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Arcyriarubin A

AlkaPlorer ID: AK002600

Synonym: 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione, 2,3-Bis(1H-indol-3-yl)maleimide 

IUPAC Name: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione

Structure

SMILES: O=C1N=C(O)C(C2=CNC3=CC=CC=C23)=C1C1=CNC2=CC=CC=C12

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InChI: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

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InChIKey: DQYBRTASHMYDJG-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 327.3430000000001

TPSA？: 81.23999999999998

MolLogP？: 4.056700000000001

Number of H-Donors: 3

Number of H-Acceptors: 1

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens A549 IC50 4140.0 nM 10.1016/j.ejmech.2018.08.002
Homo sapiens A549 IC50 56610.0 nM 10.1016/j.bmc.2009.04.043
Homo sapiens Activin receptor type-1B Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change 3.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta IC50 1190.0 nM 10.1016/j.bmcl.2008.02.058
Homo sapiens CaM kinase II delta Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 2.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change 2.8 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase beta Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 1.4 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 2000.0 nM 10.1016/s0960-894x(03)00792-3
Homo sapiens cAMP-dependent protein kinase (PKA) Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens cAMP-dependent protein kinase (PKA) Inhibition 75.0 % 10.1016/s0960-894x(98)00163-2
Homo sapiens cAMP-dependent protein kinase (PKA) Inhibition 80.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens cAMP-dependent protein kinase (PKA) Inhibition nan % 10.1016/s0960-894x(98)00163-2
Homo sapiens Casein kinase I delta Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Inhibition 99.0 % 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens CDK3/cyclin E Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 95.0 % 10.1042/0264-6021:3510095
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity -3.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 18000.0 nM 10.1016/s0960-894x(98)00163-2
Homo sapiens Cyclin-dependent kinase 1/cyclin B Inhibition 75.0 % 10.1016/s0960-894x(98)00163-2
Homo sapiens Cyclin-dependent kinase 1/cyclin B Inhibition nan % 10.1016/s0960-894x(98)00163-2
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 1.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 11690.0 nM 10.1016/s0960-894x(03)00792-3
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 5810.0 nM 10.1016/s0960-894x(03)00792-3
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Death-associated protein kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change 2.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change 2.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens ECa-109 cell line IC50 15900.0 nM 10.1016/j.ejmech.2018.08.002
Homo sapiens Ephrin type-A receptor 1 Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 IC50 50000.0 nM 10.1021/jm00033a019
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition nan % 10.1016/s0960-894x(98)00163-2
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 49.0 % 10.1042/0264-6021:3510095
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 7.8 degrees C 10.1073/pnas.0708800104
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens HCT-116 Activity nan None 10.1016/s0960-894x(03)00792-3
Homo sapiens HCT-116 IC50 nan nM 10.1016/s0960-894x(03)00792-3
Homo sapiens Hepatocyte growth factor receptor Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens HL-60 CC50 8000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 128.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Jurkat IC50 6.3 ug.mL-1 10.1016/j.bmcl.2005.03.103
Homo sapiens K562 IC50 17460.0 nM 10.1016/j.bmc.2009.04.043
Homo sapiens KB IC50 53780.0 nM 10.1016/j.bmc.2009.04.043
Homo sapiens KB 3-1 IC50 25.0 ug.mL-1 10.1016/j.bmcl.2005.03.103
Homo sapiens LIM domain kinase 1 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 113.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 96.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Inhibition 86.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase ERK2 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Inhibition 90.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 alpha Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Inhibition 88.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Inhibition 90.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Inhibition 83.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 gamma Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens MCF7 CC50 8000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Misshapen-like kinase 1 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change 3.8 degrees C 10.1073/pnas.0708800104
Homo sapiens NAD-dependent deacetylase sirtuin 1 Inhibition 52.7 % 10.1021/jm060118b
Homo sapiens NAD-dependent deacetylase sirtuin 2 IC50 4700.0 nM 10.1021/jm060118b
Homo sapiens NCI-H460 Activity nan None 10.1016/s0960-894x(03)00792-3
Homo sapiens NCI-H460 IC50 nan nM 10.1016/s0960-894x(03)00792-3
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens PC-3 IC50 10300.0 nM 10.1016/j.ejmech.2018.08.002
Homo sapiens PDZ-binding kinase Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha IC50 1599.0 nM 10.1016/j.bmcl.2004.07.061
Homo sapiens Protein kinase C alpha Inhibition 57.0 % 10.1042/0264-6021:3510095
Homo sapiens Protein kinase C alpha Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta IC50 16.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Protein kinase C beta IC50 212.0 nM 10.1016/j.bmcl.2004.07.061
Homo sapiens Protein kinase C beta IC50 304.0 nM 10.1016/j.bmcl.2004.07.061
Homo sapiens Protein kinase C beta Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon IC50 7516.0 nM 10.1016/j.bmcl.2004.07.061
Homo sapiens Protein kinase C epsilon Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C (PKC) IC50 190.0 nM 10.1021/jm00033a019
Homo sapiens Protein kinase C (PKC) Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Protein kinase C (PKC) Inhibition 75.0 % 10.1016/s0960-894x(98)00163-2
Homo sapiens Protein kinase C (PKC) Inhibition 80.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Protein kinase C theta Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 Inhibition 95.0 % 10.1042/0264-6021:3510095
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 87.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 3.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 56.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 6.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 3.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 2.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 4.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 101.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 91.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change 2.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 4.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 3.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 1.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 1.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change 1.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 8.0 % 10.1021/jm0504858
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 14.0 % 10.1021/jm0504858
Homo sapiens Serine/threonine-protein kinase PIM1 Kb 37.0 10^6/M 10.1021/jm0504858
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 27.0 nM 10.1021/jm0504858
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change 5.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 4.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 6.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 4.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 101.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens SMMC-7721 IC50 13200.0 nM 10.1016/j.ejmech.2018.08.002
Homo sapiens SMMC-7721 IC50 100000.0 nM 10.1016/j.bmc.2009.04.043
Homo sapiens Stem cell growth factor receptor Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL IC50 20000.0 nM 10.1021/jm00033a019
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Inhibition 91.0 % 10.1042/0264-6021:3510095
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Tyrosine-protein kinase SRC Inhibition 80.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Inhibition 50.0 % 10.1016/j.bmcl.2005.03.103
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 2.0 % 10.1042/bj20121418
Influenza A virus Influenza A virus log(activity) 1.0 None 10.1021/acs.jmedchem.0c01467
Influenza B virus Influenza B virus log(activity) 1.0 None 10.1021/acs.jmedchem.0c01467
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit IC50 200000.0 nM 10.1021/jm00033a019
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit IC50 3100.0 nM 10.1021/jm00079a024
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit IC50 11800.0 nM 10.1021/jm00079a024
Rattus norvegicus Protein kinase C gamma IC50 550.0 nM 10.1021/jm00079a024
Rattus norvegicus Protein kinase C (PKC) IC50 100.0 nM 10.1021/jm00079a024
Rattus norvegicus Protein kinase C (PKC) IC50 550.0 nM 10.1021/jm00079a024
Rattus norvegicus Rho-associated protein kinase 2 Inhibition 100.0 % 10.1042/0264-6021:3510095
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 13.27 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 4.76 % 10.6019/CHEMBL4495565
None NON-PROTEIN TARGET IC50 83550.0 nM 10.1016/j.bmc.2009.04.043
None Unchecked IC50 350.0 nM 10.1016/j.bmc.2009.04.043
None Unchecked IC50 11800.0 nM 10.1021/jm00079a024
None Unchecked IC50 1000000.0 nM 10.1016/S0960-894X(00)80378-9
None Unchecked Inhibition 54.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 84.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 90.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 93.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 96.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition nan % 10.1016/s0960-894x(98)00163-2
None Unchecked Selectivity 22.0 None 10.1021/jm00079a024

Metabolism Information