Galanthine
AlkaPlorer ID: AK001569
Synonym: '(-)-Galanthine', 'Galanthine'
IUPAC Name: (1S,14S,15S,16S)-4,5,14-trimethoxy-9-azatetracyclo[7.6.1.02,7.012,16]hexadeca-2,4,6,12-tetraen-15-ol
Structure
SMILES: COC1=C(OC)C=C2C(=C1)CN1CCC3=C[C@H](OC)[C@@H](O)[C@@H]2[C@@H]31
InChI: InChI=1S/C18H23NO4/c1-21-13-7-11-9-19-5-4-10-6-15(23-3)18(20)16(17(10)19)12(11)8-14(13)22-2/h6-8,15-18,20H,4-5,9H2,1-3H3/t15-,16-,17+,18+/m0/s1
InChIKey: VOIMPDXOQJYVDI-WNRNVDISSA-N
Reference
PubChem CID: 10403528
LOTUS: LTS0167735
SuperNatural Ⅲ: SN0395730-03
NPASS: NPC246597
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Zephyranthes carinata | Zephyranthes | Amaryllidaceae | Asparagales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 317.385
TPSA？: 51.16
MolLogP？: 1.6911999999999998
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | IC50 | 10000.0 | nM | 10.1021/np9008255 |
| Homo sapiens | Acetylcholinesterase | IC50 | 6100.0 | nM | 10.1021/acs.jnatprod.7b00301 |
| Homo sapiens | SK-MEL | IC50 | 10000.0 | nM | 10.1021/np9008255 |
| Mus musculus | B16-F10 | IC50 | 10000.0 | nM | 10.1021/np9008255 |
| Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | 3.1 | ug.mL-1 | 10.1016/j.bmcl.2019.126642 |
| None | NON-PROTEIN TARGET | IC50 | 10000.0 | nM | 10.1021/np9008255 |