Corynoxine
AlkaPlorer ID: AK003522
Synonym: '', '7-Isocorynoxine', "methyl(E)-2-(3R,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine-7'-yl-3-methoxyprop-2-enoate", 'Mitrinermine', 'SMR000470794', '(+/-)-Isorhynchophylline', 'MLS000728608', 'Isorhynchophylline', 'Corynoxine B', "methyl(E)-2-(3S,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine-7'-yl-3-methoxyprop-2-enoate", 'MLSMR', 'Corynoxine', 'Rhynchophylline', "methyl(E)-2-(3S,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine-7'-yl-3-methoxyprop-2-enoate", "methyl(E)-2-(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine-7'-yl-3-methoxyprop-2-enoate"
IUPAC Name: None
Structure
SMILES: CC[C@H]1CN2CC[C@]3(C(O)=[NH+]C4=CC=CC=C43)[C@@H]2C[C@@H]1/C(=C/OC)C(=O)OC
InChI: InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/p+1/b16-13-/t14-,15-,19-,22+/m0/s1
InChIKey: DAXYUDFNWXHGBE-YCBKVTMHSA-O
Source
Properties Information
Molecule Weight: 385.4840000000002
TPSA？: 72.97
MolLogP？: 1.4303000000000008
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | Thoracic aorta | IC50 | 174200.0 | nM | 10.1016/j.ejmech.2017.08.026 |