Navigation

name Structure Reference Source Properties Activities Metabolism

5-Hydroxytryptamine

AlkaPlorer ID: AK001574

Synonym: 3-(2-Aminoethyl)-1H-indol-5-ol, 3-(2-Aminoethyl)-5-hydroxyindole, Serotonin, Anthemovister, Enteramine, Hippophaine, Thrombocytin, Thrombotonin, 5 HT 

IUPAC Name: 2-(5-hydroxy-1H-indol-3-yl)ethylazanium

Structure

SMILES: [NH3+]CCC1=CNC2=C1C=C(O)C=C2

copy

InChI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1

copy

InChIKey: QZAYGJVTTNCVMB-UHFFFAOYSA-O

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain
Punica granatum Punica Lythraceae Myrtales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Actinidia deliciosa Actinidia Actinidiaceae Ericales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ananas comosus Ananas Bromeliaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Urtica dioica Urtica Urticaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hordeum vulgare Hordeum Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phaseolus vulgaris Phaseolus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Vicia villosa Vicia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Lecanora conizaeoides Lecanora Lecanoraceae Lecanorales Lecanoromycetes Ascomycota Fungi Eukaryota
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota
Saururus cernuus Saururus Saururaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phoenix dactylifera Phoenix Arecaceae Arecales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pleurotus citrinopileatus Pleurotus Pleurotaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
Vitex megapotamica Vitex Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Capsicum annuum Capsicum Solanaceae Solanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Uncaria rhynchophylla Uncaria Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Bufo bufo Bufo Bufonidae Anura Amphibia Chordata Metazoa Eukaryota
Hesperocyparis macrocarpa Hesperocyparis Cupressaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Mus musculus Mus Muridae Rodentia Mammalia Chordata Metazoa Eukaryota
Mucuna pruriens Mucuna Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Spinacia oleracea Spinacia Chenopodiaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Rheum officinale Rheum Polygonaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artemisia oranensis Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Halimeda macroloba Halimeda Halimedaceae Bryopsidales Ulvophyceae Chlorophyta Viridiplantae Eukaryota
Nitraria schoberi Nitraria Nitrariaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces plumbeus Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Potentilla multifida Potentilla Rosaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Gavia immer Gavia Gaviidae Gaviiformes Aves Chordata Metazoa Eukaryota
Hippophae rhamnoides Hippophae Elaeagnaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Buxus sempervirens Buxus Buxaceae Buxales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Avena sativa Avena Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Strychnos fendleri Strychnos Loganiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Prunus tomentosa Prunus Rosaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Juglans regia Juglans Juglandaceae Fagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aruncus dioicus Aruncus Rosaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Secale cereale Secale Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Anethum graveolens Anethum Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cucurbita pepo Cucurbita Cucurbitaceae Cucurbitales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cortinarius rubellus Cortinarius Cortinariaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
Paramuricea clavata Paramuricea Plexauridae Malacalcyonacea Anthozoa Cnidaria Metazoa Eukaryota
Beta vulgaris Beta Chenopodiaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Calliactis parasitica Calliactis Hormathiidae Actiniaria Anthozoa Cnidaria Metazoa Eukaryota
Eledone moschata Eledone Octopodidae Octopoda Cephalopoda Mollusca Metazoa Eukaryota
None Hydra Hydridae Anthoathecata Hydrozoa Cnidaria Metazoa Eukaryota
None Corallistes Corallistidae Tetractinellida Demospongiae Porifera Metazoa Eukaryota
Thelenota ananas Thelenota Stichopodidae Aspidochirotida Holothuroidea Echinodermata Metazoa Eukaryota
Panaeolus sp. Panaeolus Galeropsidaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
Octopus vulgaris Octopus Octopodidae Octopoda Cephalopoda Mollusca Metazoa Eukaryota
Sycon ciliatum Sycon Sycettidae Leucosolenida Calcarea Porifera Metazoa Eukaryota
None Pentacta Cucumariidae Dendrochirotida Holothuroidea Echinodermata Metazoa Eukaryota
Panaeolus campanulatus Panaeolus Galeropsidaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
Physalia sp. Physalia Physaliidae Siphonophorae Hydrozoa Cnidaria Metazoa Eukaryota
None Citrus Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Citrus Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 177.227

TPSA？: 63.66

MolLogP？: 0.6579000000000004

Number of H-Donors: 3

Number of H-Acceptors: 1

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 56.4 ug.mL-1 10.1016/j.bmcl.2016.10.004
Agaricus bisporus Tyrosinase IC50 350000.0 nM 10.1016/j.bmcl.2011.02.028
Bacillus subtilis Bacillus subtilis MIC 56.4 ug.mL-1 10.1016/j.bmcl.2016.10.004
Biomphalaria glabrata Esophagus Activity nan None 10.1021/np50070a027
Bos taurus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Caenorhabditis elegans Caenorhabditis elegans Activity -8.0 % 10.1038/nature05991
Caenorhabditis elegans Caenorhabditis elegans Activity -6.0 % 10.1038/nature05991
Candida albicans Candida albicans MIC 1134900.0 nM 10.1016/j.bmcl.2009.01.017
Candida albicans Isocitrate lyase IC50 53.0 ug.mL-1 10.1016/j.bmcl.2010.10.029
Candida albicans Isocitrate lyase IC50 301000.0 nM 10.1016/j.bmcl.2010.10.029
Candida albicans Isocitrate lyase IC50 301300.0 nM 10.1016/j.bmcl.2009.01.017
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase KA 28.6 uM 10.1016/j.bmc.2009.12.058
Candida glabrata CBS 138 Carbonic anhydrase Ka 16.7 uM 10.1016/j.bmcl.2010.01.054
Canis lupus familiaris Canis familiaris EC50 210.0 nM 10.1021/jm00065a015
Canis lupus familiaris Canis familiaris IA 1.0 None 10.1021/jm00065a015
Canis lupus familiaris MDCK Papp nan None 10.1016/j.bmcl.2009.07.063
Canis lupus familiaris MDCK Ratio nan None 10.1016/j.bmcl.2009.07.063
Catharanthus roseus Strictosidine synthase Km 1200000.0 nM 10.1016/j.bmcl.2006.01.098
Cavia porcellus Serotonin 1d (5-HT1d) receptor EC50 5.2 nM 10.1021/jm00101a032
Cavia porcellus Serotonin 1d (5-HT1d) receptor EC50 8.5 nM 10.1016/0960-894X(95)00417-R
Cavia porcellus Serotonin 1d (5-HT1d) receptor EC50 16.0 nM 10.1021/jm00170a007
Cavia porcellus Serotonin 1d (5-HT1d) receptor IC50 3.0 nM 10.1021/jm00101a032
Cavia porcellus Serotonin 3a (5-HT3a) receptor Intrinsic activity 1.0 None 10.1016/j.bmc.2007.02.054
Cavia porcellus Serotonin 3a (5-HT3a) receptor pD2 4.19 None 10.1021/jm900018b
Cavia porcellus Serotonin 3a (5-HT3a) receptor pD2 5.34 None 10.1016/j.bmc.2007.02.054
Cavia porcellus Serotonin 3a (5-HT3a) receptor pD2 5.78 None 10.1021/jm900018b
Cavia porcellus Serotonin 3a (5-HT3a) receptor pD2 6.85 None 10.1021/jm900018b
Cavia porcellus Serotonin 4 (5-HT4) receptor Activity 100.0 % 10.1016/S0960-894X(01)80508-4
Cavia porcellus Serotonin 4 (5-HT4) receptor EC50 5.0 nM 10.1016/S0960-894X(01)80508-4
Cavia porcellus Serotonin 4 (5-HT4) receptor EC50 5.0 nM 10.1021/jm960320m
Cavia porcellus Serotonin 4 (5-HT4) receptor EC50 10.0 nM 10.1016/j.bmcl.2012.05.034
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan nM 10.1021/jm960320m
Cavia porcellus Serotonin 4 (5-HT4) receptor Intrinsic activity 1.0 None 10.1021/jm00013a009
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 100.0 nM 10.1021/jm900018b
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 100.0 nM 10.1021/jm901126m
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 100.0 nM 10.1021/jm990151g
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 230.0 nM 10.1021/jm00014a021
Cavia porcellus Serotonin 4 (5-HT4) receptor pD2 7.0 None 10.1016/S0960-894X(00)80170-5
Cavia porcellus Serotonin 4 (5-HT4) receptor pD2 7.9 None 10.1016/S0960-894X(00)80170-5
Cavia porcellus Serotonin 4 (5-HT4) receptor pD2 8.4 None 10.1021/jm00013a009
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 KA 46.7 uM 10.1016/j.bmc.2009.12.058
Electrophorus electricus Acetylcholinesterase Inhibition 62.59 % 10.1016/j.bmcl.2012.02.057
Escherichia coli Escherichia coli MIC 56.4 ug.mL-1 10.1016/j.bmcl.2016.10.004
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 15811.4 nM None
Homo sapiens Acetylcholinesterase IC50 nan None 10.1016/j.bmcl.2012.02.057
Homo sapiens Acetylcholinesterase Inhibition 28.97 % 10.1016/j.bmcl.2012.02.057
Homo sapiens ATP-dependent DNA helicase Q1 Potency 39810.7 nM None
Homo sapiens Carbonic anhydrase I Ka 45.0 uM 10.1016/j.bmc.2007.03.004
Homo sapiens Carbonic anhydrase I Ka 45.0 uM 10.1016/j.bmcl.2008.06.075
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmc.2008.02.021
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmc.2010.01.059
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmc.2018.07.011
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2006.05.023
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2007.05.052
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2008.10.005
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2012.08.088
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2012.12.009
Homo sapiens Carbonic anhydrase I KA 45.0 uM 10.1016/j.bmcl.2016.11.027
Homo sapiens Carbonic anhydrase II Ka 50.0 uM 10.1016/j.bmc.2007.03.004
Homo sapiens Carbonic anhydrase II Ka 50.0 uM 10.1016/j.bmcl.2008.06.075
Homo sapiens Carbonic anhydrase II Ka 50.0 uM 10.1016/j.bmcl.2009.01.105
Homo sapiens Carbonic anhydrase II Ka 50.0 uM 10.1016/j.bmcl.2010.01.054
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmc.2008.02.021
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmc.2010.01.059
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmc.2018.07.011
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2006.05.023
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2007.05.052
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2008.10.005
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2012.08.088
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2012.12.009
Homo sapiens Carbonic anhydrase II KA 50.0 uM 10.1016/j.bmcl.2016.11.027
Homo sapiens Carbonic anhydrase III Ka 0.78 uM 10.1016/j.bmcl.2008.06.075
Homo sapiens Carbonic anhydrase III KA 0.78 uM 10.1016/j.bmcl.2008.10.005
Homo sapiens Carbonic anhydrase IV Ka 3.14 uM 10.1016/j.bmcl.2008.06.075
Homo sapiens Carbonic anhydrase IV KA 3.14 uM 10.1016/j.bmcl.2009.05.026
Homo sapiens Carbonic anhydrase IX KA 33.1 uM 10.1016/j.bmc.2008.02.021
Homo sapiens Carbonic anhydrase VA KA 6.33 uM 10.1016/j.bmcl.2006.11.075
Homo sapiens Carbonic anhydrase VB KA 0.11 uM 10.1016/j.bmcl.2006.11.075
Homo sapiens Carbonic anhydrase VI Ka 19.0 uM 10.1016/j.bmc.2007.03.004
Homo sapiens Carbonic anhydrase VI KA 19.0 uM 10.1016/j.bmc.2010.01.059
Homo sapiens Carbonic anhydrase VII KA 0.93 uM 10.1016/j.bmcl.2007.05.052
Homo sapiens Carbonic anhydrase XII KA 0.3 uM 10.1016/j.bmc.2008.02.021
Homo sapiens Carbonic anhydrase XIV KA 6.5 uM 10.1016/j.bmcl.2007.05.052
Homo sapiens Cerebroside-sulfatase Potency 4256.2 nM None
Homo sapiens Cyclooxygenase-1 IC50 400000.0 nM 10.1016/j.bmcl.2012.02.002
Homo sapiens Cyclooxygenase-2 IC50 400000.0 nM 10.1016/j.bmcl.2012.02.002
Homo sapiens Cytochrome P450 1A2 AC50 1995.26 nM None
Homo sapiens Cytochrome P450 1A2 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 Potency 15848.9 nM None
Homo sapiens Cytochrome P450 2D6 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 3A4 Potency 39810.7 nM None
Homo sapiens Dopamine D1 receptor Activity nan None 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D1 receptor EC50 nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Emax nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor IC50 nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Imax nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Inhibition nan % 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Kd 9690.0 nM 10.1021/jm950447w
Homo sapiens Dopamine D1 receptor Ki nan None 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D1 receptor Ki nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D1 receptor Log 1/Kd -3.99 None 10.1021/jm950447w
Homo sapiens Dopamine D2 receptor Activity 75.0 % None
Homo sapiens Dopamine D2 receptor Activity nan None 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D2 receptor IC50 0.0003 nM 10.1021/jm00382a002
Homo sapiens Dopamine D2 receptor IC50 nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Imax nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Inhibition nan % 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Ki nan None 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D2 receptor Ki nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Dopamine D2 receptor Ki nan None 10.1021/jm0341204
Homo sapiens Dopamine D2 receptor pEC50 nan None None
Homo sapiens Dopamine D3 receptor Activity 30.0 uM 10.1021/jm0211220
Homo sapiens Dopamine D3 receptor EC50 523.0 nM 10.1021/jm0211220
Homo sapiens Dopamine D3 receptor EC50 nan None 10.1021/acs.jmedchem.9b01835
Homo sapiens Dopamine D3 receptor Emax nan None 10.1021/acs.jmedchem.9b01835
Homo sapiens Dopamine D3 receptor Ki nan None 10.1021/acs.jmedchem.9b01835
Homo sapiens GABA-A receptor; anion channel IC50 nan nM 10.1016/0960-894X(95)00417-R
Homo sapiens Glycine receptor subunit alpha-1 EC50 nan None 10.1021/jm070574f
Homo sapiens Histone acetyltransferase GCN5 Potency 11220.2 nM None
Homo sapiens Histone deacetylase 6 Inhibition -3.86 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 2.0 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 15848.9 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 21192.3 nM None
Homo sapiens Liver microsomes CL nan None 10.1016/j.bmcl.2009.07.063
Homo sapiens Macrophage migration inhibitory factor IC50 400000.0 nM 10.1016/j.bmcl.2021.128445
Homo sapiens MAP/microtubule affinity-regulating kinase 4 deltaG -32.8 kcal/mol 10.1039/d2md00053a
Homo sapiens MAP/microtubule affinity-regulating kinase 4 deltaH -88200.0 cal/mol 10.1039/d2md00053a
Homo sapiens MAP/microtubule affinity-regulating kinase 4 deltaS -286.0 cal/mol/deg 10.1039/d2md00053a
Homo sapiens MAP/microtubule affinity-regulating kinase 4 IC50 2990.0 nM 10.1039/d2md00053a
Homo sapiens MAP/microtubule affinity-regulating kinase 4 K 0.3 10^6/M 10.1039/d2md00053a
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Ka 148.0 10^4/M 10.1039/d2md00053a
Homo sapiens Melatonin receptor 1A Ki 100000.0 nM 10.1016/S0960-894X(97)00444-7
Homo sapiens Melatonin receptor 1B Ki 100000.0 nM 10.1016/S0960-894X(97)00444-7
Homo sapiens Myeloperoxidase IC50 nan None 10.1021/jm4001538
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 nan None 10.1021/jm070574f
Homo sapiens POU domain, class 2, transcription factor 1 Ratio 12.1 None 10.1021/acs.jmedchem.2c01075
Homo sapiens POU domain, class 2, transcription factor 2 Activity nan None 10.1021/acs.jmedchem.2c01075
Homo sapiens POU domain, class 2, transcription factor 2 Ratio 36.4 None 10.1021/acs.jmedchem.2c01075
Homo sapiens Regulator of G-protein signaling 4 Potency 4739.8 nM None
Homo sapiens Serotonin 1a (5-HT1a) receptor Activity 98.3 % 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 1a (5-HT1a) receptor Activity 99.6 % 10.1021/jm400408r
Homo sapiens Serotonin 1a (5-HT1a) receptor Activity 99.7 % 10.1016/j.ejmech.2016.07.038
Homo sapiens Serotonin 1a (5-HT1a) receptor Activity 100.0 % 10.1016/j.bmc.2010.02.062
Homo sapiens Serotonin 1a (5-HT1a) receptor Activity 102.5 % 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 0.5 nM 10.1021/jm050725j
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 0.7 nM 10.1016/j.bmcl.2006.01.052
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 1.0 nM 10.1021/jm050725j
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 2.03 nM 10.1016/j.ejmech.2021.113243
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 3.0 nM 10.1016/j.bmc.2014.09.024
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 3.7 nM 10.1021/jm030205t
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 3.75 nM 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 5.61 nM 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 5.7 nM 10.1016/j.ejmech.2018.01.002
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 5.8 nM 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 8.71 nM 10.1021/jm0341204
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 10.0 nM 10.1016/j.ejmech.2022.114218
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 10.0 nM 10.1021/jm00101a032
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 10.96 nM 10.1016/j.ejmech.2022.114218
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 15.33 nM 10.1016/j.ejmech.2016.07.038
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 18.0 nM 10.1016/j.bmcl.2019.126703
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 19.0 nM 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 27.54 nM 10.1016/j.bmc.2015.05.042
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 30.9 nM 10.1021/acs.jmedchem.0c00814
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 30.9 nM 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 33.11 nM 10.1021/acs.jmedchem.0c00814
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 33.11 nM 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 39.0 nM 10.1021/jm400408r
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 43.0 nM 10.1016/0960-894X(95)00417-R
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 45.3 nM 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 50.12 nM 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 56.23 nM 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 58.88 nM 10.1021/acs.jmedchem.0c00814
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 69.18 nM 10.1016/j.ejmech.2017.05.047
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 97.7 nM 10.1016/j.bmcl.2018.04.059
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 128.82 nM 10.1021/acs.jmedchem.0c00814
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 128.82 nM 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 147.0 nM 10.1021/jm9015763
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 150.0 nM 10.1016/j.bmc.2009.06.019
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 169.82 nM 10.1016/j.bmc.2015.05.042
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 229.09 nM 10.1021/jm070714l
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 398.11 nM 10.1016/j.ejmech.2022.114218
Homo sapiens Serotonin 1a (5-HT1a) receptor EC50 1800.0 nM 10.1021/acs.jnatprod.9b00532
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 0.0 % 10.1016/j.ejmech.2017.05.047
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 2.0 % 10.1016/j.bmcl.2018.04.059
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1016/j.bmcl.2018.04.059
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1016/j.ejmech.2022.114218
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1021/jm9015763
Homo sapiens Serotonin 1a (5-HT1a) receptor Emax 224.0 None 10.1021/jm0341204
Homo sapiens Serotonin 1a (5-HT1a) receptor FC 6.4 None 10.1016/j.bmc.2015.05.042
Homo sapiens Serotonin 1a (5-HT1a) receptor IA 1.0 None 10.1021/jm049039v
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 1.2 nM 10.1021/jm030205t
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 2.0 nM 10.1021/jm00123a006
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 5.2 nM 10.1021/jm00101a032
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 5.6 nM 10.1021/jm00123a006
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 6.0 nM 10.1021/jm00123a006
Homo sapiens Serotonin 1a (5-HT1a) receptor IC50 nan None 10.1021/jm9015763
Homo sapiens Serotonin 1a (5-HT1a) receptor Imax nan None 10.1021/jm9015763
Homo sapiens Serotonin 1a (5-HT1a) receptor Inhibition 100.0 % 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor Intrinsic activity 1.0 None 10.1021/jm0341204
Homo sapiens Serotonin 1a (5-HT1a) receptor Intrinsic activity 1.0 None 10.1021/jm8001444
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 0.62 nM 10.1016/j.bmc.2012.05.057
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 0.9 nM 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 0.91 nM 10.1016/j.bmcl.2016.06.080
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.1 nM 10.1039/C7MD00281E
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.2 nM 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.259 nM 10.1021/jm8001444
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.3 nM 10.1016/j.ejmech.2017.05.047
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.3 nM 10.1021/acs.jmedchem.7b00839
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.4 nM 10.1016/j.bmc.2017.12.016
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 1.7 nM 10.1021/jm00044a001
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 2.08 nM 10.1016/j.ejmech.2014.08.023
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 2.48 nM 10.1016/s0960-894x(98)00222-4
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 2.48 nM 10.1021/jm960552l
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 2.5 nM 10.1021/jm00018a020
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 2.8 nM 10.1021/jm00123a006
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 3.0 nM 10.1016/j.ejmech.2019.01.031
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 3.0 nM 10.1021/jm00123a006
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 3.6 nM 10.1016/j.ejmech.2019.07.027
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 3.981 nM 10.1021/jm0341204
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 4.5 nM 10.1021/acs.jmedchem.1c00726
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 5.5 nM 10.1016/j.ejmech.2019.111736
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 9.5 nM 10.1016/j.ejmech.2013.09.018
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 50.0 nM 10.1016/j.bmc.2010.02.062
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 10000.0 nM 10.1021/jm8001444
Homo sapiens Serotonin 1a (5-HT1a) receptor %max 101.5 % 10.1016/j.ejmech.2021.113243
Homo sapiens Serotonin 1a (5-HT1a) receptor %max 103.0 % 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 1a (5-HT1a) receptor Max 100.0 % 10.1021/jm9910324
Homo sapiens Serotonin 1a (5-HT1a) receptor Max 100.0 % 10.1021/jm991065j
Homo sapiens Serotonin 1a (5-HT1a) receptor pD2 7.3 None 10.1021/jm301525w
Homo sapiens Serotonin 1a (5-HT1a) receptor pD2 7.3 None 10.1021/jm800461k
Homo sapiens Serotonin 1a (5-HT1a) receptor pD2 7.3 None 10.1021/jm9910324
Homo sapiens Serotonin 1a (5-HT1a) receptor pD2 7.3 None 10.1021/jm991065j
Homo sapiens Serotonin 1a (5-HT1a) receptor pKD 8.5 None 10.1021/jm00065a015
Homo sapiens Serotonin 1a (5-HT1a) receptor Ratio 0.0 None 10.1016/j.ejmech.2022.114218
Homo sapiens Serotonin 1a (5-HT1a) receptor Ratio 0.0 None 10.1021/acs.jmedchem.9b00062
Homo sapiens Serotonin 1a (5-HT1a) receptor Stimulation 126.0 % 10.1021/jm0341204
Homo sapiens Serotonin 1b (5-HT1b) receptor EC50 4.67 nM 10.1016/s0960-894x(98)00222-4
Homo sapiens Serotonin 1b (5-HT1b) receptor EC50 4.82 nM 10.1021/jm960552l
Homo sapiens Serotonin 1b (5-HT1b) receptor EC50 30.0 nM 10.1021/jm00170a007
Homo sapiens Serotonin 1b (5-HT1b) receptor IA 1.0 None 10.1021/jm049039v
Homo sapiens Serotonin 1b (5-HT1b) receptor IC50 5.0 nM 10.1021/jm00101a032
Homo sapiens Serotonin 1b (5-HT1b) receptor IC50 6.5 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 1b (5-HT1b) receptor IC50 12.0 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Serotonin 1b (5-HT1b) receptor IC50 16.0 nM 10.1021/jm701575k
Homo sapiens Serotonin 1b (5-HT1b) receptor IC50 29.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 1b (5-HT1b) receptor Intrinsic activity 1.0 % 10.1021/jm970457s
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 1.1 nM 10.1021/jm7011722
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 4.0 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 4.0 nM 10.1021/jm00044a001
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 4.0 nM 10.1021/jm950498t
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 4.8 nM 10.1021/jm020938y
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 5.012 nM 10.1021/jm0341204
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 6.76 nM 10.1016/s0960-894x(98)00222-4
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 6.76 nM 10.1021/jm960552l
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 7.1 nM 10.1021/jm00018a020
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 14.0 nM 10.1021/jm2006782
Homo sapiens Serotonin 1b (5-HT1b) receptor Ki 18.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 1b (5-HT1b) receptor Simulation 219.0 % 10.1021/jm970457s
Homo sapiens Serotonin 1d (5-HT1d) receptor ED50 1.2 nM 10.1021/jm00044a001
Homo sapiens Serotonin 1d (5-HT1d) receptor IA 1.0 None 10.1021/jm049039v
Homo sapiens Serotonin 1d (5-HT1d) receptor IC50 3.0 nM 10.1016/0960-894X(95)00417-R
Homo sapiens Serotonin 1d (5-HT1d) receptor IC50 3.0 nM 10.1021/jm00170a007
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 0.5 nM 10.1021/jm7011722
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 1.7 nM 10.1021/jm950498t
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 2.0 nM 10.1021/jm9805945
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 3.0 nM 10.1021/jm00164a046
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 4.8 nM 10.1021/jm00018a020
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 5.06 nM 10.1016/s0960-894x(98)00222-4
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 5.06 nM 10.1021/jm960552l
Homo sapiens Serotonin 1d (5-HT1d) receptor Ki 5.5 nM 10.1021/jm00044a001
Homo sapiens Serotonin 1d (5-HT1d) receptor pKD 7.9 None 10.1021/jm00065a015
Homo sapiens Serotonin 1d (5-HT1d) receptor Selectivity 0.4 None 10.1021/jm950498t
Homo sapiens Serotonin 1e (5-HT1e) receptor Ki 4.0 nM 10.1021/jm00164a046
Homo sapiens Serotonin 1e (5-HT1e) receptor Ki 10.72 nM 10.1016/j.bmcl.2013.12.024
Homo sapiens Serotonin 1e (5-HT1e) receptor Ki 11.0 nM 10.1016/j.bmcl.2013.12.024
Homo sapiens Serotonin 1f (5-HT1f) receptor EC50 7.9 nM 10.1021/jm0155190
Homo sapiens Serotonin 1f (5-HT1f) receptor Emax 100.0 % 10.1021/jm0155190
Homo sapiens Serotonin 2 (5-HT2) receptor pKD 5.5 None 10.1021/jm00065a015
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 75.0 % None
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 94.5 % 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 100.0 % 10.1016/j.ejmech.2016.07.038
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 100.4 % 10.1021/jm400408r
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 101.6 % 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity nan None 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 0.27 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 0.2754 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 0.51 nM 10.1021/acs.jnatprod.9b01061
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 0.5129 nM 10.1021/acs.jnatprod.9b01061
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1.1 nM 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1.5 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1.549 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1.6 nM 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1.88 nM 10.1021/jm5019274
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.344 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.344 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.35 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.35 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.57 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.6 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 2.951 nM 10.1021/acsmedchemlett.3c00014
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 3.0 nM 10.1021/acsmedchemlett.3c00014
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 5.8 nM 10.1021/jm801354e
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 7.6 nM 10.1021/ml200206z
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 11.0 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 11.0 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 12.1 nM 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 16.0 nM 10.1021/jm400408r
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 18.62 nM None
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 47.0 nM 10.1016/j.ejmech.2016.07.038
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 70.0 nM 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 125.89 nM 10.1021/jm0709034
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 130.0 nM 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 147.91 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 150.0 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 302.0 nM 10.1016/j.bmc.2014.12.011
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 661.0 nM 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor EC50 1672.0 nM 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor Efficacy 98.0 % 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 49.3 % 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 77.4 % 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 100.0 % 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 100.0 % 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 100.0 % 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 100.0 % 10.1021/jm5019274
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 100.0 % 10.1021/jm801354e
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 110.0 % 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor Emax 222.0 % 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor FC 161.0 None 10.1021/acs.jmedchem.2c00702
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 27.9 nM 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 2a (5-HT2a) receptor Inhibition nan % 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 8.2 nM 10.1021/jm030205t
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 8.2 nM 10.1021/jm050663x
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 11.5 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 14.0 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 14.0 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 17.2 nM 10.1021/acs.jmedchem.1c00726
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 120.0 nM 10.1016/j.bmc.2008.04.050
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 130.0 nM 10.1016/j.bmc.2008.04.050
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 150.0 nM 10.1016/j.bmc.2008.04.050
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 160.0 nM 10.1016/j.bmc.2008.04.050
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 320.0 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 320.0 nM 10.1021/np010471e
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 323.59 nM 10.1021/jm301656h
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 398.11 nM 10.1021/jm0341204
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 510.0 nM 10.1021/jm00044a001
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 690.0 nM 10.1021/np0601760
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None 10.1016/j.bmc.2012.12.016
Homo sapiens Serotonin 2a (5-HT2a) receptor log(ratio) 8.63 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2a (5-HT2a) receptor %max 101.0 % 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 2a (5-HT2a) receptor Relative efficacy 98.0 % 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.07079 nM 10.1016/j.bmcl.2020.127511
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.5 nM 10.1021/jm801354e
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.8511 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.86 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.86 nM 10.1021/ml200206z
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 0.92 nM 10.1021/jm5019274
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.072 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.1 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.445 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.445 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.46 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.46 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.5 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 1.5 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 4.5 nM 10.1016/j.ejmech.2018.01.002
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 4.5 nM 10.1021/acs.jmedchem.0c00424
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 5.8 nM 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 11.0 nM 10.1016/j.bmcl.2009.07.063
Homo sapiens Serotonin 2b (5-HT2b) receptor EC50 25.12 nM 10.1021/jm0709034
Homo sapiens Serotonin 2b (5-HT2b) receptor Efficacy 101.0 % 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 91.0 % 10.1016/j.bmcl.2009.07.063
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 97.0 % 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 100.0 % 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 100.0 % 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 100.0 % 10.1021/jm5019274
Homo sapiens Serotonin 2b (5-HT2b) receptor Emax 100.0 % 10.1021/jm801354e
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 10.8 nM 10.1021/acs.jmedchem.1c00726
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 12.0 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 12.0 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 13.0 nM 10.1021/jm030205t
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 13.0 nM 10.1021/jm050663x
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki 13.49 nM 10.1016/j.bmcl.2014.02.029
Homo sapiens Serotonin 2b (5-HT2b) receptor log(ratio) 8.84 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2b (5-HT2b) receptor Relative efficacy 101.0 % 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2c (5-HT2c) receptor Activity 75.0 % None
Homo sapiens Serotonin 2c (5-HT2c) receptor Activity nan None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.09 nM 10.1021/jm801354e
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.09 nM 10.1021/ml200206z
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.1349 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.14 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.166 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.17 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.17 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.182 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.19 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.1905 nM 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.21 nM 10.1021/jm5019274
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.3467 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.4 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.41 nM 10.1021/acs.jmedchem.9b01835
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.87 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 0.871 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 1.2 nM 10.1021/acsmedchemlett.3c00014
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 1.202 nM 10.1021/acsmedchemlett.3c00014
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 1.63 nM 10.1016/j.bmcl.2012.01.122
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 1.7 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 1.7 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 15.0 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 15.14 nM 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 21.0 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 21.88 nM 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 24.0 nM 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 25.0 nM 10.1016/j.bmcl.2009.07.063
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 25.12 nM 10.1021/jm0709034
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 43.65 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 44.0 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 51.29 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor EC50 190.55 nM 10.1016/j.bmc.2014.12.011
Homo sapiens Serotonin 2c (5-HT2c) receptor Efficacy 99.0 % 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 98.0 % 10.1016/j.bmcl.2009.07.063
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 100.0 % 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 100.0 % 10.1016/j.ejmech.2019.111626
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 100.0 % 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 100.0 % 10.1021/jm5019274
Homo sapiens Serotonin 2c (5-HT2c) receptor Emax 100.0 % 10.1021/jm801354e
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 1.25 nM 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 81.0 nM 10.1021/jm00170a007
Homo sapiens Serotonin 2c (5-HT2c) receptor Inhibition 71.0 % 10.1016/j.bmcl.2012.01.122
Homo sapiens Serotonin 2c (5-HT2c) receptor Inhibition 97.0 % 10.1016/j.bmcl.2012.01.122
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 6.9 nM 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 6.9 nM 10.1016/j.bmcl.2005.10.029
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 8.3 nM 10.1021/jm030205t
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 8.3 nM 10.1021/jm050663x
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 20.0 nM 10.1021/np0601760
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 35.0 nM 10.1021/jm00384a001
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 50.12 nM 10.1021/jm0341204
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 79.0 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 79.43 nM 10.1021/jm301656h
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 130.0 nM 10.1021/np010471e
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 214.0 nM 10.1016/j.bmcl.2012.01.122
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 445.0 nM 10.1016/j.bmcl.2012.01.122
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None 10.1021/acs.jmedchem.1c00726
Homo sapiens Serotonin 2c (5-HT2c) receptor log(ratio) 7.68 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor log(ratio) 7.82 None 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor log(ratio) 9.77 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor log(ratio) 9.85 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor log(ratio) 9.85 None 10.1021/acs.jmedchem.7b00584
Homo sapiens Serotonin 2c (5-HT2c) receptor %max 103.0 % 10.1016/j.bmcl.2020.127358
Homo sapiens Serotonin 2c (5-HT2c) receptor Ratio 0.12 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor Ratio 8.2 None 10.1021/acs.jmedchem.6b01194
Homo sapiens Serotonin 2c (5-HT2c) receptor Relative efficacy 99.0 % 10.1016/j.bmcl.2003.05.001
Homo sapiens Serotonin 2 receptors; 5-HT2a & 5-HT2c Ratio EC50 2.9 None 10.1016/j.bmc.2007.10.100
Homo sapiens Serotonin 2 receptors; 5-HT2a & 5-HT2c Ratio EC50 37.0 None 10.1021/jm801354e
Homo sapiens Serotonin 2 receptors; 5-HT2a & 5-HT2c Selectivity ratio 0.63 None 10.1016/j.bmc.2014.12.011
Homo sapiens Serotonin 2 receptors; 5-HT2a & 5-HT2c Selectivity ratio 0.7 None 10.1021/jm0709034
Homo sapiens Serotonin 3 (5-HT3) receptor Agonist activity 0.0 None 10.1016/s0960-894x(00)00691-0
Homo sapiens Serotonin 3 (5-HT3) receptor Agonist activity 41.0 None 10.1016/s0960-894x(00)00691-0
Homo sapiens Serotonin 3 (5-HT3) receptor Agonist activity 76.0 None 10.1016/s0960-894x(00)00691-0
Homo sapiens Serotonin 3 (5-HT3) receptor Agonist activity 90.0 None 10.1016/s0960-894x(00)00691-0
Homo sapiens Serotonin 3 (5-HT3) receptor Intrinsic activity nan None 10.1016/s0960-894x(02)00514-0
Homo sapiens Serotonin 3 (5-HT3) receptor Ki 120.0 nM 10.1016/s0960-894x(02)00514-0
Homo sapiens Serotonin 3 (5-HT3) receptor Ki 144.54 nM 10.1016/S0960-894X(01)80877-5
Homo sapiens Serotonin 3 (5-HT3) receptor -Log ED50 7.4 None 10.1016/S0960-894X(01)80877-5
Homo sapiens Serotonin 3a (5-HT3a) receptor EC50 141.0 nM 10.1016/j.bmcl.2010.11.080
Homo sapiens Serotonin 3a (5-HT3a) receptor EC50 178.0 nM 10.1016/j.bmcl.2010.11.080
Homo sapiens Serotonin 3a (5-HT3a) receptor EC50 457.09 nM 10.1021/jm070574f
Homo sapiens Serotonin 3a (5-HT3a) receptor EC50 500.0 nM 10.1021/jm070574f
Homo sapiens Serotonin 4 (5-HT4) receptor Activity 99.0 % 10.1016/j.ejmech.2009.01.015
Homo sapiens Serotonin 4 (5-HT4) receptor EC50 12.0 nM 10.1021/jm801327q
Homo sapiens Serotonin 4 (5-HT4) receptor EC50 100.0 nM 10.1038/nature05991
Homo sapiens Serotonin 4 (5-HT4) receptor FC 0.2 None 10.1021/acs.jmedchem.1c00703
Homo sapiens Serotonin 4 (5-HT4) receptor FC 2.9 None 10.1021/acs.jmedchem.1c00703
Homo sapiens Serotonin 4 (5-HT4) receptor IC50 323.0 nM 10.1016/j.ejmech.2019.111596
Homo sapiens Serotonin 4 (5-HT4) receptor Inhibition 0.0 % 10.1016/j.ejmech.2019.111596
Homo sapiens Serotonin 4 (5-HT4) receptor Inhibition 65.0 % 10.1016/j.ejmech.2019.111596
Homo sapiens Serotonin 4 (5-HT4) receptor Ki 29.51 nM 10.1016/j.ejmech.2009.01.015
Homo sapiens Serotonin 4 (5-HT4) receptor Ki 109.65 nM 10.1016/j.ejmech.2009.01.015
Homo sapiens Serotonin 4 (5-HT4) receptor Ki 246.0 nM 10.1016/j.ejmech.2019.111596
Homo sapiens Serotonin 4 (5-HT4) receptor Ki 500.0 nM 10.1021/np0601760
Homo sapiens Serotonin 4 (5-HT4) receptor Ki 1049.0 nM 10.1021/jm801327q
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 79.0 nM 10.1021/jm058018d
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 160.0 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 180.0 nM 10.1016/j.bmc.2016.03.006
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 180.0 nM 10.1016/j.bmc.2016.11.014
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 180.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 184.0 nM 10.1021/jm701575k
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 260.0 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 5a (5-HT5a) receptor IC50 280.0 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 82.0 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 110.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 126.0 nM 10.1021/jm030030n
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 130.0 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 170.0 nM 10.1021/jm2006782
Homo sapiens Serotonin 5a (5-HT5a) receptor Ki 250.0 nM 10.1021/jm030030n
Homo sapiens Serotonin 6 (5-HT6) receptor Activity 96.1 % 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 6 (5-HT6) receptor Activity 98.0 % 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 6 (5-HT6) receptor EC50 42.1 nM 10.1016/j.ejmech.2020.112709
Homo sapiens Serotonin 6 (5-HT6) receptor EC50 43.6 nM 10.1021/acs.jmedchem.8b01096
Homo sapiens Serotonin 6 (5-HT6) receptor Emax 100.0 % 10.1016/j.ejmech.2019.06.022
Homo sapiens Serotonin 6 (5-HT6) receptor Emax 100.0 % 10.1016/j.ejmech.2020.112529
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 27.5 nM 10.1021/jm901674f
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 100.0 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 120.0 nM 10.1016/j.bmc.2016.03.006
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 120.0 nM 10.1016/j.bmc.2016.11.014
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 130.0 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 180.0 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 200.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 262.0 nM 10.1021/jm701575k
Homo sapiens Serotonin 6 (5-HT6) receptor Kb nan None 10.1016/j.ejmech.2019.06.022
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 33.0 nM 10.1016/j.ejmech.2014.12.045
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 33.0 nM 10.1021/jm401895u
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 50.0 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 61.0 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 65.0 nM 10.1021/jm030030n
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 70.0 nM 10.1007/s00044-004-0121-8
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 75.0 nM 10.1021/jm990550b
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 78.0 nM 10.1016/s0960-894x(00)00453-4
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 84.0 nM 10.1021/jm2006782
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 93.0 nM 10.1021/jm8007618
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 100.0 nM 10.1016/j.bmcl.2004.05.076
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 100.0 nM 10.1016/j.bmcl.2016.03.036
Homo sapiens Serotonin 6 (5-HT6) receptor Ki 125.89 nM 10.1021/jm0341204
Homo sapiens Serotonin 7 (5-HT7) receptor Activity nan None 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 3.66 nM 10.1016/j.ejmech.2021.113243
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 4.5 nM 10.1021/acs.jmedchem.1c00110
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 5.37 nM 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 5.7 nM 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 5.754 nM 10.1016/j.ejmech.2016.07.029
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 5.8 nM 10.1016/j.ejmech.2016.07.029
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 7.0 nM 10.1016/j.bmcl.2018.04.059
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 9.333 nM 10.1021/acs.jmedchem.1c00110
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 15.0 nM 10.1021/jm8014553
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 17.0 nM 10.1021/jm500880c
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 47.86 nM 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 48.0 nM 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 70.0 nM 10.1016/j.bmc.2020.115578
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 110.0 nM 10.1021/acs.jmedchem.1c00110
Homo sapiens Serotonin 7 (5-HT7) receptor EC50 112.2 nM 10.1021/acs.jmedchem.1c00110
Homo sapiens Serotonin 7 (5-HT7) receptor Emax 100.0 % 10.1016/j.bmc.2019.07.046
Homo sapiens Serotonin 7 (5-HT7) receptor Emax 100.0 % 10.1016/j.bmcl.2018.04.059
Homo sapiens Serotonin 7 (5-HT7) receptor Emax 100.0 % 10.1021/acs.jmedchem.1c00110
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.25 nM 10.1016/j.bmc.2016.03.006
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.25 nM 10.1016/j.bmc.2016.11.014
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.29 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.47 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.49 nM 10.1016/j.bmc.2013.03.016
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 0.61 nM 10.1021/jm8007618
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 1.5 nM 10.1021/jm701575k
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 2.55 nM 10.1021/np0205102
Homo sapiens Serotonin 7 (5-HT7) receptor IC50 nan None 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin 7 (5-HT7) receptor Imax nan None 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin 7 (5-HT7) receptor Kd 3.98 nM 10.1016/j.ejmech.2014.08.023
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.11 nM 10.1016/j.ejmech.2013.01.044
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.13 nM 10.1021/jm2006782
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.17 nM 10.1021/acs.jmedchem.6b01422
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.22 nM 10.1021/jm8007618
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.8 nM 10.1016/j.ejmech.2014.12.045
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 0.8 nM 10.1021/jm401895u
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 1.4 nM 10.1016/j.ejmech.2014.04.034
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 2.1 nM 10.1021/acs.jmedchem.1c00726
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 2.12 nM 10.1016/j.bmcl.2016.06.080
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 3.162 nM 10.1021/jm0341204
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 4.0 nM 10.1021/jm030030n
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 6.0 nM 10.1016/j.ejmech.2016.07.029
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 7.943 nM 10.1016/j.ejmech.2019.111705
Homo sapiens Serotonin 7 (5-HT7) receptor Ki 8.1 nM 10.1021/jm030030n
Homo sapiens Serotonin 7 (5-HT7) receptor %max 96.9 % 10.1016/j.ejmech.2021.113243
Homo sapiens Serotonin 7 (5-HT7) receptor pIC50 nan None 10.1021/acs.jmedchem.8b00642
Homo sapiens Serotonin transporter Activity 10000.0 % 10.1016/j.bmc.2009.11.032
Homo sapiens Serotonin transporter Ki nan None 10.1016/j.ejmech.2019.111736
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 2 Km 80000.0 nM 10.1124/mol.54.2.342
Homo sapiens Solute carrier family 22 member 3 Activity nan None 10.1038/1557
Homo sapiens Solute carrier family 22 member 3 Ratio 2.5 None 10.1021/acs.jmedchem.2c01075
Homo sapiens Synaptic vesicular amine transporter IC50 1430.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Synaptic vesicular amine transporter Ki 2290.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Synaptic vesicular amine transporter Ki 7690.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Synaptic vesicular amine transporter Ki 640000.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Thyroid stimulating hormone receptor Potency 31622.8 nM None
Homo sapiens Trace amine-associated receptor 1 EC50 35100.0 nM 10.1021/acsmedchemlett.1c00527
Homo sapiens Trace amine-associated receptor 1 Emax 75.0 % 10.1021/acsmedchemlett.1c00527
Homo sapiens Transient receptor potential cation channel subfamily M member 8 Inhibition nan % 10.1016/j.bmcl.2010.09.099
Homo sapiens Tyrosinase Activity 15.0 % 10.1016/j.bmcl.2009.05.115
Homo sapiens UDP-glucuronosyltransferase 1-1 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 1-6 Activity nan None None
Homo sapiens UDP-glucuronosyltransferase 1A4 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 2B15 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 2B17 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 2B4 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Homo sapiens UDP-glucuronosyltransferase 2B7 Activity 0.0 pm/min/mg 10.1146/annurev.pharmtox.40.1.581
Methanobacterium thermoautotrophicum Carbonic anhydrase Ka 62.0 uM 10.1016/j.bmcl.2010.01.054
Methanosarcina thermophila Carbonic anhydrase KA 38.0 uM 10.1016/j.bmcl.2016.11.027
Murinae NG108-15 EC50 293.0 nM 10.1021/jm960501o
Murinae NG108-15 EC50 298.0 nM 10.1021/jm981112s
Mus musculus B16 Activity 101.0 % 10.1016/j.bmcl.2009.05.115
Mus musculus B16 IC50 30000.0 nM 10.1016/j.bmcl.2009.05.115
Mus musculus Carbonic anhydrase 15 KA 7.5 uM 10.1016/j.bmcl.2009.05.026
Mus musculus Carbonic anhydrase XIII KA 0.51 uM 10.1016/j.bmcl.2006.05.023
Mus musculus Mus musculus Hill coefficient 0.75 None 10.1021/jm00163a062
Mus musculus Serotonin 1a (5-HT1a) receptor IC50 5.0 nM 10.1021/jm00163a062
Mus musculus Serotonin 1a (5-HT1a) receptor Ki nan nM 10.1021/jm00163a062
Mus musculus Serotonin 2 (5-HT2) receptor IC50 680.0 nM 10.1021/jm00163a062
Mus musculus Serotonin 2 (5-HT2) receptor Ki 500.0 nM 10.1021/jm00163a062
Mus musculus Serotonin 2a (5-HT2a) receptor EC50 0.5248 nM 10.1021/acs.jnatprod.9b01061
Mus musculus Serotonin 2a (5-HT2a) receptor EC50 0.53 nM 10.1021/acs.jnatprod.9b01061
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 980.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 1300.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 1320.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 2900.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 3300.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 3400.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 4400.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 5100.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 6200.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 7100.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 9600.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 11000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 15000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 17200.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 20900.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 24000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 27000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 37000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 42000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 49000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 51000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 63000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 90000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 140000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 170000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 210000.0 nM 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3a (5-HT3a) receptor EC50 nan None 10.1016/j.bmc.2009.07.022
Mus musculus Serotonin 3 receptor (5HT3) Ki 361.0 nM 10.1021/jm00173a017
Mus musculus Serotonin 5a (5-HT5a) receptor Ki 150.0 nM 10.1021/jm030030n
Mus musculus Solute carrier family 22 member 5 Activity 51.3 % 10.1124/mol.59.2.358
Mus musculus Synaptic vesicular amine transporter IC50 98.0 nM 10.1021/acs.jmedchem.8b00542
Mus musculus Tyrosinase Activity 22.0 % 10.1016/j.bmcl.2009.05.115
Mus musculus Tyrosinase IC50 550000.0 nM 10.1016/j.bmcl.2009.05.115
Oryctolagus cuniculus Aorta Activity nan None 10.1021/np50076a006
Oryctolagus cuniculus Oryctolagus cuniculus EC50 158.49 nM 10.1016/S0960-894X(00)80274-7
Oryctolagus cuniculus Oryctolagus cuniculus EC50 158.49 nM 10.1021/jm00010a025
Oryctolagus cuniculus Oryctolagus cuniculus EC50 158.49 nM 10.1021/jm00063a003
Oryctolagus cuniculus Oryctolagus cuniculus EC50 300.0 nM 10.1021/jm00065a015
Oryctolagus cuniculus Oryctolagus cuniculus pD2 6.95 None 10.1021/jm00018a020
Oryctolagus cuniculus Oryctolagus cuniculus Relative maximum 1.0 None 10.1021/jm00063a003
Oryctolagus cuniculus Oryctolagus cuniculus Rel max 1.0 None 10.1021/jm00018a020
Rattus norvegicus Adrenergic receptor alpha-1 Inhibition 50.0 % 10.1021/jm950866t
Rattus norvegicus Beta-1 adrenergic receptor Ki nan None 10.1007/s00044-008-9094-3
Rattus norvegicus Dopamine D1 receptor KL 6543.0 nM 10.1021/jm950447w
Rattus norvegicus Dopamine D2 receptor KL 183000.0 nM 10.1021/jm950447w
Rattus norvegicus Dopamine D3 receptor Ki 2338.0 nM 10.1021/jm00062a025
Rattus norvegicus Inositol monophosphatase 1 Potency 19952.6 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 100.0 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 22387.2 nM None
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 nan None 10.1021/jm070574f
Rattus norvegicus Rattus norvegicus CL 7.91 % 10.1021/jm00035a012
Rattus norvegicus Rattus norvegicus EC50 977.24 nM 10.1016/0960-894X(95)00308-G
Rattus norvegicus Rattus norvegicus ED50 1.0 mg.kg-1 10.1021/jm00224a002
Rattus norvegicus Rattus norvegicus g/30min 1.15 None 10.1021/jm00170a007
Rattus norvegicus Rattus norvegicus IC50 369.0 nM 10.1021/jm970376w
Rattus norvegicus Rattus norvegicus IC50 3548.13 nM 10.1021/jm00159a017
Rattus norvegicus Rattus norvegicus IC50 28183.83 nM 10.1021/jm00159a017
Rattus norvegicus Rattus norvegicus Intrinsic activity 1.0 None 10.1021/jm00035a012
Rattus norvegicus Rattus norvegicus Ki 919.0 nM 10.1021/jm00159a017
Rattus norvegicus Rattus norvegicus Ki 3000.0 nM 10.1021/jm00054a005
Rattus norvegicus Rattus norvegicus Ki 5000.0 nM 10.1021/jm00054a005
Rattus norvegicus Rattus norvegicus Ki 5000.0 nM 10.1021/jm00107a002
Rattus norvegicus Rattus norvegicus Ki 14092.0 nM 10.1021/jm00159a017
Rattus norvegicus Rattus norvegicus Max response 340.0 uV 10.1016/0960-894X(95)00308-G
Rattus norvegicus Serotonin 1 (5-HT1) receptor IC50 5.9 nM 10.1021/jm00035a012
Rattus norvegicus Serotonin 1 (5-HT1) receptor IC50 20.0 nM 10.1021/jm00094a019
Rattus norvegicus Serotonin 1 (5-HT1) receptor Ki 2.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Activity 100.0 % 10.1016/j.bmc.2008.05.077
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Activity nan None 10.1016/j.ejmech.2013.05.027
Rattus norvegicus Serotonin 1a (5-HT1a) receptor EC50 10.0 nM 10.1021/jm00042a003
Rattus norvegicus Serotonin 1a (5-HT1a) receptor EC50 323.0 nM 10.1021/jm800176x
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Emax 100.0 % 10.1021/jm800176x
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 2.6 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 3.0 nM 10.1021/jm950866t
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 5.2 nM 10.1016/0960-894X(95)00417-R
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 5.2 nM 10.1021/jm00042a003
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 5.2 nM 10.1021/jm00170a007
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1.585 nM 10.1021/jm990151g
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1.6 nM 10.1021/jm900018b
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1.6 nM 10.1021/jm901126m
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1.7 nM 10.1021/jm00399a031
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 1.862 nM 10.1021/jm070714l
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 2.0 nM 10.1021/jm00164a046
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 2.1 nM 10.1016/j.ejmech.2013.02.033
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 2.1 nM 10.1021/jm00014a021
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 2.3 nM 10.1016/j.bmc.2016.06.038
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 2.6 nM 10.1016/j.ejmech.2011.07.022
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 3.0 nM 10.1016/j.bmc.2008.05.077
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 3.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 4.31 nM 10.1021/jm00073a016
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 4.786 nM 10.1021/jm950410b
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 7.3 nM 10.1021/jm970645i
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 7.3 nM 10.1021/jm981112s
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 9.0 nM 10.1007/s00044-008-9094-3
Rattus norvegicus Serotonin 1b (5-HT1b) receptor EC50 26.0 nM 10.1021/jm00170a007
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 4.6 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 4.9 nM 10.1016/j.bmc.2016.03.006
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 4.9 nM 10.1016/j.bmc.2016.11.014
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 5.0 nM 10.1021/jm00170a007
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 1.1 nM 10.1021/jm970645i
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 1.1 nM 10.1021/jm981112s
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 2.5 nM 10.1021/jm00014a021
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 2.512 nM 10.1021/jm990151g
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 3.467 nM 10.1021/jm00402a026
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 5.0 nM 10.1021/jm00164a046
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 5.4 nM 10.1021/jm00044a001
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 5.4 nM 10.1021/jm00399a031
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki 25.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 1d (5-HT1d) receptor EC50 5.2 nM 10.1021/jm00042a003
Rattus norvegicus Serotonin 1d (5-HT1d) receptor IC50 3.0 nM 10.1021/jm00042a003
Rattus norvegicus Serotonin 2 (5-HT2) receptor IC50 20.0 nM 10.1021/jm00101a032
Rattus norvegicus Serotonin 2 (5-HT2) receptor IC50 3600.0 nM 10.1021/jm00101a032
Rattus norvegicus Serotonin 2 (5-HT2) receptor IC50 4600.0 nM 10.1021/jm00170a007
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 6.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 7.8 nM 10.1021/jm00399a031
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 560.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 930.0 nM 10.1021/jm00399a031
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 950.0 nM 10.1021/jm00164a046
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 977.24 nM 10.1021/jm00402a026
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 2950.0 nM 10.1021/jm00384a001
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Activity 52.0 % 10.1016/j.ejmech.2013.05.027
Rattus norvegicus Serotonin 2a (5-HT2a) receptor EC50 55.8 nM 10.1021/jm030205t
Rattus norvegicus Serotonin 2a (5-HT2a) receptor EC50 57.9 nM 10.1021/jm050663x
Rattus norvegicus Serotonin 2a (5-HT2a) receptor EC50 351.0 nM 10.1021/jm030205t
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Emax 99.0 % 10.1021/jm050663x
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 0.9 nM 10.1021/jm030205t
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 0.94 nM 10.1021/jm050663x
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 600.0 nM 10.1016/j.ejmech.2013.05.027
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 2350.0 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 13000.0 nM 10.1016/j.ejmech.2013.05.027
Rattus norvegicus Serotonin 2a (5-HT2a) receptor IC50 30600.0 nM 10.1016/j.ejmech.2013.05.027
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 0.3 nM 10.1021/jm030205t
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 10.6 nM 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 600.0 nM 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 1258.0 nM 10.1021/jm900018b
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 1258.0 nM 10.1021/jm901126m
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki 1258.93 nM 10.1021/jm990151g
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ki nan None 10.1007/s00044-008-9094-3
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Ratio Ki 50.0 None 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Serotonin 2b (5-HT2b) receptor EC50 3.5 nM 10.1021/jm050663x
Rattus norvegicus Serotonin 2b (5-HT2b) receptor EC50 4.19 nM 10.1016/j.ejmech.2015.08.051
Rattus norvegicus Serotonin 2b (5-HT2b) receptor Emax 74.9 % 10.1016/j.ejmech.2015.08.051
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Activity nan None 10.1021/jm301656h
Rattus norvegicus Serotonin 2c (5-HT2c) receptor EC50 2.8 nM 10.1021/jm050663x
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Emax 94.0 % 10.1021/jm050663x
Rattus norvegicus Serotonin 2c (5-HT2c) receptor IC50 42.0 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 2c (5-HT2c) receptor IC50 81.0 nM 10.1021/jm00101a032
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Ki 10.0 nM 10.1021/jm00164a046
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Ki 23.0 nM 10.1021/jm00044a001
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Ki 31.62 nM 10.1021/jm990151g
Rattus norvegicus Serotonin 2c (5-HT2c) receptor pKD 7.5 None 10.1021/jm00065a015
Rattus norvegicus Serotonin 3 (5-HT3) receptor IC50 727.0 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 3 (5-HT3) receptor Intrinsic efficacy nan None 10.1021/jm981112s
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 66.0 nM 10.1021/jm00014a021
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 87.0 nM 10.1016/0960-894X(96)00002-9
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 120.0 nM 10.1021/jm970645i
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 120.0 nM 10.1021/jm981112s
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 320.0 nM 10.1021/jm00044a001
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 390.0 nM 10.1021/jm00086a019
Rattus norvegicus Serotonin 3 (5-HT3) receptor Ki 398.11 nM 10.1021/jm990151g
Rattus norvegicus Serotonin 3a (5-HT3a) receptor EC50 12000.0 nM 10.1016/j.bmcl.2003.09.104
Rattus norvegicus Serotonin 4 (5-HT4) receptor Activity 1.0 None 10.1016/S0960-894X(00)80352-2
Rattus norvegicus Serotonin 4 (5-HT4) receptor EC50 6.31 nM 10.1016/S0960-894X(00)80352-2
Rattus norvegicus Serotonin 4 (5-HT4) receptor EC50 17.1 nM 10.1016/0960-894X(96)00002-9
Rattus norvegicus Serotonin 4 (5-HT4) receptor ED50 16.0 nM 10.1021/jm00086a019
Rattus norvegicus Serotonin 4 (5-HT4) receptor IC50 3.7 nM 10.1016/S0960-894X(01)80508-4
Rattus norvegicus Serotonin 4 (5-HT4) receptor IC50 147.0 nM 10.1021/jm970376w
Rattus norvegicus Serotonin 4 (5-HT4) receptor Ki 37.4 nM 10.1016/0960-894X(96)00002-9
Rattus norvegicus Serotonin 4 (5-HT4) receptor Ki 187.0 nM 10.1021/jm960320m
Rattus norvegicus Serotonin 7 (5-HT7) receptor Increase nan None 10.1021/jm030826m
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 0.6026 nM 10.1021/jm030826m
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 7.33 nM 10.1016/j.bmc.2007.05.010
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 10.0 nM 10.1021/jm030030n
Rattus norvegicus Serotonin receptor 2a and 2c (5HT2A and 5HT2C) Ki 6.1 nM 10.1021/jm00396a003
Rattus norvegicus Serotonin receptor 2a and 2c (5HT2A and 5HT2C) Ki 10.6 nM 10.1021/jm00396a003
Rattus norvegicus Serotonin receptor 2a and 2c (5HT2A and 5HT2C) Ki 600.0 nM 10.1021/jm00396a003
Rattus norvegicus Serotonin receptor 2a and 2c (5HT2A and 5HT2C) nH 0.9 None 10.1021/jm00396a003
Rattus norvegicus Serotonin transporter Activity nan None 10.1074/jbc.m704456200
Rattus norvegicus Serotonin transporter Ki 740.0 nM 10.1021/jm970645i
Rattus norvegicus Serotonin transporter Ki 740.0 nM 10.1021/jm981112s
Rattus norvegicus Serotonin transporter Ki nan None 10.1016/j.ejmech.2013.02.033
Rattus norvegicus Solute carrier family 22 member 1 Activity nan None 10.1038/sj.bjp.0702065
Rattus norvegicus Solute carrier family 22 member 1 Ki 390000.0 nM 10.1023/a:1013070128668
Rattus norvegicus Solute carrier family 22 member 1 Km 37600.0 nM 10.1016/0014-5793(96)01030-7
Rattus norvegicus Solute carrier family 22 member 2 Ki 242000.0 nM 10.1023/a:1013070128668
Rattus norvegicus Solute carrier family 22 member 2 Km 3600000.0 nM 10.1074/jbc.273.47.30915
Rattus norvegicus Solute carrier family 22 member 3 Activity 30.0 % 10.1074/jbc.273.26.15971
Rattus norvegicus Solute carrier family 22 member 3 IC50 97000.0 nM 10.1074/jbc.273.49.32776
Rattus norvegicus Solute carrier family 22 member 5 Activity nan None None
Saccharomyces cerevisiae Alpha-glucosidase MAL62 IC50 300000.0 nM 10.1007/s00044-011-9699-9
Saccharomyces cerevisiae Alpha-glucosidase MAL62 Inhibition 25.6 % 10.1007/s00044-011-9699-9
Saccharomyces cerevisiae S288c Carbonic anhydrase Ka 15.0 uM 10.1016/j.bmcl.2009.01.105
Saccharomyces cerevisiae S288c Carbonic anhydrase Ka 15.0 uM 10.1016/j.bmcl.2010.01.054
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 4.97 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.21 % 10.6019/CHEMBL4495565
Staphylococcus aureus Sortase A IC50 100.0 ug.mL-1 10.1016/j.bmcl.2010.10.029
Staphylococcus aureus Staphylococcus aureus MIC 56.4 ug.mL-1 10.1016/j.bmcl.2016.10.004
Sus scrofa Serotonin 1d (5-HT1d) receptor IC50 10.0 nM 10.1016/S0960-894X(00)80274-7
Sus scrofa Serotonin 1d (5-HT1d) receptor IC50 10.0 nM 10.1021/jm00010a025
Sus scrofa Serotonin 1d (5-HT1d) receptor IC50 10.0 nM 10.1021/jm00063a003
Sus scrofa Serotonin 1d (5-HT1d) receptor Relative maximum 1.0 None 10.1021/jm00010a025
Trypanosoma cruzi (strain CL Brener) Carbonic anhydrase-like protein, putative KA 1.98 uM 10.1016/j.bmc.2018.07.011
None ADMET Activity 0.22 g 10.1021/jm00204a007
None ADMET Activity 1.23 g 10.1021/jm00204a007
None ADMET Activity 2.32 g 10.1021/jm00204a007
None ADMET Activity 2.67 g 10.1021/jm00204a007
None ADMET Activity 3.08 g 10.1021/jm00204a007
None ADMET Activity 3.18 g 10.1021/jm00204a007
None ADMET Activity 3.2 g 10.1021/jm00204a007
None ADMET Activity nan None 10.1021/jm00204a007
None ADMET Binding energy 8.9 kCal mol-1 10.1021/jm00378a021
None ADMET EC50 0.0083 ug.mL-1 10.1021/jm00204a007
None ADMET Emax 7.0 % 10.1021/jm00204a007
None ADMET Emax 37.0 % 10.1021/jm00204a007
None ADMET Emax 70.0 % 10.1021/jm00204a007
None ADMET Emax 80.0 % 10.1021/jm00204a007
None ADMET Emax 92.0 % 10.1021/jm00204a007
None ADMET Emax 95.0 % 10.1021/jm00204a007
None ADMET Emax 96.0 % 10.1021/jm00204a007
None ADMET Hill coefficient 1.04 None 10.1021/jm00073a016
None ADMET T1/2 262.8 hr 10.1021/jm050663x
None NON-PROTEIN TARGET Activity nan None 10.1021/np50070a027
None NON-PROTEIN TARGET Activity nan None 10.1021/np50076a006
None NON-PROTEIN TARGET Hill coefficient 0.85 None 10.1021/jm00163a062
None No relevant target EC50 630.0 nM 10.1016/j.ejmech.2020.112217
None No relevant target LogD nan None 10.1016/j.bmcl.2009.07.063
None No relevant target log K -1.57 None 10.1016/j.bmcl.2011.10.007
None No relevant target log K 1.15 None 10.1021/jm9003945
None No relevant target log K 1.19 None 10.1021/jm9003945
None No relevant target LogP 0.21 None 10.1021/jm9003945
None Radical scavenging activity EC50 250000.0 nM 10.1016/j.bmcl.2011.02.028
None Unchecked Activity 0.68 uM 10.1074/jbc.m704456200
None Unchecked Activity 60.0 % 10.1021/np50094a001
None Unchecked Activity 65.0 % 10.1021/np50094a001
None Unchecked Activity nan None 10.1021/np50076a006
None Unchecked Activity nan None 10.1074/jbc.m704456200
None Unchecked EC50 nan None 10.1021/jm070574f
None Unchecked ED50 126.0 pmol 10.1021/np50076a006
None Unchecked ED50 156.0 pmol 10.1021/np50076a006
None Unchecked Emax 108.0 % 10.1021/np50076a006
None Unchecked Emax 110.0 % 10.1021/np50076a006
None Unchecked Hill coefficient 0.9 None 10.1021/jm00062a025
None Unchecked IA 1.0 None 10.1021/jm00065a015
None Unchecked IC50 2.7 nM 10.1016/j.bmc.2010.07.034
None Unchecked Ka 62.0 uM 10.1016/j.bmcl.2009.01.105
None Unchecked KA 0.007 uM 10.1016/j.bmcl.2012.12.009
None Unchecked KA 0.021 uM 10.1016/j.bmcl.2012.08.088
None Unchecked KA 0.021 uM 10.1016/j.bmcl.2012.12.009
None Unchecked KA 0.1 uM 10.1016/j.bmcl.2016.11.027
None Unchecked KA 0.62 uM 10.1016/j.bmc.2018.07.011
None Unchecked KA 0.97 uM 10.1016/j.bmcl.2008.10.005
None Unchecked KA 14.2 uM 10.1016/j.bmcl.2016.01.078
None Unchecked KA 38.0 uM 10.1016/j.bmcl.2008.10.005
None Unchecked KA 56.0 uM 10.1016/j.bmc.2010.01.059
None Unchecked KA 62.0 uM 10.1016/j.bmcl.2008.10.005
None Unchecked Kcat 1.62 10'6/s 10.1016/j.bmcl.2016.11.027
None Unchecked Ki 4.6 nM 10.1021/np50094a001
None Unchecked Ki 35.0 nM 10.1021/jm7011722
None Unchecked Ki 531.0 nM 10.1021/np50094a001
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 4609.0 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio 1.0 None 10.1021/jm00035a012
None Unchecked Ratio 2.0 None 10.1016/0960-894X(95)00417-R
None Unchecked Ratio 5.0 None 10.1016/0960-894X(95)00417-R
None Unchecked Ratio EC50 0.24 None 10.1016/j.bmc.2007.10.100
None Unchecked Ratio EC50 3.2 None 10.1021/jm801354e
None Unchecked Selectivity 2.0 None 10.1021/jm00042a003
None Unchecked Selectivity ratio 0.0 None 10.1021/jm0709034

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT000617 *N[C@@H](CCC(=O)NCCc1c[nH]c2ccc(O)cc12)C(*)=O>>NCCc1c[nH]c2ccc(O)cc12 MNXR186942
AKRT000627 *N[C@@H](CCC(N)=O)C(*)=O.NCCc1c[nH]c2ccc(O)cc12>>*N[C@@H](CCC(=O)NCCc1c[nH]c2ccc(O)cc12)C(*)=O RXN-19236
AKRT001881 C=C[C@@H]1[C@H](CC=O)C(C(=O)OC)=CO[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O.NCCc1c[nH]c2ccc(O)cc12>>C=C[C@@H]1[C@H](C[C@H]2NCCc3c2[nH]c2ccc(O)cc32)C(C(=O)OC)=CO[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O None
AKRT001903 C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1CC=O.NCCc1c[nH]c2ccc(O)cc12>>C=C[C@H]1[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@H]1C[C@H]1NCCc2c1[nH]c1ccc(O)cc21 enzymemap_85944
AKRT002492 CC(=O)NCCc1c[nH]c2ccc(O)cc12>>NCCc1c[nH]c2ccc(O)cc12 67196
AKRT004408 CC(=O)[32S].NCCc1c[nH]c2ccc(O)cc12>>CC(=O)NCCc1c[nH]c2ccc(O)cc12 None
AKRT004646 CC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CC(=O)NCCc1c[nH]c2ccc(O)cc12 RXN3DJ-35528
AKRT005228 CC(C)=CCOP(=O)(O)OP(=O)(O)O.NCCc1c[nH]c2ccc(O)cc12>>CC(C)=CCc1c(O)ccc2[nH]cc(CCN)c12 enzymemap_40434
AKRT007436 CCCC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CCCC(=O)NCCc1c[nH]c2ccc(O)cc12 66164
AKRT007669 CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCc1c[nH]c2ccc(O)cc12 51396
AKRT008390 CCCCCCCC/C=C\CCCCCCCC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CCCCCCCC/C=C\CCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 51392
AKRT009069 CCCCCCCCCCCCCCCC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CCCCCCCCCCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 51384
AKRT009166 CCCCCCCCCCCCCCCCCC(=O)[CoA].NCCc1c[nH]c2ccc(O)cc12>>CCCCCCCCCCCCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 51400
AKRT010635 CN1c2c(nc(N)[nH]c2=O)NC[C@@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1.NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCN)c2c1 R02912
AKRT011507 COc1cc(/C=C/C(=O)[CoA])ccc1O.NCCc1c[nH]c2ccc(O)cc12>>COc1cc(/C=C/C(=O)NCCc2c[nH]c3ccc(O)cc23)ccc1O RXN-8710
AKRT012647 C[33S].NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCN)c2c1 None
AKRT014653 C[SAH].NCCc1c[nH]c2ccc(O)cc12>>CNCCc1c[nH]c2ccc(O)cc12 R02910
AKRT014654 C[SAH].NCCc1c[nH]c2ccc(O)cc12>>COc1ccc2[nH]cc(CCN)c2c1 enzymemap_27364
AKRT018353 NCCc1c[nH]c2ccc(O)cc12.O=C(O)[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NCCc1c[nH]c2ccc(O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)cc12 enzymemap_34561
AKRT018354 NCCc1c[nH]c2ccc(O)cc12.O=C([CoA])/C=C/c1ccc(O)c(O)c1>>O=C(/C=C/c1ccc(O)c(O)c1)NCCc1c[nH]c2ccc(O)cc12 RXN-8709
AKRT018355 NCCc1c[nH]c2ccc(O)cc12.O=C([CoA])/C=C/c1ccc(O)cc1>>O=C(/C=C/c1ccc(O)cc1)NCCc1c[nH]c2ccc(O)cc12 RXN-8711
AKRT018356 NCCc1c[nH]c2ccc(O)cc12.O=C([CoA])/C=C/c1ccccc1>>O=C(/C=C/c1ccccc1)NCCc1c[nH]c2ccc(O)cc12 RXN-8712
AKRT018357 NCCc1c[nH]c2ccc(O)cc12.O=C([CoA])c1ccccc1>>OC(=NCCc1c[nH]c2ccc(O)cc12)c1ccccc1 MNXR172606
AKRT018358 NCCc1c[nH]c2ccc(O)cc12.O=C=O>>NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O MNXR95078
AKRT018359 NCCc1c[nH]c2ccc(O)cc12>>NCCC(=O)c1cc(O)ccc1NC=O R02909
AKRT018360 NCCc1c[nH]c2ccc(O)cc12>>NCCc1c[nH]c2ccc(OS(=O)(=O)O)cc12 RXN-10777
AKRT018361 NCCc1c[nH]c2ccc(O)cc12>>O=CCc1c[nH]c2ccc(O)cc12 RXN-10778
AKRT018371 NCCc1c[nH]c2ccccc12>>NCCc1c[nH]c2ccc(O)cc12 RXN-8707
AKRT019718 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O>>NCCc1c[nH]c2ccc(O)cc12 RXN3DJ-170
AKRT019719 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O>>NCCc1c[nH]c2ccc(O)cc12.O=C=O None
AKRT023414 O=C([CoA])/C=C/c1ccc(O)c(O)c1.NCCc1c[nH]c2ccc(O)cc12>>O=C(/C=C/c1ccc(O)c(O)c1)NCCc1c[nH]c2ccc(O)cc12 enzymemap_28468
AKRT024883 Oc1ccc2[nH]c3c(c2c1)CCNC3>>NCCc1c[nH]c2ccc(O)cc12 MNXR103616