Molecule

Homolycorine

AlkaPlorer ID: AK001884

Synonym: None

IUPAC Name: None

Structure

SMILES: COC1=C(OC)C=C2C(=C1)C(=O)O[C@@H]1CC=C3CC[NH+](C)[C@H]3[C@H]21

InChI: InChI=1S/C18H21NO4/c1-19-7-6-10-4-5-13-16(17(10)19)11-8-14(21-2)15(22-3)9-12(11)18(20)23-13/h4,8-9,13,16-17H,5-7H2,1-3H3/p+1/t13-,16-,17-/m1/s1

InChIKey: WXZAKVLYZHWSNF-KBRIMQKVSA-O

Reference

Alkaloids from<i>Narcissus primigenius</i>

LOTUS: LTS0185840

SuperNatural Ⅲ: SN0423037-02

NPASS: NPC35680

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Reticularia lycoperdon	Reticularia	Reticulariaceae	Liceales	Eumycetozoa	Evosea	None	Eukaryota
Cassia sieberiana	Cassia	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Liolophura japonica	Liolophura	Chitonidae	Chitonida	Polyplacophora	Mollusca	Metazoa	Eukaryota
Stachys aegyptiaca	Stachys	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ferula persica	Ferula	Apiaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Linum perenne	Linum	Linaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Echinometra lucunter	Echinometra	Echinometridae	Camarodonta	Echinoidea	Echinodermata	Metazoa	Eukaryota
Juniperus procera	Juniperus	Cupressaceae	Cupressales	Pinopsida	Streptophyta	Viridiplantae	Eukaryota
Actaea heracleifolia	Actaea	Ranunculaceae	Ranunculales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Polystichum polyblepharum	Polystichum	Dryopteridaceae	Polypodiales	Polypodiopsida	Streptophyta	Viridiplantae	Eukaryota
Ligularia przewalskii	Ligularia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
None	None	Amaryllidaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Achillea wilsoniana	Achillea	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 316.377

TPSA？: 49.2

MolLogP？: 0.9434999999999998

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	Acetylcholinesterase	Ki	nan	None	10.1016/j.bmcl.2010.06.130
Homo sapiens	BJ	IC50	20800.0	nM	10.1016/j.bmcl.2012.08.005
Homo sapiens	CCRF-CEM	IC50	15000.0	nM	10.1016/j.bmcl.2012.08.005
Homo sapiens	G-361	IC50	32900.0	nM	10.1016/j.bmcl.2012.08.005
Homo sapiens	HeLa	IC50	50000.0	nM	10.1016/j.bmcl.2012.08.005
Homo sapiens	K562	IC50	19400.0	nM	10.1016/j.bmcl.2012.08.005
Homo sapiens	MCF7	IC50	50000.0	nM	10.1016/j.bmcl.2012.08.005