Molecule

Tylophorine

AlkaPlorer ID: AK001555

Synonym: '', 'Tylophorine'

IUPAC Name: (13aS)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizine

Structure

SMILES: COC1=CC2=C3C[C@@H]4CCCN4CC3=C3C=C(OC)C(OC)=CC3=C2C=C1OC

InChI: InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1

InChIKey: SSEUDFYBEOIWGF-AWEZNQCLSA-N

Reference

Isolation and Biological Activities of Phenanthroindolizidine and Septicine Alkaloids from the Formosan<i>Tylophora ovata</i>

PubChem CID: 92114

CAS: 482-20-2

LOTUS: LTS0165148

SuperNatural Ⅲ: SN0353896-01

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Tylophora asthmatica	Tylophora	Apocynaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 393.4830000000001

TPSA？: 40.16

MolLogP？: 4.547900000000005

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	786-0	GI50	10.33	nM	None
Homo sapiens	786-0	GI50	41.69	nM	None
Homo sapiens	A498	GI50	10.0	nM	None
Homo sapiens	A549	GI50	10.0	nM	None
Homo sapiens	A549	GI50	13.24	nM	None
Homo sapiens	A549	GI50	700.0	nM	10.1016/j.ejmech.2012.02.048
Homo sapiens	ACHN	GI50	10.0	nM	None
Homo sapiens	ACHN	GI50	14.52	nM	None
Homo sapiens	BT-549	GI50	22.49	nM	None
Homo sapiens	BT-549	GI50	39.45	nM	None
Homo sapiens	CAKI-1	GI50	16.26	nM	None
Homo sapiens	CAKI-1	GI50	25.82	nM	None
Homo sapiens	CCRF-CEM	GI50	10.4	nM	None
Homo sapiens	CCRF-CEM	GI50	15.0	nM	10.1016/j.bmcl.2007.11.054
Homo sapiens	CCRF-CEM	GI50	52.36	nM	None
Homo sapiens	COLO 205	GI50	10.0	nM	None
Homo sapiens	COLO 205	GI50	59.16	nM	None
Homo sapiens	DU-145	GI50	20.46	nM	None
Homo sapiens	DU-145	GI50	101.16	nM	None
Homo sapiens	EKVX	GI50	10.0	nM	None
Homo sapiens	EKVX	GI50	21.58	nM	None
Homo sapiens	HCC 2998	GI50	10.0	nM	None
Homo sapiens	HCC 2998	GI50	35.56	nM	None
Homo sapiens	HCT-116	GI50	10.0	nM	None
Homo sapiens	HCT-116	GI50	17.91	nM	None
Homo sapiens	HCT-15	GI50	10.52	nM	None
Homo sapiens	HCT-15	GI50	46.24	nM	None
Homo sapiens	HL-60	GI50	10.0	nM	10.1016/j.ejmech.2012.02.048
Homo sapiens	HL-60	GI50	16.48	nM	None
Homo sapiens	HL-60	GI50	85.31	nM	None
Homo sapiens	HOP-62	GI50	14.72	nM	None
Homo sapiens	HOP-62	GI50	40.93	nM	None
Homo sapiens	HOP-92	GI50	10.47	nM	None
Homo sapiens	HOP-92	GI50	36.64	nM	None
Homo sapiens	Hs-578T	GI50	403.65	nM	None
Homo sapiens	HT-29	GI50	10.0	nM	None
Homo sapiens	HT-29	GI50	34.04	nM	None
Homo sapiens	IGROV-1	GI50	10.0	nM	None
Homo sapiens	IGROV-1	GI50	43.25	nM	None
Homo sapiens	K562	GI50	10.0	nM	None
Homo sapiens	K562	GI50	377.57	nM	None
Homo sapiens	KM12	GI50	10.0	nM	None
Homo sapiens	KM12	GI50	45.19	nM	None
Homo sapiens	LOX IMVI	GI50	10.0	nM	None
Homo sapiens	LOX IMVI	GI50	11.91	nM	None
Homo sapiens	M14	GI50	14.19	nM	None
Homo sapiens	M14	GI50	50.23	nM	None
Homo sapiens	Malme-3M	GI50	19.82	nM	None
Homo sapiens	Malme-3M	GI50	363.92	nM	None
Homo sapiens	MCF7	GI50	10.0	nM	None
Homo sapiens	MCF7	GI50	10.69	nM	None
Homo sapiens	MCF7	GI50	42.0	nM	10.1016/j.bmc.2012.07.044
Homo sapiens	MDA-MB-231	GI50	10.94	nM	None
Homo sapiens	MDA-MB-435	GI50	14.66	nM	None
Homo sapiens	MDA-MB-435	GI50	29.79	nM	None
Homo sapiens	MDA-N	GI50	12.94	nM	None
Homo sapiens	MDA-N	GI50	81.66	nM	None
Homo sapiens	MOLT-4	GI50	10.0	nM	None
Homo sapiens	MOLT-4	GI50	38.19	nM	None
Homo sapiens	NCI/ADR-RES	GI50	19.5	nM	None
Homo sapiens	NCI/ADR-RES	GI50	110.92	nM	None
Homo sapiens	NCI-H226	GI50	29.38	nM	None
Homo sapiens	NCI-H23	GI50	12.33	nM	None
Homo sapiens	NCI-H23	GI50	40.55	nM	None
Homo sapiens	NCI-H322M	GI50	10.28	nM	None
Homo sapiens	NCI-H322M	GI50	43.35	nM	None
Homo sapiens	NCI-H460	GI50	10.0	nM	None
Homo sapiens	NCI-H460	GI50	30.06	nM	None
Homo sapiens	NCI-H522	GI50	40.64	nM	None
Homo sapiens	NCI-H522	GI50	56.62	nM	None
Homo sapiens	OVCAR-3	GI50	42.27	nM	None
Homo sapiens	OVCAR-3	GI50	58.88	nM	None
Homo sapiens	OVCAR-4	GI50	10.0	nM	None
Homo sapiens	OVCAR-4	GI50	41.88	nM	None
Homo sapiens	OVCAR-5	GI50	12.05	nM	None
Homo sapiens	OVCAR-5	GI50	16.56	nM	None
Homo sapiens	OVCAR-8	GI50	10.33	nM	None
Homo sapiens	OVCAR-8	GI50	38.11	nM	None
Homo sapiens	PANC-1	GI50	12.0	nM	10.1016/j.bmcl.2007.11.054
Homo sapiens	PANC-1	GI50	nan	None	10.1016/j.bmcl.2007.05.021
Homo sapiens	PC-3	GI50	12.56	nM	None
Homo sapiens	PC-3	GI50	258.82	nM	None
Homo sapiens	RPMI-8226	GI50	17.5	nM	None
Homo sapiens	RPMI-8226	GI50	90.57	nM	None
Homo sapiens	RXF 393	GI50	4.864	nM	None
Homo sapiens	RXF 393	GI50	385.48	nM	None
Homo sapiens	SF-268	GI50	14.19	nM	None
Homo sapiens	SF-268	GI50	133.35	nM	None
Homo sapiens	SF-295	GI50	10.02	nM	None
Homo sapiens	SF-295	GI50	35.73	nM	None
Homo sapiens	SF-539	GI50	15.74	nM	None
Homo sapiens	SF-539	GI50	56.36	nM	None
Homo sapiens	SK-MEL-2	GI50	10.0	nM	None
Homo sapiens	SK-MEL-2	GI50	29.72	nM	None
Homo sapiens	SK-MEL-28	GI50	9.057	nM	None
Homo sapiens	SK-MEL-28	GI50	13.71	nM	None
Homo sapiens	SK-MEL-5	GI50	10.0	nM	None
Homo sapiens	SK-MEL-5	GI50	60.67	nM	None
Homo sapiens	SK-OV-3	GI50	12.16	nM	None
Homo sapiens	SK-OV-3	GI50	12.62	nM	None
Homo sapiens	SN12C	GI50	10.54	nM	None
Homo sapiens	SN12C	GI50	42.85	nM	None
Homo sapiens	SNB-19	GI50	9.354	nM	None
Homo sapiens	SNB-19	GI50	10.0	nM	None
Homo sapiens	SNB-75	GI50	8.395	nM	None
Homo sapiens	SNB-75	GI50	84.33	nM	None
Homo sapiens	SR	GI50	10.21	nM	None
Homo sapiens	SR	GI50	66.68	nM	None
Homo sapiens	SW-620	GI50	12.42	nM	None
Homo sapiens	SW-620	GI50	73.45	nM	None
Homo sapiens	T47D	GI50	19.23	nM	None
Homo sapiens	T47D	GI50	80.17	nM	None
Homo sapiens	TK-10	GI50	16.71	nM	None
Homo sapiens	TK-10	GI50	19.36	nM	None
Homo sapiens	U-251	GI50	10.0	nM	None
Homo sapiens	U-251	GI50	22.13	nM	None
Homo sapiens	UACC-257	GI50	14.32	nM	None
Homo sapiens	UACC-257	GI50	26.61	nM	None
Homo sapiens	UACC-62	GI50	16.03	nM	None
Homo sapiens	UACC-62	GI50	164.06	nM	None
Homo sapiens	UO-31	GI50	20.8	nM	None
Homo sapiens	UO-31	GI50	39.9	nM	None
Mus musculus	RAW264.7	IC50	78.0	nM	10.1021/ml500255j
Mus musculus	RAW264.7	IC50	274.0	nM	10.1021/ml500255j
Tobacco mosaic virus	Tobacco mosaic virus	Activity	24.4	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Activity	28.6	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Activity	34.2	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Activity	37.0	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Activity	47.7	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Activity	48.3	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Activity	50.5	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Activity	53.8	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Activity	56.8	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	EC50	100.0	ug.mL-1	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	35.2	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	36.9	%	10.1021/jf303550a
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	41.7	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	43.7	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	50.6	%	10.1021/jf902543r
Tobacco mosaic virus	Tobacco mosaic virus	Inhibition	54.1	%	10.1021/jf303550a
None	NON-PROTEIN TARGET	GI50	11.0	nM	10.1016/j.bmcl.2007.11.054
None	NON-PROTEIN TARGET	IC50	55.0	nM	10.1021/ml500255j
None	NON-PROTEIN TARGET	IC50	1134.0	nM	10.1021/ml500255j
None	T-cell	Inhibition	44.0	%	10.1021/ml500255j
None	Unchecked	IC50	41.0	nM	10.1016/j.bmcl.2007.11.054
None	Unchecked	IC50	229.0	nM	10.1016/j.bmcl.2007.11.054
None	Unchecked	IC50	300.0	nM	10.1016/j.bmcl.2007.11.054