Pseudoberberine
AlkaPlorer ID: AK002900
Synonym: None
IUPAC Name: 17,18-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,13,15,17,19-octaene;chloride
Structure
SMILES: COC1=C(C=C2C=[N+]3CCC4=CC5=C(C=C4C3=CC2=C1)OCO5)OC.[Cl-]
InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-7-13-5-16-15-9-20-19(24-11-25-20)6-12(15)3-4-21(16)10-14(13)8-18(17)23-2;/h5-10H,3-4,11H2,1-2H3;1H/q+1;/p-1
InChIKey: BBHLRVYYZRFUGL-UHFFFAOYSA-M
Reference
Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
PubChem CID: 14707273
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Corydalis turtschaninovii | Corydalis | Papaveraceae | Ranunculales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 371.82000000000005
TPSA？: 40.8
MolLogP？: 0.10030000000000028
Number of H-Donors: 0
Number of H-Acceptors: 4
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HepG2 | Activity | 8.5 | None | 10.1016/j.bmcl.2008.07.005 |
| Homo sapiens | HepG2 | Activity | nan | None | 10.1016/j.bmc.2012.09.029 |
| Homo sapiens | HepG2 | Activity | nan | None | 10.1021/jm801157z |
| Homo sapiens | HepG2 | FC | 1.2 | None | 10.1016/j.bmcl.2009.09.059 |
| Homo sapiens | HepG2 | FC | 3.1 | None | 10.1016/j.bmcl.2009.09.059 |
| Homo sapiens | HepG2 | FC | 3.23 | None | 10.1016/j.bmc.2012.09.029 |
| Homo sapiens | HepG2 | FC | 3.5 | None | 10.1021/jm801157z |
| Homo sapiens | KM12C | IC50 | 467000.0 | nM | 10.1021/acs.jmedchem.0c00088 |
| Mus musculus | Mus musculus | Activity | 29.7 | % | 10.1021/jm801157z |
| Mus musculus | Mus musculus | Activity | 39.0 | % | 10.1021/jm801157z |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1021/jm801157z |
| Mus musculus | Mus musculus | FC | 3.2 | None | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 28.5 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 31.0 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 42.6 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 46.3 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 49.4 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | 53.6 | % | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | Activity | nan | None | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | FC | 2.9 | None | 10.1021/jm801157z |
| Rattus norvegicus | Rattus norvegicus | FC | 4.8 | None | 10.1021/jm801157z |
| None | Unchecked | Activity | nan | None | 10.1016/j.bmc.2012.09.029 |
| None | Unchecked | FC | 2.6 | None | 10.1016/j.bmc.2012.09.029 |