Molecule

Tryptanthrin

AlkaPlorer ID: AK001733

Synonym: None

IUPAC Name: indolo[2,1-b]quinazoline-6,12-dione

Structure

SMILES: O=C1C2=CC=CC=C2N2C1=NC1=CC=CC=C1C2=O

InChI: InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

InChIKey: VQQVWGVXDIPORV-UHFFFAOYSA-N

Reference

Brain metabolomic profiling of eastern honey bee (Apis cerana) infested with the mite Varroa destructor

PubChem CID: 73549

CAS: 13220-57-0

LOTUS: LTS0210698

SuperNatural Ⅲ: SN0397485

COCONUT: CNP0271812

data_source: manually

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Persicaria tinctoria	Persicaria	Polygonaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 248.241

TPSA？: 51.96

MolLogP？: 1.9301

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Chlorocebus sabaeus	Vero	IC50	8.0	ug.mL-1	10.1021/np3007167
Chlorocebus sabaeus	Vero	IC50	100.0	ug.mL-1	10.1021/acs.jnatprod.8b00567
Electrophorus electricus	Acetylcholinesterase	Inhibition	35.31	%	10.1016/j.bmc.2012.09.040
Equus caballus	Cholinesterase	Inhibition	-2.13	%	10.1016/j.bmc.2012.09.040
Escherichia coli	Escherichia coli	GI	nan	None	10.1021/jm901847f
Escherichia coli	Escherichia coli	GI50	2.25	ug.mL-1	10.1021/jm901847f
Escherichia coli K-12	Beta-lactamase AmpC	Potency	891.3	nM	None
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Potency	6294.6	nM	None
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Potency	7062.7	nM	None
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Potency	7924.5	nM	None
Homo sapiens	786-0	GI50	28248.8	nM	None
Homo sapiens	A498	GI50	950.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	A498	GI50	18155.16	nM	None
Homo sapiens	A549	Activity	nan	None	10.1021/np3002833
Homo sapiens	A549	GI50	2588.21	nM	None
Homo sapiens	ACHN	GI50	1995.26	nM	None
Homo sapiens	Arachidonate 5-lipoxygenase	IC50	150.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	Arachidonate 5-lipoxygenase	IC50	200000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	ATPase family AAA domain-containing protein 5	Potency	1635.3	nM	None
Homo sapiens	Bel-7402	Activity	nan	None	10.1021/np3002833
Homo sapiens	BGC-823	Activity	nan	None	10.1021/np3002833
Homo sapiens	BT-549	GI50	14554.59	nM	None
Homo sapiens	Caco-2	permeability	225.0	ucm/s	10.1021/np3007167
Homo sapiens	Caco-2	permeability	601.0	ucm/s	10.1021/np3007167
Homo sapiens	Caco-2	Ratio	1.0	None	10.1021/np3007167
Homo sapiens	CAKI-1	GI50	12331.05	nM	None
Homo sapiens	Canalicular multispecific organic anion transporter 1	Inhibition	30.0	%	10.1016/j.ejmech.2017.06.047
Homo sapiens	CCRF-CEM	GI50	9078.21	nM	None
Homo sapiens	CCRF-CEM	GI50	14470.0	nM	10.1016/j.ejmech.2020.112504
Homo sapiens	CCRF-CEM	IC50	44360.0	nM	10.1016/j.ejmech.2020.112504
Homo sapiens	c-Jun N-terminal kinase 1	Kd	23000.0	nM	10.1016/j.ejmech.2018.10.023
Homo sapiens	c-Jun N-terminal kinase 2	Activity	nan	None	10.1016/j.ejmech.2018.10.023
Homo sapiens	c-Jun N-terminal kinase 3	Activity	nan	None	10.1016/j.ejmech.2018.10.023
Homo sapiens	c-Jun N-terminal kinase, JNK	Inhibition	nan	%	10.1016/j.ejmech.2018.10.023
Homo sapiens	COLO 205	GI50	12764.39	nM	None
Homo sapiens	Cyclooxygenase-2	IC50	64.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	Cyclooxygenase-2	IC50	64.0	nM	10.1016/j.bmc.2012.09.069
Homo sapiens	Cyclooxygenase-2	IC50	64.0	nM	10.1021/np049655u
Homo sapiens	Cytochrome P450 2C19	Inhibition	9.0	%	10.1021/np3007167
Homo sapiens	Cytochrome P450 2C9	Inhibition	25.0	%	10.1021/np3007167
Homo sapiens	Cytochrome P450 3A4	Inhibition	12.0	%	10.1021/np3007167
Homo sapiens	DNA polymerase iota	Potency	89125.1	nM	None
Homo sapiens	DNA topoisomerase I	Inhibition	nan	%	10.1021/jm901847f
Homo sapiens	DNA topoisomerase II alpha	Inhibition	4.54	%	10.1016/j.bmc.2012.06.034
Homo sapiens	DNA topoisomerase II alpha	Inhibition	nan	%	10.1016/j.ejmech.2020.112504
Homo sapiens	DU-145	GI50	400.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	DU-145	GI50	10690.55	nM	None
Homo sapiens	DU-145	IC50	6220.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	EKVX	GI50	13427.65	nM	None
Homo sapiens	Geminin	Potency	1158.2	nM	None
Homo sapiens	Glucose transporter	Inhibition	-2.52	%	10.6019/CHEMBL3433997
Homo sapiens	HCC 2998	GI50	29376.5	nM	None
Homo sapiens	HCT-116	GI50	5861.38	nM	None
Homo sapiens	HCT-15	GI50	3597.49	nM	None
Homo sapiens	HCT-15	IC50	8490.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	HCT-8	Activity	nan	None	10.1021/np3002833
Homo sapiens	HEK293	IC50	4110.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	HepG2	IC50	0.3054	ug.mL-1	10.1021/jm501809x
Homo sapiens	HepG2	IC50 relative	4300.0	nM	10.6019/EOS300108
Homo sapiens	HepG2	Inhibition	9.0	%	10.1038/nature09107
Homo sapiens	HepG2	Potency	3981.1	nM	None
Homo sapiens	HFF	TD50	6.4	uM	10.1016/j.bmcl.2012.12.024
Homo sapiens	Histone acetyltransferase GCN5	Potency	10000.0	nM	None
Homo sapiens	Histone deacetylase 6	IC50	3286.0	nM	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	68.59	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	82.69	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	103.79	%	10.6019/CHEMBL4808148
Homo sapiens	Histone-lysine N-methyltransferase MLL	Potency	31622.8	nM	None
Homo sapiens	HL-60	GI50	3706.81	nM	None
Homo sapiens	HL-60	IC50	2000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	HL-60	IC50	5000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	HOP-62	GI50	12133.89	nM	None
Homo sapiens	HOP-92	GI50	44463.13	nM	None
Homo sapiens	Hs-578T	GI50	17139.57	nM	None
Homo sapiens	HT-1376	Activity	10.0	uM	10.1016/j.bmc.2012.06.034
Homo sapiens	HT-29	GI50	14757.07	nM	None
Homo sapiens	Huh-7	CC50	10000.0	nM	10.1073/pnas.0802982105
Homo sapiens	Huntingtin	Potency	11220.2	nM	None
Homo sapiens	IGROV-1	GI50	23014.42	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase	IC50	53.7	nM	10.1021/jm401195n
Homo sapiens	Indoleamine 2,3-dioxygenase	IC50	7150.0	nM	10.1021/jm401195n
Homo sapiens	Indoleamine 2,3-dioxygenase	IC50	7150.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase	IC50	498700.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	Indoleamine 2,3-dioxygenase	IC50	53700000.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase	Ki	4810.0	nM	10.1021/jm401195n
Homo sapiens	Indoleamine 2,3-dioxygenase	Ki	4810.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase 2	IC50	5000.0	nM	10.1016/j.ejmech.2016.07.013
Homo sapiens	Indoleamine 2,3-dioxygenase 2	IC50	5010.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase 2	IC50	17300.0	nM	10.1016/j.ejmech.2016.07.013
Homo sapiens	Indoleamine 2,3-dioxygenase 2	IC50	17310.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase 2	Inhibition	18.0	%	None
Homo sapiens	Indoleamine 2,3-dioxygenase 2	Inhibition	nan	%	10.1016/j.ejmech.2016.07.013
Homo sapiens	Indoleamine 2,3-dioxygenase 2	Ki	15180.0	nM	None
Homo sapiens	Indoleamine 2,3-dioxygenase 2	Ki	15200.0	nM	10.1016/j.ejmech.2016.07.013
Homo sapiens	Indoleamine 2,3-dioxygenase 2	Ratio IC50	29.7	None	10.1016/j.ejmech.2016.07.013
Homo sapiens	K562	Activity	21.9	%	10.1016/j.bmc.2017.07.003
Homo sapiens	K562	Activity	33.4	%	10.1016/j.bmc.2017.07.003
Homo sapiens	K562	Activity	52.2	%	10.1016/j.bmc.2017.07.003
Homo sapiens	K562	GI50	3184.2	nM	None
Homo sapiens	K562	IC50	8.8	ug.mL-1	10.1016/j.bmc.2017.07.003
Homo sapiens	K562	IC50	5000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	K562	IC50	15000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	KETR3	Activity	nan	None	10.1021/np3002833
Homo sapiens	KM12	GI50	6622.17	nM	None
Homo sapiens	Liver microsomes	Stability	15.0	%	10.1021/np3007167
Homo sapiens	LOX IMVI	GI50	4436.09	nM	None
Homo sapiens	M14	GI50	5649.37	nM	None
Homo sapiens	M14	GI50	15000.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	Malme-3M	GI50	13396.77	nM	None
Homo sapiens	MCF7	Activity	nan	None	10.1021/np3002833
Homo sapiens	MCF7	GI50	7194.49	nM	None
Homo sapiens	MCF7	IC50	580.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	MCF7	IC50	11100.0	nM	10.1021/np800064w
Homo sapiens	MDA-MB-231	GI50	16672.47	nM	None
Homo sapiens	MDA-MB-435	GI50	1853.53	nM	None
Homo sapiens	MDA-N	GI50	18197.01	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	17782.8	nM	None
Homo sapiens	MOLT-4	GI50	7943.28	nM	None
Homo sapiens	MOLT-4	IC50	8000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	MOLT-4	IC50	10000.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	Mothers against decapentaplegic homolog 3	Potency	3162.3	nM	None
Homo sapiens	Muscleblind-like protein 1	Potency	1412.5	nM	None
Homo sapiens	NCI/ADR-RES	GI50	22335.72	nM	None
Homo sapiens	NCI/ADR-RES	GI50	30000.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	NCI/ADR-RES	IC50	30.0	nM	10.1016/j.bmc.2017.07.003
Homo sapiens	NCI-H226	GI50	30902.95	nM	None
Homo sapiens	NCI-H23	GI50	9727.47	nM	None
Homo sapiens	NCI-H322M	GI50	11324.0	nM	None
Homo sapiens	NCI-H460	GI50	1435.49	nM	None
Homo sapiens	NCI-H460	IC50	9000.0	nM	10.1021/np800064w
Homo sapiens	NCI-H522	GI50	15000.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	NCI-H522	GI50	15346.17	nM	None
Homo sapiens	Nerve growth factor receptor Trk-A	Kd	9200.0	nM	10.1016/j.ejmech.2018.10.023
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	Kd	7200.0	nM	10.1016/j.ejmech.2018.10.023
Homo sapiens	Niemann-Pick C1 protein	Potency	2818.4	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	5173.5	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	6513.1	nM	None
Homo sapiens	OVCAR-3	GI50	4539.42	nM	None
Homo sapiens	OVCAR-4	GI50	19054.61	nM	None
Homo sapiens	OVCAR-5	GI50	15995.58	nM	None
Homo sapiens	OVCAR-8	GI50	5794.29	nM	None
Homo sapiens	Parathyroid hormone receptor	Potency	3162.3	nM	None
Homo sapiens	PC-3	GI50	648.63	nM	None
Homo sapiens	Plasma	PPB	95.9	%	10.1021/np3007167
Homo sapiens	Prelamin-A/C	Potency	354.8	nM	None
Homo sapiens	Ras-related protein Rab-9A	Potency	3162.3	nM	None
Homo sapiens	RPMI-8226	GI50	1039.92	nM	None
Homo sapiens	RXF 393	GI50	28054.34	nM	None
Homo sapiens	SF-268	GI50	19906.73	nM	None
Homo sapiens	SF-268	IC50	24400.0	nM	10.1021/np800064w
Homo sapiens	SF-295	GI50	4285.49	nM	None
Homo sapiens	SF-539	GI50	20749.14	nM	None
Homo sapiens	SK-MEL-2	GI50	10092.53	nM	None
Homo sapiens	SK-MEL-28	GI50	15812.48	nM	None
Homo sapiens	SK-MEL-5	GI50	13122.0	nM	None
Homo sapiens	SK-OV-3	GI50	2500.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	SK-OV-3	GI50	100000.0	nM	None
Homo sapiens	SN12C	GI50	12618.28	nM	None
Homo sapiens	SNB-19	GI50	25003.45	nM	None
Homo sapiens	SNB-75	GI50	30831.88	nM	None
Homo sapiens	SR	GI50	8472.27	nM	None
Homo sapiens	SW-620	GI50	5000.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	SW-620	GI50	20796.97	nM	None
Homo sapiens	T47D	GI50	8871.56	nM	None
Homo sapiens	T47D	IC50	14290.0	nM	10.1016/j.bmc.2012.06.034
Homo sapiens	TK-10	GI50	43251.38	nM	None
Homo sapiens	Tryptophan 2,3-dioxygenase	IC50	140.0	nM	10.1016/j.ejmech.2018.10.017
Homo sapiens	Tryptophan 2,3-dioxygenase	IC50	194.0	nM	10.1016/j.ejmech.2018.10.017
Homo sapiens	Tryptophan 2,3-dioxygenase	IC50	900.0	nM	10.1016/j.bmc.2019.02.014
Homo sapiens	Tryptophan 2,3-dioxygenase	IC50	3940.0	nM	10.1016/j.ejmech.2018.10.017
Homo sapiens	Tryptophan 2,3-dioxygenase	Ki	581.0	nM	10.1016/j.ejmech.2018.10.017
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	461.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	517.4	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	1299.5	nM	None
Homo sapiens	U-251	GI50	3341.95	nM	None
Homo sapiens	U-251	GI50	100000.0	nM	10.1016/s0960-894x(02)00431-6
Homo sapiens	UACC-257	GI50	3019.95	nM	None
Homo sapiens	UACC-62	GI50	3689.78	nM	None
Homo sapiens	UO-31	GI50	5058.25	nM	None
Human alphaherpesvirus 1	Human alphaherpesvirus 1	Activity	nan	None	10.1021/np3002833
Human immunodeficiency virus 1	Aberrant vpr protein	Potency	3548.1	nM	None
Human immunodeficiency virus 1	Human immunodeficiency virus 1	Activity	nan	None	10.1021/np3002833
Influenza A virus	Nonstructural protein 1	Potency	1122.0	nM	None
Leishmania mexicana	Glucose transporter	Inhibition	-3.28	%	10.6019/CHEMBL3433997
Malassezia furfur	Malassezia furfur	MIC	4.0	ug.mL-1	10.1016/j.bmc.2017.07.003
Mus musculus	Lewis lung carcinoma cell line	Inhibition	nan	%	10.1021/jm401195n
Mus musculus	Nuclear receptor ROR-gamma	Potency	11220.2	nM	None
Mycobacterium avium	Mycobacterium avium	MIC	4.0	ug.mL-1	10.1016/j.bmcl.2015.07.057
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MBC90	1.0	ug ml-1	10.1021/np3007167
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	1.6e-05	ug.mL-1	10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	0.5	ug.mL-1	10.1016/j.bmcl.2015.07.057
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	1.0	ug.mL-1	10.1016/j.bmcl.2015.07.057
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	1.0	ug.mL-1	10.1021/acs.jnatprod.8b00567
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	1.0	ug.mL-1	10.1021/np3007167
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	10.0	ug.mL-1	10.1016/j.bmc.2012.06.034
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC>90	7.59	ug ml-1	10.1021/acs.jnatprod.8b00567
Mycobacterium tuberculosis	Protein RecA	EC50	643.0	nM	None
Mycobacterium tuberculosis	Replicative DNA helicase	AC50	1078.0	nM	None
Mycobacterium tuberculosis	Replicative DNA helicase	AC50	380000.0	nM	None
Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	MIC	6.0	ug.mL-1	10.1016/j.bmcl.2015.07.057
Photinus pyralis	Luciferin 4-monooxygenase	Potency	21331.3	nM	None
Plasmodium falciparum	Hexose transporter 1	Inhibition	-2.55	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Plasmodium falciparum	AbsAC35	0.0617	uM	None
Plasmodium falciparum	Plasmodium falciparum	AbsAC35	0.181	uM	None
Plasmodium falciparum	Plasmodium falciparum	Activity	100.0	ng/ml	10.1016/j.ejmech.2021.113400
Plasmodium falciparum	Plasmodium falciparum	EC50	211.7	nM	10.1073/pnas.0802982105
Plasmodium falciparum	Plasmodium falciparum	EC50	275.6	nM	10.1073/pnas.0802982105
Plasmodium falciparum	Plasmodium falciparum	IC50	0.069	ug.mL-1	10.1016/j.ejmech.2021.113400
Plasmodium falciparum	Plasmodium falciparum	IC50	114.0	nM	10.1016/j.ejmech.2021.113400
Plasmodium falciparum	Plasmodium falciparum	IC50	288.0	nM	10.1016/j.ejmech.2021.113400
Plasmodium falciparum	Plasmodium falciparum	Inhibition	4.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	80.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	93.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Potency	3.7	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	329.4	nM	None
Plasmodium falciparum	Plasmodium falciparum	XC50	856.44	nM	10.1038/nature09107
Plasmodium falciparum 3D7	HSP40, subfamily A, putative	AbsAC1000_uM	1.835	uM	None
Plasmodium yoelii	Plasmodium yoelii	Activity	nan	None	10.1126/science.1211936
Plasmodium yoelii	Plasmodium yoelii	IC50	225.1	nM	10.1126/science.1211936
Plasmodium yoelii	Plasmodium yoelii	Schizont size	89.55	um	10.1126/science.1211936
Rattus norvegicus	Rattus norvegicus	Cmax	7613599742.18	nM	10.1021/np3007167
Rattus norvegicus	Rattus norvegicus	Cmax	10554302288.11	nM	10.1021/np3007167
Rattus norvegicus	Rattus norvegicus	Inhibition	41.0	%	10.1016/j.bmc.2017.07.003
Rattus norvegicus	Rattus norvegicus	Inhibition	42.0	%	10.1016/j.bmc.2017.07.003
Rattus norvegicus	Rattus norvegicus	Inhibition	46.0	%	10.1016/j.bmc.2017.07.003
Rattus norvegicus	Rattus norvegicus	Inhibition	80.0	%	10.1016/j.bmc.2017.07.003
Rattus norvegicus	Rattus norvegicus	T1/2	4.35	hr	10.1021/np3007167
Rattus norvegicus	Rattus norvegicus	T1/2	5.6	hr	10.1021/np3007167
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	10.32	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	21.13	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.17	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.08	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	9.2	%	10.21203/rs.3.rs-23951/v1
Staphylococcus aureus	Staphylococcus aureus	MIC	0.5	ug.mL-1	10.1016/j.bmc.2017.07.003
Toxoplasma gondii	Toxoplasma gondii	ID50	0.031	uM	10.1128/aac.00903-08
Toxoplasma gondii	Toxoplasma gondii	ID50	0.14	uM	10.1016/j.bmcl.2012.12.024
None	ADMET	TD50	62.0	uM	10.1128/aac.00903-08
None	ADMET	TI	45.0	None	10.1016/j.bmcl.2012.12.024
None	ADMET	TI	2000.0	None	10.1128/aac.00903-08
None	No relevant target	Activity	nan	None	10.1021/jm401195n
None	No relevant target	LogD	2.29	None	10.1021/np3007167
None	No relevant target	Solubility	5400.0	nM	10.1021/np3007167
None	No relevant target	Solubility	11700.0	nM	10.1021/np3007167
None	No relevant target	Solubility	12900.0	nM	10.1021/np3007167
None	No relevant target	Solubility	91020.0	nM	10.1016/j.ejmech.2020.112504
None	Unchecked	Activity	nan	None	10.1021/np500108r
None	Unchecked	CC50	17498.0	nM	None
None	Unchecked	CC50	20000.0	nM	None
None	Unchecked	Flu intensity	2740.0	None	10.1016/j.bmc.2017.07.003
None	Unchecked	Flu intensity	2826.0	None	10.1016/j.bmc.2017.07.003
None	Unchecked	IC50	195.0	nM	None
None	Unchecked	IC50	330.0	nM	None
None	Unchecked	IC50	2800.0	nM	None
None	Unchecked	IFI	2.19	%	10.1073/pnas.0802982105
None	Unchecked	IFI	2.99	%	10.1038/nature09107
None	Unchecked	Inhibition	4.09	%	10.1016/j.bmc.2012.06.034
None	Unchecked	Inhibition	30.0	%	10.1016/j.ejmech.2017.06.047
None	Unchecked	Inhibition	68.44	%	10.1016/j.bmc.2012.06.034
None	Unchecked	Inhibition	70.0	%	10.1016/j.bmc.2017.07.003
None	Unchecked	Potency	501.2	nM	None
None	Unchecked	Potency	707.9	nM	None
None	Unchecked	Potency	2511.9	nM	None
None	Unchecked	Potency	8912.5	nM	None
None	Unchecked	Potency	10000.0	nM	None
None	Unchecked	Potency	11220.2	nM	None
None	Unchecked	Potency	16360.1	nM	None