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Matrine

AlkaPlorer ID: AK001778

Synonym: '6beta-Matrine', '(+)-Darvasamine', '', 'd-Sophoridine', 'Dihydro 5-episophocarpine', 'Allmatrine', 'MLS000029265', '(+)-Allomatrine', 'Tetrahydroisosophoramine', '519-02-8', 'SMR000011610', 'Dodecahydro-3a,7a-diaza-benzodeanthracen-8-one', 'Matridin 15-one', 'Matrine', '(-)-Sophoridine', 'Sophoridine', '5?-Matridin 15-one', '6-Allomatrine', 'MLSMR', '5-Epidihydrosophocarpine', '(+)-Sophoridine', '(+)-Matrine', 'MATRINE'

IUPAC Name: (1S,2R,9R,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

Structure

SMILES: O=C1CCC[C@@H]2[C@@H]3CCCN4CCC[C@H](CN12)[C@@H]34

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InChI: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13-,15+/m1/s1

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InChIKey: ZSBXGIUJOOQZMP-COMQUAJESA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Sophora alopecuroides Sophora Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 248.36999999999995

TPSA？: 23.550000000000004

MolLogP？: 1.8717

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 6.1 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -7.71 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.06 % 10.6019/CHEMBL4495565

Metabolism Information