Normelicopicine
AlkaPlorer ID: AK002637
Synonym: None
IUPAC Name: 1-hydroxy-2,3,4-trimethoxy-10-methylacridin-9-one
Structure
SMILES: COC1=C(O)C2=C(C(OC)=C1OC)N(C)C1=CC=CC=C1C2=O
InChI: InChI=1S/C17H17NO5/c1-18-10-8-6-5-7-9(10)13(19)11-12(18)15(21-2)17(23-4)16(22-3)14(11)20/h5-8,20H,1-4H3
InChIKey: UGEKWKMLXLFVIY-UHFFFAOYSA-N
Reference
PubChem CID: 5378563
CAS: 7008-68-6
LOTUS: LTS0274473
SuperNatural Ⅲ: SN0369561
COCONUT: CNP0320511
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Medicosma fareana | Medicosma | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 315.32500000000005
TPSA？: 69.92
MolLogP？: 2.4231
Number of H-Donors: 1
Number of H-Acceptors: 6
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | KB | IC50 | 328000.0 | nM | 10.1021/np0106182 |
| Plasmodium berghei | Plasmodium berghei | Activity | 32.1 | % | 10.1021/np0106182 |
| Plasmodium falciparum | Histidine-rich protein | Activity | nan | None | 10.1021/np0106182 |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 8250.0 | nM | 10.1021/np0106182 |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 14700.0 | nM | 10.1021/np0106182 |
| None | Unchecked | Ratio IC50 | 22.0 | None | 10.1021/np0106182 |
| None | Unchecked | Ratio IC50 | 40.0 | None | 10.1021/np0106182 |