phenazine
AlkaPlorer ID: AK002992
Synonym: 'Phenazine', 'SMR000112237', 'MLS000584128', 'MLSMR'
IUPAC Name: phenazine
Structure
SMILES: C1=CC=C2N=C3C=CC=CC3=NC2=C1
InChI: InChI=1S/C12H8N2/c1-2-6-10-9(5-1)13-11-7-3-4-8-12(11)14-10/h1-8H
InChIKey: PCNDJXKNXGMECE-UHFFFAOYSA-N
Reference
Mutational analysis of a phenazine biosynthetic gene cluster in <i>Streptomyces anulatus</i> 9663
PubChem CID: 4757
CAS: 304-81-4
LOTUS: LTS0178642
COCONUT: CNP0249401
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 180.21
TPSA？: 25.78
MolLogP？: 2.7830000000000013
Number of H-Donors: 0
Number of H-Acceptors: 2
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Equus caballus | Ferritin light chain | Potency | 10000.0 | nM | None |
| Escherichia coli K-12 | Beta-lactamase AmpC | Potency | 11220.2 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 100000.0 | nM | None |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 89.1 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 89125.1 | nM | None |
| Homo sapiens | Geminin | Potency | 6513.1 | nM | None |
| Homo sapiens | HepG2 | IC50 | 7800.0 | nM | 10.1016/j.ejmech.2019.01.028 |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 44668.4 | nM | None |
| Homo sapiens | Microtubule-associated protein tau | Potency | 44668.4 | nM | None |
| Homo sapiens | Muscleblind-like protein 1 | Potency | 7079.5 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 20596.2 | nM | None |
| Homo sapiens | Prion protein | EC50 | 10000.0 | nM | 10.1021/jm034093h |
| Homo sapiens | TAR DNA-binding protein 43 | Potency | 2818.4 | nM | None |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 6250.0 | nM | 10.1021/acs.jmedchem.9b00370 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC | 6250.0 | nM | 10.1021/acs.jmedchem.9b00370 |
| None | ADMET | log Ks | 2.41 | None | 10.1016/j.bmc.2008.11.040 |
| None | No relevant target | LogP | 2.81 | None | 10.1021/jm00227a008 |
| None | No relevant target | LogP | 2.846 | None | 10.1021/jm00227a008 |
| None | Unchecked | Potency | 11220.2 | nM | None |
| None | Unchecked | Potency | 12589.3 | nM | None |
| None | Unchecked | Potency | 29092.9 | nM | None |
| None | Unchecked | Potency | 35481.3 | nM | None |