Molecule

Quindoline

AlkaPlorer ID: AK003458

Synonym: None

IUPAC Name: 10H-indolo[3,2-b]quinoline

Structure

SMILES: C1=CC=C2N=C3C(=CC2=C1)NC1=CC=CC=C13

InChI: InChI=1S/C15H10N2/c1-3-7-12-10(5-1)9-14-15(17-12)11-6-2-4-8-13(11)16-14/h1-9,16H

InChIKey: QOAKRWLMTKEDDL-UHFFFAOYSA-N

Reference

New Alkaloids from Cryptolepis sanguinolenta

PubChem CID: 98912

CAS: 243-58-3

LOTUS: LTS0007392

COCONUT: CNP0161694

data_source: manually

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Cryptolepis sanguinolenta	Cryptolepis	Apocynaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 218.259

TPSA？: 28.68

MolLogP？: 3.869300000000001

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 4

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	A2780	IC50	21500.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	A2780	IC50	24500.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	CH1	IC50	15500.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	CH1	IC50	30000.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	SK-OV-3	IC50	66000.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	Telomerase reverse transcriptase	IC50	138000.0	nM	10.1016/j.ejmech.2021.113938
Homo sapiens	Telomerase reverse transcriptase	IC50	nan	nM	10.1016/s0960-894x(00)00378-4
Plasmodium berghei	Plasmodium berghei	Activity	48.2	%	10.1021/np9605246
Plasmodium falciparum	Histidine-rich protein	Inhibition	nan	%	10.1021/jm010929+
Plasmodium falciparum	Plasmodium falciparum	IC50	0.063	ug.mL-1	10.1021/np9605246
Plasmodium falciparum	Plasmodium falciparum	IC50	0.087	ug.mL-1	10.1021/np9605246
Plasmodium falciparum	Plasmodium falciparum	IC50	0.108	ug.mL-1	10.1021/np9605246
Plasmodium falciparum	Plasmodium falciparum	IC50	36200.0	nM	10.1021/jm0010419
Plasmodium falciparum	Plasmodium falciparum	IC50	100000.0	nM	10.1021/jm010929+
Plasmodium falciparum	Plasmodium falciparum	IC50	229000.0	nM	10.1016/j.ejmech.2021.113938
Plasmodium falciparum	Plasmodium falciparum	IS	1.3	None	10.1021/jm0010419
Plasmodium yoelii	Plasmodium yoelii	Activity	42.1	%	10.1021/np9605246
Rattus norvegicus	L6	IC50	48600.0	nM	10.1021/jm0010419
Saccharomyces cerevisiae	Saccharomyces cerevisiae	IC12	150.0	ug ml-1	10.1021/np990035g
Trypanosoma cruzi	Trypanosoma cruzi	IC50	8700.0	nM	10.1021/jm0010419
Trypanosoma cruzi	Trypanosoma cruzi	IC50	14200.0	nM	10.1021/jm0010419
Trypanosoma cruzi	Trypanosoma cruzi	IC50	50000.0	nM	10.1021/jm0010419
Trypanosoma cruzi	Trypanosoma cruzi	IS	3.4	None	10.1021/jm0010419
None	ADMET	IC50	45000.0	nM	10.1021/jm0010419
None	NON-PROTEIN TARGET	IC50	15500.0	nM	10.1016/s0960-894x(00)00378-4
None	NON-PROTEIN TARGET	IC50	21500.0	nM	10.1016/s0960-894x(00)00378-4
None	NON-PROTEIN TARGET	IC50	24500.0	nM	10.1016/s0960-894x(00)00378-4
None	NON-PROTEIN TARGET	IC50	30000.0	nM	10.1016/s0960-894x(00)00378-4
None	NON-PROTEIN TARGET	IC50	66000.0	nM	10.1016/s0960-894x(00)00378-4
None	No relevant target	pKa	4.2	None	10.1016/j.ejmech.2021.113938
None	No relevant target	pKa	4.2	None	10.1021/jm050041b
None	Unchecked	IC50	138000.0	nM	10.1021/jm050041b