Mitraphylline
AlkaPlorer ID: AK001615
Synonym: 'ConMedNP.1318', '', 'Uncarin D', 'MLS000728610', '7-Isopteropodine', 'MLS000728614', 'Rauniticine-allo-oxindole A', 'Mitraphylline', 'MLSMR', 'allo-Isopteropodine', 'Ajmalicine oxindole A', 'Ajmalicine oxindole B', 'Rubradinine', 'SMR000470795', 'SMR000470796', 'Isomitraphylline', 'allo-Pteropodine', 'Isoformosanine', '5171-37-9', 'Rauniticine oxindole A', 'Isopteropodine', '509-80-8', 'SMR000440716', 'Uncarine E', 'Uncarine F', 'Uncarine C', 'Uncarine D', 'Speciofiline', 'Uncarine A', 'Speciophylline', 'Uncarine B', 'Pteropodine', 'MLS000863603'
IUPAC Name: None
Structure
SMILES: COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CC[C@]4(C(O)=[NH+]C5=CC=CC=C54)[C@@H]3C[C@H]12
InChI: InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/p+1/t12-,13-,14-,18-,21+/m0/s1
InChIKey: JMIAZDVHNCCPDM-QLMFUGSGSA-O
Reference
Capillary Zone Electrophoretic Analysis of Oxindole Alkaloids from<i>Uncaria tomentosa</i>
LOTUS: LTS0238041
SuperNatural Ⅲ: SN0169328-14
NPASS: NPC293255
Source
Properties Information
Molecule Weight: 369.4410000000001
TPSA？: 72.97
MolLogP？: 0.7926000000000013
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Aldehyde dehydrogenase 1A1 | Potency | 44668.4 | nM | None |
| Homo sapiens | Alpha-synuclein | Potency | 25118.9 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 5011.9 | nM | None |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 50.1 | nM | None |
| Homo sapiens | Geminin | Potency | 29092.9 | nM | None |
| Homo sapiens | Huntingtin | Potency | 11220.2 | nM | None |
| Homo sapiens | Lysosomal alpha-glucosidase | Potency | 1122.0 | nM | None |
| None | Unchecked | Potency | 3548.1 | nM | None |