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Isocycloheximide

AlkaPlorer ID: AK003312

Synonym: None

IUPAC Name: 4-[(2R)-2-[(1R,3R,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

Structure

SMILES: C[C@H]1C[C@@H](C)C(=O)[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C1

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InChI: InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9+,11+,12+/m0/s1

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InChIKey: YPHMISFOHDHNIV-LUTQBAROSA-N

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Properties Information

Molecule Weight: 281.35200000000003

TPSA？: 83.47

MolLogP？: 1.0415

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 158.5 nM None
Chlorocebus sabaeus Vero CC50 960.0 nM None
Chlorocebus sabaeus Vero IC50 430.0 nM None
Giardia Giardia Potency 72.9 nM None
Herpes simplex virus (type 1 / strain 17) Alpha trans-inducing protein (VP16) IC50 85413.0 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 4466.8 nM None
Homo sapiens Alpha-synuclein Potency 3548.1 nM None
Homo sapiens Ataxin-2 Potency 891.3 nM None
Homo sapiens Ataxin-2 Potency 1778.3 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 517.1 nM None
Homo sapiens BJ EC50 708.0 nM None
Homo sapiens BJ EC50 728.0 nM None
Homo sapiens BJ EC50 973.0 nM None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 1000.0 nM None
Homo sapiens COUP transcription factor 2 IC50 1032.0 nM None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Geminin Potency 4610.9 nM None
Homo sapiens Geminin Potency 20596.2 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 1000.0 nM None
Homo sapiens Heat shock protein HSP 90-alpha AC50 195.0 nM None
Homo sapiens HepG2 Potency 398.1 nM None
Homo sapiens Huntingtin Potency 354.8 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 63.1 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 651.3 nM None
Homo sapiens Jurkat IC50 6810.0 nM None
Homo sapiens microRNA 21 Potency 232.8 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 326.4 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 707.9 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 1032.3 nM None
Homo sapiens Niemann-Pick C1 protein Potency 316.2 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 410.9 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 12995.3 nM None
Homo sapiens Prelamin-A/C Potency 1000.0 nM None
Homo sapiens Ras-related protein Rab-9A Potency 316.2 nM None
Homo sapiens Survival motor neuron protein Potency 891.3 nM None
Homo sapiens TAR DNA-binding protein 43 Potency 891.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 183.6 nM None
Homo sapiens X-box-binding protein 1 IC50 210.0 nM None
Influenza A virus Nonstructural protein 1 Potency 316.2 nM None
Mus musculus DNA damage-inducible transcript 3 protein IC50 160.0 nM None
Mus musculus Heat shock factor protein 1 AC50 336.0 nM None
Mus musculus Heat shock factor protein 1 EC50 660.0 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 251.2 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 2818.4 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 35481.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 32.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 73.8 nM None
Plasmodium falciparum 3D7 HSP90 AC50 195.0 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 10000.0 nM None
Saccharomyces cerevisiae S288c 60S ribosomal protein L19-A EC50 570.0 nM None
None Unchecked AbsAC40_uM 0.16 uM None
None Unchecked AC50 307.0 nM None
None Unchecked AC50 2180.0 nM None
None Unchecked AC50 4920.0 nM None
None Unchecked AC50 70000.0 nM None
None Unchecked EC50 1.0 nM None
None Unchecked EC50 4.0 nM None
None Unchecked EC50 100.0 nM None
None Unchecked EC50 637.0 nM None
None Unchecked IC50 309.0 nM None
None Unchecked IC50 450.0 nM None
None Unchecked IC50 80000.0 nM None
None Unchecked Potency 31.6 nM None
None Unchecked Potency 79.4 nM None
None Unchecked Potency 100.0 nM None
None Unchecked Potency 231.1 nM None
None Unchecked Potency 251.2 nM None
None Unchecked Potency 316.2 nM None
None Unchecked Potency 707.9 nM None
None Unchecked Potency 794.3 nM None
None Unchecked Potency 891.3 nM None
None Unchecked Potency 1032.3 nM None
None Unchecked Potency 1122.0 nM None
None Unchecked Potency 1158.2 nM None
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 1299.5 nM None
None Unchecked Potency 1778.3 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 5623.4 nM None
None Unchecked Potency 11220.2 nM None

Metabolism Information