Stylopine
AlkaPlorer ID: AK002531
Synonym: None
IUPAC Name: (1S)-5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene
Structure
SMILES: C1=CC2=C(OCO2)C2=C1C[C@H]1C3=C(C=C4OCOC4=C3)CCN1C2
InChI: InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2/t15-/m0/s1
InChIKey: UXYJCYXWJGAKQY-HNNXBMFYSA-N
Reference
Chemical Study on the Alkaloids of<i>Corydalis hsuchowensis</i>
PubChem CID: 440583
CAS: 84-39-9
LOTUS: LTS0009184
SuperNatural Ⅲ: SN0383093-01
NPASS: NPC31311
data_source: manually
Source
Properties Information
Molecule Weight: 323.34800000000007
TPSA？: 40.16
MolLogP？: 2.799500000000001
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 6
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Leishmania donovani | Leishmania donovani | IC50 | 31.18 | ug.mL-1 | 10.1016/j.bmcl.2019.126642 |
| Mus musculus | RAW264.7 | Activity | nan | None | 10.1016/j.bmcl.2011.09.128 |
| Mus musculus | RAW264.7 | IC50 | 50000.0 | nM | 10.1016/j.bmcl.2011.09.128 |
| Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | 10.89 | ug.mL-1 | 10.1016/j.bmcl.2019.126642 |
| Trypanosoma cruzi | Trypanosoma cruzi | IC50 | 17.54 | ug.mL-1 | 10.1016/j.bmcl.2019.126642 |