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Eudistomin Y2

AlkaPlorer ID: AK002714

Synonym: None

IUPAC Name: (6-bromo-9H-pyrido[3,4-b]indol-1-yl)-(4-hydroxyphenyl)methanone

Structure

SMILES: C1=CC(=CC=C1C(=O)C2=NC=CC3=C2NC4=C3C=C(C=C4)Br)O

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InChI: InChI=1S/C18H11BrN2O2/c19-11-3-6-15-14(9-11)13-7-8-20-17(16(13)21-15)18(23)10-1-4-12(22)5-2-10/h1-9,21-22H

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InChIKey: DRIYUTQUFGEKEA-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 367.202

TPSA？: 65.98

MolLogP？: 4.415200000000002

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Bacillus subtilis Bacillus subtilis MIC 25.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Candida albicans MIC 6.25 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Isocitrate lyase IC50 50200.0 nM 10.1016/j.bmc.2012.05.002
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Homo sapiens A549 LC50 65600.0 nM 10.1016/j.bmc.2012.05.002
Micrococcus luteus Micrococcus luteus MIC 25.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Proteus vulgaris Proteus vulgaris MIC 25.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Sortase A IC50 272300.0 nM 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton rubrum Trichophyton rubrum MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
None Unchecked IC50 209300.0 nM 10.1016/j.bmc.2012.05.002

Metabolism Information