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name Structure Reference Source Properties Activities Metabolism

Nicotine

AlkaPlorer ID: AK001883

Synonym: None

IUPAC Name: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridin-1-ium

Structure

SMILES: CN1CCC[C@H]1C2=CC=CN=C2

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InChI: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m0/s1

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InChIKey: SNICXCGAKADSCV-JTQLQIEISA-O

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Ahnfeltiopsis flabelliformis Ahnfeltiopsis Phyllophoraceae Gigartinales Florideophyceae Rhodophyta None Eukaryota
Laurus nobilis Laurus Lauraceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chondromyces robustus Chondromyces Polyangiaceae Polyangiales None Myxococcota None Bacteria
Tabernaemontana odoratissima Tabernaemontana Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ephedra intermedia Ephedra Ephedraceae Ephedrales Gnetopsida Streptophyta Viridiplantae Eukaryota
Eclipta prostrata Eclipta Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Narcissus cyclamineus Narcissus Amaryllidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces cellulosae Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Rhopaloeides odorabile Rhopaloeides Spongiidae Dictyoceratida Demospongiae Porifera Metazoa Eukaryota
Meconopsis punicea Meconopsis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glaucium leiocarpum Glaucium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota
Clutia abyssinica Clutia Peraceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kielmeyera petiolaris Kielmeyera Calophyllaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hypericum elegans Hypericum Hypericaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Piper nigrum Piper Piperaceae Piperales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver bracteatum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Marchantia paleacea Marchantia Marchantiaceae Marchantiales Marchantiopsida Streptophyta Viridiplantae Eukaryota
Anemarrhena asphodeloides Anemarrhena Asparagaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Euonymus latifolius Euonymus Celastraceae Celastrales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Garcinia lucida Garcinia Clusiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Salvia multicaulis Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Rhododendron reticulatum Rhododendron Ericaceae Ericales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Eutypa lata Eutypa Diatrypaceae Xylariales Sordariomycetes Ascomycota Fungi Eukaryota
Codonopsis pilosula Codonopsis Campanulaceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tanaecium jaroba Tanaecium Bignoniaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Euonymus alatus Euonymus Celastraceae Celastrales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 163.244

TPSA？: 17.380000000000003

MolLogP？: 1.2674

Number of H-Donors: 0

Number of H-Acceptors: 1

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 11.55 % 10.6019/CHEMBL4513141
Aplysia californica Soluble acetylcholine receptor Ki 30.0 nM 10.1021/jf1019455
Aplysia californica Soluble acetylcholine receptor Ki 598.0 nM 10.1021/jm3008739
Aplysia californica Soluble acetylcholine receptor Ki 2511.89 nM 10.1016/j.bmcl.2011.12.008
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans Inhibition 1.61 % 10.6019/CHEMBL4513141
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cryptococcus neoformans Cryptococcus neoformans Inhibition -2.7 % 10.6019/CHEMBL4513141
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 IC50 4000.0 nM 10.1021/jf000873c
Drosophila melanogaster Acetylcholine receptor subunit beta-like 2 Ki 2700.0 nM 10.1021/jf1019455
Electrophorus electricus Acetylcholinesterase Inhibition 15.6 % 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition 1.2 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli Inhibition 6.98 % 10.6019/CHEMBL4513141
Gallus gallus Neuronal acetylcholine receptor subunit alpha-4 Ki 1.9 nM 10.1021/jf1019455
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Activity nan None 10.1021/jm201157c
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Activity nan None 10.1021/jm201301h
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma EC50 1000.0 nM 10.1021/jm301177j
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma IC50 1000.0 nM 10.1021/jm301177j
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Ki 1480.0 nM 10.1016/j.bmcl.2010.06.142
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Ki 5500.0 nM 10.1016/s0960-894x(00)00670-3
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Ki 6270.0 nM 10.1016/j.bmcl.2005.08.035
Homo sapiens Acetylcholine receptor; alpha1/beta1/delta/gamma Ki nan None 10.1021/np3007028
Homo sapiens Acetylcholine receptor protein alpha chain EC50 180000.0 nM 10.1016/S0960-894X(97)10080-4
Homo sapiens Acetylcholine receptor protein alpha chain IC50 21000.0 nM 10.1021/jf000873c
Homo sapiens Acetylcholine receptor protein alpha chain Intrinsic activity 100.0 % 10.1016/S0960-894X(97)10080-4
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 15848.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 39810.7 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 1000000.0 nM 10.1124/dmd.112.047068
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Caco-2 logPapp -4.71 None 10.1016/j.bmc.2009.08.022
Homo sapiens Caco-2 logPapp -4.58 None 10.1016/j.bmc.2011.03.011
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 101.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cerebroside-sulfatase Potency 2393.4 nM None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Chromobox protein homolog 1 Potency 79432.8 nM None
Homo sapiens Cyclooxygenase-1 AC50 22001.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 4100000.0 nM 10.1021/jm0489713
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A13 Kd 54000.0 nM 10.1124/dmd.112.045161
Homo sapiens Cytochrome P450 2A13 Ki 72000.0 nM 10.1124/dmd.112.045161
Homo sapiens Cytochrome P450 2A6 Activity nan None None
Homo sapiens Cytochrome P450 2A6 IC50 26300.0 nM None
Homo sapiens Cytochrome P450 2A6 IC50 579428.7 nM 10.1016/j.ejmech.2008.11.010
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Kd 470000.0 nM 10.1124/dmd.112.045161
Homo sapiens Cytochrome P450 2A6 Ki 4400.0 nM 10.1021/jm049696n
Homo sapiens Cytochrome P450 2A6 Ki 4400.0 nM None
Homo sapiens Cytochrome P450 2A6 Ki 130000.0 nM 10.1124/dmd.112.045161
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2A6 Kinact 71.1 min-1 10.2174/138920005774330639
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 142400.0 nM None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D1 receptor Potency 145.8 nM None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 4 Activity -75.7 nanoampere 10.1124/dmd.111.042432
Homo sapiens Equilibrative nucleoside transporter 4 Activity -6.3 nanoampere 10.1124/dmd.111.042432
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Fibroblast Growth Rate -0.93 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.9 None 10.6019/CHEMBL5303304
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 891.3 nM None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 Potency 4.1 nM None
Homo sapiens HEK-293T Growth Rate 0.38 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.4 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.64 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.69 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.75 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.76 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.85 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.93 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.99 None 10.6019/CHEMBL5303304
Homo sapiens HERG IC50 244299.74 nM 10.1021/jm900002x
Homo sapiens HERG IC50 244300.0 nM 10.1021/jm900002x
Homo sapiens HERG IC50 245470.89 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 245470.89 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 245470.89 nM 10.1016/j.ejmech.2007.12.025
Homo sapiens HERG IC50 245470.89 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -10.6 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 7.48 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 26679.5 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 15.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 18.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 18.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 3.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 3.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.3 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.86 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.35 None 10.1021/jm901371v
Homo sapiens Homo sapiens log Kp -5.26 cm/s 10.1021/jm060230+
Homo sapiens Homo sapiens Vdss 2.6 L.kg-1 10.1021/jm901371v
Homo sapiens IMR-32 EC50 21000.0 nM 10.1021/jm9506884
Homo sapiens IMR-32 EC50 21000.0 nM 10.1021/jm960233u
Homo sapiens IMR-32 Max 100.0 % 10.1021/jm9506884
Homo sapiens IMR-32 Max 100.0 % 10.1021/jm960233u
Homo sapiens Interleukin-8 Potency 47307.9 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K177 cell line EC50 5000.0 nM 10.1021/jm9506884
Homo sapiens K177 cell line Max 100.0 % 10.1021/jm9506884
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Microtubule-associated protein tau Potency 22387.2 nM None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 3162.3 nM None
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 Activity nan None 10.1016/j.bmcl.2013.09.023
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 Activity nan None 10.1016/j.bmcl.2013.09.023
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Activity nan None 10.1016/j.bmcl.2013.09.023
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Activity nan None 10.1016/j.bmcl.2013.09.023
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Activity nan None 10.1016/j.bmcl.2013.09.023
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscle-type nicotinic acetylcholine receptor EC50 65000.0 nM 10.1021/jm960328w
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Ki 103.0 nM 10.1016/j.bmcl.2003.09.081
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Ki 110.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Rmax 85.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Rmax 100.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha2/beta4 Rmax 114.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 EC50 127.0 nM 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Efficacy 26.0 % 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Efficacy 56.0 % 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 IC50 84.8 nM 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 EC50 132000.0 nM 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 IC50 3.8 nM 10.1016/S0960-894X(97)00347-8
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1021/jm0492406
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta2 Rmax 100.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Activity 0.16 ml 10.1021/jm049707c
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Activity 89.0 % 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Activity 100.0 % 10.1021/jm049707c
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 290.0 nM 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 1000.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 4300.0 nM 10.1016/j.bmcl.2003.09.081
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 7000.0 nM 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 7000.0 nM 10.1021/jm3006542
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 7943.28 nM 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 8000.0 nM 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 9400.0 nM 10.1016/j.bmcl.2009.01.099
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 19830.0 nM 10.1021/jm049707c
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 21000.0 nM 10.1021/jm970377o
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 23000.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 EC50 51000.0 nM 10.1021/jm960328w
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Efficacy 61.5 % 10.1016/j.bmcl.2010.06.142
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Efficacy 88.0 % 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Efficacy 92.0 % 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Emax 100.0 % 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 IC50 430.0 nM 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 IC50 1000.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 IC50 10000.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1016/j.bmcl.2016.10.078
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/np3007028
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 261.0 nM 10.1016/j.ejmech.2016.10.048
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 261.0 nM 10.1021/acs.jmedchem.0c01150
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 261.0 nM 10.1021/acs.jmedchem.5b00904
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 320.0 nM 10.1016/j.bmcl.2003.09.081
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 394.0 nM 10.1016/j.bmcl.2010.06.142
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 400.0 nM 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 400.0 nM 10.1021/jm3006542
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 440.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 530.0 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 530.0 nM 10.1016/j.bmcl.2005.04.036
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 530.0 nM 10.1016/j.bmcl.2005.08.035
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 530.0 nM 10.1021/jm050069n
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Ki 1744.44 nM 10.1021/acs.jmedchem.9b00790
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Rmax 40.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Rmax 98.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha3/beta4 Rmax 100.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Activity 0.26 ml 10.1021/jm049707c
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Activity 101.0 % 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Activity nan None 10.1016/j.ejmech.2015.06.039
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 1.0 nM 10.1021/jm300030r
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 290.0 nM 10.1021/jm200855b
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 290.0 nM 10.1021/jm201157c
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 290.0 nM 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 295.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 295.12 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 300.0 nM 10.1021/jm100765u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 300.0 nM 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 316.23 nM 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 800.0 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 2100.0 nM 10.1021/jm960328w
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 2400.0 nM 10.1021/jm4000374
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 2400.0 nM 10.1021/jm4008455
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 2400.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 3000.0 nM 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 3000.0 nM 10.1021/jm3006542
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 4000.0 nM 10.1021/jm970377o
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 4700.0 nM 10.1016/j.bmcl.2009.01.099
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 5000.0 nM 10.1016/S0960-894X(97)10080-4
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 5000.0 nM 10.1016/s0960-894x(98)00019-5
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 6600.0 nM 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 6600.0 nM 10.1021/jm900249k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 6606.93 nM 10.1021/jm070755h
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 9332.54 nM 10.1021/jm070018l
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 EC50 9400.0 nM 10.1021/jm070018l
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 70.0 % 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 70.0 % 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 88.0 % 10.1021/jm100765u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 88.0 % 10.1021/jm200855b
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 88.0 % 10.1021/jm201157c
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 92.0 % 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 92.0 % 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 93.0 % 10.1021/jm100765u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 93.0 % 10.1021/jm200855b
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 93.0 % 10.1021/jm201157c
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 100.0 % 10.1016/j.bmcl.2005.08.035
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 120.0 % 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 124.0 % 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Efficacy 125.0 % 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Emax 100.0 % 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Emax 100.0 % 10.1021/jm4000374
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Emax 100.0 % 10.1021/jm4008455
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 1.2 nM 10.1016/j.bmc.2013.03.024
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 4.9 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 370.0 nM 10.1021/jm4000374
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 370.0 nM 10.1021/jm4008455
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 370.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 398.11 nM 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 426.58 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 427.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 430.0 nM 10.1021/jm100765u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 430.0 nM 10.1021/jm200855b
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 430.0 nM 10.1021/jm201157c
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 430.0 nM 10.1021/jm400510u
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 IC50 430.0 nM 10.1021/ml500129k
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Imax 92.0 % 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Imax 159.0 % 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Inhibition nan % 10.1016/j.bmcl.2005.04.036
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Inhibition nan % 10.1016/j.bmcl.2005.08.035
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Intrinsic activity 100.0 % 10.1016/S0960-894X(97)10080-4
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.045 nM 10.1016/j.ejmech.2018.04.026
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.6 nM 10.1016/j.bmc.2013.03.024
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.05 nM 10.1007/s00044-005-0137-8
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.2 nM 10.1016/j.bmcl.2004.05.020
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1016/j.ejmech.2020.112403
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/acs.jmedchem.7b01113
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/jm0704696
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.6 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.6 nM 10.1016/j.bmcl.2005.04.036
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.6 nM 10.1016/j.bmcl.2005.08.035
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1016/j.bmcl.2003.07.035
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1021/jm010508s
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1021/jm3006542
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1021/jm301048a
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.1 nM 10.1016/j.bmcl.2003.10.033
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.2 nM 10.1021/acs.jmedchem.9b00790
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.3 nM 10.1016/s0960-894x(00)00670-3
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1021/jm990093z
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 5.5 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.1 nM 10.1016/j.bmcl.2003.09.081
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.46 nM 10.1016/j.bmcl.2010.06.142
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1021/jm4008455
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 12.59 nM 10.1016/j.bmcl.2011.12.008
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Ki 10000.0 nM 10.1016/j.bmcl.2005.02.045
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Max 100.0 % 10.1016/s0960-894x(98)00019-5
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Response 100.0 % 10.1016/j.bmcl.2005.04.036
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Response 100.0 % 10.1021/jm050069n
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Rmax 3.5 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta2 Rmax 73.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 EC50 7100.0 nM 10.1021/jm960328w
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/ml3002715
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM None
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Ki 70.0 nM 10.1021/jm301177j
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Ki 129.0 nM 10.1016/j.bmcl.2003.09.081
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Rmax 85.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Rmax 100.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor; alpha4/beta4 Rmax 108.0 % 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 1584.89 nM 10.1016/j.bmcl.2009.01.073
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 4710.0 nM 10.1021/acs.jmedchem.8b01372
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 38000.0 nM 10.1016/s0960-894x(00)00670-3
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 83000.0 nM 10.1021/jm970377o
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 91000.0 nM 10.1021/jm900249k
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit EC50 113000.0 nM 10.1021/jm040219e
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Emax 100.0 % 10.1016/j.bmcl.2009.01.073
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit IC50 7600.0 nM 10.1016/j.bmc.2013.03.024
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit IC50 21000.0 nM 10.1021/jf000873c
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Kd 1.06 nM 10.1016/j.bmcl.2004.12.069
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 620.0 nM 10.1021/jm990093z
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 630.0 nM 10.1016/j.bmcl.2005.08.035
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1000.0 nM 10.1016/j.bmc.2011.08.028
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1000.0 nM 10.1016/j.bmcl.2011.12.008
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1000.0 nM 10.1021/jm801400g
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1023.29 nM 10.1021/jm100834y
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1610.0 nM 10.1021/jm960233u
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 2110.0 nM 10.1016/j.bmcl.2010.06.142
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 3000.0 nM 10.1016/j.bmcl.2013.04.058
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 3000.0 nM 10.1021/jm3006542
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 3000.0 nM 10.1021/jm301048a
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 3800.0 nM 10.1016/j.bmc.2013.03.024
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 6290.0 nM 10.1016/j.bmc.2020.115820
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 6300.0 nM 10.1016/j.bmcl.2005.04.036
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 7200.0 nM 10.1016/j.bmcl.2004.12.069
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 10000.0 nM 10.1021/jm070574f
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 12000.0 nM 10.1021/jm070574f
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 24000.0 nM 10.1021/jm070574f
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki 25118.86 nM 10.1021/jm070574f
Homo sapiens Neuronal acetylcholine receptor protein alpha-7 subunit Ki nan None 10.1016/j.ejmech.2020.112403
Homo sapiens Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 Activity nan None 10.1021/jm201157c
Homo sapiens Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 EC50 30000.0 nM 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 Efficacy 90.0 % 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 Efficacy nan None 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 IC50 nan None 10.1021/jm201301h
Homo sapiens Neuronal acetylcholine receptor subunit alpha-3 IC50 45.0 nM 10.1021/jf000873c
Homo sapiens Neuronal acetylcholine receptor subunit alpha-3 Ki 220.0 nM 10.1016/s0960-894x(00)00670-3
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Nicotinic acetylcholine receptor alpha2/beta4 EC50 10000.0 nM 10.1021/jm960328w
Homo sapiens Nicotinic acetylcholine receptor alpha3/betaX EC50 21000.0 nM 10.1016/s0960-894x(98)00019-5
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 47307.9 nM None
Homo sapiens Nuclear receptor ROR-gamma Potency 33491.5 nM None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 94.7 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 422.8 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 2667.9 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 10000.0 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3 (5-HT3) receptor Ki 71000.0 nM 10.1016/s0960-894x(00)00670-3
Homo sapiens Serotonin 3a (5-HT3a) receptor Ki nan None 10.1021/jm070574f
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 10000.0 nM 10.1021/jm00103a005
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Skin log Kp -5.35 None 10.1016/j.bmc.2007.07.050
Homo sapiens Skin log Kp -5.26 None 10.1021/jm0611105
Homo sapiens Solute carrier family 22 member 1 Activity 53.2 uM 10.1124/mol.63.3.489
Homo sapiens Solute carrier family 22 member 1 Activity nan None None
Homo sapiens Solute carrier family 22 member 1 Inhibition -3.7 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 2 Activity nan None 10.1097/01.asn.0000019413.78751.46
Homo sapiens Solute carrier family 22 member 4 Activity 71.6 % None
Homo sapiens Solute carrier family 22 member 5 Activity 44.0 % 10.1006/bbrc.1998.8669
Homo sapiens Solute carrier family 22 member 5 Activity 82.6 % None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 6.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 11.0 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -16.5 % 10.1021/jm300212s
Homo sapiens TAR DNA-binding protein 43 Potency 39810.7 nM None
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Transient receptor potential cation channel subfamily A member 1 Activity nan None 10.1016/j.ejmech.2019.02.074
Homo sapiens Transient receptor potential cation channel subfamily A member 1 EC50 2000.0 nM 10.1016/j.ejmech.2019.02.074
Homo sapiens Transient receptor potential cation channel subfamily A member 1 EC50 17000.0 nM 10.1021/jm100062h
Homo sapiens Transient receptor potential cation channel subfamily A member 1 EC50 457088189.61 nM 10.1016/j.ejmech.2019.02.074
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4109.5 nM None
Homo sapiens U2OS Growth Rate -1.0 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.33 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.16 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.24 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.66 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.77 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate 0.86 None 10.6019/CHEMBL5303304
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition -4.81 % 10.6019/CHEMBL4513141
Lymnaea stagnalis Acetylcholine-binding protein Kd 316.23 nM 10.1016/j.ejmech.2015.07.024
Lymnaea stagnalis Acetylcholine-binding protein Kd 320.0 nM 10.1016/j.ejmech.2015.07.024
Lymnaea stagnalis Acetylcholine-binding protein Kd 478.63 nM 10.1021/jm100834y
Lymnaea stagnalis Acetylcholine-binding protein Ki 63.1 nM 10.1021/jm801400g
Lymnaea stagnalis Acetylcholine-binding protein Ki 83.0 nM 10.1021/jm301409f
Lymnaea stagnalis Acetylcholine-binding protein Ki 83.18 nM 10.1021/jm301409f
Lymnaea stagnalis Acetylcholine-binding protein Ki 100.0 nM 10.1021/jf1019455
Lymnaea stagnalis Acetylcholine-binding protein Ki 316.23 nM 10.1016/j.bmc.2011.08.028
Lymnaea stagnalis Acetylcholine-binding protein Ki 316.23 nM 10.1016/j.bmcl.2011.12.008
Lymnaea stagnalis Acetylcholine-binding protein Ki 331.13 nM 10.1021/jm100834y
Lymnaea stagnalis Acetylcholine-binding protein Ki 496.0 nM 10.1021/jm3008739
Musca domestica Acetylcholinesterase IC50 2600000.0 nM 10.1584/jpestics.17.4_231
Musca domestica Musca domestica Activity 38.3 % 10.1584/jpestics.29.43
Musca domestica Musca domestica Activity nan None 10.1584/jpestics.20.57
Musca domestica Musca domestica FC 1.0 None 10.1584/jpestics.17.4_231
Musca domestica Musca domestica LD50 14.8 ug 10.1584/jpestics.20.57
Musca domestica Musca domestica LD50 50.0 mg.kg-1 10.1021/jf000873c
Musca domestica Nicotinic acetylcholine receptor alpha 5 subunit Activity 11.9 uM 10.1584/jpestics.29.43
Musca domestica Nicotinic acetylcholine receptor alpha 5 subunit IC50 11900.0 nM 10.1271/bbb.67.980
Musca domestica Nicotinic acetylcholine receptor alpha 5 subunit Ki 2480.0 nM 10.1584/jpestics.17.4_231
Mus musculus Cytochrome P450 2A5 IC50 159955.8 nM 10.1016/j.ejmech.2008.11.010
Mus musculus Mus musculus Amnesia reversal 0.0 % 10.1021/jm00371a023
Mus musculus Mus musculus Amnesia reversal 5.0 % 10.1021/jm00371a023
Mus musculus Mus musculus Amnesia reversal 20.0 % 10.1021/jm00371a023
Mus musculus Mus musculus Bmax 544.0 fM mg-1 10.1021/jm00074a019
Mus musculus Mus musculus ED50 0.001 mg.kg-1 10.1021/jm015561v
Mus musculus Mus musculus ED50 0.004 mg.kg-1 10.1021/jm015561v
Mus musculus Mus musculus ED50 0.006 mg.kg-1 10.1021/jm015561v
Mus musculus Mus musculus ED50 0.3 mg.kg-1 10.1016/S0960-894X(97)00347-8
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1016/j.bmc.2007.10.027
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1016/j.bmc.2015.07.021
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1016/j.bmcl.2004.05.020
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1021/jm040078g
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1021/jm040160b
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1021/jm060122n
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1021/jm401602p
Mus musculus Mus musculus ED50 0.5 mg.kg-1 10.1021/np9006124
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1016/j.bmc.2007.10.027
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1016/j.bmc.2015.07.021
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1021/jm040078g
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1021/jm040160b
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1021/jm060122n
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1021/jm401602p
Mus musculus Mus musculus ED50 0.65 mg.kg-1 10.1021/np9006124
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1016/j.bmc.2007.10.027
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1016/j.bmc.2015.07.021
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/jm040078g
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/jm040160b
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/jm060122n
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/jm401602p
Mus musculus Mus musculus ED50 1.0 mg.kg-1 10.1021/np9006124
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1016/j.bmc.2007.10.027
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1016/j.bmc.2015.07.021
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1021/jm040078g
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1021/jm040160b
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1021/jm060122n
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1021/jm401602p
Mus musculus Mus musculus ED50 1.3 mg.kg-1 10.1021/np9006124
Mus musculus Mus musculus ED50 1.5 mg.kg-1 10.1016/j.bmcl.2004.05.020
Mus musculus Mus musculus ED50 1.5 mg.kg-1 10.1016/s0960-894x(03)00585-7
Mus musculus Mus musculus ED50 3.1 umol.kg-1 10.1016/s0960-894x(02)00614-5
Mus musculus Mus musculus ED50 4.44 umol.kg-1 10.1021/jm00074a019
Mus musculus Mus musculus ED50 4.81 umol.kg-1 10.1021/jm00074a019
Mus musculus Mus musculus ED50 7.4 umol.kg-1 10.1016/s0960-894x(02)00614-5
Mus musculus Mus musculus ED50 9.0 mg.kg-1 10.1016/S0960-894X(97)00347-8
Mus musculus Mus musculus ED50 12.0 mg.kg-1 10.1016/j.bmcl.2004.05.020
Mus musculus Mus musculus ED50 12.0 ug mouse-1 10.1016/s0960-894x(00)00541-2
Mus musculus Mus musculus ED50 12.0 ug mouse-1 10.1016/s0960-894x(03)00585-7
Mus musculus Mus musculus ED50 22.7 mg.kg-1 10.1021/jm901688m
Mus musculus Mus musculus ED50 74.0 nM mouse-1 10.1021/jm0100178
Mus musculus Mus musculus EDmin 0.62 uM kg-1 10.1021/jm960233u
Mus musculus Mus musculus EDmin 6.2 uM kg-1 10.1021/jm960233u
Mus musculus Mus musculus EDmin 41.0 uM kg-1 10.1021/jm960233u
Mus musculus Mus musculus Inhibition 88.0 % 10.1016/j.bmcl.2005.12.073
Mus musculus Mus musculus Inhibition 100.0 % 10.1016/j.bmcl.2005.12.073
Mus musculus Mus musculus Kd 1.41 nM 10.1021/jm00074a019
Mus musculus Mus musculus LD50 6.0 mg.kg-1 10.1021/jf000873c
Mus musculus Mus musculus Retention 27.0 % 10.1021/jm00135a020
Mus musculus Mus musculus Retention 53.0 % 10.1021/jm00135a020
Mus musculus Mus musculus Retention 70.0 % 10.1021/jm00135a020
Mus musculus Mus musculus Retention 75.0 % 10.1021/jm00135a020
Mus musculus Mus musculus Retention nan None 10.1021/jm00135a020
Mus musculus Neuronal acetylcholine receptor protein alpha-4 subunit IC50 7.0 nM 10.1021/jf000873c
Mus musculus Neuronal acetylcholine receptor protein alpha-7 subunit Efficacy 53.0 % 10.1016/s0960-894x(00)00670-3
Mus musculus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 244.0 nM 10.1021/jm3011299
Mus musculus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 480.0 nM 10.1016/s0960-894x(00)00670-3
Mus musculus Neuronal acetylcholine receptor subunit alpha-3/beta-4 Ki 167.0 nM 10.1021/jm3011299
Mus musculus Neuronal acetylcholine receptor subunit alpha-4/beta-2 EC50 720.0 nM 10.1016/j.ejmech.2015.07.029
Mus musculus Neuronal acetylcholine receptor subunit alpha-4/beta-2 EC50 724.44 nM 10.1016/j.ejmech.2015.07.029
Mus musculus Neuronal nicotinic acetylcholine receptor IC50 4.0 nM 10.1021/jm960328w
Mus musculus Neuronal nicotinic acetylcholine receptor Ki 1.2 nM 10.1016/s0960-894x(02)00614-5
Mus musculus Nicotinic acetylcholine receptor alpha-4/beta-2 Ki 3.5 nM 10.1021/jm3011299
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Transient receptor potential cation channel subfamily A member 1 EC50 10000.0 nM 10.1016/j.ejmech.2019.02.074
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Pantoea ananas Lycopene cyclase Activity 64.0 % 10.1584/jpestics.23.113
Pantoea ananas Lycopene cyclase IC50 4800.0 nM 10.1584/jpestics.23.113
Periplaneta americana Periplaneta americana MLD 310.0 nmol 10.1584/jpestics.29.43
Periplaneta americana Periplaneta americana MLD 490.0 nmol 10.1584/jpestics.29.43
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition -4.09 % 10.6019/CHEMBL4513141
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Inositol monophosphatase 1 Potency 28183.8 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Muscarinic acetylcholine receptor IC50 28000.0 nM 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Muscarinic acetylcholine receptor IC50 32000.0 nM 10.1021/jm9910627
Rattus norvegicus Muscarinic acetylcholine receptor IC50 360000.0 nM 10.1021/jm960328w
Rattus norvegicus Muscarinic acetylcholine receptor Ki 5000.0 nM 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Muscarinic acetylcholine receptor Ki 10000.0 nM 10.1016/j.bmcl.2007.12.075
Rattus norvegicus Muscarinic acetylcholine receptor Ki nan nM 10.1016/j.bmcl.2004.09.044
Rattus norvegicus Neuronal acetylcholine receptor Dopamine release 126.0 % 10.1021/jm00052a005
Rattus norvegicus Neuronal acetylcholine receptor EC50 20000.0 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor Enhancement 5.0 % 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Enhancement 8.0 % 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor IC50 3.0 nM 10.1021/jm00398a004
Rattus norvegicus Neuronal acetylcholine receptor IC50 4.0 nM 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Neuronal acetylcholine receptor IC50 6.6 nM 10.1021/jm9910627
Rattus norvegicus Neuronal acetylcholine receptor IC50 7.0 nM 10.1021/jm00398a004
Rattus norvegicus Neuronal acetylcholine receptor Inhibition 100.0 % 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor K app 6.2 nM 10.1021/jm970187d
Rattus norvegicus Neuronal acetylcholine receptor Kd 4.9e-06 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 0.01 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 0.022 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 5.2 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 10.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 430.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 11000.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 45000.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 43000000.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.0 nM 10.1016/S0960-894X(97)10080-4
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.0 nM 10.1021/jm9506884
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.0 nM 10.1021/jm960233u
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.1 nM 10.1021/jm00052a005
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.15 nM 10.1016/0960-894X(95)00154-L
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.15 nM 10.1021/jm00047a012
Rattus norvegicus Neuronal acetylcholine receptor Ki 1.3 nM 10.1016/s0960-894x(02)00298-6
Rattus norvegicus Neuronal acetylcholine receptor Ki 2.4 nM 10.1016/s0960-894x(03)00585-7
Rattus norvegicus Neuronal acetylcholine receptor Ki 8.4 nM 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Neuronal acetylcholine receptor Ki 13.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor Ki 27.0 nM 10.1016/j.bmcl.2003.09.081
Rattus norvegicus Neuronal acetylcholine receptor Mean enhancement of binding 4.7 None 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Relative potency 0.71 None 10.1021/jm00398a004
Rattus norvegicus Neuronal acetylcholine receptor Relative potency 3.3 None 10.1021/jm00398a004
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 5.5 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 12.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Ki 15.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 70.0 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 110.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 110.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 110.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 110.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 112.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Ki 112.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 1.0 nM 10.1016/s0960-894x(01)00193-7
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 29.0 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 43.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Ki 47.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Activity 37.0 % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Activity nan None 10.1021/jm200937t
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 1500.0 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 1513.56 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 23000.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 24000.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 35000.0 nM 10.1021/jm051196m
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 EC50 86000.0 nM 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Emax 37.0 % 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Emax 100.0 % 10.1021/jm051196m
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Emax 100.0 % 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Emax 100.0 % 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 IC50 10000.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 IC50 10000.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Imax 0.69 None 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Imax nan None 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Inhibition nan % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 199.53 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 220.0 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 230.0 nM 10.1021/acsmedchemlett.5b00028
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 250.0 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 251.19 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 260.0 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 288.4 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 290.0 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 440.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 440.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 440.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 440.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 443.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 443.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 443.0 nM 10.1021/jm0492406
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 481.0 nM 10.1021/jm1006148
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 530.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 600.0 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Ki 630.96 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Stimulation 100.0 % 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Activity 24.0 % 10.1016/j.bmcl.2012.10.012
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Activity 40.0 % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Activity 80.0 % 10.1016/j.bmcl.2012.10.012
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Activity 333.0 % 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Activity nan None 10.1016/j.bmcl.2012.10.012
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 7.3 nM 10.1021/jm0103561
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 67.0 nM 10.1021/jm200937t
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 67.61 nM 10.1021/jm200937t
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 77.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 210.0 nM 10.1016/j.ejmech.2015.09.006
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 220.0 nM 10.1021/np3007028
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 590.0 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 591.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 1000.0 nM 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 4000.0 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 10000.0 nM 10.1021/jm051196m
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 14000.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 EC50 19000.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Emax 40.0 % 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Emax 87.0 % 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Emax 100.0 % 10.1021/jm051196m
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 IC50 1.65 nM 10.1016/j.bmcl.2009.06.059
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 IC50 3.8 nM 10.1021/jm980721x
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Imax 0.17 None 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Imax nan None 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Inhibition nan % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.84 nM 10.1021/jm010936y
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.9333 nM 10.1021/jm070018l
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.94 nM 10.1016/j.bmcl.2009.01.099
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.94 nM 10.1021/jm020916b
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.94 nM 10.1021/jm070018l
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.94 nM 10.1021/jm900249k
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.95 nM 10.1016/j.bmcl.2005.04.036
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 0.95 nM 10.1021/jm050069n
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1016/j.bmcl.2004.02.007
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1016/s0960-894x(02)00849-1
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1021/jm010129z
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.0 nM 10.1021/jm9705115
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.01 nM 10.1021/jm0100178
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.05 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.3 nM 10.1016/s0960-894x(02)01031-4
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.4 nM 10.1016/j.bmc.2009.12.002
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.4 nM 10.1016/s0960-894x(02)00687-x
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1016/j.bmc.2007.10.027
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/jm0100178
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/jm040078g
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/jm040160b
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/jm060122n
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.5 nM 10.1021/np9006124
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 1.8 nM 10.1016/j.bmcl.2005.06.053
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1016/j.bmcl.2004.09.044
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1016/j.ejmech.2010.09.009
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.0 nM 10.1021/jm3006542
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.1 nM 10.1016/j.ejmech.2015.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.3 nM 10.1021/jm000249r
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 2.83 nM 10.1016/j.bmcl.2012.10.012
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 3.0 nM 10.1021/jm070325r
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1016/j.bmcl.2006.08.020
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1016/j.bmcl.2007.12.075
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1016/j.bmcl.2008.12.002
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1016/j.bmcl.2013.09.023
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1016/j.bmcl.2016.10.078
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1021/acs.jmedchem.0c01150
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.0 nM 10.1021/acs.jmedchem.5b00904
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.1 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 4.9 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 5.6 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 6.2 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 6.31 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 6.8 nM 10.1021/jm070325r
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 7.0 nM 10.1016/j.bmcl.2007.10.101
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 7.586 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 7.6 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 8.0 nM 10.1021/jm0103561
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.8 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.8 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.8 nM 10.1021/jm301177j
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.8 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 9.8 nM 10.1021/ml3002715
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1021/jm0492406
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 10.0 nM 10.1021/np3007028
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 11.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 11.0 nM 10.1021/acsmedchemlett.5b00028
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 11.1 nM 10.1021/jm1006148
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 12.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 13.0 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 14.13 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 19.95 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 22.0 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Ki 35.0 nM 10.1016/j.bmcl.2005.04.072
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 5.5 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm100765u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm200855b
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm201157c
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/jm400510u
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 23.0 nM 10.1021/ml500129k
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 31.62 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 33.0 nM 10.1021/jm070574f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1016/j.bmcl.2003.10.071
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1016/j.bmcl.2005.06.039
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1021/jm025613w
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 40.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 46.0 nM 10.1016/j.bmcl.2003.09.105
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 51.0 nM 10.1021/acsmedchemlett.5b00028
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 72.0 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 72.44 nM 10.1016/j.ejmech.2015.07.029
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 140.0 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 141.25 nM 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 150.0 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Ki 158.49 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-2 subunit Ki 12.0 nM 10.1016/j.bmc.2009.05.021
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Activity 43.0 % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 1071.52 nM 10.1021/jm3013568
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 1500.0 nM 10.1016/j.bmc.2007.11.068
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 13000.0 nM 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 23000.0 nM 10.1021/jm301048a
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 47000.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 54000.0 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 108700.0 nM 10.1016/j.bmcl.2015.05.094
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 109647.82 nM 10.1016/j.bmcl.2015.05.094
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit EC50 43000000.0 nM 10.1021/jm000249r
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Emax 43.0 % 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Emax 102.0 % 10.1021/jm3013568
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Emax 103.0 % 10.1021/jm301048a
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit IC50 16.0 nM 10.1016/s0960-894x(99)00477-1
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Imax 0.6 None 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Imax nan None 10.1021/jm401602p
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Inhibition nan % 10.1016/j.bmc.2015.07.021
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Intrinsic activity 59.0 % 10.1021/jm000249r
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 130.0 nM 10.1021/jm010936y
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 176.0 nM 10.1021/jm900249k
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 230.0 nM 10.1021/np3007028
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 234.0 nM 10.1016/j.bmcl.2006.08.020
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 234.0 nM 10.1016/j.bmcl.2008.12.002
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 234.0 nM 10.1016/j.bmcl.2013.09.023
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 234.0 nM 10.1021/acs.jmedchem.0c01150
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 234.0 nM 10.1021/acs.jmedchem.5b00904
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 250.0 nM 10.1016/j.ejmech.2015.06.039
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 340.0 nM 10.1016/s0960-894x(02)00849-1
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 400.0 nM 10.1016/j.bmc.2020.115820
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 450.0 nM 10.1016/s0960-894x(02)00687-x
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 450.0 nM 10.1021/jm070325r
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 460.0 nM 10.1016/j.bmcl.2004.09.044
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 469.0 nM 10.1016/j.ejmech.2010.09.009
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 480.0 nM 10.1021/jm000249r
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 517.0 nM 10.1021/jm4000374
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 517.0 nM None
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 520.0 nM 10.1021/jm4008455
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 610.0 nM 10.1021/jm401184f
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 670.0 nM 10.1016/j.bmc.2007.10.027
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 750.0 nM 10.1016/j.bmcl.2006.05.080
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 770.0 nM 10.1016/j.bmcl.2005.05.118
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 770.0 nM 10.1016/s0960-894x(01)00193-7
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1400.0 nM 10.1016/j.bmcl.2011.12.126
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1500.0 nM 10.1016/j.bmcl.2007.12.075
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 1748.0 nM 10.1016/j.bmcl.2005.02.045
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 4000.0 nM 10.1021/jm010129z
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 4000.0 nM 10.1021/jm970377o
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 6290.0 nM 10.1021/jm050069n
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 15000.0 nM 10.1021/acsmedchemlett.5b00028
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 15848.93 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki 16000.0 nM 10.1021/jm701625v
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki nan None 10.1021/jm201301h
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ki nan None 10.1021/jm301409f
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Ratio 0.93 None 10.1016/j.bmcl.2015.05.094
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Rmax 74.0 % 10.1021/jm040219e
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Rmax 97.0 % 10.1021/jm040219e
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-9 subunit IC50 2.4 nM 10.1021/jm990035d
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-9 subunit Kd 5.0 nM 10.1021/jm980233p
Rattus norvegicus Neuronal acetylcholine receptor subunit alpha-6/beta-3 Ki 3.3 nM 10.1016/j.ejmech.2015.06.039
Rattus norvegicus Neuronal acetylcholine receptor subunit beta-4 Ki 73.0 nM 10.1021/jm010936y
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.95 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus Activity 1.0 None 10.1021/jm990035d
Rattus norvegicus Rattus norvegicus Activity 25.0 % 10.1016/j.bmcl.2005.12.073
Rattus norvegicus Rattus norvegicus Activity 30.0 % 10.1016/j.ejmech.2014.04.044
Rattus norvegicus Rattus norvegicus Activity 50.0 % 10.1016/j.bmcl.2005.12.073
Rattus norvegicus Rattus norvegicus Activity 96.0 % 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Rattus norvegicus Activity 98.3 % 10.1021/jm060122n
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1016/j.bmcl.2005.12.073
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Rattus norvegicus Activity 180.0 % 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Rattus norvegicus ALB 39500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 363.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 372.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 383.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 391.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 397.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 398.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 53.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 58.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 64.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 91.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 99.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 118.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 110.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 126.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 145.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 623.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 640.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 660.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 678.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 690.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 716.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 196.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 288.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 315.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 441.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 771.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 1308.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 22000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 22830000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Concentration 0.86 nM g-1 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Concentration 2.0 nM g-1 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Concentration 2.18 nM g-1 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Concentration 134.0 nM g-1 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Control 140.0 % 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Control 144.0 % 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Control 151.0 % 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus Control 157.0 % 10.1016/S0960-894X(01)80157-8
Rattus norvegicus Rattus norvegicus CREAT 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EC50 40.0 nM 10.1021/jm970377o
Rattus norvegicus Rattus norvegicus EC50 40000.0 nM 10.1016/S0960-894X(97)10080-4
Rattus norvegicus Rattus norvegicus ED50 0.04 mg.kg-1 10.1016/S0960-894X(97)00347-8
Rattus norvegicus Rattus norvegicus ED50 0.6 umol.kg-1 10.1016/s0960-894x(02)00614-5
Rattus norvegicus Rattus norvegicus ED50 10.0 nM 10.1021/jm00398a004
Rattus norvegicus Rattus norvegicus Efficacy 1.0 None 10.1021/jm990035d
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 80.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 274.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1403.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1466.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1503.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1565.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1823.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1875.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.63 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.65 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 38.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 145700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 152300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus I.D./g tissue 0.2 % 10.1021/jm9910223
Rattus norvegicus Rattus norvegicus I.D./g tissue 0.3 % 10.1021/jm9910223
Rattus norvegicus Rattus norvegicus Intrinsic activity 100.0 % 10.1016/S0960-894X(97)10080-4
Rattus norvegicus Rattus norvegicus Ka 4400.0 M-1 10.1021/jm00182a028
Rattus norvegicus Rattus norvegicus Ka 4700000.0 M-1 10.1021/jm00182a028
Rattus norvegicus Rattus norvegicus LDH 131.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 207.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 226.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 290.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 380.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 544.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 16.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9380.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10299.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10386.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12164.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13301.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13562.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.1 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.97 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.23 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.65 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 391700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 392000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 398800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.0 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.83 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.95 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.73 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.87 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.35 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 88.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 97.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 176.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 180.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 210.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 4.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 455.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 827.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1008.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1085.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1096.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1187.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 95.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 117.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 125.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 142.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1016670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1167670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1256670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1285330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1341670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1370000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.92 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.07 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.48 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.81 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 66000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5160000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5540000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5660000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5670000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5820000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6330000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Relative potency 1.0 None 10.1021/jm00398a004
Rattus norvegicus Rattus norvegicus Relative potency 1.0 None 10.1021/jm010129z
Rattus norvegicus Rattus norvegicus Release 100.0 % 10.1021/jm960328w
Rattus norvegicus Rattus norvegicus SODIUM 142.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.23 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.87 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 2.0 hr 10.1016/j.bmc.2016.02.035
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 21.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 28.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9930.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11480.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13700.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14750.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 1 Ki 64300.0 nM None
Rattus norvegicus Solute carrier family 22 member 2 Activity nan None 10.1016/s0005-2736(99)00005-x
Rattus norvegicus Solute carrier family 22 member 2 Ki 50500.0 nM None
Rattus norvegicus Solute carrier family 22 member 3 Activity 52.0 % 10.1074/jbc.273.26.15971
Rattus norvegicus Solute carrier family 22 member 4 Activity 29.0 % 10.1016/s0005-2736(00)00189-9
Rattus norvegicus Solute carrier family 22 member 5 Inhibition nan % None
Rattus norvegicus Striatum EC50 199.53 nM 10.1021/jm070018l
Rattus norvegicus Striatum EC50 200.0 nM 10.1021/jm070018l
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 44668.4 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 22.06 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.06 % 10.6019/CHEMBL4495565
Staphylococcus aureus Staphylococcus aureus Inhibition -15.48 % 10.6019/CHEMBL4513141
Torpedo californica Acetylcholine receptor EC50 60000.0 nM 10.1021/jm970377o
Torpedo californica Acetylcholine receptor IC50 1.0 nM 10.1021/jm00398a004
Torpedo californica Acetylcholine receptor IC50 4.0 nM 10.1021/jm00398a004
Torpedo californica Acetylcholine receptor Ki 6270.0 nM 10.1021/jm050069n
Torpedo californica Acetylcholine receptor Ki 10000.0 nM 10.1021/jm970377o
Torpedo californica Acetylcholine receptor Relative potency 0.1 None 10.1021/jm00398a004
Torpedo californica Acetylcholine receptor Relative potency 0.25 None 10.1021/jm00398a004
Torpedo californica Acetylcholine receptor protein alpha chain Activity nan None 10.1584/jpestics.20.33
Torpedo californica Acetylcholine receptor protein alpha chain Activity nan None 10.1584/jpestics.20.49
Torpedo californica Acetylcholine receptor protein alpha chain IC50 23100.0 nM 10.1584/jpestics.20.33
Torpedo californica Acetylcholine receptor protein alpha chain IC50 23100.0 nM 10.1584/jpestics.20.49
Torpedo californica Acetylcholine receptor protein delta chain EC50 160000.0 nM 10.1021/jm970377o
Xenopus sp. Xenopus sp. Response 100.0 % 10.1016/S0960-894X(97)00347-8
None ADMET Activity 1.0 % 10.1021/jm060230+
None ADMET Activity 4.1 % 10.1021/jm060230+
None ADMET Activity 27.5 % 10.1021/jm060230+
None ADMET Activity 30.2 % 10.1021/jm060230+
None ADMET Activity 44.6 % 10.1021/jm060230+
None ADMET Activity nan None 10.1016/j.bmcl.2014.01.005
None ADMET Binding energy 11.2 kCal mol-1 10.1021/jm00378a021
None ADMET CL 14.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 18.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 19.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 42.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 66.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET delta logD -0.82 None 10.1021/jm0000564
None ADMET eLog D 0.23 None 10.1021/jm0200409
None ADMET F 49.0 % 10.1021/jm0000564
None ADMET Fraction ionised 0.834 None 10.1021/jm0200409
None ADMET Fu 0.15 None 10.1021/jm0200409
None ADMET Fu 0.95 None 10.1021/jm0200409
None ADMET Fu 0.95 None 10.1021/jm030408h
None ADMET log Kp -4.29 cm/s 10.1021/jm060230+
None ADMET log Pe -4.86 cm/s 10.1021/jm060230+
None ADMET log Pe -4.58 cm/s 10.1021/jm060230+
None ADMET log Pe -4.58 None 10.1021/jm0611105
None ADMET log Pe -4.23 cm/s 10.1021/jm060230+
None ADMET logP(lung) 0.32 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 2.4 hr 10.1124/dmd.108.020479
None ADMET Ratio 0.11 None 10.1124/dmd.112.045161
None ADMET Ratio Ki 0.55 None 10.1124/dmd.112.045161
None ADMET T1/2 0.1 hr 10.1021/acs.jnatprod.0c01044
None ADMET T1/2 0.9 hr 10.1021/acs.jnatprod.0c01044
None ADMET T1/2 2.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.5 L.kg-1 10.1002/jps.20373
None ADMET Vdss 2.6 L.kg-1 10.1002/jps.20373
None ADMET Vdss 2.6 L.kg-1 10.1021/jm0200409
None ADMET Vdss 2.6 L.kg-1 10.1021/jm030408h
None ADMET Vdss 2.6 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 3.3 L.kg-1 10.1002/jps.20373
None ADMET Vdss 4.7 mL/min/kg 10.1002/jps.20373
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.3 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.9 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.6 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.6 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None NON-PROTEIN TARGET Activity 63.6 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 65.2 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 67.0 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 70.5 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 72.0 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 73.3 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 75.3 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 76.4 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 80.0 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity 85.8 % 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2014.02.008
None NON-PROTEIN TARGET EC50 941600.0 nM 10.1128/aac.00523-08
None NON-PROTEIN TARGET EC50 1963000.0 nM 10.1128/aac.00523-08
None NON-PROTEIN TARGET Fu 0.95 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET IC50 3600.0 nM 10.1128/aac.00523-08
None NON-PROTEIN TARGET IC50 3700.0 nM 10.1128/aac.00523-08
None NON-PROTEIN TARGET IC50 5800.0 nM 10.1128/aac.00523-08
None NON-PROTEIN TARGET IC50 6200.0 nM 10.1128/aac.00523-08
None No relevant target LogD -0.34 None 10.1021/jm0000564
None No relevant target LogD 0.4 None 10.1021/jm0100990
None No relevant target log K -0.02 None 10.1021/jm9003945
None No relevant target log K 0.14 None 10.1021/jm9003945
None No relevant target LogP 1.17 None 10.1021/jm0611105
None No relevant target LogP 1.22 None 10.1021/jm801441s
None No relevant target LogP 1.34 None 10.1021/jm9003945
None No relevant target LogP 1.39 None 10.1021/jm801441s
None No relevant target Log PNalk 0.03 None 10.1021/jm048980b
None No relevant target pKa 3.4 None 10.1021/jm9003945
None No relevant target pKa 7.66 None 10.1584/jpestics.17.4_231
None No relevant target pKa 7.9 None 10.1584/jpestics.17.4_231
None No relevant target pKa 8.0 None 10.1021/jm0000564
None No relevant target pKa 8.08 None 10.1021/jm060230+
None No relevant target pKa 8.1 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.1 None 10.1021/jm0200409
None No relevant target pKa 8.1 None 10.1021/jm030408h
None No relevant target pKa 8.11 None 10.1007/s11095-013-1232-z
None No relevant target Retention_time 3.16 min 10.1021/jf000873c
None No relevant target Retention_time 3.18 min 10.1021/jf000873c
None No relevant target Retention_time 11.23 min 10.1021/jf000873c
None Unchecked Activity 75.0 % 10.1021/np50094a001
None Unchecked Binding selectivity 3810.0 None 10.1021/jm970377o
None Unchecked Bmax 114.5 fmol/mg 10.1016/j.bmc.2020.115820
None Unchecked Concentration 20.0 uM 10.1021/jm00147a032
None Unchecked EC50 100.0 nM 10.1016/j.bmc.2020.115820
None Unchecked EC50 5000.0 nM 10.1021/jm040219e
None Unchecked EC50 5500.0 nM 10.1021/jm040219e
None Unchecked EC50 21000.0 nM 10.1016/S0960-894X(97)10080-4
None Unchecked EC50 21000.0 nM 10.1021/jm040219e
None Unchecked EC50 22470.0 nM 10.1021/acs.jmedchem.8b01372
None Unchecked EC50 80000.0 nM 10.1021/jm040219e
None Unchecked Emax 113.0 % 10.1016/j.bmc.2020.115820
None Unchecked Functional selectivity 13.5 None 10.1021/jm970377o
None Unchecked Hill coefficient 0.9 None 10.1021/jm0100178
None Unchecked IC50 4.0 nM 10.1016/s0960-894x(98)00394-1
None Unchecked IC50 4.2 nM 10.1016/S0960-894X(97)00347-8
None Unchecked IC50 4.7 nM 10.1016/j.bmcl.2011.06.127
None Unchecked IC50 7.8 nM 10.1016/j.bmc.2020.115820
None Unchecked IC50 9.6 nM 10.1584/jpestics.20.33
None Unchecked IC50 10.0 nM 10.1016/j.bmc.2010.07.034
None Unchecked IC50 12.0 nM None
None Unchecked IC50 1140.0 nM 10.1584/jpestics.20.57
None Unchecked IC50 1250.0 nM 10.1584/jpestics.20.33
None Unchecked IC50 1550.0 nM 10.1584/jpestics.20.57
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2020.112855
None Unchecked IC50 nan None None
None Unchecked Intrinsic activity 100.0 % 10.1016/S0960-894X(97)10080-4
None Unchecked Kd 0.89 nM 10.1016/j.bmc.2020.115820
None Unchecked Kd 3.08 nM 10.1016/j.bmcl.2004.12.069
None Unchecked Kd 2884.03 nM 10.1021/jm100834y
None Unchecked Kd 3160.0 nM 10.1016/j.ejmech.2015.07.024
None Unchecked Kd 3162.28 nM 10.1016/j.ejmech.2015.07.024
None Unchecked Ki 0.85 nM 10.1016/j.bmc.2012.04.050
None Unchecked Ki 0.9 nM 10.1021/np50094a001
None Unchecked Ki 0.9333 nM 10.1021/jm070755h
None Unchecked Ki 1.0 nM 10.1021/jm070755h
None Unchecked Ki 1.1 nM 10.1021/jm00034a002
None Unchecked Ki 1.4 nM 10.1021/jm00034a002
None Unchecked Ki 1.5 nM 10.1021/jm015561v
None Unchecked Ki 1.5 nM 10.1021/jm401602p
None Unchecked Ki 2.1 nM 10.1016/s0960-894x(00)00541-2
None Unchecked Ki 2.3 nM 10.1016/j.ejmech.2016.01.025
None Unchecked Ki 2.31 nM 10.1021/acs.jmedchem.8b01372
None Unchecked Ki 2.5 nM 10.1016/j.bmcl.2004.12.069
None Unchecked Ki 4.0 nM 10.1016/j.ejmech.2016.10.048
None Unchecked Ki 4.123 nM None
None Unchecked Ki 9.8 nM 10.1021/jm201301h
None Unchecked Ki 9.8 nM 10.1021/ml500129k
None Unchecked Ki 12.0 nM 10.1021/jm0492406
None Unchecked Ki 12.0 nM 10.1021/jm4008455
None Unchecked Ki 40.0 nM 10.1021/jm0492406
None Unchecked Ki 75.3 nM 10.1016/j.bmc.2012.04.050
None Unchecked Ki 112.0 nM 10.1021/jm0492406
None Unchecked Ki 129.0 nM 10.1016/j.bmc.2012.04.050
None Unchecked Ki 130.0 nM 10.1016/j.bmcl.2003.09.105
None Unchecked Ki 146.0 nM 10.1002/ps.3413
None Unchecked Ki 168.0 nM 10.1016/j.bmcl.2010.06.142
None Unchecked Ki 234.0 nM 10.1016/j.ejmech.2016.10.048
None Unchecked Ki 260.0 nM 10.1073/pnas.0703309104
None Unchecked Ki 330.0 nM 10.1016/j.bmc.2009.12.002
None Unchecked Ki 398.11 nM 10.1021/jm801400g
None Unchecked Ki 415.0 nM 10.1073/pnas.0703309104
None Unchecked Ki 800.0 nM 10.1002/ps.3413
None Unchecked Ki 1480.0 nM 10.1584/jpestics.17.4_231
None Unchecked Ki 2000.0 nM 10.1021/jm010508s
None Unchecked Ki 4000.0 nM 10.1021/jm00034a002
None Unchecked Ki 6300.0 nM 10.1016/j.bmcl.2005.04.036
None Unchecked Ki 20000.0 nM 10.1021/jm00034a002
None Unchecked Ki nan None 10.1016/j.bmc.2012.04.050
None Unchecked Ki nan None 10.1016/j.ejmech.2020.112403
None Unchecked Ki nan None 10.1021/jm201301h
None Unchecked Ki nan None None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 20587.8 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Ratio 4.0 None 10.1016/j.bmcl.2003.09.105
None Unchecked Ratio 6.0 None 10.1021/jm970377o
None Unchecked Ratio 9.0 None 10.1016/j.bmcl.2003.09.105
None Unchecked Ratio 12.0 None 10.1016/j.bmcl.2003.09.105
None Unchecked Ratio 13.5 None 10.1021/jm970377o
None Unchecked Ratio 41.0 None 10.1016/j.bmcl.2003.09.105
None Unchecked Ratio 3810.0 None 10.1021/jm970377o
None Unchecked Ratio EC50 2.1 None 10.1128/aac.00523-08
None Unchecked Ratio IC50 0.95 None 10.1128/aac.00523-08
None Unchecked Ratio IC50 1.07 None 10.1128/aac.00523-08
None Unchecked Ratio IC50 5.0 None None
None Unchecked Ratio Ki 12.0 None 10.1021/jm4000374
None Unchecked Ratio Ki 18.0 None 10.1021/jm301409f
None Unchecked Ratio Ki 33.0 None 10.1021/jm301409f
None Unchecked Ratio Ki 44.0 None 10.1016/j.bmc.2009.05.021
None Unchecked Ratio Ki 44.0 None 10.1021/jm4000374
None Unchecked Ratio Ki 44.0 None 10.1021/jm4008455
None Unchecked Ratio Ki 53.0 None 10.1021/jm201157c
None Unchecked Ratio Ki 53.0 None 10.1021/ml500129k
None Unchecked Ratio Ki 65.0 None 10.1016/j.bmcl.2016.10.078
None Unchecked Ratio Ki 65.0 None 10.1021/acs.jmedchem.0c01150
None Unchecked Ratio Ki 190.0 None 10.1021/jm900249k
None Unchecked Ratio Ki 520.0 None 10.1021/jm4000374
None Unchecked Selectivity 44.0 None 10.1021/jm0492406
None Unchecked Selectivity 595.0 None 10.1016/S0960-894X(01)80157-8
None Unchecked Selectivity 1000.0 None 10.1021/jm010508s
None Unchecked Selectivity 4850.0 None 10.1021/jm9910627

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT010551 CN1CCC[C@@H]1c1ccc(O)nc1>>CN1CCC[C@H]1c1cccnc1 MNXR173541
AKRT010556 CN1CCC[C@H]1C1C=CCN=C1>>CN1CCC[C@H]1c1cccnc1 RXN-13060
AKRT010559 CN1CCC[C@H]1c1cccnc1.C[SAH]>>CN1CCC[C@@H]1c1ccc[n+](C)c1 MNXR177947
AKRT010560 CN1CCC[C@H]1c1cccnc1.O=C(O)[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CN1CCC[C@H]1c1ccc[n+]([C@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)c1 RXN66-83
AKRT010561 CN1CCC[C@H]1c1cccnc1>>C=O RXN-8248
AKRT010562 CN1CCC[C@H]1c1cccnc1>>CN1CCC=C1c1cccnc1 RXN-13076
AKRT010563 CN1CCC[C@H]1c1cccnc1>>CN1CCC[C@@]1(O)c1cccnc1 RXN66-146
AKRT010564 CN1CCC[C@H]1c1cccnc1>>CN1CCC[C@H]1c1ccc(O)nc1 NICOTINE-DEHYDROGENASE-RXN
AKRT010565 CN1CCC[C@H]1c1cccnc1>>C[N+]1=CCC[C@H]1c1cccnc1 RXN66-61
AKRT010566 CN1CCC[C@H]1c1cccnc1>>C[N@+]1(O)CCC[C@H]1c1cccnc1 RXN66-81
AKRT010567 CN1CCC[C@H]1c1cccnc1>>c1cncc([C@@H]2CCCN2)c1 RXN-8248
AKRT014448 C[N+]1=CCCC1.O=C(O)c1cccnc1>>CN1CCC[C@H]1c1cccnc1 R02861
AKRT023737 O=CO.c1cncc([C@@H]2CCCN2)c1>>CN1CCC[C@H]1c1cccnc1 MNXR185253