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name Structure Reference Source Properties Activities Metabolism

Isocryptolepine

AlkaPlorer ID: AK003614

Synonym: None

IUPAC Name: 5-methylindolo[3,2-c]quinoline

Structure

SMILES: CN1C=C2C(=NC3=CC=CC=C23)C2=CC=CC=C21

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InChI: InChI=1S/C16H12N2/c1-18-10-13-11-6-2-4-8-14(11)17-16(13)12-7-3-5-9-15(12)18/h2-10H,1H3

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InChIKey: GLYLOCYYFNTVGX-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Cryptolepis sanguinolenta Cryptolepis Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 232.286

TPSA？: 17.82

MolLogP？: 3.8313000000000015

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 2103.78 nM None
Homo sapiens A498 GI50 1741.81 nM None
Homo sapiens A549 GI50 2172.7 nM None
Homo sapiens A549 IC50 1210.0 nM 10.1016/j.ejmech.2015.02.047
Homo sapiens A549 IC50 1210.0 nM 10.1016/j.ejmech.2021.113938
Homo sapiens A549 Ratio IC50 6.93 None 10.1016/j.ejmech.2015.02.047
Homo sapiens ACHN GI50 1706.08 nM None
Homo sapiens BT-549 GI50 3258.37 nM None
Homo sapiens CAKI-1 GI50 2317.39 nM None
Homo sapiens CCRF-CEM GI50 1448.77 nM None
Homo sapiens COLO 205 GI50 1462.18 nM None
Homo sapiens DU-145 GI50 2312.06 nM None
Homo sapiens HCC 2998 GI50 1603.25 nM None
Homo sapiens HCT-116 GI50 1000.0 nM None
Homo sapiens HCT-15 GI50 1967.89 nM None
Homo sapiens HepG2 IC50 730.0 nM 10.1016/j.ejmech.2015.02.047
Homo sapiens HepG2 IC50 730.0 nM 10.1016/j.ejmech.2021.113938
Homo sapiens HepG2 Ratio IC50 11.41 None 10.1016/j.ejmech.2015.02.047
Homo sapiens HL-60 GI50 2037.04 nM None
Homo sapiens HOP-62 GI50 1592.21 nM None
Homo sapiens HOP-92 GI50 1914.26 nM None
Homo sapiens Hs-578T GI50 2296.15 nM None
Homo sapiens HT-29 GI50 1288.25 nM None
Homo sapiens HuCC-A1 IC50 1810.0 nM 10.1016/j.ejmech.2021.113938
Homo sapiens IGROV-1 GI50 1625.55 nM None
Homo sapiens K562 GI50 1940.89 nM None
Homo sapiens KM12 GI50 2079.7 nM None
Homo sapiens LOX IMVI GI50 1766.04 nM None
Homo sapiens M14 GI50 1625.55 nM None
Homo sapiens Malme-3M GI50 2275.1 nM None
Homo sapiens MCF7 GI50 2673.01 nM None
Homo sapiens MDA-MB-231 GI50 2349.63 nM None
Homo sapiens MDA-MB-435 GI50 2387.81 nM None
Homo sapiens MDA-N GI50 2037.04 nM None
Homo sapiens MOLT-3 IC50 730.0 nM 10.1016/j.ejmech.2021.113938
Homo sapiens MOLT-3 Ratio IC50 11.41 None 10.1016/j.ejmech.2015.02.047
Homo sapiens MOLT-4 GI50 420.73 nM None
Homo sapiens MRC5 IC50 8352.0 nM 10.1016/j.ejmech.2015.02.047
Homo sapiens NCI/ADR-RES GI50 1717.91 nM None
Homo sapiens NCI-H23 GI50 1506.61 nM None
Homo sapiens NCI-H460 GI50 1442.12 nM None
Homo sapiens NCI-H522 GI50 1406.05 nM None
Homo sapiens OVCAR-3 GI50 2355.05 nM None
Homo sapiens OVCAR-4 GI50 1918.67 nM None
Homo sapiens OVCAR-5 GI50 2142.89 nM None
Homo sapiens OVCAR-8 GI50 1595.88 nM None
Homo sapiens PC-3 GI50 2517.68 nM None
Homo sapiens RPMI-8226 GI50 1534.62 nM None
Homo sapiens SF-268 GI50 2333.46 nM None
Homo sapiens SF-295 GI50 2779.71 nM None
Homo sapiens SF-539 GI50 1721.87 nM None
Homo sapiens SK-MEL-2 GI50 1914.26 nM None
Homo sapiens SK-MEL-28 GI50 2382.32 nM None
Homo sapiens SK-MEL-5 GI50 1698.24 nM None
Homo sapiens SK-OV-3 GI50 1986.09 nM None
Homo sapiens SN12C GI50 1566.75 nM None
Homo sapiens SNB-19 GI50 2964.83 nM None
Homo sapiens SNB-75 GI50 1798.87 nM None
Homo sapiens SR GI50 397.19 nM None
Homo sapiens SW-620 GI50 1122.02 nM None
Homo sapiens T47D GI50 2065.38 nM None
Homo sapiens TK-10 GI50 3926.45 nM None
Homo sapiens U-251 GI50 2415.46 nM None
Homo sapiens UACC-257 GI50 2306.75 nM None
Homo sapiens UACC-62 GI50 1603.25 nM None
Homo sapiens UO-31 GI50 1399.59 nM None
Plasmodium falciparum Plasmodium falciparum IC50 410.0 nM 10.1016/j.ejmech.2015.02.047
Plasmodium falciparum Plasmodium falciparum IC50 462.8 nM 10.1016/j.ejmech.2015.02.047
Plasmodium falciparum Plasmodium falciparum IC50 585.0 nM 10.1016/j.ejmech.2015.02.047
Plasmodium falciparum Plasmodium falciparum IC50 778.6 nM 10.1016/j.ejmech.2015.02.047
Plasmodium falciparum Plasmodium falciparum IC50 780.0 nM 10.1016/j.bmc.2014.03.030
Plasmodium falciparum Plasmodium falciparum IC50 780.0 nM 10.1016/j.ejmech.2021.113938
Rattus norvegicus L6 IC50 1190.0 nM 10.1016/j.bmc.2014.03.030
None ADMET Ratio CC50/IC50 1.8 None 10.1016/j.ejmech.2021.113938
None NON-PROTEIN TARGET IC50 730.0 nM 10.1016/j.ejmech.2015.02.047
None NON-PROTEIN TARGET IC50 1810.0 nM 10.1016/j.ejmech.2015.02.047
None Nucleic Acid Inhibition nan % 10.1016/j.bmc.2009.08.057
None Unchecked Inhibition nan % 10.1016/j.bmc.2009.08.057
None Unchecked Ratio IC50 1.5 None 10.1016/j.bmc.2014.03.030
None Unchecked Ratio IC50 4.62 None 10.1016/j.ejmech.2015.02.047
None Unchecked Ratio IC50 10.72 None 10.1016/j.ejmech.2015.02.047
None Unchecked Ratio IC50 14.27 None 10.1016/j.ejmech.2015.02.047
None Unchecked Ratio IC50 18.04 None 10.1016/j.ejmech.2015.02.047
None Unchecked Ratio IC50 20.37 None 10.1016/j.ejmech.2015.02.047

Metabolism Information