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cycloleucine

AlkaPlorer ID: AK002667

Synonym: 'Cycloleucine'

IUPAC Name: 1-aminocyclopentane-1-carboxylic acid

Structure

SMILES: NC1(C(=O)O)CCCC1

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InChI: InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)

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InChIKey: NILQLFBWTXNUOE-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 129.159

TPSA？: 63.32000000000001

MolLogP？: 0.3424999999999993

Number of H-Donors: 2

Number of H-Acceptors: 2

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Bos taurus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Enterococcus faecium Enterococcus faecium IC50 7700000.0 nM 10.1021/jm00212a010
Escherichia coli Escherichia coli IC50 7700000.0 nM 10.1021/jm00212a010
Homo sapiens A498 GI50 1345.86 nM None
Homo sapiens A549 GI50 625172.69 nM None
Homo sapiens CAKI-1 GI50 625172.69 nM None
Homo sapiens CCRF-CEM GI50 625172.69 nM None
Homo sapiens COLO 205 GI50 625172.69 nM None
Homo sapiens DLD-1 GI50 625172.69 nM None
Homo sapiens DMS-114 GI50 625172.69 nM None
Homo sapiens DMS-273 GI50 625172.69 nM None
Homo sapiens EKVX GI50 578096.05 nM None
Homo sapiens HCC 2998 GI50 625172.69 nM None
Homo sapiens HCT-116 GI50 625172.69 nM None
Homo sapiens HCT-15 GI50 625172.69 nM None
Homo sapiens HL-60 GI50 625172.69 nM None
Homo sapiens HOP-18 GI50 625172.69 nM None
Homo sapiens HOP-62 GI50 625172.69 nM None
Homo sapiens HOP-92 GI50 625172.69 nM None
Homo sapiens HT-29 GI50 625172.69 nM None
Homo sapiens IGROV-1 GI50 625172.69 nM None
Homo sapiens K562 GI50 625172.69 nM None
Homo sapiens KM12 GI50 625172.69 nM None
Homo sapiens KM-20L2 GI50 625172.69 nM None
Homo sapiens LOX IMVI GI50 625172.69 nM None
Homo sapiens M19-MEL GI50 625172.69 nM None
Homo sapiens Malme-3M GI50 625172.69 nM None
Homo sapiens MCF7 GI50 625172.69 nM None
Homo sapiens MOLT-4 GI50 625172.69 nM None
Homo sapiens NCI/ADR-RES GI50 625172.69 nM None
Homo sapiens NCI-H226 GI50 625172.69 nM None
Homo sapiens NCI-H23 GI50 625172.69 nM None
Homo sapiens NCI-H322M GI50 248313.31 nM None
Homo sapiens NCI-H460 GI50 625172.69 nM None
Homo sapiens NCI-H522 GI50 625172.69 nM None
Homo sapiens OVCAR-3 GI50 62517.27 nM None
Homo sapiens OVCAR-4 GI50 625172.69 nM None
Homo sapiens OVCAR-5 GI50 625172.69 nM None
Homo sapiens OVCAR-8 GI50 625172.69 nM None
Homo sapiens RPMI-8226 GI50 625172.69 nM None
Homo sapiens RXF 393 GI50 625172.69 nM None
Homo sapiens S-adenosylmethionine synthase isoform type-2 IC50 1300000.0 nM 10.1021/acs.jmedchem.2c00395
Homo sapiens S-adenosylmethionine synthase isoform type-2 IC50 5600000.0 nM 10.1021/acs.jmedchem.2c00395
Homo sapiens SF-268 GI50 176603.78 nM None
Homo sapiens SF-295 GI50 625172.69 nM None
Homo sapiens SF-539 GI50 625172.69 nM None
Homo sapiens SK-MEL-2 GI50 625172.69 nM None
Homo sapiens SK-MEL-28 GI50 625172.69 nM None
Homo sapiens SK-MEL-5 GI50 625172.69 nM None
Homo sapiens SK-OV-3 GI50 625172.69 nM None
Homo sapiens SN12C GI50 90991.33 nM None
Homo sapiens SN12K1 GI50 625172.69 nM None
Homo sapiens SNB-19 GI50 99083.19 nM None
Homo sapiens SNB-75 GI50 625172.69 nM None
Homo sapiens SNB-78 GI50 244343.06 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 99.09 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 108.53 % 10.1124/mol.112.084152
Homo sapiens SW-620 GI50 625172.69 nM None
Homo sapiens U-251 GI50 625172.69 nM None
Homo sapiens UACC-257 GI50 625172.69 nM None
Homo sapiens UACC-62 GI50 625172.69 nM None
Homo sapiens UO-31 GI50 625172.69 nM None
Homo sapiens XF498 GI50 5767.66 nM None
Lacticaseibacillus casei Lacticaseibacillus casei IC50 7700000.0 nM 10.1021/jm00212a010
Mus musculus P388 GI50 625172.69 nM None
Mus musculus P388/ADR GI50 625172.69 nM None
Plasmodium berghei Plasmodium berghei MCD 640.0 mg kg-1 10.1021/jm00212a010
Plasmodium berghei Plasmodium berghei MED 640.0 mg kg-1 10.1021/jm00212a010
Rattus norvegicus Amino acid transporter Inhibition 25.0 % None
Rattus norvegicus Glutamate NMDA receptor Ki 1995262.31 nM 10.1021/jm900363q
Rattus norvegicus Jensen sarcoma Activity 0.0 % 10.1021/jm00224a031
Rattus norvegicus Jensen sarcoma Activity 5.0 % 10.1021/jm00224a031
Rattus norvegicus S-adenosylmethionine synthetase alpha and beta forms Ki 516000.0 nM 10.1016/s0960-894x(98)00267-4
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Trypanosoma cruzi Trypanosoma cruzi Inhibition nan % 10.1021/jm00216a001
None ADMET Binding energy 4.9 kCal mol-1 10.1021/jm00378a021
None NON-PROTEIN TARGET IC50 7700000.0 nM 10.1021/jm00212a010
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked IC50 209000.0 nM 10.1021/acs.jmedchem.2c00395

Metabolism Information