1-Hydroxy-N-methylacridone
AlkaPlorer ID: AK002700
Synonym: '', '1-hydroxy-10-methyl-9(10H)-acridinone', 'SMR000338128', 'MLS000755253'
IUPAC Name: 1-hydroxy-10-methylacridin-9-one
Structure
SMILES: CN1C2=CC=CC=C2C(=O)C2=C(O)C=CC=C21
InChI: InChI=1S/C14H11NO2/c1-15-10-6-3-2-5-9(10)14(17)13-11(15)7-4-8-12(13)16/h2-8,16H,1H3
InChIKey: NHYDBJFGZCQFEO-UHFFFAOYSA-N
Reference
Cytotoxic and Antiplatelet Aggregation Principles of <i>Ruta Graveolens</i>
PubChem CID: 5376484
CAS: 16584-54-6
LOTUS: LTS0118813
SuperNatural Ⅲ: SN0246086
COCONUT: CNP0398530
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Ruta graveolens | Ruta | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 225.247
TPSA？: 42.23
MolLogP？: 2.3973000000000004
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Acinetobacter baumannii | Acinetobacter baumannii | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Candida albicans | Candida albicans | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Cryptococcus neoformans | Cryptococcus neoformans | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Escherichia coli | Escherichia coli | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Homo sapiens | DNA dC->dU-editing enzyme APOBEC-3F | Potency | 891.3 | nM | None |
| Homo sapiens | HaCaT | Activity | nan | None | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HaCaT | IC50 | 50000.0 | nM | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HEK293 | CC50 | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Homo sapiens | Huntingtin | Potency | 15848.9 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 11220.2 | nM | None |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 1651.1 | nM | None |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| None | Erythrocyte | HC10 | 20.0 | uM | 10.6019/CHEMBL4513161 |
| None | Radical scavenging activity | EC50 | nan | None | 10.1016/j.ejmech.2010.08.059 |