Molecule

tetrahydropalmatine

AlkaPlorer ID: AK001766

Synonym: '', '2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino3,2-aisoquinoline', 'L-tetrahydropalmatine', 'MLS000029596', 'Tetrahydropalmatine', 'Rotundine', '(+/-)-Tetrahydropalmatine', '2,3,9,10-tetramethoxy-13aalpha-berbine', '(S)-Tetrahydropalmatine', 'SMR000008833', '(-)-Tetrahydropalmatine', 'dl-Tetrahydropalmatine', 'MLSMR', 'Corydalis B', '(-)-Rotundine(Stephania)', 'MLS002535962', 'tetrahydropalmatine', '2,3,9,10-Tetramethoxyberbine', '(-)-tetrahydropalmatine', '(S)-tetrahydropalmatine', 'TETRAHYDROPALMATINE', '(+)-Tetrahydropalmatine', '2934-97-6', '(S)-(-)-tetrahydropalmatine', 'l-Tetrahydropalmatine'

IUPAC Name: (13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline

Structure

SMILES: COC1=CC2=C(C=C1OC)[C@H]1CC3=C(CN1CC2)C(OC)=C(OC)C=C3

InChI: InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m1/s1

InChIKey: AEQDJSLRWYMAQI-QGZVFWFLSA-N

Reference

Positive Cooperation of Protoberberine Type 2 Alkaloids from<i>Corydalis cava</i>on the GABA<sub>A</sub>Binding Site

PubChem CID: 969488

CAS: 3520-14-7

LOTUS: LTS0175021

SuperNatural Ⅲ: SN0003583-02

NPASS: NPC106295

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Pedicularis chinensis	Pedicularis	Orobanchaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Maytenus octogona	Maytenus	Celastraceae	Celastrales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Taxillus yadoriki	Taxillus	Loranthaceae	Santalales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Karwinskia subcordata	Karwinskia	Rhamnaceae	Rosales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Corydalis turtschaninovii	Corydalis	Papaveraceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Coptis teeta	Coptis	Ranunculaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Phellodendron amurense	Phellodendron	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Funneliformis mosseae	Funneliformis	Glomeraceae	Glomerales	Glomeromycetes	Mucoromycota	Fungi	Eukaryota
Phellodendron chinense	Phellodendron	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Iris decora	Iris	Iridaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Coptis chinensis	Coptis	Ranunculaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Dovyalis hebecarpa	Dovyalis	Salicaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Heliothis maritima	Heliothis	Noctuidae	Lepidoptera	Insecta	Arthropoda	Metazoa	Eukaryota
Ixeris repens	Ixeris	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Russula paludosa	Russula	Russulaceae	Russulales	Agaricomycetes	Basidiomycota	Fungi	Eukaryota
Penicillium vulpinum	Penicillium	Aspergillaceae	Eurotiales	Eurotiomycetes	Ascomycota	Fungi	Eukaryota
Fibraurea recisa	Fibraurea	Menispermaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Balaenoptera borealis	Balaenoptera	Balaenopteridae	Artiodactyla	Mammalia	Chordata	Metazoa	Eukaryota
Brickellia paniculata	Brickellia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Coptis deltoidea	Coptis	Ranunculaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Agathosma bisulca	Agathosma	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Achyrocline satureioides	Achyrocline	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Corydalis yanhusuo	Corydalis	Papaveraceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Corydalis ternata	Corydalis	Papaveraceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Eremophila oppositifolia	Eremophila	Scrophulariaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Brickellia dentata	Brickellia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Corydalis decumbens	Corydalis	Papaveraceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Tylopilus plumbeoviolaceus	Tylopilus	Boletaceae	Boletales	Agaricomycetes	Basidiomycota	Fungi	Eukaryota
Pycnarrhena novoguineensis	Pycnarrhena	Menispermaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Passiflora coccinea	Passiflora	Passifloraceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Coptis japonica	Coptis	Ranunculaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 355.434

TPSA？: 40.16

MolLogP？: 3.376500000000002

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 4

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	Dopamine D1 receptor	Inhibition	39.8	%	10.1016/j.bmc.2012.12.016
Homo sapiens	Dopamine D1 receptor	Ki	nan	None	10.1016/j.bmc.2012.12.016
Homo sapiens	Dopamine D2 receptor	Inhibition	20.5	%	10.1016/j.bmc.2012.12.016
Homo sapiens	Dopamine D2 receptor	Ki	nan	None	10.1016/j.bmc.2012.12.016
Homo sapiens	Serotonin 1a (5-HT1a) receptor	Inhibition	30.4	%	10.1016/j.bmc.2012.12.016
Homo sapiens	Serotonin 1a (5-HT1a) receptor	Ki	nan	None	10.1016/j.bmc.2012.12.016
Homo sapiens	Serotonin 2a (5-HT2a) receptor	Inhibition	29.7	%	10.1016/j.bmc.2012.12.016
Homo sapiens	Serotonin 2a (5-HT2a) receptor	Ki	nan	None	10.1016/j.bmc.2012.12.016