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Doxycycline

AlkaPlorer ID: AK003186

Synonym: None

IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Structure

SMILES: C[C@H]1C2=CC=CC(O)=C2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(=N)O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21

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InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1

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InChIKey: JBIWCJUYHHGXTC-AKNGSSGZSA-N

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Properties Information

Molecule Weight: 444.4400000000001

TPSA？: 182.61

MolLogP？: 0.7023699999999999

Number of H-Donors: 7

Number of H-Acceptors: 9

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 1.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter Acinetobacter MIC 8.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter baumannii Acinetobacter baumannii Activity 25.0 uM 10.1016/j.bmc.2019.04.004
Acinetobacter baumannii Acinetobacter baumannii Activity 52.0 % 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii ED50 2.0 mg.kg-1 10.1021/acs.jmedchem.6b01805
Acinetobacter baumannii Acinetobacter baumannii Inhibition 100.0 % 10.1021/acs.jmedchem.2c01905
Acinetobacter baumannii Acinetobacter baumannii MBC99.9 0.4 ug ml-1 10.1021/acs.jmedchem.6b01805
Acinetobacter baumannii Acinetobacter baumannii MBC99.9 25.0 ug ml-1 10.1021/acs.jmedchem.6b01805
Acinetobacter baumannii Acinetobacter baumannii MIC 0.3 ug.mL-1 10.1021/acs.jmedchem.6b01805
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1128/aac.00072-08
Acinetobacter baumannii Acinetobacter baumannii MIC 25.0 ug.mL-1 10.1021/acs.jmedchem.6b01805
Acinetobacter baumannii Acinetobacter baumannii MIC 350.0 nM 10.1016/j.bmc.2012.06.030
Acinetobacter baumannii Acinetobacter baumannii MIC 560.0 nM 10.1016/j.bmc.2010.05.065
Acinetobacter baumannii Acinetobacter baumannii MIC 12500.0 nM 10.1016/j.bmc.2019.04.004
Acinetobacter baumannii Acinetobacter baumannii MIC 12500.0 nM 10.1016/j.ejmech.2019.111708
Acinetobacter baumannii Acinetobacter baumannii MIC50 2.0 ug.mL-1 10.1128/aac.01099-06
Acinetobacter baumannii Acinetobacter baumannii MIC>90 0.1 ug ml-1 10.1021/np400145u
Acinetobacter baumannii Acinetobacter baumannii MIC90 32.0 ug.mL-1 10.1128/aac.01099-06
Acinetobacter pittii Acinetobacter pittii MIC 0.5 ug.mL-1 10.1128/aac.00072-08
Aeromonas caviae Aeromonas caviae Activity 0.0 % 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae Activity 100.0 % 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae MIC90 1.0 ug.mL-1 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila Activity 0.0 % 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila Activity 100.0 % 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila MIC90 1.0 ug.mL-1 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria Activity 0.0 % 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria Activity 100.0 % 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria MIC90 1.0 ug.mL-1 10.1128/aac.01260-08
Allium sativum Superoxide dismutase [Cu-Zn] Activity 1061.0 U 10.1007/s00044-007-9020-0
Allium sativum Superoxide dismutase [Cu-Zn] Activity 1184.0 U 10.1007/s00044-007-9020-0
Allium sativum Superoxide dismutase [Cu-Zn] Activity 1510.0 U 10.1007/s00044-007-9020-0
Artemia salina Artemia salina LC50 nan None 10.1016/j.ejmech.2009.11.033
Bacillus anthracis Bacillus anthracis deltaCT 0.26 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 0.42 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 0.45 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 0.56 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 0.65 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 0.82 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 1.64 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 1.69 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 2.46 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 3.29 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 3.82 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.08 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.09 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.15 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.16 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.22 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.45 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 5.91 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.0 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.01 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.16 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.25 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.28 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.29 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.32 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.34 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.37 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.38 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.46 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.47 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.52 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.53 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.54 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.56 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.57 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.59 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.6 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.61 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.63 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.66 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.67 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.77 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.79 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.8 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.82 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.87 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.88 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.92 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.93 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.94 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.95 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.98 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 6.99 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.0 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.01 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.02 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.04 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.07 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.11 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.14 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.16 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.18 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.19 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.2 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.21 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.22 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.23 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.24 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.25 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.26 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.29 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.32 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.36 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.38 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.46 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.48 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.52 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.53 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.54 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.55 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.57 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.58 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.6 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.61 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.63 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.66 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.68 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.69 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.7 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.71 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.72 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.73 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.74 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.77 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.78 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.8 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.81 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.83 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.86 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.87 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.88 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.89 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.9 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.91 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.93 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.95 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.96 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.97 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 7.98 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.0 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.01 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.02 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.03 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.08 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.09 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.1 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.11 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.12 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.13 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.16 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.18 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.2 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.21 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.22 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.23 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.26 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.28 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.32 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.33 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.34 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.35 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.38 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.39 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.42 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.44 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.51 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.53 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.58 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.6 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.64 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.73 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.77 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.79 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.81 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.82 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 8.89 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 9.27 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 9.32 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 9.46 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 9.67 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis deltaCT 9.7 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis FC 2.0 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis FC 150.0 None 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis MIC 0.03 ug.mL-1 10.1128/aac.01050-06
Bacillus anthracis Bacillus anthracis MIC 0.06 ug.mL-1 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis MIC 0.06 ug.mL-1 10.1128/aac.00737-08
Bacillus anthracis Bacillus anthracis MIC 0.25 ug.mL-1 10.1128/aac.00737-08
Bacillus anthracis Bacillus anthracis MIC 1.0 ug.mL-1 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis MIC 16.0 ug.mL-1 10.1128/aac.00247-10
Bacillus anthracis Bacillus anthracis MIC 270.0 nM 10.1016/j.bmc.2010.05.065
Bacillus cereus Bacillus cereus IZ 31.0 mm 10.1021/np9702244
Bacillus spizizenii Bacillus spizizenii MIC 1.56 ug.mL-1 10.1016/j.bmc.2015.08.029
Bacillus subtilis Bacillus subtilis IZ 34.0 mm 10.1021/np9702244
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Bacillus subtilis Bacillus subtilis MIC 1560.0 nM 10.1021/jm061349l
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Brucella abortus Brucella abortus MIC 560.0 nM 10.1016/j.bmc.2010.05.065
Brucella suis Brucella suis MIC 560.0 nM 10.1016/j.bmc.2010.05.065
Brugia malayi Brugia malayi Activity 76.3 % 10.1021/acs.jmedchem.8b01854
Brugia malayi Brugia malayi Activity 96.7 % 10.1021/acs.jmedchem.8b01854
Burkholderia cepacia Burkholderia cepacia Activity 22.0 % 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia Activity 61.0 % 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia MIC50 16.0 ug.mL-1 10.1128/aac.00954-06
Burkholderia cepacia Burkholderia cepacia MIC90 32.0 ug.mL-1 10.1128/aac.00954-06
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.016 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.03 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.13 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.25 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.5 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 1.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 90.0 nM 10.1016/j.bmc.2010.05.065
Campylobacter coli Campylobacter coli Activity 33.9 % 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli Activity 59.6 % 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli MIC90 16.0 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni Activity 33.9 % 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni Activity 59.6 % 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC90 16.0 ug.mL-1 10.1128/aac.01260-08
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlamydia pneumoniae Chlamydia pneumoniae MBC90 0.06 ug ml-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00046-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC90 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis Activity 30.0 % 10.1128/aac.00231-07
Chlamydia trachomatis Chlamydia trachomatis Activity 80.0 % 10.1128/aac.00231-07
Chlamydia trachomatis Chlamydia trachomatis Activity nan None 10.1128/aac.00231-07
Chlamydia trachomatis Chlamydia trachomatis Inhibition nan % 10.1021/acs.jmedchem.0c00371
Chlamydia trachomatis Chlamydia trachomatis MBC 0.015 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC 0.06 ug ml-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.06 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.06 ug ml-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.015 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.03 ug.mL-1 10.1128/aac.00046-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.03 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.06 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.5 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC50 0.06 ug.mL-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.06 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.06 ug.mL-1 10.1128/aac.01343-09
Corynebacterium amycolatum Corynebacterium amycolatum MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC50 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium amycolatum Corynebacterium amycolatum MIC90 0.5 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC50 0.03 ug.mL-1 10.1128/aac.01129-07
Corynebacterium jeikeium Corynebacterium jeikeium MIC90 1.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium minutissimum Corynebacterium minutissimum MIC50 0.25 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium pseudodiphtheriticum Corynebacterium pseudodiphtheriticum MIC90 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC 0.06 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC50 8.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium striatum Corynebacterium striatum MIC90 16.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium urealyticum Corynebacterium urealyticum MIC90 4.0 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC 0.125 ug.mL-1 10.1128/aac.01129-07
Corynebacterium xerosis Corynebacterium xerosis MIC50 0.5 ug.mL-1 10.1128/aac.01129-07
Coxiella burnetii Coxiella burnetii MIC 0.25 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 0.5 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 1.0 ug.mL-1 10.1128/aac.01424-08
Coxiella burnetii Coxiella burnetii MIC 2.0 ug.mL-1 10.1128/aac.01424-08
dengue virus type 2 dengue virus type 2 IC50 50000.0 nM 10.1016/j.ejmech.2019.05.010
dengue virus type 2 dengue virus type 2 IC50 55600.0 nM 10.1016/j.ejmech.2021.113527
Dialister invisus Dialister invisus Activity 4.0 ug ml-1 10.1128/aac.00538-07
Dialister invisus Dialister invisus Activity nan None 10.1128/aac.00538-07
Dialister invisus Dialister invisus MIC nan None 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus Activity 4.0 ug ml-1 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus Activity nan None 10.1128/aac.00538-07
Dialister micraerophilus Dialister micraerophilus MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes Activity 4.0 ug ml-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes Activity nan None 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC50 0.25 ug.mL-1 10.1128/aac.00538-07
Dialister pneumosintes Dialister pneumosintes MIC90 0.25 ug.mL-1 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens Activity 4.0 ug ml-1 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens Activity nan None 10.1128/aac.00538-07
Dialister propionicifaciens Dialister propionicifaciens MIC 0.06 ug.mL-1 10.1128/aac.00538-07
Ehrlichia canis Ehrlichia canis Activity nan None 10.1128/aac.00358-07
Enterobacteriaceae Enterobacteriaceae Activity 10.9 % 10.1128/aac.01519-08
Enterobacteriaceae Enterobacteriaceae Activity 18.2 % 10.1128/aac.01519-08
Enterobacteriaceae Enterobacteriaceae MIC50 16.0 ug.mL-1 10.1128/aac.01519-08
Enterobacteriaceae Enterobacteriaceae MIC90 16.0 ug.mL-1 10.1128/aac.01519-08
Enterobacter sp. Enterobacter sp. MIC 8.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Enterococcus avium Enterococcus avium MIC 8.0 ug.mL-1 10.1128/aac.00908-07
Enterococcus faecalis Enterococcus faecalis IZ 35.0 mm 10.1021/np9702244
Enterococcus faecalis Enterococcus faecalis MBC50 16.0 mg/L 10.1128/aac.00344-06
Enterococcus faecalis Enterococcus faecalis MBC90 64.0 mg/L 10.1128/aac.00344-06
Enterococcus faecalis Enterococcus faecalis MIC 0.094 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecalis Enterococcus faecalis MIC 0.125 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecalis Enterococcus faecalis MIC 0.19 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1021/jm00035a016
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC 2.0 ug.mL-1 10.1128/aac.00908-07
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1128/aac.00908-07
Enterococcus faecalis Enterococcus faecalis MIC 6.0 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecalis Enterococcus faecalis MIC 6.25 ug.mL-1 10.1016/s0960-894x(02)00369-4
Enterococcus faecalis Enterococcus faecalis MIC 6.25 ug.mL-1 10.1021/jm00035a016
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1128/aac.00908-07
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecalis Enterococcus faecalis MIC50 4.0 ug.mL-1 10.1128/aac.00344-06
Enterococcus faecalis Enterococcus faecalis MIC50 16.0 ug.mL-1 10.1128/aac.00344-06
Enterococcus faecalis Enterococcus faecalis MIC90 32.0 ug.mL-1 10.1128/aac.00344-06
Enterococcus faecalis Enterococcus faecalis MIC90 64.0 ug.mL-1 10.1128/aac.00344-06
Enterococcus faecium Enterococcus faecium IC50 nan None 10.1016/j.ejmech.2019.07.052
Enterococcus faecium Enterococcus faecium MIC 0.094 ug.mL-1 10.1128/aac.01710-09
Enterococcus faecium Enterococcus faecium MIC 8.0 ug.mL-1 10.1128/aac.00576-06
Enterococcus faecium Enterococcus faecium MIC 16.0 ug.mL-1 10.1128/aac.00576-06
Escherichia coli DNA repair protein RecN Activity nan None 10.1021/acs.jmedchem.0c00328
Escherichia coli Escherichia coli Activity 6.25 uM 10.1016/j.bmc.2019.04.004
Escherichia coli Escherichia coli Activity 16.0 % 10.1128/aac.01260-08
Escherichia coli Escherichia coli Activity 18.5 % 10.1128/aac.01176-07
Escherichia coli Escherichia coli Activity 33.3 % 10.1128/aac.01176-07
Escherichia coli Escherichia coli Activity 61.1 % 10.1128/aac.01176-07
Escherichia coli Escherichia coli Activity 66.7 % 10.1128/aac.01176-07
Escherichia coli Escherichia coli Activity 76.0 % 10.1128/aac.01260-08
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00043-09
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01783-09
Escherichia coli Escherichia coli IC50 580.0 nM 10.1016/j.bmc.2019.01.002
Escherichia coli Escherichia coli IC50 730.0 nM 10.1016/j.ejmech.2020.113021
Escherichia coli Escherichia coli IC50 9200.0 nM 10.1021/jm00035a016
Escherichia coli Escherichia coli IC50 75000.0 nM 10.1021/jm00035a016
Escherichia coli Escherichia coli IC50 nan None 10.1016/j.ejmech.2019.07.052
Escherichia coli Escherichia coli MBC99.9 6.25 ug ml-1 10.1021/acs.jmedchem.6b01805
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 0.128 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01260-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm00035a016
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 0.78 ug.mL-1 10.1016/j.bmc.2015.08.029
Escherichia coli Escherichia coli MIC 0.83 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/np4003096
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 1.17 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 1.25 ug.mL-1 10.1128/aac.00357-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2009.11.033
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 3.0 ug.mL-1 10.1128/aac.00043-09
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1021/acs.jmedchem.6b01805
Escherichia coli Escherichia coli MIC 3.3 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 3.7 ug.mL-1 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00043-09
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/np4003096
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1021/jm00035a016
Escherichia coli Escherichia coli MIC 14.0 ug.mL-1 10.1128/aac.00357-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00357-07
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1021/jm00035a016
Escherichia coli Escherichia coli MIC 25000.0 nM 10.1016/j.ejmech.2019.111708
Escherichia coli Escherichia coli MIC 50000.0 nM 10.1016/j.bmc.2019.04.004
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00787-09
Escherichia coli Escherichia coli MIC50 2.0 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1128/aac.01176-07
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1128/aac.01260-08
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.01176-07
Escherichia coli LexA repressor Activity nan None 10.1021/acs.jmedchem.0c00328
Escherichia coli K-12 Cell division inhibitor sulA Activity nan None 10.1021/acs.jmedchem.0c00328
Escherichia coli K-12 Recombinase A Activity nan None 10.1021/acs.jmedchem.0c00328
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 11193.6 nM None
[Haemophilus] ducreyi [Haemophilus] ducreyi MIC 4.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 24242.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 3396.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Amyloid-beta A4 protein Inhibition 93.1 % 10.1016/j.ejmech.2020.113112
Homo sapiens Amyloid-beta A4 protein Inhibition 100.0 % 10.1016/j.ejmech.2020.112593
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cerebroside-sulfatase Potency 3793.3 nM None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome c oxidase subunit 1 Inhibition nan % 10.1021/acsmedchemlett.0c00632
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA polymerase kappa Potency 39810.7 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D1 receptor Potency 819.9 nM None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Ferrochelatase, mitochondrial Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Flap endonuclease 1 Potency 23778.1 nM None
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HeLa IC50 30000.0 nM 10.1016/0960-894X(96)00418-0
Homo sapiens HeLa MNTC 40.0 uM 10.1016/0960-894X(96)00418-0
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.bmcl.2011.06.113
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2011.06.021
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2012.07.034
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2014.06.014
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2014.07.113
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2015.03.011
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2016.04.059
Homo sapiens HepG2 CC50 20000.0 nM 10.1016/j.ejmech.2021.113722
Homo sapiens HepG2 IC50 20000.0 nM 10.1016/j.bmc.2009.05.022
Homo sapiens HepG2 IC50 20000.0 nM 10.1016/j.ejmech.2009.11.005
Homo sapiens HepG2 IC50 53000.0 nM 10.1016/0960-894X(96)00418-0
Homo sapiens HepG2 MNTC 60.0 uM 10.1016/0960-894X(96)00418-0
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone acetyltransferase GCN5 Potency 39810.7 nM None
Homo sapiens Histone deacetylase 6 Inhibition -42.18 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -41.48 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -3.66 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -1.51 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 2667.9 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 28183.8 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens CL 0.3 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 0.46 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 0.46 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.19 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.2 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Cmax 6900.0 nM 10.1128/aac.00527-07
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 93.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens F 93.0 % 10.1021/jm901421c
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.93 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.94 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.99 None 10.1021/jm901371v
Homo sapiens Homo sapiens T1/2 7.0 hr 10.1128/aac.00527-07
Homo sapiens Homo sapiens T1/2 10.5 hr 10.1128/aac.00529-07
Homo sapiens Homo sapiens T1/2 14.0 hr 10.1128/aac.00529-07
Homo sapiens Homo sapiens Tmax 2.0 hr 10.1128/aac.00527-07
Homo sapiens Homo sapiens Vdss 0.69 L.kg-1 10.1021/jm901371v
Homo sapiens HT-1080 IC50 21400.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 IC50 15000.0 nM 10.1016/j.bmc.2009.05.022
Homo sapiens K562 IC50 15000.0 nM 10.1016/j.ejmech.2009.11.005
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 400000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 13 IC50 20000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 13 IC50 40000.0 nM 10.1016/j.bmc.2007.01.026
Homo sapiens Matrix metalloproteinase-2 IC50 24000.0 nM 10.1016/j.bmc.2007.01.026
Homo sapiens Matrix metalloproteinase-2 IC50 56000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase-2 Inhibition nan % 10.1016/j.bmcl.2009.03.126
Homo sapiens Matrix metalloproteinase 3 IC50 25000.0 nM 10.1016/j.bmc.2007.01.026
Homo sapiens Matrix metalloproteinase 3 IC50 32000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 7 IC50 28000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 8 IC50 26000.0 nM 10.1021/acs.jmedchem.1c01855
Homo sapiens Matrix metalloproteinase 8 IC50 31000.0 nM 10.1016/j.bmc.2007.01.026
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Inhibition nan % 10.1016/j.bmcl.2009.03.126
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens microRNA 21 IC50 433000.0 nM 10.1021/acsmedchemlett.9b00091
Homo sapiens microRNA 21 Inhibition 40.0 % 10.1021/acsmedchemlett.9b00091
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 23109.3 nM None
Homo sapiens PC-3 T/C 49.0 % 10.1021/jm401642q
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Porphobilinogen deaminase Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein-arginine deiminase type-4 IC50 860000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Protein-arginine deiminase type-4 Ki 630000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Proteinase-activated receptor 2 Activity nan None 10.1128/aac.01540-08
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 23778.1 nM None
Homo sapiens RKO Activity nan None 10.1128/aac.00692-07
Homo sapiens RKO FC 3.0 None 10.1128/aac.00692-07
Homo sapiens RKO FC 5.0 None 10.1128/aac.00692-07
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum albumin Log K' 0.01 None 10.1021/jm010960b
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 1 Inhibition 27.4 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 11 Activity nan None 10.1254/jjp.88.69
Homo sapiens Solute carrier family 22 member 6 Activity nan None 10.1254/jjp.88.69
Homo sapiens Solute carrier family 22 member 8 Activity nan None 10.1254/jjp.88.69
Homo sapiens Superoxide dismutase Activity nan None 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase K 1.34 10'6L/mol 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase K 6.73 10'7L/mol 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase K 7.9 10'6L/mol 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase Kq 1.01 10'13L/mol/s 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase Kq 6.42 10'12L/mol/s 10.1007/s00044-007-9020-0
Homo sapiens Superoxide dismutase Kq 7.73 10'12L/mol/s 10.1007/s00044-007-9020-0
Homo sapiens SW1353 Activity nan None 10.1016/j.bmc.2007.01.026
Homo sapiens THP-1 IC50 20000.0 nM 10.1016/j.bmcl.2009.08.013
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 50118.7 nM None
Issatchenkia orientalis ATP binding cassette transporter Abc1p Activity nan None 10.1128/aac.01095-08
Klebsiella aerogenes Klebsiella aerogenes MIC 2250.0 nM 10.1016/j.bmc.2012.12.030
Klebsiella aerogenes Klebsiella aerogenes MIC 56000.0 nM 10.1021/jm500194e
Klebsiella aerogenes Klebsiella aerogenes MIC 72000.0 nM 10.1016/j.bmc.2012.12.030
Klebsiella pneumoniae Klebsiella pneumoniae Activity 6.25 uM 10.1016/j.bmc.2019.04.004
Klebsiella pneumoniae Klebsiella pneumoniae IC50 nan None 10.1016/j.ejmech.2019.07.052
Klebsiella pneumoniae Klebsiella pneumoniae MBC99.9 0.78 ug ml-1 10.1021/acs.jmedchem.6b01805
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.6b01805
Klebsiella pneumoniae Klebsiella pneumoniae MIC 25000.0 nM 10.1016/j.bmc.2019.04.004
Klebsiella pneumoniae Klebsiella pneumoniae MIC 25000.0 nM 10.1016/j.ejmech.2019.111708
Klebsiella pneumoniae Klebsiella pneumoniae MIC nan None 10.1021/jm500194e
Legionella pneumophila Legionella pneumophila MIC 1.0 ug.mL-1 10.1128/aac.01315-06
Leptospira interrogans serovar Portlandvere Leptospira interrogans serovar Portlandvere Activity nan None 10.1128/aac.00240-07
Listeria monocytogenes Listeria monocytogenes MIC 0.03 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
Listeria monocytogenes Listeria monocytogenes MIC90 0.125 ug.mL-1 10.1128/aac.01129-07
Litomosoides sigmodontis Litomosoides sigmodontis Activity 99.9 % 10.1021/acs.jmedchem.8b01854
Metamycoplasma hominis Metamycoplasma hominis MIC 0.008 ug.mL-1 10.1128/aac.00090-09
Metamycoplasma hominis Metamycoplasma hominis MIC 0.008 ug.mL-1 10.1128/aac.00746-09
Metamycoplasma hominis Metamycoplasma hominis MIC 0.016 ug.mL-1 10.1128/aac.00849-08
Metamycoplasma hominis Metamycoplasma hominis MIC 0.12 ug.mL-1 10.1128/aac.00960-07
Metamycoplasma hominis Metamycoplasma hominis MIC 32.0 ug.mL-1 10.1128/aac.00960-07
Metamycoplasma hominis Metamycoplasma hominis MIC50 0.125 ug.mL-1 10.1128/aac.00090-09
Metamycoplasma hominis Metamycoplasma hominis MIC50 2.0 ug.mL-1 10.1128/aac.00746-09
Metamycoplasma hominis Metamycoplasma hominis MIC50 2.0 ug.mL-1 10.1128/aac.00849-08
Metamycoplasma hominis Metamycoplasma hominis MIC90 2.0 ug.mL-1 10.1128/aac.00746-09
Metamycoplasma hominis Metamycoplasma hominis MIC90 8.0 ug.mL-1 10.1128/aac.00090-09
Metamycoplasma hominis Metamycoplasma hominis MIC90 8.0 ug.mL-1 10.1128/aac.00849-08
Micrococcus luteus Micrococcus luteus MIC 8.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus Activity 23.0 % 10.1021/jm400161p
Mus musculus Mus musculus Activity nan None 10.1128/aac.00529-07
Mus musculus Mus musculus Activity nan None 10.1128/aac.01050-06
Mus musculus Mus musculus AUC 13700.0 ng.hr.mL-1 10.1128/aac.01050-06
Mus musculus Mus musculus AUC 23400.0 ng.hr.mL-1 10.1128/aac.01050-06
Mus musculus Mus musculus AUC 57200.0 ng.hr.mL-1 10.1128/aac.01050-06
Mus musculus Mus musculus Cmax 9000.09 nM 10.1128/aac.01050-06
Mus musculus Mus musculus Cmax 15075.15 nM 10.1128/aac.01050-06
Mus musculus Mus musculus Cmax 27000.27 nM 10.1128/aac.01050-06
Mus musculus Mus musculus Cmin 1.33 ug ml-1 10.1128/aac.01050-06
Mus musculus Mus musculus Cmin 1.67 ug ml-1 10.1128/aac.01050-06
Mus musculus Mus musculus Cmin 6.0 ug ml-1 10.1128/aac.01050-06
Mus musculus Mus musculus T1/2 2.8 hr 10.1128/aac.00529-07
Mus musculus Mus musculus TIME 144.0 hr 10.1128/aac.00529-07
Mus musculus N2a Activity nan None 10.1021/acs.jmedchem.5b01696
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mycobacterium tuberculosis Mycobacterium tuberculosis IC50 nan None 10.1016/j.ejmech.2019.07.052
Mycobacteroides abscessus Mycobacteroides abscessus MIC50 64.0 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC90 64.0 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC50 8.0 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC90 64.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 4.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 64.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium mageritense Mycolicibacterium mageritense MIC 0.03 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC50 8.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC90 32.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 760.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 1950.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 2980.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.03 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1560.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 3125.0 nM 10.1128/aac.00803-09
Mycoplasma putrefaciens Mycoplasma putrefaciens MIC 0.03 ug.mL-1 10.1128/aac.00420-07
Mycoplasma putrefaciens Mycoplasma putrefaciens MIC50 0.125 ug.mL-1 10.1128/aac.00420-07
Mycoplasma putrefaciens Mycoplasma putrefaciens MIC50 0.25 ug.mL-1 10.1128/aac.00420-07
Mycoplasma putrefaciens Mycoplasma putrefaciens MIC90 0.25 ug.mL-1 10.1128/aac.00420-07
Mycoplasma putrefaciens Mycoplasma putrefaciens MIC90 2.0 ug.mL-1 10.1128/aac.00420-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.007 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.00849-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01315-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.125 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.25 ug.mL-1 10.1128/aac.00849-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.125 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.25 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.25 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.5 ug.mL-1 10.1128/aac.00849-08
Naegleria gruberi Naegleria gruberi Inhibition 59.8 % 10.6019/CHEMBL4513101
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.5 ug.mL-1 10.1016/s0960-894x(02)00437-7
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 32.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium berghei Plasmodium berghei Activity 0.06 % 10.1128/aac.00529-07
Plasmodium berghei Plasmodium berghei Activity 3.0 % 10.1128/aac.00529-07
Plasmodium berghei Plasmodium berghei Activity nan None 10.1128/aac.00529-07
Plasmodium falciparum Hemozoin IC50 1000000.0 nM 10.1021/acs.jmedchem.0c02022
Plasmodium falciparum Plasmodium falciparum Activity 9.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 12.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 13.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 24.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 41.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 44.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 69.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 83.6 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 87.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 89.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 97.2 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 121.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum EC50 6000.0 nM 10.1016/j.ejmech.2021.113722
Plasmodium falciparum Plasmodium falciparum IC50 0.4833 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 0.814 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 0.8569 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 1.175 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 1.846 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 1.863 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 2.135 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 2.281 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 2.372 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 2.413 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 120.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 211.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 302.5 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 432.2 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 453.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 603.1 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 720.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 720.0 nM 10.1128/aac.01090-09
Plasmodium falciparum Plasmodium falciparum IC50 1200.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 1444.1 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 1490.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 1700.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 3300.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 4276.01 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC50 4600.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 4800.0 nM 10.1016/j.ejmech.2011.06.021
Plasmodium falciparum Plasmodium falciparum IC50 5000.0 nM 10.1016/j.bmcl.2011.06.113
Plasmodium falciparum Plasmodium falciparum IC50 5000.0 nM 10.1016/j.ejmech.2012.07.034
Plasmodium falciparum Plasmodium falciparum IC50 5000.0 nM 10.1016/j.ejmech.2014.07.113
Plasmodium falciparum Plasmodium falciparum IC50 5000.0 nM 10.1016/j.ejmech.2015.03.011
Plasmodium falciparum Plasmodium falciparum IC50 5100.0 nM 10.1016/j.ejmech.2019.111983
Plasmodium falciparum Plasmodium falciparum IC50 5320.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 5420.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 6000.0 nM 10.1016/j.ejmech.2014.06.014
Plasmodium falciparum Plasmodium falciparum IC50 6000.0 nM 10.1016/j.ejmech.2016.04.059
Plasmodium falciparum Plasmodium falciparum IC50 6000.0 nM 10.1016/j.ejmech.2016.09.029
Plasmodium falciparum Plasmodium falciparum IC50 6500.0 nM 10.1016/j.bmc.2009.05.022
Plasmodium falciparum Plasmodium falciparum IC50 6500.0 nM 10.1016/j.bmcl.2009.08.013
Plasmodium falciparum Plasmodium falciparum IC50 6500.0 nM 10.1016/j.ejmech.2009.11.005
Plasmodium falciparum Plasmodium falciparum IC50 8400.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 8400.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 8400.0 nM 10.1128/aac.01462-08
Plasmodium falciparum Plasmodium falciparum IC50 8700.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 9000.0 nM 10.1016/j.bmcl.2007.10.027
Plasmodium falciparum Plasmodium falciparum IC50 9100.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 9100.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 9200.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 9700.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 9700.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 10200.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 10600.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 10700.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 10800.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 10900.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 11060.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 11500.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 11600.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 12000.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 12100.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 12800.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 12900.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 12900.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 13200.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 13300.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 13300.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 13400.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 13700.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 14900.0 nM 10.1021/jm901357n
Plasmodium falciparum Plasmodium falciparum IC50 14900.0 nM 10.1128/aac.00183-10
Plasmodium falciparum Plasmodium falciparum IC50 18000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC90 19434.92 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC99 27201.3 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum Ratio IC50 10.0 None 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum Ratio IC50 13.0 None 10.1128/aac.00312-09
Plasmodium vivax Plasmodium vivax Activity 56.0 % 10.1021/jm201095h
Plasmodium yoelii Plasmodium yoelii Efficacy 40.0 % 10.1021/jm201095h
Plasmodium yoelii Plasmodium yoelii Efficacy 100.0 % 10.1021/jm201095h
Plesiomonas shigelloides Plesiomonas shigelloides Activity 0.0 % 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides Activity 100.0 % 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Prescottella equi Prescottella equi MBC50 32.0 mg/L 10.1128/aac.00344-06
Prescottella equi Prescottella equi MBC90 128.0 mg/L 10.1128/aac.00344-06
Prescottella equi Prescottella equi MIC 0.015 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC50 1.0 ug.mL-1 10.1128/aac.00344-06
Prescottella equi Prescottella equi MIC50 1.0 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC90 1.0 ug.mL-1 10.1128/aac.01129-07
Prescottella equi Prescottella equi MIC90 2.0 ug.mL-1 10.1128/aac.00344-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 12.5 uM 10.1016/j.bmc.2019.04.004
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 nan None 10.1016/j.ejmech.2019.07.052
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC99.9 25.0 ug ml-1 10.1021/acs.jmedchem.6b01805
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b00867
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1016/j.bmc.2015.08.029
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1021/acs.jmedchem.6b01805
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00867
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25000.0 nM 10.1016/j.bmc.2019.04.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 45000.0 nM 10.1016/j.bmc.2021.116110
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 90000.0 nM 10.1016/j.bmc.2022.116762
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 90000.0 nM 10.1016/j.ejmech.2019.111708
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 112000.0 nM 10.1021/jm500194e
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1021/acs.jmedchem.6b00867
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.12 None 10.1021/jm901371v
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 294.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 312.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 325.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 367.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 395.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 411.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 59.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 0.667 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 158.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 161.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 176.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 180.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 210.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 613.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 636.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 653.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 670.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 873.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 890.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 186.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 239.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 255.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 372.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 372.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 551.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 19.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 22.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 26.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 86.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 116.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1380.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1393.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1460.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1546.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1633.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1738.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.1 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.48 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 125700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 95.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 100.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 117.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 161.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 188.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 339.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6462.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6922.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7583.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7696.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12090.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13980.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.63 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.9 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.07 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.88 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 381000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 391500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 391700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.4 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.77 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.15 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.52 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 67.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 105.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 131.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 147.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 166.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 674.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 736.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 909.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1023.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1090.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1122.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 103.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 105.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 109.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 118.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1055000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1104670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1181330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1183000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1186670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1333670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.76 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.89 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.02 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.11 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.12 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5230000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5350000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5570000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5780000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5810000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5990000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.73 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.43 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.35 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 7500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8030.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8420.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15370.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 21192.3 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 1.7 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 1.9 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 2.0 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 2.6 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 2.9 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 3.3 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 4.0 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 10.5 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 20.5 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 34.1 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 39.5 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 40.6 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 40.8 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 45.4 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 51.1 % 10.1128/aac.00349-10
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 819.9 nM None
Salmonella enterica subsp. enterica serovar Abony Salmonella enterica subsp. enterica serovar Abony MIC 6.25 ug.mL-1 10.1016/j.bmc.2015.08.029
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis Activity 13.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis Activity 82.2 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi Activity 13.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi Activity 82.2 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi Activity 13.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi Activity 82.2 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 13.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 82.2 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 4500.0 nM 10.1016/j.bmc.2012.12.030
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 144000.0 nM 10.1016/j.bmc.2012.12.030
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score -0.02175 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Shigella boydii Shigella boydii Activity 34.7 % 10.1128/aac.01260-08
Shigella boydii Shigella boydii Activity 52.5 % 10.1128/aac.01260-08
Shigella boydii Shigella boydii IZ 38.0 mm 10.1021/np9702244
Shigella boydii Shigella boydii MIC 0.25 ug.mL-1 10.1128/aac.01260-08
Shigella boydii Shigella boydii MIC50 16.0 ug.mL-1 10.1128/aac.01260-08
Shigella boydii Shigella boydii MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae Activity 34.7 % 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae Activity 52.5 % 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae IZ 37.0 mm 10.1021/np9702244
Shigella dysenteriae Shigella dysenteriae MIC 0.25 ug.mL-1 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae MIC50 16.0 ug.mL-1 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri Activity 34.7 % 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri Activity 52.5 % 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri MIC 0.25 ug.mL-1 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri MIC50 16.0 ug.mL-1 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei Activity 34.7 % 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei Activity 52.5 % 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei IZ 30.0 mm 10.1021/np9702244
Shigella sonnei Shigella sonnei MIC 0.25 ug.mL-1 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei MIC50 16.0 ug.mL-1 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/jm501628s
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00206-07
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 0.5 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus FC 2.0 None 10.1128/aac.00922-07
Staphylococcus aureus Staphylococcus aureus IC50 30.0 nM 10.1016/j.bmc.2019.01.002
Staphylococcus aureus Staphylococcus aureus IC50 110.0 nM 10.1016/j.ejmech.2020.113021
Staphylococcus aureus Staphylococcus aureus IC50 250.0 nM 10.1016/j.ejmech.2019.07.052
Staphylococcus aureus Staphylococcus aureus IC50 280.0 nM 10.1021/acs.jnatprod.0c01119
Staphylococcus aureus Staphylococcus aureus IZ 27.0 mm 10.1016/j.bmcl.2012.05.112
Staphylococcus aureus Staphylococcus aureus IZ 35.0 mm 10.1021/np9702244
Staphylococcus aureus Staphylococcus aureus MBC 2.0 uM 10.1021/acs.jmedchem.5b02004
Staphylococcus aureus Staphylococcus aureus MBC 2.0 uM 10.1021/acs.jmedchem.7b01903
Staphylococcus aureus Staphylococcus aureus MBC50 8.0 mg/L 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus MBC90 32.0 mg/L 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus MBC99.9 12.5 ug ml-1 10.1021/acs.jmedchem.6b01805
Staphylococcus aureus Staphylococcus aureus MBEC 46.9 uM 10.1021/acs.jmedchem.5b02004
Staphylococcus aureus Staphylococcus aureus MBEC 46.9 uM 10.1021/acs.jmedchem.7b01903
Staphylococcus aureus Staphylococcus aureus MIC 0.008 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.01247-08
Staphylococcus aureus Staphylococcus aureus MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.12.060
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.7b00133
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00035a016
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00576-06
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00908-07
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.01422-07
Staphylococcus aureus Staphylococcus aureus MIC 0.256 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00576-06
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00908-07
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01422-07
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1016/j.bmc.2015.08.029
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00908-07
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/np4003096
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.01422-07
Staphylococcus aureus Staphylococcus aureus MIC 3.13 ug.mL-1 10.1021/acs.jmedchem.6b01805
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.bmcl.2012.05.112
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.11.033
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00576-06
Staphylococcus aureus Staphylococcus aureus MIC 6.0 ug.mL-1 10.1128/aac.01098-07
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/s0960-894x(02)00369-4
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2012.05.112
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.7b00133
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00576-06
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00985-09
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.01422-07
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1021/jm00035a016
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.7b00133
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/s0960-894x(02)00437-7
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/s0960-894x(02)00369-4
Staphylococcus aureus Staphylococcus aureus MIC 1560.0 nM 10.1021/jm061349l
Staphylococcus aureus Staphylococcus aureus MIC 3000.0 nM 10.1021/jm500194e
Staphylococcus aureus Staphylococcus aureus MIC 17600.0 nM 10.1016/j.bmc.2010.05.065
Staphylococcus aureus Staphylococcus aureus MIC 30000.0 nM 10.1021/jm061349l
Staphylococcus aureus Staphylococcus aureus MIC50 2.0 ug.mL-1 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1128/aac.00344-06
Staphylococcus aureus Staphylococcus aureus Ratio 23.0 None 10.1021/acs.jmedchem.5b02004
Staphylococcus aureus Staphylococcus aureus Survival 92.0 % 10.1021/jm501628s
Streptococcus gordonii Streptococcus gordonii MBC=>99 32.8 ug ml-1 10.1016/j.bmc.2016.09.040
Streptococcus gordonii Streptococcus gordonii MIC 0.41 ug.mL-1 10.1016/j.bmc.2016.09.040
Streptococcus gordonii Streptococcus gordonii MIC 0.51 ug.mL-1 10.1016/j.bmc.2016.09.040
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.9 % 10.1128/aac.01388-08
Streptococcus pneumoniae Streptococcus pneumoniae Activity 19.9 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 25.2 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 40.6 % 10.1128/aac.01387-07
Streptococcus pneumoniae Streptococcus pneumoniae IC50 250.0 nM 10.1016/j.ejmech.2019.07.052
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01387-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2016.07.029
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.01387-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01387-07
Streptococcus pneumoniae Streptococcus pneumoniae PD50 10.26 mg kg-1 10.1016/j.bmc.2016.07.029
Streptococcus pyogenes Streptococcus pyogenes MBC50 8.0 mg/L 10.1128/aac.00344-06
Streptococcus pyogenes Streptococcus pyogenes MBC90 16.0 mg/L 10.1128/aac.00344-06
Streptococcus pyogenes Streptococcus pyogenes MIC50 2.0 ug.mL-1 10.1128/aac.00344-06
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.00344-06
Ureaplasma Ureaplasma MIC 32.0 ug.mL-1 10.1128/aac.00960-07
Vibrio alginolyticus Vibrio alginolyticus Activity 0.0 % 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus Activity 100.0 % 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae Activity 0.0 % 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae Activity 100.0 % 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis Activity 0.0 % 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis Activity 100.0 % 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 0.0 % 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 100.0 % 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. Activity 0.0 % 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. Activity 100.0 % 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus Activity 0.0 % 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus Activity 100.0 % 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC50 0.12 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC90 0.12 ug.mL-1 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica Activity 4.3 % 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica Activity 95.7 % 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC50 1.0 ug.mL-1 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC90 2.0 ug.mL-1 10.1128/aac.01260-08
Yersinia pestis Yersinia pestis MIC 560.0 nM 10.1016/j.bmc.2010.05.065
Yersinia pseudotuberculosis Yersinia pseudotuberculosis Activity 4.3 % 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis Activity 95.7 % 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC 0.12 ug.mL-1 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC50 1.0 ug.mL-1 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC90 2.0 ug.mL-1 10.1128/aac.01260-08
None ADMET Activity nan None 10.1128/aac.01540-08
None ADMET CL 0.46 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET IC50 nan None 10.1021/jm901357n
None ADMET MRT 25.0 hr 10.1124/dmd.108.020479
None ADMET permeability 20.0 10'-6 cm/s 10.1021/jm901421c
None ADMET Ratio CC50/EC50 3.3 None 10.1016/j.ejmech.2021.113722
None ADMET Ratio IC50 nan None 10.1021/jm901357n
None ADMET T1/2 14.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.69 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LTKB_BD DILI severity score 3.0 None 10.1016/j.drudis.2011.05.007
None NON-PROTEIN TARGET Activity 0.0 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 13.9 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 82.2 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 97.8 % 10.1128/aac.01460-06
None NON-PROTEIN TARGET Activity 100.0 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmc.2016.11.013
None NON-PROTEIN TARGET CC50 20000.0 nM 10.1016/j.ejmech.2016.09.029
None NON-PROTEIN TARGET Fu 0.12 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 8.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 10.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MBC 2.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 4.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 8.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 16.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC 25.0 mg/ml 10.1128/aac.00788-09
None NON-PROTEIN TARGET MBC 32.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MBC90 16.0 ug ml-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 6.3e-05 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 0.000125 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 0.008 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.015 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.031 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.032 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.0625 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.063 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01584-07
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00304-10
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 90.0 nM 10.1016/j.bmc.2010.05.065
None NON-PROTEIN TARGET MIC 390.0 ug.mL-1 10.1128/aac.00788-09
None NON-PROTEIN TARGET MIC 560.0 nM 10.1016/j.bmc.2010.05.065
None NON-PROTEIN TARGET MIC 780.0 ug.mL-1 10.1128/aac.00788-09
None NON-PROTEIN TARGET MIC 870.0 nM 10.1016/j.bmc.2016.06.048
None NON-PROTEIN TARGET MIC 1100.0 nM 10.1016/j.bmc.2016.06.048
None NON-PROTEIN TARGET MIC50 0.000125 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 0.00025 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 0.125 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC50 0.125 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC50 0.125 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.01584-07
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.01584-07
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC50 4.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 8.0 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC50 8.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 nan None 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 0.00025 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 0.0005 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 0.25 ug.mL-1 10.1128/aac.01247-08
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 1.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 1.0 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC90 1.0 ug.mL-1 10.1128/aac.01584-07
None NON-PROTEIN TARGET MIC90 2.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 2.0 ug.mL-1 10.1128/aac.01584-07
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.01129-07
None NON-PROTEIN TARGET MIC90 16.0 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC90 16.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 32.0 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC90 nan None 10.1128/aac.00849-08
None NON-PROTEIN TARGET MNTC 60.0 uM 10.1016/0960-894X(96)00418-0
None NON-PROTEIN TARGET Potency 8407.1 nM None
None NON-PROTEIN TARGET Ratio 0.66 None 10.1016/0960-894X(96)00418-0
None No relevant target Log Kmemb -2.8 None 10.1021/jm0309001
None Phospholipidosis Phospholipidosis nan None 10.1021/ci6004542
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Unchecked Activity 8.0 % 10.1016/j.bmc.2007.01.026
None Unchecked Activity 78.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Activity 80.0 % 10.1021/jm400161p
None Unchecked Activity 85.0 % 10.1021/acsmedchemlett.1c00216
None Unchecked Activity 89.0 % 10.1016/j.bmc.2007.01.026
None Unchecked Activity nan None 10.1016/j.ejmech.2016.09.020
None Unchecked EC50 17.0 nM 10.1021/acsmedchemlett.1c00216
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 3100.0 nM 10.1016/j.bmcl.2009.08.013
None Unchecked IC50 35000.0 nM 10.1016/0960-894X(96)00418-0
None Unchecked IC50 366000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 380000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 433000.0 nM 10.1021/acsmedchemlett.9b00091
None Unchecked IC50 555000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 567000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 nan None None
None Unchecked Inhibition 20.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Inhibition 39.6 % 10.1016/j.ejmech.2020.112593
None Unchecked Inhibition 44.0 % 10.1128/aac.00620-10
None Unchecked Inhibition nan % 10.1021/jm400902y
None Unchecked Kd 908.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 940.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1420.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1620.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 2000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Ki nan None None
None Unchecked MIC 100.0 ug.mL-1 10.1016/j.ejmech.2016.09.020
None Unchecked MIC 200.0 ug.mL-1 10.1016/j.ejmech.2016.09.020
None Unchecked Potency 5623.4 nM None
None Unchecked Ratio 1.8 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio 2.0 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio CC50/IC50 3.3 None 10.1016/j.ejmech.2014.06.014
None Unchecked Ratio CC50/IC50 3.3 None 10.1016/j.ejmech.2016.04.059
None Unchecked Ratio CC50/IC50 3.3 None 10.1016/j.ejmech.2016.09.029
None Unchecked Ratio CC50/IC50 4.0 None 10.1016/j.bmcl.2011.06.113
None Unchecked Ratio CC50/IC50 4.0 None 10.1016/j.ejmech.2012.07.034
None Unchecked Ratio CC50/IC50 4.0 None 10.1016/j.ejmech.2014.07.113
None Unchecked Ratio CC50/IC50 4.0 None 10.1016/j.ejmech.2015.03.011
None Unchecked Ratio CC50/IC50 4.2 None 10.1016/j.ejmech.2011.06.021
None Unchecked Ratio IC50 2.3 None 10.1016/j.bmc.2009.05.022
None Unchecked Ratio IC50 2.3 None 10.1016/j.ejmech.2009.11.005
None Unchecked Ratio IC50 3.1 None 10.1016/j.bmc.2009.05.022
None Unchecked Ratio IC50 3.1 None 10.1016/j.ejmech.2009.11.005
None Unchecked TIME 0.008333 hr 10.1128/aac.00620-10
None Unchecked TIME 0.04722 hr 10.1128/aac.00620-10
None Unchecked TIME 0.05556 hr 10.1128/aac.00620-10

Metabolism Information