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name Structure Reference Source Properties Activities Metabolism

cyclo(L-Pro-L-Val)

AlkaPlorer ID: AK001757

Synonym: '', 'cyclo-Val-Pro-diketopiperazine', '156617-55-9', 'cyclo-Pro- Val', '27483-18-7', 'cyclo(D)-Pro-(D)-Val', '2854-40-2', 'Cyclo(D)-Pro-(D)-Val', '(3S,8aS)-3-Isopropylhexahydropyrrolo1,2-apyrazine-1,4-dione', 'Cyclo(D-Pro-L-Val)', 'Cyclo-(L-Pro-L-Val)', 'cyclo-(l-val-l-pro)', 'cyclo (L)-Pro-(L)-Val', 'cyclo(L-Pro-L-Val)'

IUPAC Name: (3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Structure

SMILES: CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C1=O

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InChI: InChI=1S/C10H16N2O2/c1-6(2)8-10(14)12-5-3-4-7(12)9(13)11-8/h6-8H,3-5H2,1-2H3,(H,11,13)/t7-,8-/m0/s1

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InChIKey: XLUAWXQORJEMBD-YUMQZZPRSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Ulva pertusa Ulva Ulvaceae Ulvales Ulvophyceae Chlorophyta Viridiplantae Eukaryota
Cryptocarya leucophylla Cryptocarya Lauraceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Callyspongia pseudoreticulata Callyspongia Callyspongiidae Haplosclerida Demospongiae Porifera Metazoa Eukaryota
Polistes rothneyi Polistes Vespidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota
Eschweilera coriacea Eschweilera Lecythidaceae Ericales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum amurense Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pseudomonas aeruginosa Pseudomonas Pseudomonadaceae Pseudomonadales Gammaproteobacteria Pseudomonadota None Bacteria
Sanguisorba tenuifolia Sanguisorba Rosaceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Uvaria tanzaniae Uvaria Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Amansia glomerata Amansia Rhodomelaceae Ceramiales Florideophyceae Rhodophyta None Eukaryota
Streptomyces triangulatus Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Stelletta clavosa Stelletta Ancorinidae Tetractinellida Demospongiae Porifera Metazoa Eukaryota
Turbo stenogyrus Turbo Turbinidae Trochida Gastropoda Mollusca Metazoa Eukaryota
Uvaria hamiltonii Uvaria Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Lobophora papenfussii Lobophora Dictyotaceae Dictyotales Phaeophyceae None None Eukaryota
Senecio serra Senecio Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Salvadora persica Salvadora Salvadoraceae Brassicales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Exallage chrysotricha Exallage Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Solanum pimpinellifolium Solanum Solanaceae Solanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Eucalyptus cladocalyx Eucalyptus Myrtaceae Myrtales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Entada abyssinica Entada Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aspergillus violaceus Aspergillus Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Psammosilene tunicoides Psammosilene Caryophyllaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hypericum scabrum Hypericum Hypericaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Syringa reticulata Syringa Oleaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 196.25

TPSA？: 49.41

MolLogP？: 0.1317999999999997

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus cereus Bacillus cereus Activity nan None 10.1021/np960095b
Bacillus subtilis Bacillus subtilis MIC 18.2 ug.mL-1 10.1016/j.bmcl.2015.06.010
Escherichia coli Escherichia coli MIC 20.0 ug.mL-1 10.1016/j.bmcl.2015.06.010
Homo sapiens HCT-116 Activity nan None 10.1021/acsmedchemlett.2c00196
Homo sapiens HCT-116 EC50 100000.0 nM 10.1021/acsmedchemlett.2c00196
Homo sapiens HEK293 EC50 100000.0 nM 10.1021/acsmedchemlett.2c00196
Homo sapiens Neurokinin 1 receptor Activity nan None 10.1021/np50106a005
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1021/acsmedchemlett.2c00196
Micrococcus luteus Micrococcus luteus Activity nan None 10.1021/np960095b
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/np960095b
Staphylococcus aureus Staphylococcus aureus MIC 16.3 ug.mL-1 10.1016/j.bmcl.2015.06.010
None NON-PROTEIN TARGET IC50 2.79 ug.mL-1 10.1021/np100902f
None NON-PROTEIN TARGET IC50 6.59 ug.mL-1 10.1021/np100902f
None NON-PROTEIN TARGET Inhibition nan % 10.1021/np100902f
None Unchecked Activity nan None 10.1021/acsmedchemlett.2c00196
None Unchecked EC50 100000.0 nM 10.1021/acsmedchemlett.2c00196
None Unchecked IC50 6200.0 nM 10.1021/acsmedchemlett.2c00196

Metabolism Information