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name Structure Reference Source Properties Activities Metabolism

5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one

AlkaPlorer ID: AK003154

Synonym: None

IUPAC Name: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one

Structure

SMILES: CCCC1=NN(C)C2=C1N=C(C1=CC(S(=O)(=O)N3CCN(C)CC3)=CC=C1OCC)NC2=O

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InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

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InChIKey: BNRNXUUZRGQAQC-UHFFFAOYSA-N

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Reference

PubChem CID: 25181564

CAS: 139755-83-2

COCONUT: CNP0250743

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 474.58700000000033

TPSA？: 113.42

MolLogP？: 1.610899999999999

Number of H-Donors: 1

Number of H-Acceptors: 8

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Phosphodiesterase 1 IC50 400.0 nM 10.1016/s0960-894x(02)00030-6
Bos taurus Phosphodiesterase 1 IC50 561.0 nM 10.1016/j.bmcl.2005.03.102
Bos taurus Phosphodiesterase 1 IC50 739.0 nM 10.1016/j.bmcl.2004.02.040
Bos taurus Phosphodiesterase 1 IC50 1100.0 nM 10.1021/jm030056e
Bos taurus Phosphodiesterase 1 IC50 1100.0 nM 10.1021/jm0300577
Bos taurus Phosphodiesterase 1 IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Bos taurus Phosphodiesterase 2A IC50 10000.0 nM 10.1021/jm000558h
Bos taurus Phosphodiesterase 2A IC50 43000.0 nM 10.1016/s0960-894x(03)00440-2
Bos taurus Phosphodiesterase 3B IC50 9200.0 nM 10.1021/jm030056e
Bos taurus Phosphodiesterase 3B IC50 9200.0 nM 10.1021/jm0300577
Bos taurus Phosphodiesterase 5A IC50 6.0 nM 10.1021/jm030056e
Bos taurus Phosphodiesterase 5A IC50 6.0 nM 10.1021/jm0300577
Bos taurus Phosphodiesterase 5A IC50 10.0 nM 10.1016/j.bmcl.2008.09.108
Bos taurus Phosphodiesterase 5A IC50 10.0 nM 10.1016/j.bmcl.2009.10.071
Bos taurus Phosphodiesterase 5A IC50 10.0 nM 10.1016/j.bmcl.2012.04.094
Bos taurus Phosphodiesterase 5A IC50 3300.0 nM 10.1016/j.ejmech.2019.05.026
Bos taurus Phosphodiesterase 5A Inhibition 98.0 % 10.1016/j.ejmech.2019.05.026
Bos taurus Phosphodiesterase 6 IC50 19.77 nM 10.1016/j.bmcl.2004.02.040
Bos taurus Phosphodiesterase 6 IC50 25.0 nM 10.1016/j.bmcl.2005.03.102
Bos taurus Phosphodiesterase 6 IC50 28.0 nM 10.1016/s0960-894x(03)00440-2
Bos taurus Phosphodiesterase 6 IC50 40.0 nM 10.1016/j.bmcl.2005.02.090
Bos taurus Phosphodiesterase 6 IC50 74.0 nM 10.1021/jm0300577
Bos taurus Phosphodiesterase 6A IC50 140.0 nM 10.1016/j.bmcl.2009.10.071
Bos taurus Phosphodiesterase 6C IC50 33.0 nM 10.1021/jm060113e
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Canis lupus familiaris Canis familiaris ED50 0.0051 mg.kg-1 10.1021/jm025545d
Canis lupus familiaris Canis familiaris ED50 0.0051 mg.kg-1 10.1021/jm0401098
Canis lupus familiaris Canis familiaris ED50 5.1 ug ml-1 10.1016/s0960-894x(02)01036-3
Canis lupus familiaris Canis familiaris T1/2 5.2 hr 10.1021/jm0155042
Canis lupus familiaris Canis familiaris T1/2 5.2 hr 10.1021/jm0256068
Canis lupus familiaris Phosphodiesterase 5A IC50 1.0 nM 10.1016/s0960-894x(03)00440-2
Canis lupus familiaris Phosphodiesterase 5A IC50 3.9 nM 10.1021/jm000558h
Canis lupus familiaris Plasma Fu 0.26 None 10.1039/C4MD00148F
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Escherichia coli K-12 Beta-lactamase AmpC Potency 50118.7 nM None
Homo sapiens A549 IC50 nan None 10.1016/j.bmcl.2018.11.043
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 6920.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 1493.0 nM None
Homo sapiens Adenosine A1 receptor Ki 871.0 nM None
Homo sapiens Adenosine A2a receptor AC50 441.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 253.0 nM None
Homo sapiens Adenosine A2a receptor Ki 142.0 nM None
Homo sapiens Adenosine A2a receptor Ki 199.53 nM 10.1021/jm300280e
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 4098.5 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens ATP-binding cassette sub-family C member 11 Activity 79.0 % 10.1124/mol.104.007138
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump IC50 16430.0 nM 10.1124/dmd.112.047068
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Caco-2 logPapp -4.32 None 10.1016/j.bmc.2011.03.011
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 5011.9 nM None
Homo sapiens Delta opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine D5 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 707.9 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Hepatocyte CL 6.0 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte CL 14.8 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
Homo sapiens Hepatocyte logCL 0.7782 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 3300.0 nM 10.1021/jm900002x
Homo sapiens HERG IC50 3311.31 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 3311.31 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 3311.31 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 3311.31 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HERG IC50 31622.78 nM 10.1016/j.vascn.2014.07.002
Homo sapiens HERG IC50 100000.0 nM 10.1016/j.ejmech.2008.11.009
Homo sapiens HERG IC50 100000.0 nM 10.1016/j.vascn.2014.07.002
Homo sapiens HERG IC50 100000.0 nM 10.1021/jm0208875
Homo sapiens HERG IC50 158489.32 nM 10.1016/j.vascn.2014.07.002
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 FC nan None 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 FC nan None 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 Inhibition -71.51 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 0.2 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b00908
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 6.0 mL.min-1.kg-1 10.1124/dmd.111.042309
Homo sapiens Homo sapiens CL 9.1 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 9.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 40.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fa 0.92 None 10.1021/jm901371v
Homo sapiens Homo sapiens FA 92.0 None 10.1021/jm001101a
Homo sapiens Homo sapiens F_fraction 0.41 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.74 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.6 None 10.1021/jm901371v
Homo sapiens Homo sapiens Pc 87000000.0 cm s-1 10.1021/jm001101a
Homo sapiens Homo sapiens Ratio 0.83 None 10.1021/jm001101a
Homo sapiens Homo sapiens Vdss 1.4 L.kg-1 10.1021/jm901371v
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 Activity 46.0 % None
Homo sapiens Multidrug resistance-associated protein 4 IC50 20000.0 nM 10.1124/mol.63.5.1094
Homo sapiens Multidrug resistance-associated protein 5 Activity 16.2 % 10.1021/jm2014666
Homo sapiens Multidrug resistance-associated protein 5 Activity 22.0 % 10.1074/jbc.m005463200
Homo sapiens Multidrug resistance-associated protein 5 IC50 80000.0 nM 10.1124/mol.63.5.1094
Homo sapiens Multidrug resistance-associated protein 5 Inhibition 85.0 % 10.1021/jm2014666
Homo sapiens Multidrug resistance-associated protein 5 Ki 1200.0 nM 10.1021/jm2014666
Homo sapiens Multidrug resistance-associated protein 7 Activity 41.0 % 10.1124/mol.63.2.351
Homo sapiens Mu opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens PC-3 FC 1.037 None 10.1038/nchembio790
Homo sapiens PDE5A/PDE6C Ki 25.0 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 1 IC50 270.0 nM 10.1016/s0960-894x(03)00440-2
Homo sapiens Phosphodiesterase 1 IC50 350.0 nM 10.1021/jm040217u
Homo sapiens Phosphodiesterase 1 IC50 400.0 nM 10.1016/j.bmcl.2005.05.090
Homo sapiens Phosphodiesterase 1 IC50 819.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 1 IC50 1100.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 1 IC50 1500.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 10A IC50 3100.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 10A IC50 5400.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 10A IC50 6800.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 10A IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 10A IC50 10000.0 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 11A IC50 2300.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 11A IC50 3000.0 nM 10.1016/j.bmcl.2008.09.108
Homo sapiens Phosphodiesterase 11A IC50 3000.0 nM 10.1016/j.bmcl.2009.10.071
Homo sapiens Phosphodiesterase 11A IC50 4210.0 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 11A IC50 4930.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 11A IC50 6100.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 11A IC50 7800.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 1A IC50 600.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.bmcl.2005.02.025
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1021/jm030056e
Homo sapiens Phosphodiesterase 2A IC50 10000.0 nM 10.1021/jm0300577
Homo sapiens Phosphodiesterase 2A IC50 63000.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 2 and 5 (PDE2 and PDE5) Ratio 4000.0 None 10.1021/jm025545d
Homo sapiens Phosphodiesterase 2 and 5 (PDE2 and PDE5) Ratio 8900.0 None 10.1021/jm0202573
Homo sapiens Phosphodiesterase 2 and 5 (PDE2 and PDE5) Selectivity 4000.0 None 10.1016/s0960-894x(02)01036-3
Homo sapiens Phosphodiesterase 2 and 5 (PDE2 and PDE5) Selectivity 8910.0 None 10.1021/jm020521s
Homo sapiens Phosphodiesterase 3 IC50 500.0 nM 10.1016/s0960-894x(02)00030-6
Homo sapiens Phosphodiesterase 3 IC50 7000.0 nM 10.1016/j.bmcl.2004.03.021
Homo sapiens Phosphodiesterase 3 IC50 7000.0 nM 10.1016/j.bmcl.2005.02.025
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 3 IC50 10000.0 nM 10.1021/jm000558h
Homo sapiens Phosphodiesterase 3 IC50 14600.0 nM 10.1016/j.bmcl.2004.02.040
Homo sapiens Phosphodiesterase 3 IC50 65000.0 nM 10.1016/0960-894X(96)00323-X
Homo sapiens Phosphodiesterase 3 IC50 100000.0 nM 10.1016/s0960-894x(03)00440-2
Homo sapiens Phosphodiesterase 3A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A IC50 26000.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) IC50 ratio 3500.0 None 10.1021/jm000081+
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) IC50 ratio 3500.0 None 10.1021/jm000336j
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) IC50 ratio 4100.0 None 10.1021/jm0155042
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) IC50 ratio 8000.0 None 10.1016/j.bmcl.2004.02.040
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Ratio 3500.0 None 10.1016/s0960-894x(01)00466-8
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Ratio 4100.0 None 10.1021/jm0256068
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Ratio 7000.0 None 10.1021/jm025545d
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Ratio 12858.0 None 10.1021/jm0202573
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Selectivity 7000.0 None 10.1016/s0960-894x(02)01036-3
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Selectivity 12900.0 None 10.1021/jm020521s
Homo sapiens Phosphodiesterase 3 and 5 (PDE3 and PDE5) Selectivity ratio 3500.0 None 10.1016/j.bmcl.2003.12.090
Homo sapiens Phosphodiesterase 4 IC50 500.0 nM 10.1016/s0960-894x(02)00030-6
Homo sapiens Phosphodiesterase 4 IC50 7800.0 nM 10.1021/jm030056e
Homo sapiens Phosphodiesterase 4 IC50 7800.0 nM 10.1021/jm0300577
Homo sapiens Phosphodiesterase 4 IC50 8300.0 nM 10.1021/jm000558h
Homo sapiens Phosphodiesterase 4 IC50 9100.0 nM 10.1016/j.bmcl.2012.04.094
Homo sapiens Phosphodiesterase 4 IC50 9600.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 4 IC50 10000.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 4 IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 4 IC50 11000.0 nM 10.1016/s0960-894x(03)00440-2
Homo sapiens Phosphodiesterase 4A IC50 5000.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 4 and 5 (PDE4 and PDE5) IC50 ratio 2600.0 None 10.1021/jm000336j
Homo sapiens Phosphodiesterase 4 and 5 (PDE4 and PDE5) Ratio 2555.0 None 10.1021/jm0202573
Homo sapiens Phosphodiesterase 4 and 5 (PDE4 and PDE5) Ratio 3000.0 None 10.1021/jm025545d
Homo sapiens Phosphodiesterase 4 and 5 (PDE4 and PDE5) Selectivity 2560.0 None 10.1021/jm020521s
Homo sapiens Phosphodiesterase 4 and 5 (PDE4 and PDE5) Selectivity 3000.0 None 10.1016/s0960-894x(02)01036-3
Homo sapiens Phosphodiesterase 4B IC50 20000.0 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 4D AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D IC50 20000.0 nM 10.1016/j.bmc.2010.01.070
Homo sapiens Phosphodiesterase 5A Control relaxation 150.0 % 10.1021/jm000336j
Homo sapiens Phosphodiesterase 5A EC50 8.7 nM 10.1021/jm000558h
Homo sapiens Phosphodiesterase 5A EC50 42.0 nM 10.1021/jm0155042
Homo sapiens Phosphodiesterase 5A EC50 1000.0 nM 10.1016/j.bmcl.2020.127337
Homo sapiens Phosphodiesterase 5A FC 0.6 None 10.1021/acs.jmedchem.6b00908
Homo sapiens Phosphodiesterase 5A FC 1.9 None 10.1021/acs.jmedchem.6b00908
Homo sapiens Phosphodiesterase 5A IC50 1.0 nM 10.1016/j.ejmech.2019.05.026
Homo sapiens Phosphodiesterase 5A IC50 1.4 nM 10.1016/j.bmc.2022.117092
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1016/j.bmcl.2003.12.090
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1016/j.bmcl.2014.09.082
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1016/s0960-894x(01)00466-8
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1021/jm000081+
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1021/jm000336j
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1021/jm0155042
Homo sapiens Phosphodiesterase 5A IC50 1.6 nM 10.1021/jm0256068
Homo sapiens Phosphodiesterase 5A IC50 1.78 nM 10.1016/j.bmcl.2004.02.040
Homo sapiens Phosphodiesterase 5A IC50 2.2 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 5A IC50 2.2 nM 10.1021/acs.jmedchem.5b01813
Homo sapiens Phosphodiesterase 5A IC50 2.2 nM 10.1021/acs.jmedchem.7b01370
Homo sapiens Phosphodiesterase 5A IC50 3.0 nM 10.1016/0960-894X(96)00323-X
Homo sapiens Phosphodiesterase 5A IC50 3.0 nM 10.1016/j.bmcl.2005.03.102
Homo sapiens Phosphodiesterase 5A IC50 3.0 nM 10.1021/acs.jmedchem.0c01120
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1016/j.bmcl.2003.12.027
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1016/j.bmcl.2008.10.037
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1016/j.bmcl.2010.03.106
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1016/s0960-894x(02)00646-7
Homo sapiens Phosphodiesterase 5A IC50 3.5 nM 10.1021/jm060113e
Homo sapiens Phosphodiesterase 5A IC50 3.6 nM 10.1016/0960-894X(96)00323-X
Homo sapiens Phosphodiesterase 5A IC50 3.6 nM 10.1021/acs.jmedchem.0c01093
Homo sapiens Phosphodiesterase 5A IC50 3.631 nM 10.1016/j.bmc.2008.07.022
Homo sapiens Phosphodiesterase 5A IC50 3.65 nM 10.1016/j.ejmech.2018.02.039
Homo sapiens Phosphodiesterase 5A IC50 3.9 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 5A IC50 3.981 nM 10.1021/acs.jmedchem.8b00180
Homo sapiens Phosphodiesterase 5A IC50 4.0 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Phosphodiesterase 5A IC50 4.31 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 5A IC50 4.577 nM None
Homo sapiens Phosphodiesterase 5A IC50 4.66 nM 10.1016/j.ejmech.2019.111852
Homo sapiens Phosphodiesterase 5A IC50 4.9 nM 10.1021/acs.jmedchem.0c01120
Homo sapiens Phosphodiesterase 5A IC50 5.0 nM 10.1021/acs.jmedchem.0c00983
Homo sapiens Phosphodiesterase 5A IC50 5.1 nM 10.1021/acs.jmedchem.8b01209
Homo sapiens Phosphodiesterase 5A IC50 5.22 nM 10.1039/d2md00206j
Homo sapiens Phosphodiesterase 5A IC50 5.6 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 5A IC50 6.6 nM 10.1016/j.bmcl.2005.05.090
Homo sapiens Phosphodiesterase 5A IC50 6.6 nM 10.1016/s0960-894x(02)00030-6
Homo sapiens Phosphodiesterase 5A IC50 6.607 nM 10.1016/j.bmc.2008.07.022
Homo sapiens Phosphodiesterase 5A IC50 8.5 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Phosphodiesterase 5A IC50 8.5 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Phosphodiesterase 5A IC50 11.0 nM 10.1016/j.bmcl.2004.03.021
Homo sapiens Phosphodiesterase 5A IC50 20.0 nM 10.1016/j.bmcl.2005.02.090
Homo sapiens Phosphodiesterase 5A IC50 20.0 nM 10.1021/jm060265+
Homo sapiens Phosphodiesterase 5A IC50 53.0 nM 10.1021/jm701400r
Homo sapiens Phosphodiesterase 5A IC50 75.0 nM 10.1021/np800049y
Homo sapiens Phosphodiesterase 5A IC50 12590.0 nM 10.1016/j.bmcl.2017.07.013
Homo sapiens Phosphodiesterase 5A IC50 562341325190.35 nM 10.1016/j.bmcl.2007.05.064
Homo sapiens Phosphodiesterase 5A Inhibition 54.9 % 10.1021/acs.jmedchem.0c01132
Homo sapiens Phosphodiesterase 5A Inhibition 74.0 % 10.1016/j.ejmech.2018.02.039
Homo sapiens Phosphodiesterase 5A Inhibition 98.0 % 10.1016/j.ejmech.2018.02.039
Homo sapiens Phosphodiesterase 5A Inhibition 100.0 % 10.1016/j.bmcl.2020.127337
Homo sapiens Phosphodiesterase 5A Ki 1.6 nM 10.1016/j.ejmech.2018.09.028
Homo sapiens Phosphodiesterase 5A Ki 1.87 nM 10.1016/s0960-894x(02)01036-3
Homo sapiens Phosphodiesterase 5A Ki 1.87 nM 10.1021/jm025545d
Homo sapiens Phosphodiesterase 5A Ki 1.91 nM 10.1021/jm0202573
Homo sapiens Phosphodiesterase 5A Ki 1.91 nM 10.1021/jm020521s
Homo sapiens Phosphodiesterase 5A Ki 10.0 nM 10.1021/jm040217u
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphodiesterase 6 IC50 0.5 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 6 IC50 9.5 nM 10.1016/j.ejmech.2022.114170
Homo sapiens Phosphodiesterase 6 IC50 25.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 6 IC50 40.0 nM 10.1021/jm060265+
Homo sapiens Phosphodiesterase 6 Ki 30.0 nM 10.1021/acs.jmedchem.1c00115
Homo sapiens Phosphodiesterase 6 Ki 50.0 nM 10.1021/jm040217u
Homo sapiens Phosphodiesterase 6A AC50 211.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 6C IC50 24.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 6C IC50 36.42 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 6C IC50 39.2 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 6C IC50 160.0 nM 10.1021/np800049y
Homo sapiens Phosphodiesterase 7 IC50 10000.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 7 IC50 10000.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 7 IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 7A IC50 4690.0 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 7A IC50 22000.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 8 IC50 10000.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 8A IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 8A IC50 10000.0 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase 8A IC50 100000.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 9A IC50 3400.0 nM 10.1016/j.bmcl.2005.02.083
Homo sapiens Phosphodiesterase 9A IC50 3600.0 nM 10.1016/j.bmc.2015.03.005
Homo sapiens Phosphodiesterase 9A IC50 5600.0 nM 10.1016/j.ejmech.2012.12.009
Homo sapiens Phosphodiesterase 9A IC50 10000.0 nM 10.1021/acs.jmedchem.9b00123
Homo sapiens Phosphodiesterase 9A IC50 10000.0 nM 10.1021/jm301159y
Homo sapiens Phosphodiesterase, PDE1/PDE5 Ratio 120.0 None 10.1021/jm025545d
Homo sapiens Phosphodiesterase, PDE1/PDE5 Ratio 136.0 None 10.1021/jm0202573
Homo sapiens Phosphodiesterase, PDE1/PDE5 Selectivity 120.0 None 10.1016/s0960-894x(02)01036-3
Homo sapiens Phosphodiesterase, PDE1/PDE5 Selectivity 140.0 None 10.1021/jm020521s
Homo sapiens Phosphodiesterase, PDE1/PDE5 Selectivity 327.1 None 10.1016/j.bmcl.2003.12.027
Homo sapiens Phosphodiesterases; PDE5 & PDE6 Ratio 7.0 None 10.1016/s0960-894x(02)00646-7
Homo sapiens Phosphodiesterases; PDE5 & PDE6 Selectivity 7.1 None 10.1016/j.bmcl.2003.12.027
Homo sapiens Plasma Fu 0.064 None 10.1039/C4MD00148F
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 5a (5-HT5a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Sodium channel protein type V alpha subunit IC50 501187.23 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Sodium channel protein type V alpha subunit IC50 1258925.41 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 22.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 30.8 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 45.9 % 10.1021/jm300212s
Homo sapiens THLE-2 LC50 100000.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 89125.1 nM None
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 100000.0 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit pIC50 nan None 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) IC50 158489.32 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) IC50 398107.17 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel subunit Kv4.3 IC50 501187.23 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Whole blood Retention_time 5.54 min 10.1007/s00044-012-9977-1
Mus musculus Indoleamine 2,3-dioxygenase 1 IC50 100000.0 nM 10.1016/j.bmcl.2012.10.010
Mus musculus Indoleamine 2,3-dioxygenase 2 IC50 4500.0 nM 10.1016/j.bmcl.2012.10.010
Mus musculus Indoleamine 2,3-dioxygenase 2 Inhibition 55.0 % 10.1016/j.bmcl.2012.10.010
Mus musculus Liver Drug metabolism 90.0 % 10.1016/j.bmc.2015.03.005
Mus musculus Mus musculus LC50 nan None 10.1021/acs.jmedchem.6b00908
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Tryptophan 2,3-dioxygenase Inhibition nan % 10.1016/j.bmcl.2012.10.010
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Aorta EC50 56.23 nM 10.1021/jm701400r
Oryctolagus cuniculus Aorta EC50 269.15 nM 10.1021/jm701400r
Oryctolagus cuniculus Aorta Emax 56.0 % 10.1021/jm701400r
Oryctolagus cuniculus Aorta Emax 76.0 % 10.1021/jm701400r
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Corpus cavernosum EC50 8.7 nM 10.1016/j.bmcl.2015.02.041
Oryctolagus cuniculus Corpus cavernosum EC50 169.82 nM 10.1021/jm701400r
Oryctolagus cuniculus Corpus cavernosum Emax 105.0 % 10.1021/jm701400r
Oryctolagus cuniculus Oryctolagus cuniculus AUC 305.0 None 10.1016/j.bmc.2015.03.005
Oryctolagus cuniculus Oryctolagus cuniculus EC50 7.9 nM 10.1016/s0960-894x(03)00440-2
Oryctolagus cuniculus Oryctolagus cuniculus ED50 0.11 umol.kg-1 10.1021/jm0256068
Oryctolagus cuniculus Oryctolagus cuniculus ED50 14.25 ug 10.1016/j.ejmech.2018.02.039
Plasmodium falciparum Plasmodium falciparum Potency 10417.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 15101.4 nM None
Plasmodium falciparum Plasmodium falciparum Potency 16944.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 1457.0 nM None
Rattus norvegicus Alpha-1b adrenergic receptor Ki 806.0 nM None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Aorta Activity 50.0 % 10.1016/j.bmcl.2014.05.004
Rattus norvegicus Artery EC50 140.0 nM 10.1016/j.bmcl.2018.11.043
Rattus norvegicus Corpus cavernosum EC50 1000.0 nM 10.1016/j.bmcl.2020.127337
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peripheral myelin protein 22 Potency 25574.8 nM None
Rattus norvegicus Phosphodiesterase 1 IC50 260.0 nM 10.1016/0960-894X(96)00323-X
Rattus norvegicus Phosphodiesterase 1 IC50 300.0 nM 10.1021/jm000558h
Rattus norvegicus Phosphodiesterase 2A IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
Rattus norvegicus Phosphodiesterase 4 IC50 4600.0 nM 10.1016/j.bmcl.2004.03.021
Rattus norvegicus Phosphodiesterase 5A IC50 0.3 nM 10.1016/s0960-894x(02)00401-8
Rattus norvegicus Phosphodiesterase 5A IC50 2.0 nM 10.1016/j.bmcl.2018.11.043
Rattus norvegicus Phosphodiesterase 5A Ki 1.8 nM 10.1021/jm0401098
Rattus norvegicus Plasma Fu 0.04 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/acs.jmedchem.9b00123
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm301159y
Rattus norvegicus Rattus norvegicus ALB 36700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 37700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 232.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 300.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 304.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 319.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 335.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 336.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 344.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 356.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 363.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 377.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 383.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 396.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 33.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 41.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 45.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 45.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 47.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 61.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 65.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 57.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 68.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 70.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 71.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 72.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 76.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 78.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 82.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 95.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 141.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 156.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 610.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 633.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 651.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 691.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 706.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 743.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 765.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 770.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 776.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 796.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 155.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 170.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 188.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 190.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 203.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 212.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 228.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 241.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 248.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 253.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 284.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 489.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 29670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 110.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 23.0 % 10.1021/acs.jmedchem.7b00523
Rattus norvegicus Rattus norvegicus F 23.0 % 10.1021/jm301159y
Rattus norvegicus Rattus norvegicus GLUC 1373.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1440.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1446.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1453.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1470.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1480.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1503.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1510.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1536.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1540.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1630.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.02 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.55 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.03 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.63 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.08 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 97.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 100.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 106.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 107.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 107.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 110.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 119.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 120.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 130.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 133.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 142.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 157.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 13.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7128.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7722.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7802.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7975.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8681.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8874.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9298.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10278.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10538.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12359.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12448.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12663.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 95.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.92 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.12 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.4 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.47 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.9 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.97 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.83 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 26.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 381000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 384300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 386300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 389800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 390300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 390700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 392300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 403000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.22 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.78 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.05 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.23 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.9 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.5 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.33 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 13.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 15.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 36.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 53.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 54.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 74.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 79.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 81.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 122.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 138.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 3.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 348.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 491.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 617.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 658.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 689.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 756.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 762.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 821.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 847.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 877.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 891.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 955.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 84.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 95.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 97.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 102.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 126.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 128.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 629670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 802000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 944330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1001170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1027000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1090670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1112670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1124830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1148670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1163000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1202170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1264670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.71 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.84 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.85 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.88 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.98 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.11 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.39 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.45 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 51300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 54300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Ratio 55.89 None 10.1016/j.bmcl.2009.03.125
Rattus norvegicus Rattus norvegicus RBC 5050000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5210000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5350000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5390000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5430000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5440000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5490000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5590000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5640000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5720000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5750000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.67 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.75 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.35 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.02 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 0.3 hr 10.1021/jm0155042
Rattus norvegicus Rattus norvegicus T1/2 0.3 hr 10.1021/jm0256068
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8270.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9450.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9700.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11320.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13370.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1151 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.6944 None 10.1101/2020.04.03.023846
Staphylococcus aureus Quinolone resistance protein norA Inhibition 22.9 % 10.1021/acs.jmedchem.6b01439
Trypanosoma brucei Class 1 phosphodiesterase PDEB1 Inhibition 51.5 % 10.1016/j.bmcl.2012.01.119
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CL 9.1 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 16.6 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 30.5 mL.min-1.kg-1 10.1021/acs.jmedchem.9b00123
None ADMET CL 49.32 mL.min-1.kg-1 10.1021/acs.jmedchem.8b01041
None ADMET CL 49.32 mL.min-1.kg-1 10.1021/acs.jmedchem.8b01209
None ADMET CL 89.9 mL.min-1.kg-1 10.1124/dmd.111.042309
None ADMET CL 131.83 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 150.0 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 258.2 mL.min-1.g-1 10.1021/acs.jmedchem.8b01041
None ADMET CL 258.2 mL.min-1.g-1 10.1021/acs.jmedchem.8b01209
None ADMET CL 462.69 mL.min-1.kg-1 10.1021/acs.jmedchem.8b01041
None ADMET CL 462.69 mL.min-1.kg-1 10.1021/acs.jmedchem.8b01209
None ADMET Cmax 160.14 nM 10.1021/acs.jmedchem.9b00123
None ADMET ERH 89.0 % 10.1021/acs.jmedchem.8b01041
None ADMET ERH 89.0 % 10.1021/acs.jmedchem.8b01209
None ADMET F 11.0 % 10.1021/jm025545d
None ADMET F 15.0 % 10.1021/jm0155042
None ADMET F 15.0 % 10.1021/jm0256068
None ADMET F 34.0 % 10.1021/acs.jmedchem.9b00123
None ADMET F 54.0 % 10.1021/jm0155042
None ADMET F 54.0 % 10.1021/jm0256068
None ADMET Fu 0.066 None 10.1016/j.bmc.2015.03.005
None ADMET Fu 0.094 None 10.1124/dmd.111.042309
None ADMET K 0.1291 None 10.1021/acs.jmedchem.8b01041
None ADMET K 0.1291 None 10.1021/acs.jmedchem.8b01209
None ADMET MRT 2.6 hr 10.1124/dmd.108.020479
None ADMET Papp 48000000.0 cm s-1 10.1021/jm001101a
None ADMET Peff 27.5 nm/s 10.1021/acs.jmedchem.6b00908
None ADMET permeability 37.9 10'-6 cm/s 10.1016/j.bmc.2015.03.005
None ADMET permeability 45.5 10'-6 cm/s 10.1016/j.bmc.2015.03.005
None ADMET PPB 82.39 % 10.6019/CHEMBL3301361
None ADMET PPB 90.12 % 10.6019/CHEMBL3301361
None ADMET PPB 95.53 % 10.6019/CHEMBL3301361
None ADMET Ratio 1.2 None 10.1016/j.bmc.2015.03.005
None ADMET T1/2 0.0895 hr 10.1016/j.bmcl.2020.127254
None ADMET T1/2 0.0895 hr 10.1021/acs.jmedchem.1c00862
None ADMET T1/2 0.0895 hr 10.1021/acs.jmedchem.8b01041
None ADMET T1/2 0.65 hr 10.1021/acs.jmedchem.9b00123
None ADMET T1/2 1.1 hr 10.1021/acs.jmedchem.9b00123
None ADMET T1/2 3.9 hr 10.1124/dmd.108.020479
None ADMET T1/2 5.37 hr 10.1021/acs.jmedchem.8b01209
None ADMET Tmax 1.6 hr 10.1021/acs.jmedchem.9b00123
None ADMET Vdss 1.4 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 1.6 L.kg-1 10.1021/acs.jmedchem.9b00123
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Molecular identity unknown PPB 96.0 % 10.1016/j.bmc.2015.03.005
None NON-PROTEIN TARGET FC nan None 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET Fu 0.04 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.962 None 10.1124/dmd.111.042309
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Inhibition nan % 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET LC50 100000.0 nM 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET Potency 1058.4 nM None
None NON-PROTEIN TARGET Selectivity ratio 0.4 None 10.1021/acs.jmedchem.6b00908
None No relevant target LogD 2.29 None 10.1016/j.ejmech.2008.11.009
None No relevant target LogD 2.69 None 10.1016/j.bmc.2015.03.005
None No relevant target LogD 2.69 None 10.1016/j.bmc.2022.117092
None No relevant target LogD 2.7 None 10.1016/0960-894X(96)00323-X
None No relevant target LogD 2.7 None 10.1016/j.bmcl.2008.10.037
None No relevant target LogD7.4 2.8 None 10.6019/CHEMBL3301361
None No relevant target LogP 2.511 None 10.1016/j.bmc.2008.07.022
None No relevant target LogP 2.58 None 10.1016/j.bmc.2015.03.005
None No relevant target Peff 27.5 nm/s 10.1016/j.ejmech.2018.03.005
None No relevant target pKa 4.86 None 10.1016/j.bmc.2015.03.005
None No relevant target pKa 6.7 None 10.1124/dmd.111.042309
None No relevant target solubility nan None 10.1016/j.bmcl.2018.11.043
None No relevant target Solubility 180.0 ug.mL-1 10.1016/j.bmc.2022.117092
None No relevant target Solubility 20000.0 nM 10.6019/CHEMBL3301361
None Unchecked EC50 19.0 nM 10.1021/jm0256068
None Unchecked FC 0.6 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC 1.8 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC 1.9 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC nan None 10.1016/j.ejmech.2018.03.005
None Unchecked Hepatotoxicity (acute) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 1.2 nM 10.1021/acs.jmedchem.0c00983
None Unchecked IC50 2.2 nM 10.1016/j.ejmech.2022.114170
None Unchecked IC50 3.0 nM 10.1016/j.bmcl.2009.03.125
None Unchecked IC50 3.3 nM 10.1021/jm200644r
None Unchecked IC50 5.0 nM 10.1016/j.ejmech.2018.03.046
None Unchecked IC50 10.0 nM 10.1016/j.bmcl.2009.03.125
None Unchecked IC50 10.0 nM 10.1021/acs.jmedchem.1c00261
None Unchecked IC50 11.0 nM 10.1016/j.bmcl.2005.02.025
None Unchecked IC50 13.0 nM 10.1016/j.bmcl.2018.11.043
None Unchecked IC50 30.0 nM 10.1016/j.bmcl.2009.03.125
None Unchecked IC50 30.0 nM 10.1016/j.bmcl.2010.03.106
None Unchecked IC50 100.0 nM 10.1016/j.bmcl.2012.04.094
None Unchecked IC50 140.0 nM 10.1016/j.bmcl.2008.09.108
None Unchecked IC50 230.0 nM 10.1021/jm301159y
None Unchecked IC50 4600.0 nM 10.1016/j.bmcl.2005.02.025
None Unchecked IC50 5830.0 nM 10.1021/jm301159y
None Unchecked IC50 7310.0 nM 10.1021/jm301159y
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2004.03.021
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2005.02.025
None Unchecked IC50 10000.0 nM 10.1016/j.bmcl.2005.02.083
None Unchecked IC50 10000.0 nM 10.1021/jm301159y
None Unchecked IC50 27500.0 nM 10.1021/np800049y
None Unchecked IC50 nan None None
None Unchecked IC50 ratio 7.0 None 10.1021/jm0155042
None Unchecked IC50 ratio 8.0 None 10.1021/jm000081+
None Unchecked IC50 ratio 8.0 None 10.1021/jm000336j
None Unchecked IC50 ratio 10.0 None 10.1021/jm000081+
None Unchecked IC50 ratio 11.0 None 10.1016/j.bmcl.2004.02.040
None Unchecked IC50 ratio 140.0 None 10.1021/jm000081+
None Unchecked IC50 ratio 140.0 None 10.1021/jm000336j
None Unchecked IC50 ratio 160.0 None 10.1021/jm0155042
None Unchecked IC50 ratio 415.0 None 10.1016/j.bmcl.2004.02.040
None Unchecked IC50 ratio 2600.0 None 10.1021/jm000081+
None Unchecked IC50 ratio 2900.0 None 10.1021/jm0155042
None Unchecked IC50 ratio 12000.0 None 10.1021/jm0155042
None Unchecked IC50 ratio 100000.0 None 10.1021/jm000336j
None Unchecked Inhibition 98.9 % 10.1016/j.bmc.2014.10.009
None Unchecked Inhibition nan % 10.1016/j.bmc.2022.117092
None Unchecked Inhibition nan % 10.1016/j.ejmech.2018.03.005
None Unchecked Ki nan None None
None Unchecked Potency 707.9 nM None
None Unchecked Ratio 4.0 None 10.1021/jm025545d
None Unchecked Ratio 7.0 None 10.1021/jm0256068
None Unchecked Ratio 8.0 None 10.1016/s0960-894x(01)00466-8
None Unchecked Ratio 8.0 None 10.1021/jm0202573
None Unchecked Ratio 12.0 None 10.1021/jm0202573
None Unchecked Ratio 12.0 None 10.1021/jm0300577
None Unchecked Ratio 140.0 None 10.1016/s0960-894x(01)00466-8
None Unchecked Ratio 160.0 None 10.1021/jm0256068
None Unchecked Ratio 180.0 None 10.1021/jm0300577
None Unchecked Ratio 2600.0 None 10.1016/s0960-894x(01)00466-8
None Unchecked Ratio 2900.0 None 10.1021/jm0256068
None Unchecked Ratio 10000.0 None 10.1021/jm0256068
None Unchecked Ratio 100000.0 None 10.1016/s0960-894x(01)00466-8
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 2.0 None 10.1016/j.ejmech.2018.02.039
None Unchecked Ratio IC50 2.2 None 10.1021/np800049y
None Unchecked Ratio IC50 4.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 4.2 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 5.0 None 10.1021/acs.jmedchem.0c00983
None Unchecked Ratio IC50 5.0 None 10.1021/acs.jmedchem.7b00523
None Unchecked Ratio IC50 6.5 None 10.1016/j.bmcl.2018.11.043
None Unchecked Ratio IC50 8.0 None 10.1021/acs.jmedchem.9b00123
None Unchecked Ratio IC50 10.0 None 10.1016/j.bmcl.2020.127097
None Unchecked Ratio IC50 11.0 None 10.1016/j.bmcl.2008.10.037
None Unchecked Ratio IC50 12.0 None 10.1021/acs.jmedchem.7b01370
None Unchecked Ratio IC50 16.0 None 10.1016/j.bmcl.2014.09.082
None Unchecked Ratio IC50 107.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 180.0 None 10.1021/acs.jmedchem.7b01370
None Unchecked Ratio IC50 190.0 None 10.1021/acs.jmedchem.9b00123
None Unchecked Ratio IC50 367.0 None 10.1021/np800049y
None Unchecked Ratio IC50 500.0 None 10.1016/j.bmcl.2014.09.082
None Unchecked Ratio IC50 642.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 682.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 892.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 964.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 1144.0 None 10.1021/acs.jmedchem.9b00123
None Unchecked Ratio IC50 1392.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 2320.0 None 10.1021/acs.jmedchem.9b00123
None Unchecked Ratio IC50 2545.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 2773.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 3091.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 3928.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 4642.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 10000.0 None 10.1016/j.ejmech.2012.12.009
None Unchecked Ratio IC50 11250.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 17857.0 None 10.1016/j.bmc.2015.03.005
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2018.11.043
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2018.02.039
None Unchecked Ratio Ki 7.0 None 10.1016/j.ejmech.2018.09.028
None Unchecked Ratio Ki 140.0 None 10.1016/j.ejmech.2018.02.039
None Unchecked Ratio Ki 2560.0 None 10.1016/j.ejmech.2018.02.039
None Unchecked Ratio Ki 8910.0 None 10.1016/j.ejmech.2018.02.039
None Unchecked Ratio Ki 12900.0 None 10.1016/j.ejmech.2018.02.039
None Unchecked Selectivity 3.2 None 10.1021/jm0401098
None Unchecked Selectivity 4.0 None 10.1016/s0960-894x(02)01036-3
None Unchecked Selectivity 8.0 None 10.1021/jm020521s
None Unchecked Selectivity 9.0 None 10.1021/jm0401098
None Unchecked Selectivity 11.6 None 10.1021/jm020521s
None Unchecked Selectivity 180.0 None 10.1021/jm0401098
None Unchecked Selectivity 2920.0 None 10.1021/jm0401098
None Unchecked Selectivity 12750.0 None 10.1021/jm0401098
None Unchecked Selectivity 12790.0 None 10.1021/jm0401098
None Unchecked Selectivity ratio 8.0 None 10.1016/j.bmcl.2003.12.090
None Unchecked Selectivity ratio 10.0 None 10.1016/j.bmcl.2009.03.125
None Unchecked Selectivity ratio 16.0 None 10.1016/j.bmcl.2014.10.008
None Unchecked Selectivity ratio 140.0 None 10.1016/j.bmcl.2003.12.090
None Unchecked Selectivity ratio 2600.0 None 10.1016/j.bmcl.2003.12.090
None Unchecked Selectivity ratio 100000.0 None 10.1016/j.bmcl.2003.12.090

Metabolism Information