Cyclo(4-hydroxy-R-Pro-S-Leu)
AlkaPlorer ID: AK001813
Synonym: None
IUPAC Name: (3S,7R,8aR)-7-hydroxy-3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Structure
SMILES: CC(C)C[C@@H]1N=C(O)[C@H]2C[C@@H](O)CN2C1=O
InChI: InChI=1S/C11H18N2O3/c1-6(2)3-8-11(16)13-5-7(14)4-9(13)10(15)12-8/h6-9,14H,3-5H2,1-2H3,(H,12,15)/t7-,8+,9-/m1/s1
InChIKey: YEHIUWVXPQQDMC-HRDYMLBCSA-N
Reference
Gabosines P and Q, new carbasugars from Streptomyces sp. and their α-glucosidase inhibitory activity
PubChem CID: 10537232
LOTUS: LTS0030029
SuperNatural Ⅲ: SN0448066-03
NPASS: NPC96510
{NPAtlas: NPA000032
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Aureobasidium pullulans | Aureobasidium | Saccotheciaceae | Dothideales | Dothideomycetes | Ascomycota | Fungi | Eukaryota |
| Streptomyces sp. RM-14-6 | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 226.27599999999995
TPSA？: 73.13000000000001
MolLogP？: 0.3329999999999999
Number of H-Donors: 2
Number of H-Acceptors: 3
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli | Escherichia coli | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| Homo sapiens | A549 | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| Micrococcus luteus | Micrococcus luteus | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| Salmonella enterica | Salmonella enterica | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| Staphylococcus aureus | Staphylococcus aureus | Activity | None | None | 10.1021/acs.jnatprod.6b00948 |
| None | Unchecked | Inhibition | None | % | 10.1016/j.bmcl.2016.09.021 |