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name Structure Reference Source Properties Activities Metabolism

streptol

AlkaPlorer ID: AK003258

Synonym: 'Sulfanilamide'

IUPAC Name: 4-aminobenzenesulfonamide

Structure

SMILES: NC1=CC=C(S(N)(=O)=O)C=C1

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InChI: InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

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InChIKey: FDDDEECHVMSUSB-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 172.20900000000003

TPSA？: 86.18

MolLogP？: -0.0838

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Anopheles gambiae AGAP002992-PA Ki 862.0 nM 10.1016/j.bmc.2015.03.081
Aspergillus niger Aspergillus niger MIC 50.0 ug.mL-1 10.1007/s00044-012-0320-7
Astrosclera willeyana Astrosclerin-3 Ki 7700.0 nM 10.1016/j.bmc.2012.01.007
Bacillus cereus Bacillus cereus DIZ nan None 10.1016/j.ejmech.2013.03.012
Bacillus cereus Bacillus cereus MIC 55.0 ug.mL-1 10.1007/s00044-012-0320-7
Bacillus cereus Bacillus cereus MIC nan None 10.1016/j.ejmech.2013.03.012
Bacillus spizizenii Bacillus spizizenii MIC nan None 10.1016/j.ejmech.2019.01.062
Bacillus subtilis Bacillus subtilis Inhibition 10.5 mm 10.1016/j.bmcl.2004.09.084
Bacillus subtilis Bacillus subtilis Inhibition 11.5 mm 10.1016/j.bmcl.2004.09.084
Bacillus subtilis Bacillus subtilis Inhibition 13.0 mm 10.1016/j.bmcl.2004.09.084
Bacillus subtilis Bacillus subtilis MIC 128.0 ug 10.1016/j.bmcl.2007.07.043
Bacillus subtilis Bacillus subtilis MIC 128.0 ug.mL-1 10.1016/j.bmc.2006.10.027
Bacillus subtilis Bacillus subtilis Zone of inhibition nan None 10.1016/j.bmcl.2003.08.017
Bos taurus Carbonic anhydrase Log II50 0.0 None 10.1021/jm00125a005
Bos taurus Carbonic anhydrase II K 0.133 /s 10.1021/acs.jmedchem.5b01643
Bos taurus Carbonic anhydrase II K 2.3 10'4/M/s 10.1021/acs.jmedchem.5b01643
Bos taurus Carbonic anhydrase II Kd 5880.0 nM 10.1021/acs.jmedchem.5b01643
Bos taurus Carbonic anhydrase II Ki 851.14 nM 10.1016/j.bmcl.2010.11.050
Bos taurus Carbonic anhydrase II Ki 25118.86 nM 10.1016/j.bmcl.2010.11.050
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1016/j.bmcl.2004.12.009
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1016/s0960-894x(00)00178-5
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1016/s0960-894x(03)00091-x
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm0108202
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm021123s
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm031057+
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm9900523
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm9901879
Bos taurus Carbonic anhydrase IV Ki 3000.0 nM 10.1021/jm990479+
Bos taurus Carbonic anhydrase IV Ki 2999853181190.79 nM 10.1016/j.bmcl.2005.08.071
Bos taurus Carbonic anhydrase IV Ki 2999853181190.79 nM 10.1016/s0960-894x(02)00954-x
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Brucella suis biovar 1 Carbonic anhydrase Kinact 2500.0 nM 10.1021/jm901855h
Candida albicans Candida albicans Activity nan None 10.1016/j.bmcl.2006.11.079
Candida albicans Candida albicans MIC 60.0 ug.mL-1 10.1007/s00044-012-0320-7
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase FC 2.3 None 10.1021/jm1013242
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 7627.0 nM 10.1016/j.bmc.2009.05.002
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 7627.0 nM 10.1021/jm300203r
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 7630.0 nM 10.1021/jm1013242
Candida glabrata CBS 138 Carbonic anhydrase Ki 8011.0 nM 10.1016/j.bmcl.2013.02.092
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Ki 765.0 nM 10.1021/jm300203r
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Ki 770.0 nM 10.1021/jm1013242
Enterococcus faecalis Enterococcus faecalis IZ 14.2 mm 10.1016/j.ejmech.2014.08.016
Enterococcus faecalis Enterococcus faecalis MIC 128.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Enterococcus faecalis Enterococcus faecalis MIC 100000000.0 nM 10.1016/j.ejmech.2014.08.016
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmcl.2006.11.079
Escherichia coli Escherichia coli Antibiotic resistance nan None 10.1016/s0960-894x(98)00536-8
Escherichia coli Escherichia coli DIZ nan None 10.1016/j.ejmech.2013.03.012
Escherichia coli Escherichia coli Inhibition 16.5 mm 10.1016/j.bmcl.2004.09.084
Escherichia coli Escherichia coli Inhibition 18.0 mm 10.1016/j.bmcl.2004.09.084
Escherichia coli Escherichia coli Inhibition 20.5 mm 10.1016/j.bmcl.2004.09.084
Escherichia coli Escherichia coli IZ 15.8 mm 10.1016/j.ejmech.2014.08.016
Escherichia coli Escherichia coli IZ 20.43 mm 10.1016/j.bmcl.2004.10.076
Escherichia coli Escherichia coli IZ 22.3 mm 10.1016/j.bmcl.2004.10.076
Escherichia coli Escherichia coli IZ 22.86 mm 10.1016/j.bmcl.2004.10.076
Escherichia coli Escherichia coli IZ 25.55 mm 10.1016/j.bmcl.2004.10.076
Escherichia coli Escherichia coli -Log C -2.11 None 10.1021/jm00361a014
Escherichia coli Escherichia coli -Log C 2.824 None 10.1021/jm00361a014
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Escherichia coli Escherichia coli MIC 55.0 ug.mL-1 10.1007/s00044-012-0320-7
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Escherichia coli Escherichia coli MIC 128.0 ug 10.1016/j.bmcl.2007.07.043
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmc.2006.10.027
Escherichia coli Escherichia coli MIC 25000000.0 nM 10.1016/j.ejmech.2014.08.016
Escherichia coli Escherichia coli MIC nan None 10.1016/j.ejmech.2013.03.012
Escherichia coli Escherichia coli MIC nan None 10.1016/j.ejmech.2019.01.062
Escherichia coli Escherichia coli Zone of inhibition 20.4 mM 10.1016/j.bmcl.2003.08.017
Escherichia coli Escherichia coli Zone of inhibition 22.3 mM 10.1016/j.bmcl.2003.08.017
Escherichia coli Escherichia coli Zone of inhibition 22.8 mM 10.1016/j.bmcl.2003.08.017
Escherichia coli Escherichia coli Zone of inhibition 25.4 mM 10.1016/j.bmcl.2003.08.017
Escherichia coli K-12 Dihydropteroate synthase GII50 25000.0 None 10.1021/jm00136a015
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Carbonic anhydrase 1 Ki 431.0 nM 10.1016/j.bmcl.2006.01.044
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Carbonic anhydrase 1 Ki 454.0 nM 10.1021/jm0512600
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 145240.0 nM 10.1016/j.bmc.2019.01.012
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Inhibition 10.19 % 10.1016/j.bmc.2019.01.012
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Butyrylcholinesterase IC50 138790.0 nM 10.1016/j.bmc.2019.01.012
Homo sapiens Butyrylcholinesterase Inhibition 5.19 % 10.1016/j.bmc.2019.01.012
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase I Ki 300.0 nM 10.1016/j.bmc.2014.03.041
Homo sapiens Carbonic anhydrase I Ki 1000.0 nM 10.1021/acs.jmedchem.9b00282
Homo sapiens Carbonic anhydrase I Ki 5000.0 nM 10.1016/j.bmc.2012.01.052
Homo sapiens Carbonic anhydrase I Ki 5000.0 nM 10.1016/j.bmcl.2010.02.042
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2012.05.037
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmc.2017.08.047
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2004.12.052
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2006.01.044
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2011.03.055
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2016.03.014
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm0512600
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm0612057
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm1013242
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase I Ki 25000.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmc.2012.08.018
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2003.09.063
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2004.04.106
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2004.07.087
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2004.10.070
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2005.02.087
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2005.04.058
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2005.06.054
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2005.08.048
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/j.bmcl.2014.02.030
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/s0960-894x(00)00178-5
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/s0960-894x(00)00722-8
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1016/s0960-894x(03)00091-x
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm0108202
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm021123s
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm031057+
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm9900523
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm9901879
Homo sapiens Carbonic anhydrase I Ki 28000.0 nM 10.1021/jm990479+
Homo sapiens Carbonic anhydrase I Ki 42870.0 nM 10.1016/j.bmc.2015.10.009
Homo sapiens Carbonic anhydrase I Ki 28002705950106.27 nM 10.1016/j.bmcl.2005.08.071
Homo sapiens Carbonic anhydrase I Ki 28183829312644.49 nM 10.1016/s0960-894x(02)00954-x
Homo sapiens Carbonic anhydrase I Kinact 25.0 uM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase I Kinact 25000.0 nM 10.1016/j.bmcl.2007.04.063
Homo sapiens Carbonic anhydrase II IC50 256.0 nM 10.1016/j.ejmech.2020.112994
Homo sapiens Carbonic anhydrase II IC50 260.0 nM 10.1016/j.ejmech.2013.04.035
Homo sapiens Carbonic anhydrase II IC50 2400.0 nM 10.1016/j.bmcl.2004.07.085
Homo sapiens Carbonic anhydrase II IC50 7500.0 nM 10.1016/j.ejmech.2017.03.023
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II K 0.2053 /s 10.1021/acs.jmedchem.5b01643
Homo sapiens Carbonic anhydrase II K 3.7 10'4/M/s 10.1021/acs.jmedchem.5b01643
Homo sapiens Carbonic anhydrase II Kd 5550.0 nM 10.1021/acs.jmedchem.5b01643
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2012.01.052
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2012.05.037
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmc.2017.08.047
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2004.12.052
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2006.01.044
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2009.10.009
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2010.02.042
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2010.11.064
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2011.03.055
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2013.11.021
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2015.06.079
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2016.01.023
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2016.03.014
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm050483n
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm0512600
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm0612057
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm1013242
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm300203r
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II Ki 240.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase II Ki 296.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2003.09.063
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2004.04.106
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2004.07.087
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2004.10.070
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2005.02.087
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2005.04.058
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2005.06.054
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2005.08.048
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/j.bmcl.2014.02.030
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/s0960-894x(00)00178-5
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/s0960-894x(00)00722-8
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1016/s0960-894x(03)00091-x
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm0108202
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm021123s
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm031057+
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm9900523
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm9901879
Homo sapiens Carbonic anhydrase II Ki 300.0 nM 10.1021/jm990479+
Homo sapiens Carbonic anhydrase II Ki 363.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 628.0 nM 10.1016/j.bmc.2015.10.009
Homo sapiens Carbonic anhydrase II Ki 1000.0 nM 10.1021/acs.jmedchem.9b00282
Homo sapiens Carbonic anhydrase II Ki 10100.0 nM 10.1016/j.bmc.2012.08.018
Homo sapiens Carbonic anhydrase II Ki 28000.0 nM 10.1016/j.bmc.2014.03.041
Homo sapiens Carbonic anhydrase II Ki 300000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrase II Ki 3333496.47 nM 10.1016/j.bmcl.2005.08.071
Homo sapiens Carbonic anhydrase II Ki 3333496.47 nM 10.1016/s0960-894x(02)00954-x
Homo sapiens Carbonic anhydrase II Ki 3334264.13 nM 10.1016/j.bmcl.2010.03.104
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Carbonic anhydrase II Kinact 0.24 uM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase II Kinact 240.0 nM 10.1016/j.bmcl.2007.04.063
Homo sapiens Carbonic anhydrase II Selectivity 1.02 None 10.1016/j.bmcl.2004.10.070
Homo sapiens Carbonic anhydrase III Ki 988.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase III Ki 100000.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase III Ki 988000.0 nM 10.1016/j.bmc.2007.08.037
Homo sapiens Carbonic anhydrase IV Ki 3000.0 nM 10.1016/s0960-894x(00)00722-8
Homo sapiens Carbonic anhydrase IV Ki 9760.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase IV Ki 9760.0 nM 10.1016/j.bmcl.2004.12.009
Homo sapiens Carbonic anhydrase IV Ki 9760.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase IX IC50 290.0 nM 10.1016/j.ejmech.2013.04.035
Homo sapiens Carbonic anhydrase IX IC50 298.0 nM 10.1016/j.ejmech.2020.112994
Homo sapiens Carbonic anhydrase IX IC50 12000.0 nM 10.1016/j.ejmech.2017.03.023
Homo sapiens Carbonic anhydrase IX IC50 12000.0 nM 10.1016/j.ejmech.2021.113837
Homo sapiens Carbonic anhydrase IX Ki 238.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase IX Ki 238.0 nM 10.1021/jm0612057
Homo sapiens Carbonic anhydrase IX Ki 238.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase IX Ki 238.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmc.2012.01.052
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmc.2012.05.037
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmc.2017.08.047
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2004.03.099
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2004.04.106
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2004.07.087
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2004.10.070
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2005.02.087
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2005.04.058
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2005.08.048
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2011.03.055
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/j.bmcl.2014.02.030
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1016/s0960-894x(03)00091-x
Homo sapiens Carbonic anhydrase IX Ki 294.0 nM 10.1021/jm021123s
Homo sapiens Carbonic anhydrase IX Ki 1000.0 nM 10.1021/acs.jmedchem.9b00282
Homo sapiens Carbonic anhydrase IX Ki 294000.0 nM 10.1016/j.bmcl.2004.09.085
Homo sapiens Carbonic anhydrases; II & IX Ki 1.02 Ratio 10.1016/j.bmcl.2005.02.087
Homo sapiens Carbonic anhydrases; II & IX Selectivity 1.02 None 10.1016/j.bmcl.2004.07.087
Homo sapiens Carbonic anhydrase VA IC50 32000.0 nM 10.1016/j.bmcl.2004.07.085
Homo sapiens Carbonic anhydrase VA Ki 32000.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase VA Ki 32000.0 nM 10.1021/jm050483n
Homo sapiens Carbonic anhydrase VA Ki 32000.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VA Kinact 32000.0 nM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase VB Ki 3650.0 nM 10.1021/jm050483n
Homo sapiens Carbonic anhydrase VB Ki 3650.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VB Kinact 3650.0 nM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase VI Ki 941.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase VI Ki 941.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase VI Ki 941.0 nM 10.1021/jm0612057
Homo sapiens Carbonic anhydrase VI Ki 941.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase VI Ki 941.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VII Ki 70.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase VII Ki 70.0 nM 10.1016/j.bmcl.2004.12.052
Homo sapiens Carbonic anhydrase VII Ki 70.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmc.2012.01.052
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmc.2012.05.037
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmc.2017.08.047
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2005.06.054
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2005.08.048
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2011.03.055
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2011.07.090
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1016/j.bmcl.2014.02.030
Homo sapiens Carbonic anhydrase XII Ki 37.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XII Ki 1000.0 nM 10.1021/acs.jmedchem.9b00282
Homo sapiens Carbonic anhydrase XIII Ki 32.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XIII Ki 35.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase XIV Ki 5400.0 nM 10.1016/j.bmc.2012.01.052
Homo sapiens Carbonic anhydrase XIV Ki 5400.0 nM 10.1016/j.bmc.2013.11.016
Homo sapiens Carbonic anhydrase XIV Ki 5400.0 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase XIV Ki 5400.0 nM 10.1021/jm901524f
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholesterol 24-hydroxylase Activity 75.0 % None
Homo sapiens Chromobox protein homolog 1 Potency 79432.8 nM None
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition -17.8 % 10.1021/jm060706p
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HepG2 IC50 80.0 nM 10.1007/s00044-011-9737-7
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -5.99 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.55 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 IC50 200.0 nM 10.1007/s00044-011-9737-7
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MDA-MB-231 IC50 90.0 nM 10.1007/s00044-011-9737-7
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein argonaute-2 deltaH -1.7 kcal/mol 10.1016/j.bmcl.2020.127637
Homo sapiens Protein argonaute-2 deltaS 15.7 cal/mol.K 10.1016/j.bmcl.2020.127637
Homo sapiens Protein argonaute-2 Ka 5.9 10^4/M 10.1016/j.bmcl.2020.127637
Homo sapiens Protein argonaute-2 Kd 17000.0 nM 10.1016/j.bmcl.2020.127637
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 113.76 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 155.79 % 10.1124/mol.112.084152
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 1000.0 nM None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 35481.3 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 10000.0 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition nan None 10.1016/j.bmcl.2004.09.084
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug 10.1016/j.bmcl.2007.07.043
Klebsiella pneumoniae Klebsiella pneumoniae MIC 80.0 ug.mL-1 10.1007/s00044-012-0320-7
Klebsiella pneumoniae Klebsiella pneumoniae Zone of inhibition nan None 10.1016/j.bmcl.2003.08.017
Malassezia furfur Malassezia furfur MIC 80.0 ug.mL-1 10.1021/jm300203r
Malassezia pachydermatis Malassezia pachydermatis MIC 10.0 ug.mL-1 10.1021/jm300203r
Methanobacterium thermoautotrophicum Carbonic anhydrase Ki 57800.0 nM 10.1016/j.bmcl.2004.09.085
Methanosarcina thermophila Carbonic anhydrase Ki 250.0 nM 10.1016/j.bmcl.2004.09.085
Methanosarcina thermophila Carbonic anhydrase Ki 3930.0 nM 10.1016/j.bmcl.2004.09.085
Mus musculus Carbonic anhydrase 15 Ki 9610.0 nM 10.1021/jm801267c
Mus musculus Carbonic anhydrase 15 Ki 9610.0 nM 10.1021/jm901524f
Mus musculus Carbonic anhydrase XIII Ki 32.0 nM 10.1016/j.bmcl.2004.04.106
Mus musculus Carbonic anhydrase XIII Ki 32.0 nM 10.1016/j.bmcl.2004.12.052
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mycobacterium tuberculosis Carbonic anhydrase Ki 29600.0 nM 10.1016/j.bmcl.2009.10.009
Mycobacterium tuberculosis Mycobacterium tuberculosis GI 0.0 % 10.1021/acs.jnatprod.7b00570
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 10.0 uM 10.1021/acs.jnatprod.7b00570
Mycobacterium tuberculosis PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Ki 6240.0 nM 10.1016/j.bmcl.2010.11.064
Mycobacterium tuberculosis PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Ki 7110.0 nM 10.1021/jm1013242
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 9230.0 nM 10.1016/j.bmcl.2010.11.064
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 9840.0 nM 10.1021/jm1013242
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 9840.0 nM 10.1021/jm9003126
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 100.0 ug.mL-1 10.1016/j.bmcl.2006.11.079
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Pasteurella multocida Pasteurella multocida IZ 22.0 mm 10.1016/j.bmcl.2006.11.001
Pasteurella multocida Pasteurella multocida IZ 25.0 mm 10.1016/j.bmcl.2006.11.001
Pasteurella multocida Pasteurella multocida IZ 28.0 mm 10.1016/j.bmcl.2006.11.001
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.7b00570
Plasmodium falciparum Plasmodium falciparum Potency 4775.5 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa DIZ nan None 10.1016/j.ejmech.2013.03.012
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 13.5 mm 10.1016/j.bmcl.2004.09.084
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 15.5 mm 10.1016/j.bmcl.2004.09.084
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 17.5 mm 10.1016/j.bmcl.2004.09.084
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 65.0 ug.mL-1 10.1007/s00044-012-0320-7
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug 10.1016/j.bmcl.2007.07.043
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1016/j.bmc.2006.10.027
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1016/j.ejmech.2013.03.012
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1016/j.ejmech.2019.01.062
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Rattus norvegicus Activity 10.0 % 10.1016/j.bmc.2019.01.012
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 250.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 295.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 315.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 316.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 324.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 351.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 53.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 66.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 71.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 72.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 77.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 90.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 156.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 186.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 216.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 703.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 705.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 723.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 761.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 813.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 1013.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 187.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 205.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 230.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 269.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 400.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 651.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 23000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 92.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 116.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 129.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1496.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1506.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1563.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1653.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1806.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1816.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.85 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.05 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.53 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 126000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 136200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Inhibition 10.0 % 10.1016/j.bmc.2019.01.012
Rattus norvegicus Rattus norvegicus LDH 100.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 102.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 107.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 124.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 165.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 408.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12247.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12536.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12736.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13215.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13223.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15741.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 83.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 93.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 22.47 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.13 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.33 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.78 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.83 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 365000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 369700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 372200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 378000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.53 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.05 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 42.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 191.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 253.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 353.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 374.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 389.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 760.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1021.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1193.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1320.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1809.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2086.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 109.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 125.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 130.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1174000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1225330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1297330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1318000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1322170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1550000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.81 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.59 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.94 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.05 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.26 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 57300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5450000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5710000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5720000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5740000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5850000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.62 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.3 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.23 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 19.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 24.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14050.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14180.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15800.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18030.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Saccharomyces cerevisiae S288c Carbonic anhydrase Ki 18500.0 nM 10.1016/j.bmc.2008.12.035
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis IZ 10.0 mm 10.1016/j.bmcl.2006.11.001
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis IZ 12.0 mm 10.1016/j.bmcl.2006.11.001
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis IZ 16.0 mm 10.1016/j.bmcl.2006.11.001
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi DIZ nan None 10.1016/j.ejmech.2013.03.012
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC nan None 10.1016/j.ejmech.2013.03.012
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 14.2 mm 10.1016/j.ejmech.2014.08.016
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 100000000.0 nM 10.1016/j.ejmech.2014.08.016
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 14.84 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 16.04 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.04 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.73 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 53.84 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.1687 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmcl.2006.11.079
Staphylococcus aureus Staphylococcus aureus Antibiotic resistance nan None 10.1016/s0960-894x(98)00536-8
Staphylococcus aureus Staphylococcus aureus DIZ nan None 10.1016/j.ejmech.2013.03.012
Staphylococcus aureus Staphylococcus aureus Inhibition 20.5 mm 10.1016/j.bmcl.2004.09.084
Staphylococcus aureus Staphylococcus aureus Inhibition 22.5 mm 10.1016/j.bmcl.2004.09.084
Staphylococcus aureus Staphylococcus aureus Inhibition 25.0 mm 10.1016/j.bmcl.2004.09.084
Staphylococcus aureus Staphylococcus aureus IZ 16.8 mm 10.1016/j.ejmech.2014.08.016
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1007/s00044-012-0320-7
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2022.128695
Staphylococcus aureus Staphylococcus aureus MIC 12500000.0 nM 10.1016/j.ejmech.2014.08.016
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.ejmech.2013.03.012
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.ejmech.2019.01.062
Staphylococcus epidermidis Staphylococcus epidermidis MIC 512.0 ug 10.1016/j.bmcl.2007.07.043
Staphylococcus epidermidis Staphylococcus epidermidis MIC 512.0 ug.mL-1 10.1016/j.bmc.2006.10.027
Streptococcus pneumoniae Streptococcus pneumoniae IZ 15.8 mm 10.1016/j.ejmech.2014.08.016
Streptococcus pneumoniae Streptococcus pneumoniae MIC 25000000.0 nM 10.1016/j.ejmech.2014.08.016
Stylophora pistillata Alpha carbonic anhydrase Ki 364.0 nM 10.1016/j.bmc.2009.05.063
Stylophora pistillata Alpha carbonic anhydrase Ki 364.0 nM 10.1016/j.bmcl.2010.11.124
Stylophora pistillata Carbonic anhydrase Ki 300.0 nM 10.1016/j.bmcl.2010.11.124
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Ki 652.0 nM 10.1016/j.bmcl.2015.11.104
Thalassiosira weissflogii Delta carbonic anhydrase Ki 181.0 nM 10.1016/j.bmcl.2013.11.021
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Ki 628.0 nM 10.1016/j.bmcl.2015.11.104
Vibrio Vibrio MIC 512.0 ug.mL-1 10.1016/j.bmc.2006.10.027
Vibrio harveyi Vibrio harveyi Activity nan None 10.1016/j.bmcl.2006.11.079
Vibrio sp. Vibrio sp. MIC 512.0 ug 10.1016/j.bmcl.2007.07.043
None ADMET Inhibitor level 143.0 None 10.1021/jm990479+
None ADMET Inhibitor level 148.0 None 10.1021/jm990479+
None ADMET Inhibitor level 151.0 None 10.1021/jm990479+
None ADMET Inhibitor level 159.0 None 10.1021/jm990479+
None ADMET Inhibitor level 164.0 None 10.1021/jm990479+
None ADMET LD50 3500.0 mg.kg-1 10.1016/j.bmc.2019.01.012
None ADMET Log 1/C -0.3 None 10.1016/j.bmcl.2004.08.051
None ADMET -Log alpha -2.98 None 10.1021/jm00361a014
None ADMET log Ks 2.76 None 10.1016/j.bmc.2008.11.040
None ADMET pC -0.301 None 10.1016/j.bmcl.2004.12.057
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Inhibition 7.0 mm 10.1016/j.bmcl.2004.09.084
None NON-PROTEIN TARGET Inhibition 7.5 mm 10.1016/j.bmcl.2004.09.084
None NON-PROTEIN TARGET MIC 80.0 ug.mL-1 10.1021/jm300203r
None NON-PROTEIN TARGET MIC 160.0 ug.mL-1 10.1021/jm300203r
None NON-PROTEIN TARGET Potency 0.7 nM None
None No relevant target Log K -0.0315 None 10.1021/jm00361a014
None No relevant target LogP -1.69 None 10.1021/jm00218a017
None No relevant target LogP -1.6 None 10.1016/j.bmcl.2004.08.051
None No relevant target LogP -0.83 None 10.1021/jm00218a017
None No relevant target LogP -0.62 None 10.1021/jm0611105
None No relevant target LogP 0.025 None 10.1016/j.bmcl.2004.12.057
None No relevant target LogP 1.47 None 10.1007/s00044-011-9737-7
None No relevant target pKa 10.08 None 10.1021/jm00361a014
None No relevant target pKa 10.43 None 10.1021/jm00136a015
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 1.0 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 1000.0 nM None
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked EII50 25.0 None 10.1021/jm00136a015
None Unchecked FC 1.0 None 10.1021/jm00187a025
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 nan None None
None Unchecked Inhibition nan % 10.1016/j.bmcl.2020.127637
None Unchecked Ki 68.0 nM 10.1021/acsmedchemlett.0c00417
None Unchecked Ki 95.3 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 95.3 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 245.0 nM 10.1021/jm300203r
None Unchecked Ki 250.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 250.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 250.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 251.0 nM 10.1016/j.bmc.2012.02.029
None Unchecked Ki 277.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 316.0 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 447.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 447.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 447.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 471.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 471.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 471.0 nM 10.1021/jm301611m
None Unchecked Ki 488.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 488.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 488.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 583.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 715.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 765.0 nM 10.1016/j.bmc.2009.05.002
None Unchecked Ki 803.0 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 808.0 nM 10.1016/j.bmcl.2016.07.060
None Unchecked Ki 867.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 893.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 893.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 893.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 893.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 893.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 946.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 1086.0 nM 10.1016/j.bmcl.2010.11.064
None Unchecked Ki 1360.0 nM 10.1021/jm031057+
None Unchecked Ki 1720.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 1845.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 1845.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 1975.0 nM 10.1016/j.bmcl.2015.04.037
None Unchecked Ki 2500.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 2500.0 nM 10.1016/j.bmcl.2010.02.042
None Unchecked Ki 3895.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 5080.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 5800.0 nM 10.1016/j.bmc.2014.12.009
None Unchecked Ki 6076.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 6510.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 7110.0 nM 10.1021/jm9003126
None Unchecked Ki 8800.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 9210.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 9210.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 9251.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 9251.0 nM 10.1021/jm400939k
None Unchecked Ki 9840.0 nM 10.1021/jm9000488
None Unchecked Ki 23442.29 nM 10.1016/j.bmcl.2004.08.051
None Unchecked Ki 25400.0 nM 10.1016/j.bmc.2010.06.056
None Unchecked Ki 57300.0 nM 10.1021/jm4000616
None Unchecked Ki 69310.0 nM 10.1016/j.bmc.2012.08.018
None Unchecked Ki 130000.0 nM 10.1021/jm00367a001
None Unchecked Ki 399944749.76 nM 10.1021/jm00187a025
None Unchecked Ki 433510878.39 nM 10.1021/jm00187a025
None Unchecked Ki 43651583224016.66 nM 10.1016/j.bmcl.2004.12.057
None Unchecked Ki nan None None
None Unchecked Kinact 454.0 nM 10.1016/j.bmcl.2007.04.063
None Unchecked Kinact 1845.0 nM 10.1016/j.bmcl.2007.04.063
None Unchecked Potency 31622.8 nM None
None Unchecked Ratio 0.096 None 10.1016/j.bmcl.2010.02.042
None Unchecked Ratio 0.22 None 10.1021/jm031057+
None Unchecked Ratio 3.25 None 10.1016/j.bmcl.2004.12.009
None Unchecked Ratio 10.0 None 10.1016/j.bmcl.2010.02.042
None Unchecked Ratio Ki 0.02 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.03 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.3 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.52 None 10.1021/jm0512600
None Unchecked Ratio Ki 0.55 None 10.1016/j.bmcl.2006.01.044
None Unchecked Ratio Ki 0.8 None 10.1016/j.bmc.2012.05.037
None Unchecked Ratio Ki 0.81 None 10.1016/j.bmcl.2011.03.055
None Unchecked Ratio Ki 0.81 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 1.22 None 10.1016/j.bmc.2017.08.047
None Unchecked Ratio Ki 2.5 None 10.1021/jm1013242
None Unchecked Ratio Ki 3.3 None 10.1021/jm1013242
None Unchecked Ratio Ki 3.5 None 10.1021/jm1013242
None Unchecked Ratio Ki 6.48 None 10.1016/j.bmc.2017.08.047
None Unchecked Ratio Ki 6.5 None 10.1016/j.bmc.2012.05.037
None Unchecked Ratio Ki 6.5 None 10.1016/j.bmcl.2011.03.055
None Unchecked Ratio Ki 6.5 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 32.5 None 10.1021/jm1013242
None Unchecked Ratio Ki 85.0 None 10.1016/j.bmc.2012.05.037
None Unchecked Ratio Ki 85.0 None 10.1016/j.bmcl.2011.03.055
None Unchecked Ratio Ki 85.0 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 85.01 None 10.1016/j.bmc.2017.08.047
None Unchecked Ratio Ki 675.0 None 10.1016/j.bmc.2012.05.037
None Unchecked Ratio Ki 675.0 None 10.1016/j.bmcl.2011.03.055
None Unchecked Ratio Ki 675.0 None 10.1016/j.bmcl.2011.07.090
None Unchecked Ratio Ki 675.66 None 10.1016/j.bmc.2017.08.047
None Unchecked Selectivity 0.07 None 10.1016/j.bmcl.2004.07.085
None Unchecked Selectivity ratio 120.0 None 10.1016/j.bmc.2009.11.021

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT020661 Nc1ccc(S(N)(=O)=O)cc1.N=c1[nH]c2c(c(=O)[nH]1)N=C(COP(=O)(O)OP(=O)(O)O)CN2>>N=c1[nH]c2c(c(=O)[nH]1)N=C(CNc1ccc(S(N)(=O)=O)cc1)CN2 enzymemap_40087
AKRT020662 Nc1ccc(S(N)(=O)=O)cc1>>Nc1ccc(S(=O)(=O)O)cc1 enzymemap_77432
AKRT021175 Nc1nc2c(c(=O)[nH]1)N=C(COP(=O)(O)OP(=O)(O)O)CN2.Nc1ccc(S(N)(=O)=O)cc1>>Nc1nc2c(c(=O)[nH]1)N=C(CNc1ccc(S(N)(=O)=O)cc1)CN2 enzymemap_40087