.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 15.0 nM 10.1021/np2006499
None NON-PROTEIN TARGET IC50 18.0 nM 10.1021/jm011010t
None NON-PROTEIN TARGET IC50 19.6 nM 10.1021/ml400281w
None NON-PROTEIN TARGET IC50 20.0 nM 10.1016/j.bmcl.2004.06.080
None NON-PROTEIN TARGET IC50 21.0 nM 10.1016/j.ejmech.2014.05.028
None NON-PROTEIN TARGET IC50 90.0 nM 10.1021/np9802872
None NON-PROTEIN TARGET IC50 100.0 nM 10.1021/jm101318b
None NON-PROTEIN TARGET IC50 100.0 nM 10.1021/jm301201z
None NON-PROTEIN TARGET IC50 144.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 144.0 nM 10.1021/jm3013097
None NON-PROTEIN TARGET IC50 144.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 193.0 nM 10.1021/jm5008193
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/jm2012886
None NON-PROTEIN TARGET IC50 205.0 nM 10.1016/j.bmc.2012.10.001
None NON-PROTEIN TARGET IC50 205.0 nM 10.1021/jm300388h
None NON-PROTEIN TARGET IC50 211.0 nM 10.1021/jm400043d
None NON-PROTEIN TARGET IC50 230.0 nM 10.1016/j.ejmech.2011.10.013
None NON-PROTEIN TARGET IC50 230.0 nM 10.1021/jm200392p
None NON-PROTEIN TARGET IC50 246.0 nM 10.1021/jm011010t
None NON-PROTEIN TARGET IC50 260.0 nM 10.1021/np070458f
None NON-PROTEIN TARGET IC50 375.0 nM 10.1021/jm070194u
None NON-PROTEIN TARGET IC50 439.73 nM 10.1016/j.bmcl.2011.01.097
None NON-PROTEIN TARGET IC50 439.73 nM 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET IC50 540.0 nM 10.1016/j.bmcl.2004.06.080
None NON-PROTEIN TARGET IC50 600.0 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 600.0 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 1040.0 nM 10.1016/j.bmc.2008.02.029
None NON-PROTEIN TARGET IC50 2818.38 nM 10.1016/j.bmc.2007.07.024
None NON-PROTEIN TARGET IC50 375000.0 nM 10.1016/j.bmc.2011.05.030
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.061
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.11.030
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2011.10.013
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2014.02.018
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm200392p
None NON-PROTEIN TARGET LC50 500.0 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET LC50 1580.0 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET LC50 2000.0 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET Ratio IC50 224.18 None 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET TGI 1.6 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET TGI 320.0 nM 10.1016/j.ejmech.2015.02.051
None NON-PROTEIN TARGET TGI 790.0 nM 10.1016/j.ejmech.2015.02.051
None No relevant target LogD 3.69 None 10.1021/jm00169a014
None No relevant target LogP 3.9 None 10.1016/j.ejmech.2009.12.043
None No relevant target LogP 5.2 None 10.1021/jm021012t
None No relevant target pKa 5.4 None 10.1021/jm020941h
None No relevant target pKa 5.96 None 10.1021/jm020941h
None No relevant target pKa 7.4 None 10.1021/jm020941h
None No relevant target pKa 7.59 None 10.1021/jm020941h
None Nucleic Acid Activity 100.0 % 10.1021/np50078a006
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Unchecked Activity 0.7 uM 10.1074/jbc.m706175200
None Unchecked Activity 31.3 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
None Unchecked Activity 40.0 uM 10.1074/jbc.m706175200
None Unchecked Activity 52.89 % 10.1016/j.ejmech.2013.10.076
None Unchecked Activity 69.7 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
None Unchecked Activity 84.8 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
None Unchecked Activity 140.3 pM of drug (10e6*cells)-1 10.1016/0960-894X(95)00300-I
None Unchecked Activity nan None 10.1016/j.bmc.2011.05.030
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/jm4001117
None Unchecked Activity nan None 10.1021/jm900476c
None Unchecked Activity nan None 10.1039/c3md00130j
None Unchecked EC50 8200.0 nM 10.1021/np960144k
None Unchecked Fold_increase 8.0 None 10.1016/j.bmcl.2003.12.015
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 17.0 nM 10.1128/aac.00355-07
None Unchecked IC50 500.0 nM 10.1016/j.bmc.2009.02.029
None Unchecked IC50 500.0 nM 10.1016/j.bmcl.2009.03.121
None Unchecked IC50 500.0 nM 10.1016/j.bmcl.2009.04.009
None Unchecked IC50 680.0 nM 10.1128/aac.00355-07
None Unchecked IC50 950.0 nM 10.1016/j.bmc.2007.12.026
None Unchecked IC50 1000.0 nM 10.1016/j.bmcl.2007.12.016
None Unchecked IC50 1000.0 nM 10.1016/s0960-894x(01)00759-4
None Unchecked IC50 1150.0 nM 10.1016/j.bmcl.2009.04.010
None Unchecked IC50 1500.0 nM 10.1021/jm3009629
None Unchecked IC50 1660.0 nM 10.1016/j.bmc.2007.12.026
None Unchecked IC50 2000.0 nM 10.1016/j.bmcl.2008.11.036
None Unchecked IC50 2100.0 nM 10.1021/jm4004347
None Unchecked IC50 2100.0 nM 10.1021/jm500530v
None Unchecked IC50 2100.0 nM 10.1021/jm801064y
None Unchecked IC50 4000.0 nM 10.1021/np50109a024
None Unchecked IC50 4000.0 nM 10.1021/np50122a002
None Unchecked IC50 25191.0 nM None
None Unchecked IC50 nan None None
None Unchecked Inhibition 16.0 % 10.1021/jm3009629
None Unchecked Inhibition 37.0 % 10.1021/jm3009629
None Unchecked Inhibition 45.0 % 10.1021/jm3009629
None Unchecked Inhibition 50.0 % 10.1021/jm3009629
None Unchecked Inhibition 53.0 % 10.1021/jm3009629
None Unchecked Inhibition nan % 10.1016/j.bmc.2015.03.085
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.5b00310
None Unchecked Inhibition nan % 10.1021/ml200195s
None Unchecked Ki 22585.0 nM None
None Unchecked Ki nan None None
None Unchecked Log CR 2.38 None 10.1021/jm00169a014
None Unchecked Potency 2.3 nM None
None Unchecked Potency 251.2 nM None
None Unchecked Potency 1412.5 nM None
None Unchecked Ratio 0.5 None 10.1021/jm3009629
None Unchecked Ratio 19.9 None 10.1016/0960-894X(95)00300-I
None Unchecked Ratio 210.0 None 10.1021/np0003443
None Unchecked Ratio IC50 1.0 None 10.1021/jm801064y
None Unchecked Ratio IC50 27.5 None 10.1021/jm4001117
None Unchecked Ratio IC50 210.0 None 10.1021/np010032f
None Unchecked Ratio IC50 210.0 None 10.1021/np0106384
None Unchecked RBA 0.98 None 10.1016/j.bmc.2010.05.003
None Unchecked RBA 1.21 None 10.1016/j.bmc.2010.05.003
None Unchecked RBA 1.37 None 10.1016/j.bmc.2010.05.003
None Unchecked Selectivity Index 6.85 None 10.1128/aac.01043-07

Metabolism Information