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10-Methoxycanthin-6-one

AlkaPlorer ID: AK002471

Synonym: '', '10-Hydroxycanthin-6-one; Me ether', '10-Methoxycanthin-6-one'

IUPAC Name: 12-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one

Structure

SMILES: COC1=CC=C2C(=C1)C1=CC=NC3=C1N2C(=O)C=C3

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InChI: InChI=1S/C15H10N2O2/c1-19-9-2-4-13-11(8-9)10-6-7-16-12-3-5-14(18)17(13)15(10)12/h2-8H,1H3

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InChIKey: FDBMONUDUKGKGY-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 250.257

TPSA？: 43.6

MolLogP？: 2.4473000000000003

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus MIC 200000.0 nM 10.1021/np050250z
Bacillus cereus Bacillus cereus MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.06.001
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.06.001
Bos taurus Calf thymus DNA Activity 30.0 % 10.1021/np50078a006
Candida albicans Candida albicans MIC 100000.0 nM 10.1021/np050250z
Cryptococcus neoformans Cryptococcus neoformans MIC 200000.0 nM 10.1021/np050250z
Homo sapiens DU-145 IC50 1.58 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens HCC1395 IC50 14.7 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens KB ED50 2.1 ug ml-1 10.1021/np50026a016
Ralstonia solanacearum Ralstonia solanacearum MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.06.001
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 50000.0 nM 10.1021/np050250z
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2018.06.001
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 200000.0 nM 10.1021/np050250z
None NON-PROTEIN TARGET Activity nan None 10.1039/C2MD20047C
None Nucleic Acid Activity nan None 10.1021/np50078a006

Metabolism Information