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name Structure Reference Source Properties Activities Metabolism

Fanchinin

AlkaPlorer ID: AK002058

Synonym: None

IUPAC Name: (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene

Structure

SMILES: COC1=CC=C2C=C1OC1=CC=C(C=C1)C[C@H]1C3=C(C=C(OC)C(=C3)OC3=C4C(=CC(OC)=C3OC)CCN(C)[C@H]4C2)CCN1C

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InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

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InChIKey: WVTKBKWTSCPRNU-KYJUHHDHSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Lathyrus aphaca Lathyrus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Penicillium implicatum Penicillium Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Asparagus umbellatus Asparagus Asparagaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Carapichea ipecacuanha Carapichea Rubiaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Erythrina chiriquensis Erythrina Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Physeter catodon Physeter Physeteridae Artiodactyla Mammalia Chordata Metazoa Eukaryota
Dictyota bartayresiana Dictyota Dictyotaceae Dictyotales Phaeophyceae None None Eukaryota
Pachygone dasycarpa Pachygone Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stemona japonica Stemona Stemonaceae Pandanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artemisia palustris Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phelipanche arenaria Phelipanche Orobanchaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chondrodendron microphyllum Chondrodendron Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Elettaria cardamomum Elettaria Zingiberaceae Zingiberales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tapinoma erraticum Tapinoma Formicidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota
Bupleurum scorzonerifolium Bupleurum Apiaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Melianthus major Melianthus Francoaceae Geraniales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stephania tetrandra Stephania Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cyclea barbata Cyclea Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Anaxagorea luzonensis Anaxagorea Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Clitocybe fasciculata Clitocybe Clitocybaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota
Cyclea peltata Cyclea Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Vulpicida juniperinus Vulpicida Parmeliaceae Lecanorales Lecanoromycetes Ascomycota Fungi Eukaryota
Phoradendron reichenbachianum Phoradendron Viscaceae Santalales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Sinomenium acutum Sinomenium Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cissampelos pareira Cissampelos Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 622.7620000000001

TPSA？: 61.860000000000014

MolLogP？: 7.162400000000009

Number of H-Donors: 0

Number of H-Acceptors: 8

RingCount: 8

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Candida albicans Candida albicans MIC80 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01203
Chlorocebus sabaeus Vero CC50 14920.0 nM 10.1101/2020.03.20.999730
Chlorocebus sabaeus Vero C1008 CC50 5170.0 nM 10.6019/CHEMBL4651402
Chlorocebus sabaeus Vero C1008 CC50 33000.0 nM 10.6019/CHEMBL4495565
Chlorocebus sabaeus Vero C1008 pCC50 5.29 None 10.6019/CHEMBL4651402
Electrophorus electricus Acetylcholinesterase Inhibition 15.48 % 10.1016/j.bmc.2012.09.040
Entamoeba histolytica Entamoeba histolytica IC50 10.51 ug.mL-1 10.1007/s00044-011-9767-1
Entamoeba histolytica Entamoeba histolytica IC50 25.16 ug.mL-1 10.1007/s00044-011-9767-1
Equus caballus Cholinesterase Inhibition -1.1 % 10.1016/j.bmc.2012.09.040
Homo sapiens 786-0 GI50 3054.92 nM None
Homo sapiens 786-0 GI50 43451.02 nM None
Homo sapiens A498 GI50 7328.25 nM None
Homo sapiens A498 GI50 60534.09 nM None
Homo sapiens A549 GI50 7194.49 nM None
Homo sapiens A549 GI50 100000.0 nM None
Homo sapiens A673 GI50 4000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens A673 LC50 8900.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens A673 TGI 6000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens ACHN GI50 7925.01 nM None
Homo sapiens ACHN GI50 17139.57 nM None
Homo sapiens Alpha-galactosidase A Potency 891.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 12589.3 nM None
Homo sapiens Ataxin-2 Potency 25118.9 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 16353.5 nM None
Homo sapiens BT-549 GI50 7726.81 nM None
Homo sapiens BT-549 GI50 100000.0 nM None
Homo sapiens CAKI-1 GI50 3515.6 nM None
Homo sapiens CAKI-1 GI50 100000.0 nM None
Homo sapiens CCRF-CEM Activity nan None 10.1016/j.ejmech.2020.112810
Homo sapiens CCRF-CEM GI50 3539.97 nM None
Homo sapiens CCRF-CEM GI50 33036.95 nM None
Homo sapiens CCRF-CEM IC50 15800.0 nM 10.1016/j.ejmech.2020.112810
Homo sapiens Cellular tumor antigen p53 Potency 31622.8 nM None
Homo sapiens COLO 205 GI50 2118.36 nM None
Homo sapiens COLO 205 GI50 100000.0 nM None
Homo sapiens DLD-1 GI50 9289.66 nM None
Homo sapiens DMS-114 GI50 7362.07 nM None
Homo sapiens DMS-273 GI50 6309.57 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 23715.0 nM None
Homo sapiens DNA polymerase iota Potency 89125.1 nM None
Homo sapiens DU-145 GI50 7870.46 nM None
Homo sapiens DU-145 GI50 100000.0 nM None
Homo sapiens ECa-109 cell line Activity 0.15 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 0.54 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 3.68 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 8.01 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 13.1 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 18.8 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 67.5 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 87.1 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line Activity 88.2 % 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line FC 232.6 None 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line IC50 29.37 nM 10.1021/acs.jmedchem.2c02061
Homo sapiens ECa-109 cell line IC50 29.4 nM 10.1021/acs.jmedchem.2c02061
Homo sapiens EKVX GI50 9594.01 nM None
Homo sapiens EKVX GI50 100000.0 nM None
Homo sapiens Flap endonuclease 1 Potency 89125.1 nM None
Homo sapiens Geminin Potency 58.0 nM None
Homo sapiens Geminin Potency 6513.1 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 7079.5 nM None
Homo sapiens HCC1806 GI50 5100.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC1806 LC50 15000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC1806 TGI 8500.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC1937 GI50 4200.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC1937 LC50 21000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC1937 TGI 10000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC 2998 GI50 1710.02 nM None
Homo sapiens HCC70 GI50 3400.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC70 LC50 11000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCC70 TGI 5900.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens HCT-116 GI50 4497.8 nM None
Homo sapiens HCT-116 GI50 50466.13 nM None
Homo sapiens HCT-15 GI50 7780.37 nM None
Homo sapiens HEK-293T CC50 1000.0 nM 10.1021/acs.jnatprod.3c00159
Homo sapiens HEL IC50 7450.0 nM 10.1039/C8MD00125A
Homo sapiens HEL IC50 16780.0 nM 10.1016/j.ejmech.2017.11.007
Homo sapiens HEL IC50 19740.0 nM 10.1016/j.ejmech.2019.111898
Homo sapiens HepaRG Activity nan None 10.1016/j.ejmech.2020.112810
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2020.112810
Homo sapiens HepG2 IC50 6820.0 nM 10.1016/j.bmcl.2016.12.029
Homo sapiens HepG2 IC50 relative 1400.0 nM 10.6019/EOS300108
Homo sapiens HepG2 Potency 8912.5 nM None
Homo sapiens HepG2 Potency 28183.8 nM None
Homo sapiens Histone deacetylase 6 Inhibition -4.06 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 3.75 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 GI50 7798.3 nM None
Homo sapiens HL-60 GI50 99540.54 nM None
Homo sapiens HOP-18 GI50 9418.9 nM None
Homo sapiens HOP-62 GI50 5942.92 nM None
Homo sapiens HOP-92 GI50 1794.73 nM None
Homo sapiens HOP-92 GI50 57147.86 nM None
Homo sapiens Hs-578T GI50 8629.79 nM None
Homo sapiens Hs-578T GI50 30060.76 nM None
Homo sapiens HT-29 GI50 2999.16 nM None
Homo sapiens HT-29 GI50 100000.0 nM None
Homo sapiens HUVEC Activity nan None 10.1016/j.ejmech.2020.112810
Homo sapiens HUVEC EC50 nan None 10.1016/j.bmcl.2010.07.090
Homo sapiens IGROV-1 GI50 9204.5 nM None
Homo sapiens IGROV-1 GI50 49203.95 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 5804.8 nM None
Homo sapiens K562 GI50 1566.75 nM None
Homo sapiens K562 GI50 41209.75 nM None
Homo sapiens K562 IC50 6430.0 nM 10.1016/j.ejmech.2019.111898
Homo sapiens K562 IC50 11760.0 nM 10.1039/C8MD00125A
Homo sapiens K562 IC50 13810.0 nM 10.1016/j.ejmech.2017.11.007
Homo sapiens KB ED50 5800.0 nM 10.1021/np980144f
Homo sapiens KM12 GI50 6698.85 nM None
Homo sapiens KM12 GI50 100000.0 nM None
Homo sapiens KM-20L2 GI50 3801.89 nM None
Homo sapiens L02 IC50 44250.0 nM 10.1039/C8MD00125A
Homo sapiens LOX IMVI GI50 3296.1 nM None
Homo sapiens LOX IMVI GI50 100000.0 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 50118.7 nM None
Homo sapiens M14 GI50 260.02 nM None
Homo sapiens M14 GI50 26181.83 nM None
Homo sapiens M19-MEL GI50 8241.38 nM None
Homo sapiens Malme-3M GI50 9749.9 nM None
Homo sapiens Malme-3M GI50 100000.0 nM None
Homo sapiens MCF7 GI50 6426.88 nM None
Homo sapiens MCF7 GI50 82035.15 nM None
Homo sapiens MCF7 IC50 8620.0 nM 10.1016/j.bmcl.2016.12.029
Homo sapiens MCF7 IC50 19580.0 nM 10.1016/j.ejmech.2019.111898
Homo sapiens MDA-MB-231 GI50 5000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-MB-231 GI50 5636.38 nM None
Homo sapiens MDA-MB-231 GI50 19769.7 nM None
Homo sapiens MDA-MB-231 IC50 8940.0 nM 10.1039/C8MD00125A
Homo sapiens MDA-MB-231 IC50 18450.0 nM 10.1016/j.ejmech.2019.111898
Homo sapiens MDA-MB-231 IC50 21970.0 nM 10.1016/j.ejmech.2017.11.007
Homo sapiens MDA-MB-231 LC50 12000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-MB-231 TGI 7400.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-MB-435 GI50 1874.99 nM None
Homo sapiens MDA-MB-435 GI50 100000.0 nM None
Homo sapiens MDA-MB-453 GI50 3300.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-MB-453 LC50 7100.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-MB-453 TGI 4800.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens MDA-N GI50 5382.7 nM None
Homo sapiens MDA-N GI50 100000.0 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens microRNA 21 Potency 23280.9 nM None
Homo sapiens MOLT-4 GI50 4698.94 nM None
Homo sapiens MOLT-4 GI50 100000.0 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 19952.6 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 35481.3 nM None
Homo sapiens NCI/ADR-RES GI50 5308.84 nM None
Homo sapiens NCI/ADR-RES GI50 100000.0 nM None
Homo sapiens NCI-H226 GI50 9705.1 nM None
Homo sapiens NCI-H226 GI50 100000.0 nM None
Homo sapiens NCI-H23 GI50 8433.35 nM None
Homo sapiens NCI-H23 GI50 77446.18 nM None
Homo sapiens NCI-H322M GI50 8090.96 nM None
Homo sapiens NCI-H322M GI50 100000.0 nM None
Homo sapiens NCI-H460 GI50 6714.29 nM None
Homo sapiens NCI-H522 GI50 6606.93 nM None
Homo sapiens NCI-H522 GI50 34753.62 nM None
Homo sapiens Niemann-Pick C1 protein Inhibition nan % 10.1021/acs.jmedchem.8b00035
Homo sapiens OVCAR-3 GI50 7464.49 nM None
Homo sapiens OVCAR-4 GI50 2421.03 nM None
Homo sapiens OVCAR-5 GI50 9036.49 nM None
Homo sapiens OVCAR-5 GI50 100000.0 nM None
Homo sapiens OVCAR-8 GI50 8375.29 nM None
Homo sapiens OVCAR-8 GI50 53703.18 nM None
Homo sapiens Panel NCI-60 (60 carcinoma cell lines) GI50 10.0 nM 10.1021/jm049838d
Homo sapiens PC-3 GI50 8147.04 nM None
Homo sapiens PC-3 GI50 100000.0 nM None
Homo sapiens PC-3 IC50 5860.0 nM 10.1039/C8MD00125A
Homo sapiens PC-3 IC50 7870.0 nM 10.1016/j.ejmech.2017.11.007
Homo sapiens P-glycoprotein 1 Activity 2.5 fold 10.1097/00001813-199803000-00008
Homo sapiens P-glycoprotein 1 Activity nan None 10.1007/s00280-003-0742-5
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2020.115553
Homo sapiens PLC-PRF-5 IC50 18460.0 nM 10.1016/j.ejmech.2017.01.008
Homo sapiens RPMI-8226 GI50 4436.09 nM None
Homo sapiens RXF 393 GI50 5081.59 nM None
Homo sapiens SF-268 GI50 8053.78 nM None
Homo sapiens SF-268 GI50 74644.88 nM None
Homo sapiens SF-295 GI50 8933.05 nM None
Homo sapiens SF-295 GI50 36224.3 nM None
Homo sapiens SF-539 GI50 4775.29 nM None
Homo sapiens SF-539 GI50 20137.24 nM None
Homo sapiens SJRH30 GI50 3000.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens SJRH30 LC50 6100.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens SJRH30 TGI 4300.0 nM 10.1021/acs.jnatprod.0c00946
Homo sapiens SK-MEL-2 GI50 7568.33 nM None
Homo sapiens SK-MEL-2 GI50 100000.0 nM None
Homo sapiens SK-MEL-28 GI50 8147.04 nM None
Homo sapiens SK-MEL-28 GI50 100000.0 nM None
Homo sapiens SK-MEL-5 GI50 6095.37 nM None
Homo sapiens SK-MEL-5 GI50 57279.6 nM None
Homo sapiens SK-OV-3 GI50 5902.01 nM None
Homo sapiens SK-OV-3 GI50 45814.19 nM None
Homo sapiens SN12C GI50 8203.52 nM None
Homo sapiens SN12C GI50 100000.0 nM None
Homo sapiens SN12K1 GI50 7063.18 nM None
Homo sapiens SNB-19 GI50 6606.93 nM None
Homo sapiens SNB-19 GI50 17378.01 nM None
Homo sapiens SNB-75 GI50 6546.36 nM None
Homo sapiens SNB-75 GI50 43151.91 nM None
Homo sapiens SNB-78 GI50 9440.61 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 75.74 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 220.23 % 10.1124/mol.112.084152
Homo sapiens SR GI50 2471.72 nM None
Homo sapiens SR GI50 12050.36 nM None
Homo sapiens Survival motor neuron protein Potency 14125.4 nM None
Homo sapiens SW-620 GI50 7345.14 nM None
Homo sapiens SW-620 GI50 100000.0 nM None
Homo sapiens T47D GI50 9527.96 nM None
Homo sapiens T47D GI50 100000.0 nM None
Homo sapiens TK-10 GI50 8413.95 nM None
Homo sapiens TK-10 GI50 22908.68 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 707.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2237.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2592.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 4463.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5011.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5173.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 6683.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8414.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11220.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 56234.1 nM None
Homo sapiens U-251 GI50 7655.97 nM None
Homo sapiens U-251 GI50 35727.28 nM None
Homo sapiens U-937 Activity 69.0 % 10.1016/j.bmc.2012.06.017
Homo sapiens U-937 FC 0.9 None 10.1016/j.bmc.2012.06.017
Homo sapiens U-937 IC50 50000.0 nM 10.1016/j.bmc.2012.06.017
Homo sapiens U-937 MED 50.0 uM 10.1016/j.bmc.2012.06.017
Homo sapiens UACC-257 GI50 5794.29 nM None
Homo sapiens UACC-257 GI50 43052.66 nM None
Homo sapiens UACC-62 GI50 3899.42 nM None
Homo sapiens UACC-62 GI50 100000.0 nM None
Homo sapiens UO-31 GI50 4931.74 nM None
Homo sapiens UO-31 GI50 100000.0 nM None
Homo sapiens XF498 GI50 10641.43 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 22387.2 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Mus musculus P388 ED50 0.4 ug ml-1 10.1021/np50091a004
Mus musculus P388 GI50 1774.19 nM None
Mus musculus P388/ADR GI50 3054.92 nM None
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2017.06.005
Plasmodium falciparum Plasmodium falciparum ED50 160.0 ng/ml 10.1021/np50091a004
Plasmodium falciparum Plasmodium falciparum ED50 179.0 ng/ml 10.1021/np50091a004
Plasmodium falciparum Plasmodium falciparum IC50 257.0 nM 10.1021/np980144f
Plasmodium falciparum Plasmodium falciparum IC50 288.0 nM 10.1021/np980144f
Plasmodium falciparum Plasmodium falciparum Potency 2078.7 nM None
Rattus norvegicus Adrenergic receptor alpha-1 Ki 691.83 nM 10.1021/np030022+
Rattus norvegicus Aorta IC50 13489.63 nM 10.1021/np030022+
Rattus norvegicus Aorta IC50 29512.09 nM 10.1021/np030022+
Rattus norvegicus Muscarinic acetylcholine receptor Ki 73.0 nM 10.1021/np50075a001
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 35481.3 nM None
Rattus norvegicus Voltage-gated L-type calcium channel Ki 741.31 nM 10.1021/np030022+
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 3.743 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Activity nan None 10.1021/acs.jnatprod.3c00159
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC50 1100.0 nM 10.1101/2020.04.16.044016
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 284.0 nM 10.1021/acs.jnatprod.3c00159
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 3000.0 nM 10.1101/2020.03.20.999730
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 3980.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 3981.07 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 11660.0 nM 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 50100.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 50118.72 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.81 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 9.46 % 10.21203/rs.3.rs-23951/v1
Staphylococcus aureus Staphylococcus aureus MIC 6.0 ug.mL-1 10.1016/j.bmc.2019.07.023
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmc.2019.07.023
None ADMET LC50 5010.0 nM 10.1016/j.bmc.2013.09.022
None ADMET permeability nan None 10.1021/acs.jnatprod.3c00159
None ADMET Selectivity index 2.83 None 10.6019/CHEMBL4495565
None ADMET Selectivity index 4.97 None 10.1101/2020.03.20.999730
None Fibroblast Activity nan None 10.1021/acs.jmedchem.8b00035
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET ED50 2.1 ug ml-1 10.1021/np50091a004
None NON-PROTEIN TARGET ED50 3.7 ug ml-1 10.1021/np50091a004
None NON-PROTEIN TARGET IC50 1480.0 nM 10.1016/j.bmcl.2010.07.090
None No relevant target solubility 14.6 10^-3mg/ml 10.1021/acs.jmedchem.2c02061
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112810
None Unchecked Activity nan None 10.1021/acs.jmedchem.8b00035
None Unchecked Activity nan None 10.1021/acs.jnatprod.3c00159
None Unchecked EC50 2150.0 nM 10.1016/j.bmc.2013.09.022
None Unchecked IC50 2000.0 nM 10.1016/j.ejmech.2019.05.027
None Unchecked IC50 2160.0 nM 10.1021/acs.jmedchem.8b00035
None Unchecked IC50 6100.0 nM 10.1039/C8MD00125A
None Unchecked IC50 10980.0 nM 10.1016/j.ejmech.2017.11.007
None Unchecked IC50 15010.0 nM 10.1016/j.ejmech.2017.01.008
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112810
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 2511.9 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 6513.1 nM None
None Unchecked Potency 7079.5 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14581.0 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Ratio 2.33 None 10.1016/j.bmc.2013.09.022
None Unchecked Selectivity Index 20.0 None 10.1021/np980144f
None Unchecked Selectivity Index 22.0 None 10.1021/acs.jmedchem.8b00035
None Unchecked Selectivity Index 22.0 None 10.1021/np980144f

Metabolism Information