Molecule

Naramycin B

AlkaPlorer ID: AK003320

Synonym: None

IUPAC Name: 4-[(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

Structure

SMILES: C[C@H]1C[C@H](C)C(=O)[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C1

InChI: InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11+,12+/m0/s1

InChIKey: YPHMISFOHDHNIV-GAIPPQHRSA-N

Reference

Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of <i>Streptomyces</i> sp.

PubChem CID: 120760

CAS: 1412-79-9

LOTUS: LTS0036511

SuperNatural Ⅲ: SN0456653-05

NPASS: NPC200085

{

NPAtlas: NPA012393

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Streptomyces blastmyceticus	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria
Croton californicus	Croton	Euphorbiaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Malva crispa	Malva	Malvaceae	Malvales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Albugo candida	Albugo	Albuginaceae	Albuginales	None	Oomycota	None	Eukaryota
Polysphondylium violaceum	Polysphondylium	Dictyosteliaceae	Dictyosteliales	Eumycetozoa	Evosea	None	Eukaryota
Dendrobium rotundatum	Dendrobium	Orchidaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Graphis elongata	Graphis	Graphidaceae	Ostropales	Lecanoromycetes	Ascomycota	Fungi	Eukaryota
Distolasterias nipon	Distolasterias	Asteriidae	Forcipulatida	Asteroidea	Echinodermata	Metazoa	Eukaryota
Rhinella paracnemis	Rhinella	Bufonidae	Anura	Amphibia	Chordata	Metazoa	Eukaryota
Toxicodendron succedaneum	Toxicodendron	Anacardiaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ceiba pentandra	Ceiba	Malvaceae	Malvales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Streptomyces griseus	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria
Picrorhiza kurrooa	Picrorhiza	Plantaginaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ratibida latipalearis	Ratibida	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Phellinus xeranticus	Phellinus	Hymenochaetaceae	Hymenochaetales	Agaricomycetes	Basidiomycota	Fungi	Eukaryota
Weddellina squamulosa	Weddellina	Podostemaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Streptomyces sp. H7667	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria
Homarus americanus	Homarus	Nephropidae	Decapoda	Malacostraca	Arthropoda	Metazoa	Eukaryota
Culcitium canescens	Culcitium	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Angelica capitellata	Angelica	Apiaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 281.35200000000003

TPSA？: 83.47

MolLogP？: 1.0415

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bacillus anthracis	Anthrax lethal factor	Potency	125.9	nM	None
Bacillus anthracis	Anthrax lethal factor	Potency	199.5	nM	None
Homo sapiens	Cytochrome P450 1A2	AC50	39810.72	nM	None
Homo sapiens	Cytochrome P450 2C19	AC50	15848.93	nM	None
Homo sapiens	Cytochrome P450 2C19	Potency	15848.9	nM	None
Homo sapiens	Cytochrome P450 2C9	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2D6	AC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	AC50	nan	None	None
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	12.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	15.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	16.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	22.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	25.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	33.0	mm	10.1021/np900163f
Homo sapiens	Glycogen synthase kinase-3 beta	IZ	nan	None	10.1021/np900163f
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	84.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	133.4	nM	None
Mus musculus	Nuclear receptor ROR-gamma	Potency	100.0	nM	None
Mus musculus	Nuclear receptor ROR-gamma	Potency	28183.8	nM	None
None	Unchecked	Potency	446.7	nM	None
None	Unchecked	Potency	1258.9	nM	None
None	Unchecked	Potency	3162.3	nM	None
None	Unchecked	Potency	35481.3	nM	None